Cell co-culture device

Abstract

The utility model provides a cell co-culture device, which belongs to the field of cell co-culture devices and comprises a bottom plate, the top of the bottom plate is fixedly connected with a box body, the top of the box body is fixedly connected with an upper cover, the bottom of the bottom plate is fixedly connected with a plurality of bottom feet, the side wall of the box body is rotatably connected with a box door, and the outer side wall of the box door is fixedly connected with a handle. A supporting plate is fixedly connected to the inner side wall of the box body, a sliding groove is fixedly connected to the top of the supporting plate, a plurality of culture dishes are arranged at the top of the sliding groove, a fixing cover is fixedly connected to the tops of the culture dishes, fixing blocks are fixedly connected to the two sides of each culture dish, a separation block is arranged between any two culture dishes, and a rotating shaft is rotationally connected to the interior of each separation block. According to the cell culture device disclosed by the utility model, the motor drives the plurality of stirring rods to do circular motion, so that cells in the culture dish are suspended and fully contacted with a culture solution, the cells are fully dispersed in the culture solution, and the cell culture is facilitated.

Description

TECHNICAL FIELD

[0001] The utility model relates to cell co-culture device field, specifically, relate to a cell co-culture device. BACKGROUND

[0002] Cell co-culture is an experimental technique that involves culturing two or more different types of cells together in the same culture environment. This technique can simulate more complex cell-cell interactions in vivo, providing a more realistic model for studying cell-to-cell communication, cell function regulation, and mechanisms of disease development. For example, in oncology research, co-culturing tumor cells with stromal cells or immune cells can help scientists understand how cell interactions in the tumor microenvironment affect tumor growth and metastasis. In addition, co-culture systems are widely used in tissue engineering, drug screening, and toxicology testing. Through carefully designed co-culture models, researchers can better explore the dynamic processes in living organisms, providing valuable insights for disease treatment and new drug development.

[0003] In the process of cell culture, some types of cells, such as blood cells or certain tumor cell lines, need to grow in a suspended state to maintain their normal physiological functions and proliferation ability. However, traditional cell culture devices sometimes cannot effectively keep these cells in a completely suspended state, causing cells to settle at the bottom, which not only limits the cell's nutrient absorption and gas exchange, but also can cause local cell density unevenness, thereby affecting the normal growth and division of cells.

[0004] How to invent a cell co-culture device to improve these problems has become a problem that needs to be solved by those skilled in the art. UTILITY MODEL CONTENT

[0005] In order to make up for the above shortcomings, the utility model provides a cell co-culture device, which aims to improve the problems mentioned in the above background.

[0006] The utility model is realized as follows:

[0007] The utility model provides a cell co -culture device, including the bottom plate, the top fixedly connected with the box of bottom plate, the top fixedly connected with the upper cover of box, the bottom fixedly connected with a plurality of bottom feet of bottom plate, the lateral wall rotationally connected with the box door of box, the outside wall fixedly connected with the handle of box door, the inside wall fixedly connected with the support plate of box, the top fixedly connected with the sliding slot of support plate, a plurality of petri dishes are provided with the top of sliding slot, the top fixedly connected with the fixed lid of petri dish, the both sides fixedly connected with the fixed block of petri dish, the top rotationally connected with the moving lid of one fixed block, the partition block is all provided with between any two petri dishes, the inside rotationally connected with the pivot of partition block, a plurality of stirring rods are fixedly connected on the pivot, the bottom of petri dish is provided with drive assembly.

[0008] Preferably, the upper cover and the box door are transparent, and the stirring rod is located in the interior of the petri dish.

[0009] Preferably, the outside wall of the box is provided with a control panel, and the control panel is provided with a display screen and a plurality of control buttons.

[0010] Preferably, the inside wall of the box is fixedly connected with a controller, the bottom of the support plate is fixedly connected with a temperature control module, a plurality of air vents are formed in the support plate, and the air vents are located above the temperature control module.

[0011] Preferably, the drive assembly comprises a motor fixedly connected to the top of the bottom plate, an output shaft is provided on the top output end of the motor, a sliding block is fixedly connected to the bottom of the lowermost petri dish, recesses are provided on the two sides of the sliding block, connecting pieces are provided in the recesses, wire boxes are fixedly connected to the two side walls of the sliding slot, springs are fixedly connected to the inside wall of the wire boxes, clamping blocks are fixedly connected to the ends of the springs, and the two clamping blocks are electrically connected with the motor and the controller respectively.

[0012] Preferably, the sliding block and the sliding slot are slidingly arranged, the clamping block is hemispherically arranged and is made of metal, and the clamping block is engaged with the recess on the sliding block.

[0013] Preferably, a boss is provided on the output shaft, and the output shaft is clamped with the pivot through the boss.

[0014] The utility model discloses a beneficial effect is: through setting up multiple petri dishes, can cultivate multiple groups of cells simultaneously, be favorable to the comparison of each group of cells, through the pushing force that spring is to the clamping block, and the clamping block is clamped into the recess on the sliding block, and the placement of multiple petri dishes is completed, and when the clamping block is in the recess of the sliding block, and with the contact piece contact, the circuit of motor and controller is communicated, makes the motor drive multiple stirring rods to make the circular motion, makes the cell in petri dish suspension and fully contact with culture solution, makes the cell fully dispersed in culture solution, is favorable to the culture of cell. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical scheme of the embodiment of the utility model, the following will be to the drawing needed to use in the embodiment briefly introduced, should understand, the following drawing only shows some embodiments of the utility model, therefore should not be seen as the limitation to the scope, for ordinary skilled person in the art comes, under the premise of not paying the creative labor, can also obtain other related drawings according to these drawings.

[0016] Figure 1 It is a kind of cell co-culture device three-dimensional structure schematic diagram provided in the embodiment of the utility model;

[0017] Figure 2 It is a kind of cell co-culture device box internal structure schematic diagram provided in the embodiment of the utility model;

[0018] Figure 3 It is a kind of cell co-culture device stirring rod position schematic diagram provided in the embodiment of the utility model;

[0019] Figure 4 It is a kind of cell co-culture device sliding block position schematic diagram provided in the embodiment of the utility model;

[0020] Figure 5 It is Figure 4 Enlarged view of A in

[0021] Figure 6 It is a kind of cell co-culture device boss position schematic diagram provided in the embodiment of the utility model.

[0022] In the drawing: 1, bottom plate;2, box;3, foot;4, box door;5, handle;6, support plate;7, sliding slot;8, petri dish;9, fixed cover;10, fixed block;11, moving cover;12, partition block;13, rotating shaft;14, stirring rod;15, display screen;16, control button;17, controller;18, temperature control module;19, motor;20, output shaft;21, sliding block;22, connecting piece;23, spring;24, clamping block;25, boss;26, upper cover;27, wire box. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the utility model embodiment clearer, the technical scheme in the utility model embodiment will be clearly and completely described below in combination with the drawings in the utility model embodiment. Obviously, the described embodiment is part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by the person skilled in the art without creative labor belong to the protection scope of the utility model.

[0024] Embodiment, refer to Figures 1-6 A cell co-culture device, including bottom plate 1, the top of bottom plate 1 is fixedly connected with box 2, the top of box 2 is fixedly connected with upper cover 26, the bottom of bottom plate 1 is fixedly connected with multiple bottom feet 3, the lateral wall of box 2 is rotatably connected with box door 4, the outer lateral wall of box door 4 is fixedly connected with handle 5, the inner lateral wall of box 2 is fixedly connected with support plate 6, the top of support plate 6 is fixedly connected with sliding groove 7, multiple culture dishes 8 are arranged on the top of sliding groove 7, the top of culture dish 8 is fixedly connected with fixed cover 9, the two sides of culture dish 8 are fixedly connected with fixed block 10, the top of one of fixed block 10 is rotatably connected with moving cover 11, the inside of separation block 12 is rotatably connected with rotating shaft 13, multiple stirring rods 14 are fixedly connected on rotating shaft 13, the bottom of culture dish 8 is provided with driving assembly, upper cover 26 and box door 4 are transparently arranged, stirring rod 14 is located in the inside of culture dish 8, the outer lateral wall of box 2 is provided with control panel, display screen 15 and multiple control buttons 16 are arranged on control panel, the inner lateral wall of box 2 is fixedly connected with controller 17, the bottom of support plate 6 is fixedly connected with temperature control module 18, multiple air holes are formed in support plate 6, the air holes are located above temperature control module 18, driving assembly includes motor 19 fixedly connected on the top of bottom plate 1, the top output end of motor 19 is provided with output shaft 20, the bottom of the lowermost culture dish 8 is fixedly connected with sliding block 21, recesses are arranged on the two sides of sliding block 21, connecting piece 22 is arranged in the inside of recess, the two lateral walls of sliding groove 7 are fixedly connected with wire box 27, the inner lateral wall of wire box 27 is fixedly connected with spring 23, the end of spring 23 is fixedly connected with clamping block 24, two clamping blocks 24 are electrically connected with motor 19 and controller 17 respectively, sliding block 21 is slidably arranged with sliding groove 7, clamping block 24 is hemispherically arranged and is made of metal material, clamping block 24 is engaged with the recess on sliding block 21, the output shaft 20 is provided with boss 25, and the output shaft 20 is clamped with rotating shaft 13 through boss 25.

[0025] The working principle of the cell co-culture device is as follows: the cells to be cultured and the culture solution are placed in the plurality of culture dishes 8, the box door 4 is opened, the sliding block 21 below the culture dishes 8 is aligned with the sliding groove 7, the plurality of culture dishes 8 are pushed into the box body 2, the boss 25 on the output shaft 20 is clamped into the rotating shaft 13, the clamping of the rotating shaft 13 and the output shaft 20 is completed, at the same time, the pushing force of the spring 23 on the clamping block 24 is applied, the clamping block 24 is clamped into the groove on the sliding block 21, the sliding block 21 and the sliding groove 7 are fixed, the placement of the plurality of culture dishes 8 is completed, when the clamping block 24 is in the groove of the sliding block 21, the connecting piece 22 is contacted, the circuit of the motor 19 and the controller 17 is communicated, the motor 19 starts to rotate, the rotating shaft 13 is driven to rotate through the output shaft 20, the plurality of stirring rods 14 are driven to make circular motion through the rotating of the rotating shaft 13, the cells in the culture dishes 8 are suspended and fully contacted with the culture solution, which is beneficial to the culture of the cells.

[0026] It should be noted that the specific model and specifications of the motor need to be selected and determined according to the actual specifications of the device, and the specific selection calculation method adopts the existing technology in the art, so it will not be described in detail.

[0027] The above only describes preferred embodiments of the present application and is not intended to limit the present application. For those skilled in the art, the present application can be changed and modified in various ways. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A cell co-culture device, comprising a base plate (1), characterized in that, A box body (2) is fixedly connected to the top of the base plate (1), and a top cover (26) is fixedly connected to the top of the box body (2). Multiple feet (3) are fixedly connected to the bottom of the base plate (1). A box door (4) is rotatably connected to the side wall of the box body (2). A handle (5) is fixedly connected to the outer side wall of the box door (4). A support plate (6) is fixedly connected to the inner side wall of the box body (2). A slide groove (7) is fixedly connected to the top of the support plate (6). Multiple petri dishes are arranged on the top of the slide groove (7). (8) A fixed cover (9) is fixedly connected to the top of the petri dish (8), and fixed blocks (10) are fixedly connected to both sides of the petri dish (8). A movable cover (11) is rotatably connected to the top of one of the fixed blocks (10). A partition block (12) is provided between any two petri dishes (8). A rotating shaft (13) is rotatably connected inside the partition block (12). Multiple stirring rods (14) are fixedly connected to the rotating shaft (13). A driving component is provided at the bottom of the petri dish (8).

2. The cell co-culture device according to claim 1, characterized in that, The top cover (26) and the box door (4) are both transparent, and the stirring rod (14) is located inside the petri dish (8).

3. The cell co-culture device according to claim 1, characterized in that, The outer wall of the housing (2) is provided with a control panel, which is provided with a display screen (15) and multiple control buttons (16).

4. The cell co-culture device according to claim 1, characterized in that, A controller (17) is fixedly connected to the inner wall of the box (2), and a temperature control module (18) is fixedly connected to the bottom of the support plate (6). Multiple ventilation holes are provided on the support plate (6), and the ventilation holes are located above the temperature control module (18).

5. A cell co-culture device according to claim 3, characterized in that, The drive assembly includes a motor (19) fixedly connected to the top of the base plate (1). The top output end of the motor (19) is provided with an output shaft (20). The bottom of the lowest petri dish (8) is fixedly connected with a slider (21). The slider (21) has grooves on both sides. A connecting piece (22) is provided inside the groove. The two side walls of the slide (7) are fixedly connected with wire boxes (27). The inner side wall of the wire box (27) is fixedly connected with a spring (23). The end of the spring (23) is fixedly connected with a locking block (24). The two locking blocks (24) are electrically connected to the motor (19) and the controller (17) respectively.

6. The cell co-culture device according to claim 5, characterized in that, The slider (21) is slidably disposed with the groove (7), the locking block (24) is hemispherical and made of metal, and the locking block (24) engages with the groove on the slider (21).

7. A cell co-culture device according to claim 5, characterized in that, The output shaft (20) is provided with a boss (25), and the output shaft (20) is engaged with the rotating shaft (13) through the boss (25).

Images