Sample collecting device of microfluidic equipment

Abstract

The utility model provides a sample collecting device of microfluidic equipment, which relates to the technical field of microfluidic, and comprises a collecting pipe clamp and a limiting device, the limiting device is fixedly arranged on the collecting pipe clamp, and when the collecting pipe clamp moves in place towards a liquid outlet of the microfluidic equipment, the limiting device is used for limiting the liquid outlet of the microfluidic equipment. A preset distance is kept between the collecting pipe clamp and a liquid outlet of the microfluidic equipment; the molded surface of the limiting device is matched with the molded surface of the bottle opening of the collecting pipe to be installed. The collecting pipe clamp is obliquely arranged; the limiting device is fixed to the left side or the right side of the collecting pipe clamp in an inverted mode, and the inclination angle of the limiting device is consistent with the inclination angle of the collecting pipe clamp. The collecting pipe clamp can drive the collecting pipe to move in the horizontal direction. The limiting device is arranged on the collecting pipe clamp, so that a proper distance is always kept between the collecting pipe and the liquid outlet, product waste is avoided, equipment damage is prevented, and operation is simple, convenient and reliable.

Description

TECHNICAL FIELD

[0001] The utility model relates to micro -fluidic technique field, concretely relates to a sample collection device of micro -fluidic equipment. BACKGROUND

[0002] Micro -fluidic technology is a kind of technology that is accurately controlled and manipulated fluid at micron scale, and its core is to integrate the sample preparation, reaction, separation, detection etc. Basic operation unit in biological, chemical, medical analysis process to micron scale chip, to complete the analysis whole process automatically. With the development of biological, chemical, medical etc. Field, micro -fluidic technology has become an important research field of multidisciplinary crossing. In nanotechnology field, micro -fluidic device can prepare nanoparticles in a highly repetitive and high throughput manner, and practice shows that using micro -fluidic device can not only greatly improve the reaction yield, but also can improve the particle size and shape distribution.

[0003] At present, in the preparation process of mRNA and lipid nanoparticles (LNPs), micro -fluidic equipment is generally used to complete mixing. This method not only can well control the size uniformity of liposome, but also can accurately control the liposome size, drug encapsulation amount etc. Characteristics by adjusting the flow parameters of each phase fluid, has significant technical advantages.

[0004] However, in the actual use process of micro -fluidic equipment, since the collection tube needs to be manually clamped to the collection tube clamp for product collection, the following technical problems often occur: when the distance between the collection tube and the liquid outlet is too large, part of the product will be lost, causing product waste;When the distance between the collection tube and the liquid outlet is too small, the collection tube nozzle is easy to scratch the liquid outlet, not only will damage the micro -fluidic equipment, but also will affect the accuracy of the equipment. These problems seriously affect the use effect and product yield of micro -fluidic equipment. UTILITY MODEL CONTENTS

[0005] The utility model aims at providing a kind of sample collection device of micro -fluidic equipment, can realize guaranteeing that the distance between collection tube and liquid outlet keeps appropriate, avoid product waste and equipment damage.

[0006] To achieve the above object, the utility model realizes by the following technical scheme:

[0007] A kind of sample collection device of micro -fluidic equipment, including: collection tube clamp and limiting device, the limiting device is fixedly arranged on the collection tube clamp, when collection tube clamp moves to position to micro -fluidic equipment liquid outlet, the collection tube clamp and the liquid outlet of micro -fluidic equipment keep predetermined distance between;The profile of the limiting device is engaged with the bottle mouth profile to be installed collection tube.

[0008] Further, the limiting device is L-shaped structure.

[0009] Further, the L-shaped structure includes a short side and a long side, the length of the short side is 2-4mm, and the length of the long side is 20-40mm.

[0010] Further, the collecting tube clamp is arranged in an inclined manner.

[0011] Further, the limiting device is fixed on the collecting tube clamp in an inverted manner, and the inclination angle of the limiting device is consistent with the inclination angle of the collecting tube clamp.

[0012] Further, the limiting device is fixed on the left side or the right side of the collecting tube clamp.

[0013] Further, the collecting tube clamp can drive the collecting tube to move in the horizontal direction.

[0014] Compared with the prior art, the utility model has the following beneficial effects:

[0015] First, the device is provided with a limiting device on the collecting tube clamp, and the profile of the limiting device is matched with the profile of the collecting tube bottle mouth, so that the collecting tube can keep a predetermined distance from the liquid outlet after installation. This structural design can ensure that the distance between the collecting tube and the liquid outlet is not too large, avoid the splashing of liquid when flowing out of the liquid outlet, and prevent product waste. On the other hand, it also avoids the distance between the collecting tube and the liquid outlet being too small, which can prevent the damage of the microfluidic device.

[0016] Second, the device can realize the precise positioning of the collecting tube position through a simple mechanical structure. The operator only needs to push the collecting tube into the collecting tube clamp until the profile of the limiting device is completely matched, without the need for repeated position adjustment, thereby improving the convenience and reliability of the operation.

[0017] Third, the device can avoid product waste and prevent equipment damage, thereby achieving the expected technical effect. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 The structure diagram of the device installed on the microfluidic device is shown in the figure.

[0019] Figure 2 The structure diagram of the device at the initial stage of work is shown in the figure.

[0020] Figure 3 The schematic diagram of the movement process of the collecting tube clamp is shown in the figure.

[0021] Figure 4 The structure diagram of the device after the collecting tube clamp is moved to the position is shown in the figure.

[0022] Figure 5 For Figure 4 a side view schematic diagram of the device;

[0023] Figure:

[0024] 1, the liquid outlet; 2, the collection pipe clamp; 3, the collection pipe; 4, the limiting device; 4.1, the short side; 4.2, the long side. DETAILED DESCRIPTION

[0025] The technical scheme of the present application will be described clearly and completely in conjunction with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0026] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0027] The present application provides a kind of microfluidic device's sample collection device, including collection pipe clamp 2 and limiting device 4, the limiting device 4 is fixedly arranged on collection pipe clamp 2.The profile of limiting device 4 is matched with the bottle mouth profile of collection pipe 3, when collection pipe clamp 2 moves to the position of microfluidic device liquid outlet 1, the distance between collection pipe clamp 2 and the liquid outlet 1 of microfluidic device can be kept predetermined.

[0028] In the present embodiment, limiting device 4 adopts L-shaped structure. Specifically, the L-shaped structure includes short side 4.1 and long side 4.2, wherein the length of short side 4.1 is 2-4 millimeters, preferably 3 millimeters; the length of long side 4.2 is 20-40 millimeters, preferably 30 millimeters. This size design can well adapt to most specifications of collection pipe 3, so that collection pipe 3 can maintain a proper distance with liquid outlet 1 after being installed in place.

[0029] The collecting pipe clamp 2 in the utility model is arranged in an inclined manner, which can keep the collecting pipe 3 at a certain angle when collecting samples, and is beneficial to the smooth inflow of the samples. The limiting device 4 is fixed on the collecting pipe clamp 2 in an inverted manner, and the inclination angle of the limiting device 4 is consistent with the inclination angle of the collecting pipe clamp 2, so that the profile of the limiting device 4 can be well matched with the bottle mouth profile of the collecting pipe 3. The limiting device 4 can be fixed on the left side or the right side of the collecting pipe clamp 2, and the design provides greater installation flexibility.

[0030] The collecting pipe clamp 2 can drive the collecting pipe 3 to move in the horizontal direction. Specifically, when the equipment is in standby state, the liquid outlet 1 and the collecting device are misaligned at a certain angle; when the sample needs to be collected, the collecting pipe clamp 2 drives the collecting pipe 3 to slowly move left until it stops right below the liquid outlet 1, at which time the liquid outlet 1 starts to flow out liquid.

[0031] The specific use method of the utility model is as follows: first, the collecting pipe 3 is clamped into the collecting pipe clamp 2, and then the collecting pipe 3 is pushed from bottom to top until the bottle mouth of the collecting pipe 3 is fully matched with the profile of the limiting device 4. At this time, the collecting pipe 3 is already at the appropriate height position. Then the collecting pipe clamp 2 drives the collecting pipe 3 to move left until it stops at the position right below the liquid outlet 1. At this time, the liquid outlet 1 starts to flow out liquid, and since the distance between the collecting pipe 3 and the liquid outlet 1 is fixed by the limiting device 4, the liquid can accurately flow into the collecting pipe 3, neither causing sample waste due to too far distance nor causing the collecting pipe 3 to collide with the liquid outlet 1 due to too close distance.

[0032] The above-mentioned embodiments are only for illustrating the technical concept and characteristics of the utility model, and the purpose is to enable those skilled in the art to understand the content of the utility model and implement it, and it cannot limit the protection scope of the utility model. Any equivalent transformation or modification according to the spirit and essence of the utility model shall be covered within the protection scope of the utility model.

Claims

1. A sample collection device for a microfluidic device, characterized by, The application relates to a collecting tube clamp and a limiting device, wherein the limiting device is fixedly arranged on the collecting tube clamp, a predetermined distance is kept between the collecting tube clamp and the liquid outlet of a micro-fluidic device when the collecting tube clamp moves to the position of the liquid outlet of the micro-fluidic device, and the profile of the limiting device is matched with the profile of the bottle opening of the collecting tube. The limiting device is in an L-shaped structure.

2. The sample collection device of a microfluidic device according to claim 1, wherein, The L-shaped structure comprises a short side and a long side, the length of the short side is 2-4 mm, and the length of the long side is 20-40 mm.

3. The sample collection device of a microfluidic device of claim 2, wherein, The collecting tube clamp is arranged in an inclined manner.

4. The sample collection device of a microfluidic device of claim 2, wherein, The limiting device is fixed on the collecting tube clamp in an upside-down manner, and the inclination angle of the limiting device is consistent with the inclination angle of the collecting tube clamp.

5. The sample collection device of a microfluidic device of claim 4, wherein, The limiting device is fixed on the left side or the right side of the collecting tube clamp.

6. The sample collection device of a microfluidic device of claim 1, wherein, The collecting tube clamp can drive the collecting tube to move in the horizontal direction.

7. A sample collection device for a microfluidic device according to any one of claims 1 to 6, wherein, ​

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