Chromatographic column for nucleic acid protein sample treatment

Abstract

The utility model discloses a chromatographic column for nucleic acid protein sample treatment, and relates to the technical field of chromatographic columns, the chromatographic column comprises a chromatographic column tube and dismounting assemblies, the chromatographic column tube is an integrally formed stainless steel structure, the chromatographic column tube is internally provided with an internal filler, the dismounting assemblies are arranged at two ends of the chromatographic column tube, and the dismounting assemblies are arranged on the chromatographic column tube. The dismounting and mounting assembly comprises external thread connectors, internal thread mounting sleeves, thread reinforcing holes, reinforcing screws, a sample inlet / outlet, silica gel sealing gaskets and plastic protective plugs, and the external thread connectors are arranged on the outer sides of the two ends of the chromatographic column tube. According to the chromatographic column for nucleic acid protein sample treatment, the whole device can be quickly disassembled and assembled through the disassembling and assembling assembly, so that equipment can be conveniently maintained, the interior of the column tube is regularly checked and cleaned, the service life of the chromatographic column is prolonged, the whole device is more stable and not prone to damage through the protection assembly, the internal corrosion resistance is enhanced, and the service life of the chromatographic column is prolonged. The interior of the column pipe is not easily damaged.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, specifically to a chromatography column for nucleic acid protein sample processing. Background Technology

[0002] Nucleic acid and protein sample processing refers to the process of breaking down a sample to quantitatively transfer the analyte into a solution for analysis. This process is crucial in biological experiments because it directly affects the accuracy and reliability of subsequent experiments. Chromatographic columns are a method in chemical analysis used to separate various compounds in a mixture. In nucleic acid and protein sample processing, chromatographic columns primarily function in separation, purification, and analysis. Through their unique structure and separation mechanism, they can effectively process and separate nucleic acid and protein samples. However, current chromatographic columns still have the following shortcomings:

[0003] For example, patent application CN219764561U discloses a chromatographic column. This column can avoid interference from metal ions on materials, thus preventing interference with component identification. The ceramic coating has good acid and alkali resistance. The ceramic coating has good wear resistance, which increases the service life of the column body and the de-aging piston. The ceramic coating is radiation resistant and has high strength, but it is not easy to quickly disassemble and assemble, making regular maintenance inconvenient.

[0004] Therefore, in view of this, we have studied and improved the existing structure to propose a chromatographic column for nucleic acid protein sample processing. Utility Model Content

[0005] The purpose of this invention is to provide a chromatographic column for nucleic acid and protein sample processing to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a chromatographic column for nucleic acid protein sample processing, comprising a column tube and a disassembly assembly. The column tube is an integrally formed stainless steel structure, and internal packing is provided inside the column tube. The disassembly assembly is located at both ends of the column tube and includes an external threaded connector, an internal threaded mounting sleeve, a threaded reinforcement hole, a reinforcement screw, a sample inlet / outlet, a silicone sealing gasket, and a plastic protective plug. The external threaded connector is located on the outer side of both ends of the column tube, and the outer surface of the external threaded connector is threadedly connected to the internal threaded mounting sleeve. Two sets of internal threaded mounting sleeves are symmetrically arranged, and threaded reinforcement holes are opened on the surfaces of the internal threaded mounting sleeves.

[0007] Furthermore, the inner side of the threaded reinforcement hole is threaded with reinforcement screws, and four sets of reinforcement screws are symmetrically arranged.

[0008] Furthermore, the internal threaded mounting sleeve has a sample inlet and outlet, and the inner surface of the sample inlet and outlet is provided with a silicone sealing gasket. A plastic protective plug is engaged and connected to the inner side of the sample inlet and outlet.

[0009] Furthermore, the chromatographic column tube has sieve plates that are snapped together at both ends, and a blade ring is provided on the outer side of the sieve plate.

[0010] Furthermore, a rubber sealing gasket is provided on the outer surface of the blade ring, and the blade ring is engaged with both ends of the chromatographic column tube.

[0011] Furthermore, the chromatographic column tube and the external threaded connector are a tightly connected integrated structure, and the surface of the chromatographic column tube is provided with protective components for enhanced protection.

[0012] Furthermore, the protective component includes an anti-slip pad, a stainless steel reinforcing mesh, a rigid reinforcing protective layer, and a polytetrafluoroethylene coating, with the anti-slip pad disposed on the outer surface of the chromatographic column tube.

[0013] Furthermore, the chromatographic column tube is provided with a stainless steel reinforcing mesh inside, and a rigid reinforcing protective layer is installed on the inner side of the stainless steel reinforcing mesh. The inner surface of the rigid reinforcing protective layer is provided with a polytetrafluoroethylene coating.

[0014] This invention provides a chromatographic column for nucleic acid and protein sample processing, which has the following beneficial effects:

[0015] 1. This utility model incorporates a disassembly and assembly component, comprising an external threaded connector, an internal threaded mounting sleeve, a threaded reinforcement hole, a reinforcement screw, a sample inlet / outlet, a silicone sealing gasket, and a plastic protective plug. In use, the internal threaded mounting sleeve is fixed to both ends of the chromatographic column tube through the threaded connection between the internal threaded mounting sleeve and the external threaded connector. The reinforcement screw is then threaded into the inner side of the threaded reinforcement hole to reinforce the connection between the internal threaded mounting sleeve and the external threaded connector. The plastic protective plug engages with the sample inlet / outlet to block it. The silicone sealing gasket enhances the sealing of the sample inlet / outlet. This allows for rapid disassembly and assembly of the entire device, facilitating equipment maintenance and upkeep, regular inspection and cleaning of the column interior, and extending the column's lifespan.

[0016] 2. This utility model incorporates a protective component, including an anti-slip pad, a stainless steel reinforcing mesh, a rigid reinforcing protective layer, and a polytetrafluoroethylene (PTFE) coating. During use, the anti-slip pad protects the outer side of the chromatographic column, enhancing its anti-slip effect and preventing it from slipping and falling. The stainless steel reinforcing mesh increases the overall hardness of the column, making it less prone to breakage. The rigid reinforcing protective layer improves the column's compressive strength, preventing deformation. The PTFE coating possesses excellent chemical corrosion resistance and high-temperature stability, enhancing the internal corrosion resistance of the column. This makes the device more stable and less susceptible to damage, with enhanced internal corrosion resistance and reduced risk of internal column damage. Attached Figure Description

[0017] Figure 1 This is a three-dimensional structural diagram of the disassembly and assembly components of a chromatographic column for nucleic acid and protein sample processing according to the present invention;

[0018] Figure 2 This is a three-dimensional structural schematic diagram of a chromatographic column for nucleic acid and protein sample processing according to the present invention;

[0019] Figure 3 This is a three-dimensional cross-sectional view of a chromatographic column for nucleic acid and protein sample processing according to the present invention.

[0020] In the diagram: 1. Chromatographic column tube; 2. Internal packing material; 3. Assembly / disassembly assembly; 301. External threaded connector; 302. Internal threaded mounting sleeve; 303. Threaded reinforcement hole; 304. Reinforcing screw; 305. Sample inlet / outlet; 306. Silicone gasket; 307. Plastic protective plug; 4. Sieve plate; 5. Blade ring; 6. Rubber gasket; 7. Protective assembly; 701. Anti-slip pad; 702. Stainless steel reinforcing mesh; 703. Rigid reinforced protective layer; 704. Polytetrafluoroethylene coating. Detailed Implementation

[0021] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of this utility model.

[0022] like Figures 1 to 3As shown, a chromatographic column for nucleic acid protein sample processing includes a column tube 1 and a disassembly assembly 3. The column tube 1 is a one-piece stainless steel structure, and an internal packing 2 is provided inside the column tube 1. The disassembly assembly 3 is located at both ends of the column tube 1, and the disassembly assembly 3 includes an external threaded connector 301, an internal threaded mounting sleeve 302, a threaded reinforcement hole 303, a reinforcement screw 304, a sample inlet / outlet 305, a silicone sealing gasket 306, and a plastic protective plug 307. The external threaded connector 301 is located on the outer side of both ends of the column tube 1, and the outer surface of the external threaded connector 301 is threadedly connected to the internal threaded mounting sleeve 302. Two sets of internal threaded mounting sleeves 302 are symmetrically arranged, and the surfaces of the internal threaded mounting sleeves 302 and the internal threaded mounting sleeves 302 are provided with threaded reinforcement holes 303.

[0023] The specific operation is as follows: During use, the internal threaded mounting sleeve 302 is fixed to both ends of the chromatographic column tube 1 by connecting the internal threaded mounting sleeve 302 to the external threaded connector 301. The connection between the internal threaded mounting sleeve 302 and the external threaded connector 301 is reinforced by connecting the reinforcing screw 304 to the threaded reinforcing hole 303. The sample inlet and outlet 305 are blocked by engaging the plastic protective plug 307 with the sample inlet and outlet 305. The sealing performance of the sample inlet and outlet 305 is enhanced by the silicone sealing gasket 306.

[0024] Please refer to Figure 1 and Figure 3 The threaded reinforcement hole 303 has a threaded connection to a reinforcement screw 304, and four sets of reinforcement screws 304 are symmetrically arranged. The internal threaded mounting sleeve 302 has a sample inlet / outlet 305, and a silicone sealing gasket 306 is provided on the inner surface of the sample inlet / outlet 305. A plastic protective plug 307 is engaged with the inner side of the sample inlet / outlet 305. The two ends of the chromatographic column tube 1 are engaged with a sieve plate 4, and a blade ring 5 is provided on the outer side of the sieve plate 4. A rubber sealing gasket 6 is provided on the outer surface of the blade ring 5, and the blade ring 5 is engaged with the two ends of the chromatographic column tube 1. The external threaded connector 301 is a tightly integrated structure, and the surface of the chromatographic column tube 1 is provided with a protective component 7 for enhanced protection. The protective component 7 includes an anti-slip pad 701, a stainless steel reinforcing mesh 702, a rigid reinforcing protective layer 703, and a polytetrafluoroethylene coating 704. The anti-slip pad 701 is provided on the outer surface of the chromatographic column tube 1, and a stainless steel reinforcing mesh 702 is provided inside the chromatographic column tube 1. A rigid reinforcing protective layer 703 is installed on the inner side of the stainless steel reinforcing mesh 702, and a polytetrafluoroethylene coating 704 is provided on the inner surface of the rigid reinforcing protective layer 703.

[0025] The specific operation is as follows: When in use, the anti-slip pad 701 is used to protect the outside of the chromatographic column tube 1 to enhance the anti-slip effect and prevent it from slipping and falling during use. The stainless steel reinforcing mesh 702 can enhance the overall hardness of the chromatographic column tube 1, making it less prone to breakage. The hard reinforced protective layer 703 can improve the compressive strength of the chromatographic column tube 1, making it less prone to deformation. The polytetrafluoroethylene coating 704 has excellent chemical corrosion resistance and high temperature stability, which can enhance the corrosion resistance of the inside of the chromatographic column tube 1.

[0026] In summary, as Figures 1 to 3 As shown, this chromatographic column for nucleic acid protein sample processing is used as follows: First, the internal threaded mounting sleeve 302 is fixed to both ends of the column tube 1 by connecting the internal threaded mounting sleeve 302 to the external threaded connector 301. Then, the connection between the internal threaded mounting sleeve 302 and the external threaded connector 301 is reinforced by connecting the reinforcing screw 304 to the threaded reinforcement hole 303. Finally, the sample inlet and outlet 305 are blocked by engaging the plastic protective plug 307 with the sample inlet and outlet 305, and sealed with a silicone sealing gasket 306. To enhance the sealing of the sample inlet and outlet 305, the anti-slip pad 701 protects the outside of the chromatographic column tube 1 during use, enhancing the anti-slip effect and preventing it from slipping and falling during use. The stainless steel reinforcing mesh 702 enhances the overall hardness of the chromatographic column tube 1, making it less prone to breakage. The hard reinforcing protective layer 703 improves the compressive strength of the chromatographic column tube 1, making it less prone to deformation. The polytetrafluoroethylene coating 704 has excellent chemical corrosion resistance and high temperature stability, which enhances the corrosion resistance of the inside of the chromatographic column tube 1.

[0027] The embodiments of this utility model are given for illustrative and descriptive purposes only, and are not intended to be exhaustive or to limit the utility model to the forms disclosed. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described in order to better illustrate the principles and practical applications of this utility model, and to enable those skilled in the art to understand this utility model and design various embodiments with various modifications suitable for a particular purpose.

Claims

1. A chromatographic column for nucleic acid protein sample processing, comprising a column tube (1) and a disassembly assembly (3), characterized in that: The chromatographic column tube (1) is an integrally formed stainless steel structure, and the internal packing (2) is provided inside the chromatographic column tube (1). The disassembly and assembly components (3) are located at both ends of the chromatographic column tube (1), and the disassembly and assembly components (3) include an external threaded connector (301), an internal threaded mounting sleeve (302), a threaded reinforcement hole (303), a reinforcement screw (304), a sample inlet and outlet (305), a silicone sealing gasket (306), and a plastic protective plug (307). The external threaded connector (301) is located on the outer side of both ends of the chromatographic column tube (1), and the outer surface of the external threaded connector (301) is threadedly connected to the internal threaded mounting sleeve (302). Two sets of internal threaded mounting sleeves (302) are symmetrically arranged. The surfaces of the internal threaded mounting sleeves (302) and the internal threaded mounting sleeves (302) are provided with threaded reinforcement holes (303).

2. The chromatographic column for nucleic acid protein sample processing according to claim 1, characterized in that, The threaded reinforcement hole (303) is threaded with a reinforcement screw (304) inside, and four sets of reinforcement screws (304) are symmetrically arranged.

3. The chromatographic column for nucleic acid protein sample processing according to claim 1, characterized in that, The internal threaded mounting sleeve (302) has a sample inlet and outlet (305) inside, and a silicone sealing gasket (306) is provided on the inner surface of the sample inlet and outlet (305). A plastic protective plug (307) is engaged and connected to the inner side of the sample inlet and outlet (305).

4. The chromatographic column for nucleic acid protein sample processing according to claim 1, characterized in that, The chromatographic column tube (1) has a sieve plate (4) connected to both ends inside, and a blade ring (5) is provided on the outside of the sieve plate (4).

5. A chromatographic column for nucleic acid protein sample processing according to claim 4, characterized in that, The outer surface of the blade ring (5) is provided with a rubber sealing gasket (6), and the blade ring (5) is engaged with both ends of the chromatographic column tube (1).

6. A chromatographic column for nucleic acid protein sample processing according to claim 1, characterized in that, The chromatographic column tube (1) and the external threaded connector (301) are an integrated structure that is tightly connected, and the surface of the chromatographic column tube (1) is provided with a protective component (7) for enhanced protection.

7. A chromatographic column for nucleic acid protein sample processing according to claim 6, characterized in that, The protective component (7) includes an anti-slip pad (701), a stainless steel reinforcing mesh (702), a rigid reinforcing protective layer (703), and a polytetrafluoroethylene coating (704), with the anti-slip pad (701) disposed on the outer surface of the chromatographic column tube (1).

8. A chromatographic column for nucleic acid protein sample processing according to claim 1, characterized in that, The chromatographic column tube (1) is provided with a stainless steel reinforcing mesh (702) inside, and a hard reinforcing protective layer (703) is installed on the inner side of the stainless steel reinforcing mesh (702). The inner surface of the hard reinforcing protective layer (703) is provided with a polytetrafluoroethylene coating (704).

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