Ioversol purification device

Abstract

The utility model provides an ioversol purifying device which comprises a supporting frame, a settling tank, a solvent tank and an air compressor are arranged in the supporting frame, the lower end of the settling tank is arranged in a necking mode and is in threaded connection with a storage pipe, an air outlet is formed in one side of the upper portion of the settling tank, an air inlet is formed in the upper end of the solvent tank, and an air outlet is formed in one side of the lower portion of the solvent tank. The input end of the air compressor is connected with an air outlet pipeline, and the output end of the air compressor is connected with an air inlet pipeline. According to the present invention, the solvent is evaporated through the negative pressure form so as to achieve the crystallization precipitation of the ioversol, and the quality of the purified ioversol can be improved at the low temperature.

Description

Technical Field

[0001] This invention relates to the field of purification equipment technology, and in particular to an iodophorol purification device. Background Technology

[0002] Ioflucan is primarily used in various angiographic examinations, including: cerebral angiography, peripheral arterial angiography, visceral artery angiography, renal artery and aortic angiography; cardiovascular angiography, including coronary angiography, arterial and venous digital subtraction angiography; intravenous urography; and contrast-enhanced CT scans (including head and body CT).

[0003] While high-performance liquid chromatography (HPLC) preparative columns can achieve complete purification with a single column separation, the expensive column packing material and large amount of solvent make it unsuitable for large-scale industrial production. Iodroxil, however, is slightly soluble in dimethyl sulfoxide and slightly soluble in methanol. Furthermore, methanol has a low boiling point and readily evaporates. By evaporating a small amount of methanol, the iodroxil can be precipitated, ensuring that other impurities are minimized and significantly improving the purity of the prepared iodroxil. Summary of the Invention

[0004] To address the aforementioned problems, this invention discloses an iodofol purification device, comprising a support frame. The support frame houses a precipitation tank, a solvent tank, and an air compressor. The lower end of the precipitation tank is constricted and threadedly connected to a storage tube. A solution containing iodofol is placed in the precipitation tank. By reducing the amount of solvent, iodofol is precipitated and deposited into the storage tube.

[0005] An air outlet is provided on one side of the upper part of the precipitation tank, and an air inlet is provided at the upper end of the solvent tank. The air inlet and outlet pipes of the air compressor are connected, and the output pipe of the air compressor is connected to the air inlet pipe. Methanol is used as the solvent. When the air compressor is working, the pressure in the precipitation tank decreases, causing the solvent to vaporize. The vaporized solvent enters the solvent tank, causing iodofol in the precipitation tank to precipitate to saturation, thus achieving purification.

[0006] Preferably, the sedimentation tank is equipped with a stirring mechanism, which includes a drive motor. The output end of the drive motor is fixedly connected to a rotating rod, which extends downward into the interior of the sedimentation tank. Several scrapers are fixedly connected to the lower end of the rotating rod, and the scrapers are fitted onto the inclined surface at the bottom of the sedimentation tank. When the drive motor is started, the scrapers rotate, scraping the iodofol from the inclined surface into the storage tube.

[0007] Preferably, an X-shaped clamping member is provided between the precipitation tank and the solvent tank. A heat pipe is installed inside the clamping member, with both ends of the heat pipe attached to the side walls of the precipitation tank and the solvent tank, respectively. Vaporization absorbs heat, while liquefaction releases heat; the heat is transferred through the heat pipe.

[0008] Preferably, the upper and lower side walls of the settling tank are respectively fixedly connected to an inlet and an outlet. Untreated material is injected into the settling tank through the inlet, while treated material is discharged through the outlet.

[0009] Preferably, the support frame is internally equipped with a water pump and a waste liquid tank, and the upper side wall of the storage pipe is provided with a drain outlet. By connecting the pipe and starting the water pump, the residual material in the sedimentation tank is pumped into the waste liquid tank, at which point the storage tank can be removed.

[0010] Preferably, a solvent outlet pipe is fixedly connected to the lower end of the solvent tank. The solvent outlet pipe delivers the solvent from the solvent tank.

[0011] Preferably, the support frame has drawers inside. The drawers store relevant tools, pipes, etc.

[0012] The beneficial effects of this invention are as follows:

[0013] 1. A precipitation tank, solvent pipe, air compressor, etc. are added. The material in the precipitation tank crystallizes under negative pressure. The negative pressure evaporation method can greatly reduce the impact of temperature changes on the quality of iodophorol.

[0014] 2. Equipped with a stirring mechanism, the scraper scrapes the precipitated iodofol onto the inclined surface into the storage tube during the rotation of the scraper, which facilitates the collection of iodofol. Attached Figure Description

[0015] Figure 1 This is a three-dimensional schematic diagram of the present invention;

[0016] Figure 2 This is a front view of the present invention;

[0017] Figure 3 This is a three-dimensional schematic diagram of the stirring mechanism of the present invention.

[0018] List of reference numerals in the attached diagram:

[0019] 1. Support frame; 2. Water pump; 3. Drawer; 4. Air compressor; 5. Solvent tank; 6. Clamping component; 7. Sedimentation tank; 8. Air outlet; 9. Air inlet; 10. Stirring mechanism; 11. Feed inlet; 12. Waste liquid tank; 13. Discharge inlet; 14. Storage pipe; 15. Drain pipe; 16. Solvent drain pipe;

[0020] 101. Scraper; 102. Rotating rod; 103. Drive motor. Detailed Implementation

[0021] The present invention will be further illustrated below with reference to the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. It should be noted that the terms "front," "rear," "left," "right," "up," and "down" used in the following description refer to directions in the accompanying drawings, and the terms "inner" and "outer" refer to directions toward or away from the geometric center of a specific component, respectively.

[0022] like Figures 1 to 3 As shown, an iodofol purification device includes a support frame 1, which is composed of several longitudinally and transversely arranged rods welded together. The support frame 1 is equipped with a precipitation tank 7, a solvent tank 5 and an air compressor 4. The lower end of the precipitation tank 7 is narrowed, which facilitates the centralized collection of precipitated iodofol. A storage tube 14 is threadedly connected to the precipitation tank 7, which is used to store the precipitated iodofol.

[0023] When the device is in use, the material to be treated is injected into the precipitation tank 7, and the iodofol is purified by reducing the amount of solvent in it.

[0024] An air outlet 8 is provided on the upper side of the sedimentation tank 7, and an air inlet 9 is provided at the upper end of the solvent tank 5. The air inlet 9 is connected to the input end of the air compressor 4 and the air outlet 8, and the output end of the air compressor 4 is connected to the air inlet 9.

[0025] The solvent used to purify iodofol is methanol. When the air compressor 4 is working, the internal pressure of the precipitation tank 7 decreases, causing the methanol to vaporize. As the solvent decreases, the solute iodofol precipitates out, thus achieving the purification of iodofol. The vaporized methanol will then be liquefied in the solvent tank 5.

[0026] A stirring mechanism 10 is provided on the sedimentation tank 7. The stirring mechanism scrapes the precipitated iodofol. The stirring mechanism 10 includes a drive motor 103. The output end of the drive motor 103 is fixedly connected to a rotating rod 102. The rotating rod 102 extends downward into the interior of the sedimentation tank 7. Several scrapers 101 are fixedly connected to the lower end of the rotating rod 102. The scrapers 101 are fitted onto the inclined surface at the bottom of the sedimentation tank 7. When the drive motor 103 is started, the rotating rod 102 is driven to rotate. As the rotating scrapers 101 rotate, the iodofol on the inclined surface at the bottom of the sedimentation tank 7 is scraped into the storage tube 14.

[0027] An X-shaped clamping member 6 is provided between the precipitation tank 7 and the solvent tank 5, with both ends of the clamping member 6 being arc-shaped to ensure a full fit with the precipitation tank 7 and the solvent tank 5. A heat pipe is installed inside the clamping member 6, with its two ends attached to the side walls of the precipitation tank 7 and the solvent tank 5, respectively. The heat pipe is used for heat transfer. During the processing, the solvent undergoes a phase change, which causes temperature changes. Therefore, the heat pipe ensures temperature uniformity and the smooth and continuous operation of the device. Furthermore, the clamping member 6 also supports and fixes the precipitation tank 7 and the solvent tank 5.

[0028] The upper and lower side walls of the sedimentation tank 7 are respectively fixedly connected to the inlet 11 and the outlet 13. The ends of the inlet 11 and the outlet 13 are equipped with flanges. The material to be processed is fed into the sedimentation tank 7 through the inlet 11, while the processed material is sent out of the sedimentation tank 7 through the outlet 13. The processed material also contains iodophorol, so it needs to be concentrated and purified to improve the yield.

[0029] The support frame 1 is equipped with a water pump 2 and a waste liquid tank 12. The upper side wall of the storage pipe 14 is provided with a drain pipe 15. After one round of processing is completed and the storage pipe 14 needs to be removed, although the material is sent out through the material outlet pipe 13, there is still residue in the sedimentation tank 7. Therefore, the drain pipe 15 is connected through a pipeline, the water pump 2 works, and pumps the residual material in the sedimentation tank 7 to the waste liquid tank 12. Then the storage pipe 14 can be rotated and removed. In addition, during normal processing, the drain pipe 15 is in a blocked state.

[0030] A solvent drain pipe 16 is fixedly connected to the lower end of the solvent tank 5. When the solvent in the solvent tank 5 needs to be reused or transferred, the solvent in the solvent tank 5 is sent out through the solvent drain pipe 16.

[0031] The support frame 1 has a drawer 3 inside. The drawer 3 stores tools, pipes, etc., for easy management of the operating device.

[0032] The technical means disclosed in this invention are not limited to those disclosed in the above embodiments, but also include technical solutions composed of any combination of the above technical features.

Claims

1. An iodofol purification apparatus, characterized in that, Includes a support frame (1), inside which are arranged a sedimentation tank (7), a solvent tank (5) and an air compressor (4), the lower end of the sedimentation tank (7) is narrowed and threadedly connected to a storage tube (14). An air outlet (8) is provided on one side of the upper part of the sedimentation tank (7), and an air inlet (9) is provided at the upper end of the solvent tank (5). The air inlet (8) is connected to the input end of the air compressor (4) and the air outlet (8) through a pipeline, and the output end of the air compressor (4) is connected to the air inlet (9) through a pipeline.

2. The iodofol purification apparatus according to claim 1, characterized in that: The sedimentation tank (7) is provided with a stirring mechanism (10), which includes a drive motor (103). The output end of the drive motor (103) is fixedly connected to a rotating rod (102), and the rotating rod (102) extends downward into the interior of the sedimentation tank (7). The lower end of the rotating rod (102) is fixedly connected to several scrapers (101), and the scrapers (101) are fitted on the inclined surface at the bottom of the sedimentation tank (7).

3. The iodofol purification apparatus according to claim 1, characterized in that: An X-shaped clamping member (6) is provided between the precipitation tank (7) and the solvent tank (5). A heat pipe is provided inside the clamping member (6), and the two ends of the heat pipe are respectively attached to the side walls of the precipitation tank (7) and the solvent tank (5).

4. The iodofol purification apparatus according to claim 1, characterized in that: The upper and lower side walls of the sedimentation tank (7) are respectively fixedly connected to the inlet (11) and the outlet (13).

5. The iodofol purification apparatus according to claim 1, characterized in that: The support frame (1) is equipped with a water pump (2) and a waste liquid tank (12), and the upper side wall of the storage pipe (14) is provided with a drain pipe (15).

6. The iodofol purification apparatus according to claim 1, characterized in that: The solvent tank (5) is fixedly connected to a solvent drain pipe (16) at its lower end.

7. The iodofol purification apparatus according to claim 1, characterized in that: The support frame (1) has a drawer (3) inside.

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