Mass spectrometer for detecting concentration of cyclosporine A in human whole blood

Abstract

The utility model relates to the technical field of mass spectrometers, and discloses a mass spectrometer for detecting the concentration of cyclosporine A in human whole blood, which comprises a sampler, a fixed box is fixedly mounted at the bottom of an inner cavity of the sampler, a through hole is formed in the upper part of an inner cavity of the fixed box, a motor is fixedly mounted at the rear part of the inner cavity of the fixed box, and a through hole is formed in the inner cavity of the fixed box. A first gear is fixedly connected to an output shaft of the motor in a sleeving mode, a gear ring is meshed with the outer edge of the first gear, edge rings are fixedly installed on the upper portion and the lower portion of the gear ring respectively, a sliding groove is formed in an inner cavity of the fixing box, a tooth groove is formed in an inner cavity of the gear ring, second gears are evenly meshed with the outer edge of the tooth groove, and a rotating shaft is fixedly connected to the middle of the second gears in a sleeving mode; the stroke of a motor is adjusted through a pressure sensor, sample bottles are fixed through a clamping plate, the device can conveniently fix the sample bottles with different sizes, the practicability of the device is improved, the situation that the air tightness is affected by shaking of the sample bottles is avoided, and the accuracy of a detection result is guaranteed.

Description

TECHNICAL FIELD

[0001] The utility model relates to mass spectrometer technical field especially relates to a kind of mass spectrometer for detecting cyclosporine A concentration in human whole blood. BACKGROUND

[0002] Cyclosporine A is an immunosuppressive drug acting on T lymphocytes, which is a neutral cyclic polypeptide composed of 11 amino acid residues. Cyclosporine A is commonly used to alleviate rejection after organ transplantation and is applied after kidney, liver, heart, pancreas, lung and small intestine transplantation surgery. It can also be used for various autoimmune diseases, such as active and refractory rheumatoid arthritis, lupus nephritis with massive proteinuria in systemic lupus erythematosus, psoriatic arthritis, Behcet's disease uveitis, iridocyclitis and inflammatory bowel disease.

[0003] In the prior art, when detecting the concentration of cyclosporine A in the patient's body, a mass spectrometer is needed. Some devices cannot fix the sample bottle well when sampling, which may cause the sample bottle to shake, affecting the air tightness during sampling, making the detection result of the device not accurate enough, and the device can only use a single size of sample bottle, which has poor practicability. Therefore, to solve the above problems, the utility model provides a mass spectrometer for detecting cyclosporine A concentration in human whole blood. UTILITY MODEL CONTENT

[0004] In view of the deficiencies of the prior art, the utility model provides a mass spectrometer for detecting cyclosporine A concentration in human whole blood. The pressure sensor senses the sample weight to adjust the motor stroke, so that the motor drives the three clamps to move closer to each other and clamp and fix the sample bottle. This device can fix sample bottles of different sizes, improve the practicability of the device, increase the stability of the sample bottle, avoid the shaking of the sample bottle affecting the air tightness, and improve the accuracy of the detection result.

[0005] The utility model provides following technical scheme: a kind of mass spectrometer for detecting cyclosporine A concentration in human whole blood, including sampler, fixed mounting is equipped with fixed box in the sampler inner cavity bottom, the upper portion of the fixed box inner cavity is equipped with through-hole, motor is fixedly installed in the rear portion of the fixed box inner cavity, gear one is fixedly sleeved on the motor output shaft, gear one outer extension is engaged with gear ring, the upper and lower portions of the gear ring are respectively fixedly installed with ring, the inner cavity of the fixed box is equipped with sliding slot, the quantity of the sliding slot is two and respectively mutually fits with ring, gear slot is equipped in the inner cavity of the gear ring, gear two is evenly engaged with in gear slot outer extension, the quantity of gear two is three, rotating shaft is fixedly sleeved in the middle of gear two, the rotating shaft is movably sleeved in the inner cavity of fixed box, swinging arm is fixedly sleeved on the rotating shaft and located gear two directly above, the end of the swinging arm away from rotating shaft is fixedly installed with clamping plate, pressure sensor is fixedly installed in the inner cavity bottom of the fixed box, sample bottle is arranged in the inner cavity of the fixed box and located pressure sensor directly above, the stroke of motor is adjusted by pressure sensor, so that clamping plate is fixed to sample bottle, it is convenient for device to fix sample bottle of different sizes, improve the practicability of device, avoid that sample bottle shakes and influence air tightness, guarantee the accuracy of detection result.

[0006] Preferably, the top of the sampler inner cavity is fixedly installed with an electric push rod, the electric push rod is two in number and symmetrically distributed left and right, the bottom end of the electric push rod is fixedly installed with a pump, the upper part of the pump is fixedly installed with a sample conduit, the upper end of the sample conduit is fixedly installed on the top of the sampler inner cavity, by setting the electric push rod to drive the sampling device to move up and down, it is convenient for the device to realize sampling of the sample, and interference from external factors during sampling is avoided.

[0007] Preferably, the bottom of the pump is fixedly sleeved with a sleeve, the bottom of the sleeve is provided with a threaded groove, the threaded groove is engaged with a threaded cylinder, the bottom of the threaded cylinder is fixedly installed with a sealing plate, the bottom of the sealing plate is fixedly installed with a sampling tube, the sampling tube is located directly above the sample bottle, by rotating the sealing plate and using the engagement between the threaded groove and the threaded cylinder to take down and replace the sampling tube, it is avoided that the sampling tube is left with previous samples, and contamination caused by contact between samples is prevented.

[0008] Preferably, the front of the sampler is movably connected with a front door through a shaft, the left part of the sampler is provided with a heat dissipation opening, the upper part of the sampler is fixedly installed with an ionization unit, the right part of the sampler is fixedly installed with a mass spectrometer, the upper part of the mass spectrometer is movably connected with an upper cover through a shaft, the sample is ionized by the ionization unit, which is conducive to subsequent detection, the ionized sample enters the mass spectrometer, and the cyclosporine A concentration in human whole blood is detected by the mass spectrometer.

[0009] Compared with the prior art, the utility model has the following beneficial effects:

[0010] 1、When the sample bottle is placed into the inner cavity of the fixing box, the pressure sensor senses the weight of the sample bottle and starts the motor, so that the motor drives the transmission mechanism, the transmission mechanism makes the swing arm swing, so that the three clamping plates are close to each other and clamp and fix the sample bottle, the pressure sensor can flexibly adjust the stroke of the motor according to the different weight of the sample bottle, so that the device can fix the sample bottles with different sizes, the practicability of the device is improved, the stability of the sample bottle during sampling is effectively improved, the large shaking of the sample bottle is avoided, the air tightness during sampling is affected, the sample bottle is prevented from being poured to affect the subsequent detection result, and the accuracy of the detection result is improved.

[0011] 2、After the sample bottle is fixed, the sealing plate is driven by the telescopic end of the electric push rod to tightly contact the bottle opening of the sample bottle, then the pump is started, and the sample in the sample bottle is sampled through the sampling pipe, after sampling, the electric push rod is retracted to drive the sampling pipe to return to the original position, before the next sampling, the sampling pipe is taken down by rotating the sealing plate and utilizing the meshing between the threaded groove and the threaded cylinder, so that the sampling pipe is more convenient and fast to disassemble and assemble, residual samples on the sampling pipe are effectively avoided, contact between samples is prevented to cause pollution, detection accidents are reduced, and the working efficiency of the device is improved. BRIEF DESCRIPTION OF DRAWINGS

[0012] Figure 1 It is a schematic diagram of the external structure of the utility model;

[0013] Figure 2 It is a schematic diagram of sampling of the utility model;

[0014] Figure 3 It is a schematic diagram of the external structure of the fixing device of the utility model;

[0015] Figure 4 It is a schematic diagram of the internal structure of the fixing device of the utility model;

[0016] Figure 5 It is a schematic diagram of the sectional structure of the fixing structure of the utility model;

[0017] Figure 6 It is a schematic diagram of the sampling structure of the utility model.

[0018] In the drawing: 1, sampler; 2, fixing box; 3, through hole; 4, motor; 5, gear one; 6, gear ring; 7, ring; 8, sliding groove; 9, gear slot; 10, gear two; 11, rotating shaft; 12, swing arm; 13, clamping plate; 14, pressure sensor; 15, sample bottle; 16, electric push rod; 17, pump; 18, sample conduit; 19, sleeve; 20, threaded groove; 21, threaded cylinder; 22, sealing plate; 23, sampling pipe; 24, front door; 25, heat dissipation opening; 26, ionization unit; 27, mass spectrometer; 28, upper cover. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the utility model.

[0020] Please refer to Figures 1-6 A mass spectrometer for detecting cyclosporine A concentration in human whole blood, including sampler 1, fixedly installed with fixed box 2 at the bottom of the inner cavity of sampler 1, a through hole 3 is formed in the upper part of the inner cavity of fixed box 2, a motor 4 is fixedly installed at the rear part of the inner cavity of fixed box 2, a gear one 5 is fixedly sleeved on the output shaft of motor 4, a gear ring 6 is engaged outside gear one 5, a ring 7 is fixedly installed on the upper and lower parts of gear ring 6 respectively, a sliding slot 8 is formed in the inner cavity of fixed box 2, the number of sliding slot 8 is two and it is mutually fitted with ring 7, a gear slot 9 is formed in the inner cavity of gear ring 6, gear two 10 is uniformly engaged outside gear slot 9, the number of gear two 10 is three, a rotating shaft 11 is fixedly sleeved in the middle of gear two 10, rotating shaft 11 is movably sleeved in the inner cavity of fixed box 2, a swing arm 12 is fixedly sleeved on rotating shaft 11 and located directly above gear two 10, a clamping plate 13 is fixedly installed at the end of swing arm 12 away from rotating shaft 11, a pressure sensor 14 is fixedly installed at the bottom of the inner cavity of fixed box 2, a sample bottle 15 is arranged in the inner cavity of fixed box 2 and located directly above pressure sensor 14, the sample to be detected is placed in sample bottle 15, then sample bottle 15 is placed on pressure sensor 14 through through hole 3, after pressure sensor 14 senses the weight of sample bottle 15, motor 4 is started, so that motor 4 drives gear one 5 to rotate, gear one 5 drives gear ring 6 to rotate in the inner cavity of fixed box 2 by the fitting of ring 7 and sliding slot 8, gear ring 6 drives gear two 10 to rotate through gear slot 9 in the rotating process, gear two 10 drives swing arm 12 to swing by rotating shaft 11, so that three clamping plates 13 clamp sample bottle 15, pressure sensor 14 can flexibly adjust the stroke of motor 4 according to the different weights of sample bottle 15, so as to fix sample bottles 15 of different sizes, improve the practicability of the device, effectively increase the stability of sample bottle 15 during sampling, avoid the influence of large shaking of sample bottle 15 on the sealing performance during sampling, prevent sample bottle 15 from being poured and affecting the subsequent detection results, and improve the accuracy of the detection results.

[0021] The top of the inner cavity of the sampler 1 is fixedly provided with two electric push rods 16 which are symmetrically distributed left and right. The bottom end of each electric push rod 16 is fixedly provided with a pump 17. The upper part of the pump 17 is fixedly provided with a sample conduit 18. The upper end of the sample conduit 18 is fixedly provided at the top of the inner cavity of the sampler 1. The bottom of the pump 17 is fixedly sleeved with a sleeve 19. The bottom of the sleeve 19 is provided with a threaded groove 20. The threaded groove 20 is engaged with a threaded cylinder 21. The bottom of the threaded cylinder 21 is fixedly provided with a sealing plate 22. The bottom of the sealing plate 22 is fixedly provided with a sampling tube 23. The sampling tube 23 is located directly above the sample bottle 15. The front part of the sampler 1 is movably connected with a front door 24 through a shaft. The left part of the sampler 1 is provided with a heat dissipation opening 25. The upper part of the sampler 1 is fixedly provided with an ionization unit 26. The right part of the sampler 1 is fixedly provided with a mass spectrometer 27. The upper part of the mass spectrometer 27 is movably connected with an upper cover 28 through a shaft. After the sample bottle 15 is fixed, the electric push rod 16 is started to drive the sealing plate 22 to tightly contact the bottle opening of the sample bottle 15. Then the pump 17 is started and the sample in the sample bottle 15 is sampled through the sampling tube 23. After sampling is completed, the electric push rod 16 is retracted to drive the sampling tube 23 to return to the original position. Before the next sampling, the sealing plate 22 is rotated and the sampling tube 23 is removed by the engagement between the threaded groove 20 and the threaded cylinder 21, so that the sampling tube 23 is more convenient and fast to disassemble and assemble, effectively avoids that the sampling tube 23 is left with the previous sample, prevents the samples from contacting to cause pollution, reduces the occurrence of detection accidents, and promotes the working efficiency of the device.

[0022] Working principle: the sample to be detected is placed in the sample bottle 15, and then the sample bottle 15 is placed on the pressure sensor 14 through the through hole 3. After the pressure sensor 14 senses the weight of the sample bottle 15, the motor 4 is started to drive the gear one 5 to rotate. The gear one 5 drives the gear ring 6 to rotate in the inner cavity of the fixed box 2 by the engagement of the ring 7 and the sliding groove 8. The gear ring 6 drives the gear two 10 to rotate by the gear slot 9 during rotation. The gear two 10 drives the swing arm 12 to swing by the rotating shaft 11, so that the three clamping plates 13 clamp the sample bottle 15, which is convenient for fixing the sample bottle 15 directly below the sampling tube 23. The electric push rod 16 is started to drive the sealing plate 22 to tightly contact the bottle opening of the sample bottle 15. Then the pump 17 is started and the sample in the sample bottle 15 is sampled through the sampling tube 23. After sampling is completed, the electric push rod 16 is retracted to drive the sampling tube 23 to return to the original position. Before the next sampling, the sealing plate 22 is rotated and the sampling tube 23 is removed by the engagement between the threaded groove 20 and the threaded cylinder 21, which is convenient for replacement.

Claims

1. A mass spectrometer for detecting the concentration of cyclosporin A in human whole blood comprising a sampler (1), characterised in that: The inner cavity bottom of the sampler (1) is fixedly installed with a fixed box (2), a through hole (3) is formed in the upper part of the inner cavity of the fixed box (2), a motor (4) is fixedly installed at the rear part of the inner cavity of the fixed box (2), a gear one (5) is fixedly sleeved on the output shaft of the motor (4), a gear ring (6) is engaged outside the gear one (5), a ring (7) is fixedly installed on the upper and lower parts of the gear ring (6) respectively, a sliding groove (8) is formed in the inner cavity of the fixed box (2), the number of the sliding grooves (8) is two and they are mutually fitted with the rings (7) respectively, a gear slot (9) is formed in the inner cavity of the gear ring (6), gear twos (10) are uniformly engaged outside the gear slot (9), the number of the gear twos (10) is three, a rotating shaft (11) is fixedly sleeved in the middle of the gear two (10), the rotating shaft (11) is movably sleeved in the inner cavity of the fixed box (2), a swing arm (12) is fixedly sleeved on the rotating shaft (11) and located directly above the gear two (10), a clamping plate (13) is fixedly installed on the end of the swing arm (12) away from the rotating shaft (11), a pressure sensor (14) is fixedly installed at the bottom of the inner cavity of the fixed box (2), a sample bottle (15) is arranged in the inner cavity of the fixed box (2) and located directly above the pressure sensor (14).

2. A mass spectrometer for detecting the concentration of cyclosporin A in human whole blood according to claim 1, characterized in that: The inner cavity top of the sampler (1) is fixedly installed with an electric push rod (16), the number of the electric push rods (16) is two and they are symmetrically distributed left and right, a pump (17) is fixedly installed at the bottom end of the electric push rod (16), a sample conduit (18) is fixedly installed on the upper part of the pump (17), and the upper end of the sample conduit (18) is fixedly installed at the inner cavity top of the sampler (1).

3. A mass spectrometer for detecting the concentration of cyclosporin A in human whole blood according to claim 2, characterised in that: A sleeve (19) is fixedly sleeved at the bottom of the pump (17), a threaded groove (20) is formed in the bottom of the sleeve (19), a threaded cylinder (21) is engaged in the threaded groove (20), a sealing plate (22) is fixedly installed at the bottom of the threaded cylinder (21), a sampling tube (23) is fixedly installed at the bottom of the sealing plate (22), and the sampling tube (23) is located directly above the sample bottle (15).

4. The mass spectrometer for detecting the concentration of cyclosporin A in human whole blood according to claim 1, characterized in that: A front door (24) is movably connected to the front part of the sampler (1) through a shaft, a heat dissipation opening (25) is formed in the left part of the sampler (1), an ionization unit (26) is fixedly installed on the upper part of the sampler (1), a mass spectrometer (27) is fixedly installed on the right part of the sampler (1), and an upper cover (28) is movably connected to the upper part of the mass spectrometer (27) through a shaft.

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