Raw material supply system for mixing device and raw material supply device for supplying raw material to mixing device

Abstract

The utility model provides a raw material supply system of a mixing device and a raw material supply device for supplying raw materials to the mixing device. The raw material supply system comprises a raw material supply device and a controller, the raw material supply device comprises a funnel-shaped body, the funnel-shaped body is provided with an upper end, a lower end and an inner surface, the caliber of the upper end is larger than that of the lower end, and the lower end is communicated with a mixing device; the valve is arranged on the funnel-shaped body and is positioned between the lower end and the mixing device; and the cleaning device is provided with a plurality of cleaning liquid output ends, and the plurality of cleaning liquid output ends are arranged at the upper end position so as to clean the inner surface. The raw material supply system can achieve the effects of automatically adding the raw materials, reducing flying of the powdery raw materials and reducing residues of the raw materials.

Description

TECHNICAL FIELD

[0001] The utility model relates to a raw material supply system and raw material supply device, especially a raw material supply system and raw material supply device can add raw materials and clean automatically. BACKGROUND

[0002] Polypeptide is a kind of short-chain amino acid, plays multiple important roles in various biological systems, including signal transduction, regulation of cellular processes and maintenance of structural components. In recent years, the demand for polypeptides in medicine, cosmetic medicine and other aspects is growing, such as disease treatment, vaccine, cosmetics, etc., which requires a large polypeptide synthesis device to manufacture a large amount of polypeptides.

[0003] The polypeptide synthesis device can prepare different polypeptide products according to the type, quantity and sequence of added amino acids. The current large polypeptide synthesis device adds amino acids by manually opening the gate of the mixing tank and adding amino acids into the mixing tank to manufacture polypeptides. However, manually adding amino acids is time-consuming and laborious, so a system that can automatically add amino acid raw materials to the mixing tank is needed. In addition, amino acids are in powder form, and powder-like amino acid raw materials are easily left on any object, so how to automatically add powder-like amino acid raw materials to the mixing tank without residue is also a problem to be solved. Furthermore, the shape of the amino acid raw material bag is square, and the powder-like amino acid raw material is easy to fly when pouring, which affects the preparation of polypeptides, so how to reduce the flying of amino acid raw materials is also a problem to be solved.

[0004] Therefore, the known polypeptide synthesis device still needs to be improved. SUMMARY

[0005] To solve the above problems, the purpose of the utility model is to provide a raw material supply device that can be automatically cleaned, with a funnel-shaped body communicating with the mixing tank and a cleaning device, which can clean the inner surface of the funnel-shaped body after the raw material is poured, so that the raw material left on the inner surface is cleaned into the mixing tank.

[0006] Another purpose of the utility model is to provide a raw material bag with a conical shape, which conforms to the shape of the funnel-shaped body, so that the raw material bag can enter the space of the funnel-shaped body, and the opening of the raw material bag is closer to the mixing tank. When the opening of the raw material bag is opened, the flying of powder-like raw materials can be reduced. In addition, the opening of the raw material bag is sewn with a single or double line of suture, which can easily open the raw material bag by pulling the suture, facilitating the addition of raw materials.

[0007] Still another purpose of the utility model is to provide an automatic raw material supply system, which uses a mechanical arm to suspend and move the raw material bag, and clamps the suture of the raw material bag to disassemble the raw material bag seal, and then automatically adds raw materials to the mixing tank.

[0008] The "setting" and similar phrases described throughout the utility model mainly include connecting and still being able to separate without damaging the component, or connecting and making the component inseparable, and a person with ordinary knowledge in the art can select according to the material quality of the component to be connected or assembly requirements.

[0009] The "coupling" phrase described throughout the utility model includes direct or indirect connection in electrical and / or signal, and a person with ordinary knowledge in the art can select according to the use requirements.

[0010] The "controller" described throughout the utility model includes at least one "processor", which refers to various data processing devices with specific functions and realized by hardware or hardware and software, to process and analyze information and / or generate corresponding control information, such as electronic controllers, servers, cloud platforms, virtual machines, desktop computers, notebook computers, tablet computers or smart phones, and a person with ordinary knowledge in the art of the utility model can understand. In addition, it can include corresponding data receiving or transmission units to receive or transmit the required data. In addition, it can include a corresponding database / storage unit to store the required data. In particular, unless specifically excluded or contradictory, the processor can be a collection of multiple processors based on a distributed system architecture, used for processes, mechanisms and results including / representing information stream processing between multiple processors.

[0011] The utility model provides a kind of raw material supply system of mixing device, wherein the mixing device includes mixing tank and cleaning liquid tank.The raw material supply system includes: raw material supply device and controller.The raw material supply device includes: funnel-shaped body, with upper end, lower end and inner surface, wherein the upper end has upper opening, the lower end has lower opening, the caliber of the upper opening is greater than the caliber of the lower opening, the lower end is connected with the mixing tank, and the lower opening is communicated with the mixing tank;Valve is arranged on the funnel-shaped body and is located between the lower opening and the mixing tank;And cleaning device has multiple cleaning liquid output ends, wherein the multiple cleaning liquid output ends are obliquely arranged on the upper end, so that the cleaning device cleans the inner surface in spiral manner.The controller is coupled with the raw material supply device, configured to control the opening and closing of the valve, and control the cleaning of the inner surface by the cleaning device.

[0012] The utility model further provides raw material bag loaded with raw material, the shape of the raw material bag is conical, and the raw material bag has first end and second end, second end has raw material opening, wherein the caliber of the first end is greater than the caliber of the second end, and the raw material opening is sewn with suture.

[0013] The utility model further provides the clamping device coupled with the controller for clamping the first end of the raw material bag and moving the raw material bag, and the thread taking device coupled with the controller for clamping and pulling out the suture to open the raw material opening, and then adding the raw material in the raw material bag into the mixing tank.

[0014] The utility model further provides a raw material supply device for providing raw material to the mixing device. The raw material supply device comprises a funnel-shaped body, a valve and a cleaning device. The funnel-shaped body has an upper end, a lower end and an inner surface, wherein the diameter of the upper end is larger than the diameter of the lower end, and the lower end is in communication with the mixing device. The valve is arranged on the funnel-shaped body and located between the lower end and the mixing device. The cleaning device has a plurality of cleaning liquid output ends, and the plurality of cleaning liquid output ends are arranged at the upper end position to clean the inner surface. BRIEF DESCRIPTION OF DRAWINGS

[0015] The above objects and advantages of the utility model will become more immediately apparent to those having ordinary knowledge in the art after referring to the following detailed description and drawings.

[0016] Figure 1 is the schematic diagram of the raw material supply system of the utility model.

[0017] Figure 2 is the schematic diagram of the connection between the raw material supply device and the mixing device of the utility model.

[0018] Figure 3 is the schematic diagram of the raw material supply device of the utility model.

[0019] Figure 4 is the schematic diagram of the raw material bag of the utility model.

[0020] Figure 5 is the relationship schematic diagram of the clamping device, the thread taking device, the funnel-shaped body and the raw material bag of the utility model.

[0021] Figure 6 is the schematic diagram of the raw material bag after opening of the utility model.

[0022] Figure 7 is the relationship schematic diagram of the stirring device and the funnel-shaped body of the utility model.

[0023] Figure 8 is the schematic diagram of the raw material supply system of the utility model when adding raw material.

[0024] Figure 9 is the schematic diagram of the stirring device stirring raw material of the utility model.

[0025] Figure 10 This is a schematic diagram of another embodiment of the raw material supply system of this utility model when adding raw materials. Detailed Implementation

[0026] To make the above and other objects, features and advantages of this utility model more apparent and understandable, preferred embodiments of this utility model are described below in conjunction with the accompanying drawings; in addition, the same symbols in different drawings are considered to be the same and their descriptions will be omitted.

[0027] Please refer to Figure 1 As shown, Figure 1 This diagram shows a schematic of the raw material supply system of this invention. The raw material supply system 10 of this invention can be applied to mixing devices in any field, such as those used in pharmaceuticals, food manufacturing, polypeptide synthesis, and DNA / RNA synthesis. The mixing device includes a mixing tank and a cleaning solution tank. The raw material supply system 10 of this invention includes a raw material supply device 100, a controller 200, a clamping device 210, a wire taking device 220, a stirring device 230, and a raw material bag 300. The controller 200 can be coupled to the raw material supply device 100, the clamping device 210, the wire taking device 220, and the stirring device 230. The clamping device 210 can clamp and move the raw material bag 300.

[0028] Please refer to Figures 2-3 As shown, Figure 2 This diagram shows the connection between the raw material supply device and the mixing device of this utility model. Figure 3 This diagram shows a schematic of the raw material supply device of the present invention. In one embodiment of the present invention, the mixing device 50 includes a mixing tank 510, a stirrer 520, and a cleaning liquid tank (not shown). The raw material supply device 100 of the present invention can be connected to the mixing tank 510 of the mixing device 50, and the raw material supply device 100 includes a funnel-shaped body 110, a valve 120, a cleaning device 130, and a connecting part 140. The funnel-shaped body 110 has an upper end 112, a lower end 114, and an inner surface 116, wherein the upper end 112 has an upper opening, and the lower end 114 has a lower opening. The diameter of the upper opening is larger than the diameter of the lower opening, and the lower end 114 is connected to the connecting part 140. The connecting part 140 is connected to the mixing tank 510 of the mixing device 50, so that the lower opening, the connecting part 140, and the mixing tank 510 are in communication with each other. Therefore, the funnel-shaped body 110 can be connected to the mixing tank 510 of the mixing device 50 through the connecting part 140 to serve as the raw material inlet of the mixing tank 510. In a preferred embodiment, the diameter of the lower end 114 or the lower opening is 50 mm. The valve 120 is located at the lower end 114 of the funnel-shaped body 110 and between the lower opening and the mixing tank 510, serving as a gate between the raw material inlet and the mixing tank 510.

[0029] Please continue to refer toFigures 2-3 The cleaning device 130 of this utility model includes a cleaning fluid guide pipe 132 and a plurality of cleaning fluid output ends 134. The cleaning fluid guide pipe 132 extends from the cleaning fluid tank (not shown) to the plurality of cleaning fluid output ends 134 to deliver cleaning fluid to the plurality of cleaning fluid output ends 134. The plurality of cleaning fluid output ends 134 are disposed at the upper end 112 of the funnel-shaped body 110 to clean the inner surface 116 of the funnel-shaped body 110. In one embodiment, the plurality of cleaning fluid output ends 134 may be disposed on the upper end 112 of the funnel-shaped body 110, or located above the upper end 112 of the funnel-shaped body 110 without contacting the upper end 112, and can still achieve the effect of cleaning the inner surface 116 of the funnel-shaped body 110. In a preferred embodiment, a plurality of cleaning fluid output ends 134 are inclinedly disposed at the upper end 112 of the funnel-shaped body 110, so that the cleaning device 130 cleans the inner surface 116 of the funnel-shaped body 110 (e.g., ...) in a spiral manner with the cleaning fluid. Figure 3 (As shown by the dashed line in the diagram). In this invention, the cleaning solution can be any liquid required for mixing or reacting raw materials in pharmaceuticals, food manufacturing, polypeptide synthesis, and DNA synthesis. In the first embodiment of this invention, the cleaning solution can be a solvent. In a preferred embodiment, the solvent can be dimethylformamide (DMF).

[0030] Please refer to Figure 4 As shown, Figure 4 This diagram shows the raw material bag of the present invention. The raw material bag 300 of the present invention can contain raw material 350 to be supplied to the mixing device 50. In the first embodiment of the present invention, when the raw material supply system 10 is applied to the mixing device for synthesizing polypeptides, the raw material 350 is powdered amino acids. The raw material bag 300 has a first end 310 and a second end 320. The diameter of the first end 310 is larger than the diameter of the second end 320, so the shape of the raw material bag 300 is conical to conform to the shape of the funnel-shaped body 110 of the raw material supply device 100. The first end 310 of the raw material bag 300 can be sewn with a single or double thread 340 (e.g., ...). Figure 4 The material bag 300 is sewn shut (as shown) or sealed by other means (such as heat sealing). The second end 320 of the material bag 300 has a material opening, which is sewn shut with a single or double thread 330.

[0031] Please refer to Figure 5 As shown, Figure 5This diagram illustrates the relationship between the clamping device and thread-taking device of this invention, the raw material supply device, and the raw material bag. The clamping device 210 of this invention can clamp the first end 310 of the raw material bag 300 and move the raw material bag 300. The clamping device 210 can move the raw material bag 300 horizontally or vertically to suspend the raw material bag 300 above the funnel-shaped body 110 or within the space inside the funnel-shaped body 110. In one embodiment, the clamping device 210 can move the raw material bag 300 from above the funnel-shaped body 110 down into the space inside the funnel-shaped body 110. The thread-taking device 220 of this invention can clamp and pull out the suture thread 330 of the raw material bag 300 to open the raw material opening. In one embodiment, the raw material opening is sewn with a single suture thread, and the thread-taking device 220 can clamp and pull out the single suture thread of the raw material bag to open the raw material opening. In another embodiment, the raw material opening is sewn with double sutures. In this embodiment, the double sutures include a first suture thread and a second suture thread. The suture taking device includes a first suture taking part and a second suture taking part. The first suture taking part clamps the first suture thread, and the second suture taking part clamps the second suture thread. The first suture taking part and the second suture taking part pull out the first suture thread and the second suture thread to open the raw material opening. After the raw material opening of the raw material bag is opened, the raw material 350 in the raw material bag 300 can be added to the mixing tank (e.g., via the funnel-shaped body 110) through the funnel-shaped body 110. Figure 6 (As shown). In one embodiment of this utility model, the clamping device 210 and the wire taking device 220 can be a robotic arm.

[0032] Please refer to Figure 7 As shown, Figure 7 This diagram illustrates the relationship between the stirrer and the funnel-shaped body of this invention. The stirring device 230 of this invention includes a motor 231, a stirring element 232, and a connecting arm 233. The connecting arm 233 can move the motor 231 above the funnel-shaped body 110, and the motor 231 can rotate the stirring element 232. When the raw material 350 is poured into the funnel-shaped body 110 but gets stuck between the funnel-shaped body 110 and the mixing tank 510, the controller 200 can control the connecting arm 233 of the stirring device 230 to move above the funnel-shaped body 110, causing the stirring element 232 to extend into the funnel-shaped body 110 and rotate, thereby pushing the raw material 350 into the mixing tank 510. In one embodiment of this invention, the stirring element 232 can be made of polytetrafluoroethylene or stainless steel.

[0033] The controller 200 of the raw material supply system 10 can control the opening and closing of the valve 120 of the raw material supply device 100, control the cleaning device 130 to clean the inner surface 116 of the funnel-shaped body 110, and control the actions of the clamping device 210 and the thread taking device 220. The valve 120 can be realized by a controllable electric valve or solenoid valve and corresponding structure, and the cleaning device 130 can also include a pump for generating airflow to flow the cleaning liquid. Both of them can be understood by those skilled in the art, and thus will not be described in detail.

[0034] Therefore, please refer to Figures 1-6 When the raw material is to be added to the mixing device 50, the controller 200 controls as follows: (1) controls the clamping device 210 to clamp the first end 310 of the raw material bag 300 and move the raw material bag 300 above the funnel-shaped body 110; (2) controls the thread taking device 220 to clamp the suture thread 330 of the raw material bag 300; (3) controls the clamping device 210 to lower the raw material bag 300 to the inner space of the funnel-shaped body 110, and controls the thread taking device 220 to pull out the suture thread 330 of the raw material bag 300 at the same time as the raw material bag 300 is lowered, so as to open the raw material opening, and make the raw material 350 fall out of the raw material bag 300 and gather on the valve 120 (as shown in Figure 8 ); (4) controls the valve 120 to open, and controls the stirring device 230 to extend into the inner space of the funnel-shaped body 110 and rotate the stirring element 232, so as to push the raw material 350 into the mixing tank 510 of the mixing device 50 (as shown in Figure 9 ); (5) after the raw material 350 in the raw material bag 300 enters the mixing tank 510, controls the cleaning device 130 to clean the inner surface 116 of the funnel-shaped body 110 and the stirring element 232; and (6) controls the valve 120 to close.

[0035] In another embodiment, the controller 200 can also control as follows: (1) controls the clamping device 210 to clamp the first end 310 of the raw material bag 300 and move the raw material bag 300 above the funnel-shaped body 110; (2) controls the thread taking device 220 to clamp the suture thread 330 of the raw material bag 300; (3) controls the valve 120 to open; (4) controls the clamping device 210 to lower the raw material bag 300 to the inner space of the funnel-shaped body 110, and controls the thread taking device 220 to pull out the suture thread 330 of the raw material bag 300 at the same time as the raw material bag 300 is lowered, so as to open the raw material opening, and make the raw material 350 enter the mixing tank 510 of the mixing device 50 (as shown in Figure 10(5) the controller 200 controls the cleaning device 130 to clean the inner surface 116 of the funnel-shaped body 110 after the raw material in the raw material bag 300 enters the mixing tank 510; and (6) the controller 200 controls the valve 120 to be closed. In this embodiment, when the raw material 350 is poured into the funnel-shaped body 110 but is stuck between the funnel-shaped body 110 and the mixing tank 510, the controller 200 further controls the stirring device 230 to extend into the inner space of the funnel-shaped body 110 and rotates the stirring element 232 to push the raw material 350 into the mixing tank 510 of the mixing device 50, and then controls the cleaning device 130 to clean the inner surface 116 of the funnel-shaped body 110 and the stirring element 232.

[0036] In each of the above embodiments, the mixing tank 510 can have a waste liquid discharge hole at or on the bottom thereof, and the mixing device 50 can include a waste liquid tank (not shown) connected to the waste liquid discharge hole, and a valve between the waste liquid tank and the mixing tank 510 can open and close the waste liquid discharge hole. When the synthesis of a substance (e.g., a polypeptide, DNA, RNA, etc.) is completed, the valve of the waste liquid discharge hole can be opened to allow the waste liquid to flow into the waste liquid tank to discharge the waste liquid.

[0037] In each of the above embodiments, the shape of the conical raw material bag 300 conforms to the shape of the space inside the funnel-shaped body 110, so that the raw material bag 300 can open the raw material opening in the space inside the funnel-shaped body 110, thereby reducing the loss of the raw material 350 when added to the mixing tank 510. In addition, since the raw material 350 can remain on the inner surface 116 of the funnel-shaped body 110 when added, which can affect the synthesis of, for example, a polypeptide, the cleaning device 130 of the present application uses the solvent used in the synthesis of the polypeptide to clean the inner surface 116 of the funnel-shaped body 110 and the stirring element 232, so that the raw material 350 does not remain on the inner surface 116 of the funnel-shaped body 110 and the stirring element 232.

[0038] In another embodiment, the raw material bag 300 can also be an element of the raw material supply device 100.

[0039] In the second embodiment of the present application, the raw material supply system 10 can be applied to a mixing device for synthesizing DNA or RNA. When the raw material supply system 10 is applied to a mixing device for synthesizing DNA or RNA, the raw material 350 in the raw material bag 300 is an amidite, and the cleaning liquid is DMF or other solvents. In the second embodiment, the procedure for adding the amidite to the mixing device is the same as the procedure for adding the amino acid to the mixing device in the first embodiment.

[0040] In summary, the raw material feeding system of the utility model can achieve the effect of automatically adding raw materials into the mixing device through the connection of the controller and the raw material feeding device. Furthermore, the flying of the powdery raw materials can be reduced through the funnel-shaped body and the conical raw material bag of the raw material feeding device. In addition, the residual raw materials can be reduced through the cleaning device arranged at the upper position of the funnel-shaped body.

[0041] Although the utility model has been disclosed by the above preferred embodiments, it is not intended to limit the utility model, and any person skilled in the art can make various changes and modifications to the above embodiments without departing from the spirit and scope of the utility model, which still belongs to the technical scope protected by the utility model, therefore, the protection scope of the utility model should include the meaning recorded in the appended claims and all changes within the equivalent scope. In addition, when the above several embodiments can be combined, the utility model includes any combined embodiment.

[0042] Symbol explanation

[0043] 10: raw material feeding system

[0044] 100: raw material feeding device

[0045] 110: funnel-shaped body

[0046] 112: upper end

[0047] 114: lower end

[0048] 116: inner surface

[0049] 120: valve

[0050] 130: cleaning device

[0051] 132: cleaning liquid flow guide pipe

[0052] 134: cleaning liquid output end

[0053] 140: connecting part

[0054] 200: controller

[0055] 210: clamping device

[0056] 220: wire taking device

[0057] 230: stirring device

[0058] 231: motor

[0059] 232: stirring element

[0060] 233: connecting arm

[0061] 300: raw material bag

[0062] 310: first end

[0063] 320: second end

[0064] 330, 340: suture

[0065] 350: raw material

[0066] 50: mixing device

[0067] 510: mixing tank

[0068] 520: stirrer

Claims

1. A raw material supply system of a mixing apparatus, wherein the mixing apparatus includes a mixing tank and a cleaning liquid tank, characterized by, The raw material feeding system comprises: A raw material feeding device comprising: A funnel-shaped body having an upper end, a lower end, and an inner surface, wherein the upper end has an upper opening, the lower end has a lower opening, the upper opening has a larger diameter than the lower opening, the lower end is connected to the mixing tank, and the lower opening is in communication with the mixing tank; A valve disposed on the funnel-shaped body and located between the lower opening and the mixing tank; and A cleaning device having a plurality of cleaning liquid output ends, wherein the plurality of cleaning liquid output ends are disposed at the upper end in a tilted manner, so that the cleaning device cleans the inner surface in a spiral manner; and A controller coupled to the raw material feeding device and configured to control the opening and closing of the valve and to control the cleaning of the inner surface by the cleaning device.

2. The raw material supply system according to claim 1, wherein The raw material feeding system further comprises: A raw material bag containing raw materials, which is conical in shape and has: A first end; and A second end having a raw material opening, wherein the first end has a larger diameter than the second end, and the raw material opening is sewn with a suture thread; A clamping device coupled to the controller for clamping the first end of the raw material bag and moving the raw material bag; a thread taking device coupled to the controller for clamping and pulling out the suture thread to open the raw material opening, thereby adding the raw materials in the raw material bag to the mixing tank; and An agitating device coupled to the controller for rotating in the space of the funnel-shaped body to push the raw materials into the mixing tank.

3. The raw material feeding system of claim 2, wherein: The thread taking device comprises a first thread taking part and a second thread taking part, the suture thread comprises a first suture sub-thread and a second suture sub-thread, the first thread taking part clamps the first suture sub-thread, the second thread taking part clamps the second suture sub-thread, and the first thread taking part and the second thread taking part pull out the first suture sub-thread and the second suture sub-thread to open the raw material opening; and The controller is further configured to control the cleaning of the agitating device by the cleaning device.

4. The raw material supply system according to Claim 3, wherein The clamping device moves the raw material bag from above the funnel-shaped body into the space of the funnel-shaped body, so that the raw material bag is suspended in the space of the funnel-shaped body.

5. The raw material supply system according to Claim 1, wherein The raw material feeding device further comprises a connecting part connected to the lower end and the mixing tank, and the lower opening, the connecting part, and the mixing tank are in communication with each other.

6. The raw material supply system according to Claim 1, wherein The cleaning device further comprises a cleaning liquid flow guide pipe connected to the plurality of cleaning liquid output ends, wherein the cleaning liquid flow guide pipe extends from the cleaning liquid tank to the plurality of cleaning liquid output ends to transport the cleaning liquid to the plurality of cleaning liquid output ends.

7. The raw material supply system according to Claim 1, wherein The diameter of the lower opening is 50 mm, and the cleaning liquid is dimethylformamide (DMF).

8. A material supply device for supplying a material to a mixing device, characterized by The raw material feeding system comprises: A funnel-shaped body having an upper end, a lower end, and an inner surface, wherein the upper end has a larger diameter than the lower end, and the lower end is in communication with the mixing device; A valve disposed on the funnel-shaped body and located between the lower end and the mixing device; and A cleaning device having a plurality of cleaning liquid output ends, wherein the plurality of cleaning liquid output ends are disposed at the upper end in a tilted manner, so that the cleaning device cleans the inner surface in a spiral manner; and A controller coupled to the raw material feeding device and configured to control the opening and closing of the valve and to control the cleaning of the inner surface by the cleaning device. A cleaning device has a plurality of cleaning liquid outlets arranged at the upper end position to clean the inner surface.

9. The raw material supply apparatus according to claim 8, wherein The raw material feeding device further includes a raw material bag containing the raw material, wherein the raw material bag is conical in shape and has: a first end; and a second end having a raw material opening, wherein the first end has a larger diameter than the second end, and the raw material opening is sewn with a thread.

10. The raw material supply apparatus according to claim 8, wherein The plurality of cleaning liquid outlets are arranged obliquely at the upper end position, so that the cleaning device cleans the inner surface with cleaning liquid in a spiral manner, the lower end has a diameter of 50 mm, and the cleaning liquid is dimethylformamide (DMF).

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