Bioreactor sterile connecting device

Abstract

The utility model provides a bioreactor sterile connecting device, and relates to the technical field of biological medicine. Comprising a working frame, a bioreactor body, a connecting pipeline and connectors, a supporting assembly is arranged on the surface of the working frame, the bioreactor body is arranged on the surface of the supporting assembly, the multiple connectors are formed in the surface of the working frame, and a lifting mechanism is arranged on the side surface of the working frame; the lifting mechanism comprises an electric sliding rail frame fixedly installed on the side surface of the working frame, and a sliding frame is slidably connected into the electric sliding rail frame. The height of the connecting pipeline can be adjusted by sliding the sliding frame in the electric sliding rail frame, and when the sliding frame slides to a proper position, one end of the threaded knob is inserted into the fixing hole by rotating the threaded knob, so that the sliding frame is fixed at the required height, and the biological reaction can be carried out at different stages of the biological reaction. The height of the connecting pipeline can be adjusted according to actual conditions, so that the dynamic requirements under various biological reaction scenes are met.

Description

Technical Field

[0001] This application relates to the field of biomedical technology, specifically to a sterile connection device for a bioreactor. Background Technology

[0002] Microbial contamination is a serious problem in bioreactor processes used for biomedical research and development. Bacterial or fungal contamination can lead to cell death, abnormal metabolites, and other issues. In such cases, aseptic connection devices are required. A bioreactor aseptic connection device is a specialized device used to establish connections between a bioreactor and other related equipment (such as feed pipes, discharge pipes, gas supply devices, etc.) and can maintain a sterile state during the connection process.

[0003] Chinese utility model patent CN204752695U discloses a sterile quick connector for an animal cell culture bioreactor. This sterile quick connector includes a female connector, a male connector, and a protective sleeve for the male connector that is movably connected to the male connector. The male and female connectors are sealed together. The male connector has a toothed rack, and the inner wall of the protective sleeve has elastic barbs that engage with the toothed rack. This utility model is applicable to the field of microbial culture.

[0004] However, the above-mentioned patents still have the following drawbacks: Although they can solve the problem of aseptic connection between pipes during the microbial reaction process, eliminate joint rotation during the connection process, ensure that the male and female joints will not fall off after connection, and ensure no leakage during use, they cannot conveniently and quickly adjust the height of the access pipe. During the bioreactor process, the height of the access pipe needs to be adjusted at different experimental or production stages. If the height of the access pipe cannot be conveniently and quickly adjusted, it will increase the complexity of operation. Operators will need to spend more time disassembling and reinstalling parts of the device, which not only reduces work efficiency but may also introduce the risk of contamination during operation. In order to solve the above problems, an aseptic connection device for bioreactors is proposed. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this application provides a sterile connection device for bioreactors, which solves the problems mentioned in the background section.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this application provides the following technical solution: a sterile connection device for a bioreactor, comprising a work frame, a bioreactor body, a connecting pipe, and interfaces. A support assembly is provided on the surface of the work frame, the bioreactor body is disposed on the surface of the support assembly, and multiple interfaces are disposed on the surface of the work frame. A lifting mechanism is provided on the side surface of the work frame, the lifting mechanism including an electric slide rail fixedly installed on the side surface of the work frame, a sliding frame slidably connected inside the electric slide rail, the connecting pipe being disposed inside the sliding frame, a fixing assembly provided on the side surface of the sliding frame, the fixing assembly including a fixing frame fixedly connected to the side surface of the sliding frame, a threaded knob threadedly connected to the surface of the fixing frame, and multiple fixing holes adapted to one end of the threaded knob being opened on the side surface of the electric slide rail.

[0009] By adopting the above technical solution, the sliding frame slides inside the electric slide rail, enabling the height adjustment of the connecting pipe. Whether based on the needs of different biological reaction stages or to adapt to the height of different interfaces, the position of the connecting pipe can be conveniently adjusted by driving the electric slide rail. When the sliding frame slides to the appropriate position, rotating the threaded knob inserts one end into the fixing hole, thereby fixing the sliding frame at the required height, ensuring the stability of the connecting pipe during operation, and preventing the reliability of the connection from being affected by accidental sliding.

[0010] Preferably, the connecting pipe is composed of a rigid pipe and a flexible pipe, one end of the connecting pipe is provided with a connecting component, and the surface of the connecting pipe is provided with a snap-fit ​​component.

[0011] By adopting the above technical solution, the connecting pipe consists of rigid pipe and flexible pipe. The rigid pipe part can provide better structural support and ensure the stability of the pipe shape, while the flexible pipe part increases the flexibility of the pipe, making it easy to adjust the angle and position within a certain range to adapt to different connection requirements and spatial layouts.

[0012] Preferably, the connecting component includes a connecting port connected to one end of the interface, the inner wall of the connecting port is provided with an elastic diaphragm, and one end of the connecting pipe is connected to a puncture connector, the puncture connector being adapted to the connecting port.

[0013] By adopting the above technical solution, when the puncture connector is inserted into the connection port, the elastic diaphragm can tightly wrap the puncture connector, forming an effective sterile barrier.

[0014] Preferably, the snap-fit ​​assembly includes multiple snap-fit ​​blocks fixedly connected to the surface of the connecting pipe, multiple snap-fit ​​brackets fixedly connected to the side surface of the connecting port, the snap-fit ​​brackets being adapted to the snap-fit ​​blocks, and a sealing gasket being adhered to the surface of the connecting port.

[0015] By adopting the above technical solution, when the connecting pipe is connected to the connecting port, the snap-fit ​​block and the snap-fit ​​bracket snap together to prevent the connecting pipe from accidentally falling off.

[0016] Preferably, the bottom of the work frame is provided with a bottom block assembly, the bottom block assembly including a bottom block fixedly connected to the bottom of the work frame, and an anti-slip pad is adhered to the bottom of the bottom block.

[0017] By adopting the above technical solution, the bottom block is fixed to the bottom of the work frame, and the anti-slip pads bonded to its bottom increase the friction between the device and the placement surface, preventing the device from sliding during operation.

[0018] Preferably, the side surface of the work frame is provided with a support assembly, the support assembly including a connecting frame fixedly connected to the side surface of the work frame, and one end of the connecting frame is fixedly connected to the support frame.

[0019] By adopting the above technical solution, one end of the connecting frame is fixed to the side surface of the working frame, and the support frame at the other end can enhance the stability of the bioreactor body.

[0020] Preferably, the surface of the sliding frame is provided with a pressing mechanism, the pressing mechanism including a pressing frame fixedly connected to the upper surface of the sliding frame, an electric push rod fixedly installed on the inner wall of the pressing frame, and a pressing plate fixedly connected to one end of the electric push rod.

[0021] By adopting the above technical solution, after the connecting pipe is placed inside the sliding frame, the electric push rod fixedly installed on the inner wall of the pressing frame can be used to push the pressing plate down, thereby fixing the rigid part of the connecting pipe inside the sliding frame.

[0022] (III) Beneficial Effects

[0023] This application provides a sterile connection device for a bioreactor. It has the following beneficial effects:

[0024] 1. This bioreactor aseptic connection device, through the coordinated arrangement of a lifting mechanism and a fixing component, allows the height of the connecting pipe to be adjusted by sliding the sliding frame inside the electric slide rail. When the sliding frame slides to the appropriate position, rotating the threaded knob inserts one end into the fixing hole, thereby fixing the sliding frame at the required height. Thus, at different stages of the bioreactor, the height of the connecting pipe can be adjusted according to the actual situation, thereby meeting the dynamic needs of various bioreactor scenarios.

[0025] 2. This bioreactor aseptic connection device, through the coordinated arrangement of the connection component and the snap-fit ​​component, allows the puncture connector to be inserted into the connection port, enabling the elastic diaphragm to tightly wrap around the puncture connector, forming an effective aseptic barrier to prevent external microorganisms from entering the bioreactor or contaminating the materials inside the connection pipe. At the same time, it ensures the sealing of the connection. Furthermore, when the connection pipe is connected to the connection port, the snap-fit ​​block and the snap-fit ​​bracket interlock to prevent the connection pipe from accidentally falling off, ensuring the long-term stability of the connection. Attached Figure Description

[0026] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0027] Figure 1 This is a three-dimensional structural diagram of the present application;

[0028] Figure 2 This is a structural schematic diagram of the fixing component, support component, and base block component of this application;

[0029] Figure 3 For this application Figure 2 Enlarged structural diagram of section A in the middle;

[0030] Figure 4 This is a schematic diagram of the lifting mechanism and pressing mechanism of this application.

[0031] In the picture:

[0032] 1. Working frame; 101. Bioreactor body; 102. Connecting pipes; 103. Interface;

[0033] 2. Lifting mechanism; 201. Electric slide rail frame; 202. Sliding frame;

[0034] 3. Pressing mechanism; 301. Pressing frame; 302. Electric push rod; 303. Pressing plate;

[0035] 4. Fixing components; 401. Fixing bracket; 402. Threaded knob; 403. Fixing hole;

[0036] 5. Snap-fit ​​assembly; 501. Snap-fit ​​block; 502. Snap-fit ​​bracket; 503. Sealing gasket;

[0037] 6. Support components; 601. Connecting frame; 602. Support frame;

[0038] 7. Connecting components; 701. Connecting port; 702. Elastic diaphragm; 703. Puncture connector;

[0039] 8. Base block assembly; 801. Base block; 802. Anti-slip mat. Detailed Implementation

[0040] It should be noted that in the description of the embodiments of this application, the terms "front," "rear," "left," "right," "up," "down," etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application. The terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication between two elements. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0041] The present application will be further described in detail below with reference to the accompanying drawings and embodiments.

[0042] Reference Figures 1 to 4 This application provides a sterile connection device for a bioreactor, including a work frame 1, a bioreactor body 101, a connecting pipe 102, and an interface 103. A support component 6 is provided on the surface of the work frame 1, and the bioreactor body 101 is disposed on the surface of the support component 6. Multiple interfaces 103 are disposed on the surface of the work frame 1. A lifting mechanism 2 is provided on the side surface of the work frame 1. The lifting mechanism 2 includes an electric slide rail 201 fixedly installed on the side surface of the work frame 1. A sliding frame 202 is slidably connected inside the electric slide rail 201. The connecting pipe 102 is disposed inside the sliding frame 202. A fixing component 4 is provided on the side surface of the sliding frame 202. The fixing component 4 includes a fixing frame 401 fixedly connected to the side surface of the sliding frame 202. A threaded knob 402 is threadedly connected to the surface of the fixing frame 401. Multiple fixing holes 403 adapted to one end of the threaded knob 402 are opened on the side surface of the electric slide rail 201. The sliding bracket 202 slides inside the electric slide rail bracket 201, allowing the height of the connecting pipe 102 to be adjusted. Whether according to the needs of different biological reaction stages or to adapt to the height of different interfaces 103, the position of the connecting pipe 102 can be conveniently adjusted by driving the electric slide rail bracket 201. When the sliding bracket 202 slides to the appropriate position, the threaded knob 402 is rotated so that one end is inserted into the fixing hole 403, thereby fixing the sliding bracket 202 at the required height, ensuring the stability of the connecting pipe 102 during operation, and preventing the reliability of the connection from being affected by accidental sliding.

[0043] Reference Figure 3This application provides a bioreactor aseptic connection device, including a connection pipe 102, which is composed of a rigid pipe and a flexible pipe. A connection component 7 is provided at one end of the connection pipe 102, and a snap-fit ​​component 5 is provided on the surface of the connection pipe 102.

[0044] The connection component 7 includes a connection port 701 connected to one end of the interface 103. An elastic diaphragm 702 is provided on the inner wall of the connection port 701. A puncture connector 703 is connected to one end of the connection pipe 102. The puncture connector 703 is adapted to the connection port 701.

[0045] The snap-fit ​​assembly 5 includes multiple snap-fit ​​blocks 501 fixedly connected to the surface of the connecting pipe 102, multiple snap-fit ​​brackets 502 fixedly connected to the side surface of the connecting port 701, the snap-fit ​​brackets 502 are adapted to the snap-fit ​​blocks 501, and a sealing gasket 503 is adhered to the surface of the connecting port 701. The connecting pipe 102 consists of a rigid pipe and a flexible pipe. The rigid pipe provides better structural support to ensure the stability of the pipe shape, while the flexible pipe increases the flexibility of the pipe, making it easy to adjust the angle and position within a certain range to adapt to different connection requirements and spatial layouts. When the puncture connector 703 is inserted into the connecting port 701, the elastic diaphragm 702 can tightly wrap the puncture connector 703 to form an effective sterile barrier, preventing external microorganisms from entering the bioreactor or contaminating the substances inside the connecting pipe, while ensuring the sealing of the connection and ensuring that the bioreactor can be carried out in a sterile environment. When the connecting pipe 102 is connected to the connecting port 701, the locking block 501 and the locking bracket 502 lock together to prevent the connecting pipe 102 from accidentally falling off, ensuring the long-term stability of the connection, especially under conditions such as vibration during the operation of the bioreactor.

[0046] Reference Figure 2 and Figure 4 In one aspect of this embodiment, a bottom block assembly 8 is provided at the bottom of the work frame 1. The bottom block assembly 8 includes a bottom block 801 fixedly connected to the bottom of the work frame 1, and an anti-slip pad 802 is adhered to the bottom of the bottom block 801.

[0047] A support assembly 6 is provided on the side surface of the work frame 1. The support assembly 6 includes a connecting frame 601 fixedly connected to the side surface of the work frame 1, and a support frame 602 is fixedly connected to one end of the connecting frame 601.

[0048] A pressing mechanism 3 is provided on the surface of the sliding frame 202. The pressing mechanism 3 includes a pressing frame 301 fixedly connected to the upper surface of the sliding frame 202. An electric push rod 302 is fixedly installed on the inner wall of the pressing frame 301, and a pressing plate 303 is fixedly connected to one end of the electric push rod 302. The bottom block 801 is fixed to the bottom of the working frame 1. The anti-slip pad 802 adhered to its bottom increases the friction between the device and the placement plane, preventing the device from sliding during operation and ensuring that the bioreactor works in a stable state. One end of the connecting frame 601 is fixed to the side surface of the working frame 1, and the support frame 602 at the other end can enhance the stability of the bioreactor body 101. When the connecting pipe 102 is placed inside the sliding frame 202, the pressing plate 303 can be pushed down by the electric push rod 302 fixedly installed on the inner wall of the pressing frame 301, thereby fixing the rigid part of the connecting pipe 102 inside the sliding frame 202.

[0049] All electrical devices in this plan are powered by an external power source.

[0050] Working principle: In use, the connecting pipe 102 to be connected is placed inside the sliding frame 202, and then the pressing mechanism 3 is used to fix the connecting pipe 102 inside the sliding frame 202. Then, the piercing connector 703 is inserted into the connecting port 701, so that the elastic diaphragm 702 can tightly wrap the piercing connector 703. When the connecting pipe 102 is connected to the connecting port 701, the snap-fit ​​block 501 and the snap-fit ​​bracket 502 snap into each other. Then, the sliding frame 202 slides inside the electric slide rail frame 201, so that the height of the connecting pipe 102 can be adjusted. When the sliding frame 202 slides to the appropriate position, the threaded knob 402 is rotated so that one end is inserted into the fixing hole 403, thereby fixing the sliding frame 202 at the required height.

[0051] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sterile connection device for a bioreactor, comprising a work frame (1), a bioreactor body (101), a connecting pipe (102), and an interface (103), characterized in that: The surface of the work frame (1) is provided with a support assembly (6), the bioreactor body (101) is provided on the surface of the support assembly (6), a plurality of interfaces (103) are provided on the surface of the work frame (1), a lifting mechanism (2) is provided on the side surface of the work frame (1), the lifting mechanism (2) includes an electric slide rail frame (201) fixedly installed on the side surface of the work frame (1), a sliding frame (202) is slidably connected inside the electric slide rail frame (201), the connecting pipe (102) is provided inside the sliding frame (202), a fixing assembly (4) is provided on the side surface of the sliding frame (202), the fixing assembly (4) includes a fixing frame (401) fixedly connected to the side surface of the sliding frame (202), a threaded knob (402) is threadedly connected to the surface of the fixing frame (401), and a plurality of fixing holes (403) adapted to one end of the threaded knob (402) are opened on the side surface of the electric slide rail frame (201).

2. The aseptic connection device for a bioreactor according to claim 1, characterized in that: The connecting pipe (102) is composed of a rigid pipe and a flexible pipe. A connecting component (7) is provided at one end of the connecting pipe (102), and a snap-fit ​​component (5) is provided on the surface of the connecting pipe (102).

3. The aseptic connection device for a bioreactor according to claim 2, characterized in that: The connecting component (7) includes a connecting port (701) connected to one end of the interface (103), the inner wall of the connecting port (701) is provided with an elastic diaphragm (702), and one end of the connecting pipe (102) is connected to a piercing connector (703), which is adapted to the connecting port (701).

4. The aseptic connection device for a bioreactor according to claim 3, characterized in that: The snap-fit ​​assembly (5) includes multiple snap-fit ​​blocks (501) fixedly connected to the surface of the connecting pipe (102), and multiple snap-fit ​​brackets (502) fixedly connected to the side surface of the connecting port (701). The snap-fit ​​brackets (502) are adapted to the snap-fit ​​blocks (501), and a sealing gasket (503) is adhered to the surface of the connecting port (701).

5. The aseptic connection device for a bioreactor according to claim 1, characterized in that: The bottom of the work frame (1) is provided with a bottom block assembly (8), the bottom block assembly (8) includes a bottom block (801) fixedly connected to the bottom of the work frame (1), and an anti-slip pad (802) is glued to the bottom of the bottom block (801).

6. The aseptic connection device for a bioreactor according to claim 1, characterized in that: The support assembly (6) includes a connecting frame (601) fixedly connected to the side surface of the work frame (1), and a support frame (602) is fixedly connected to one end of the connecting frame (601).

7. The aseptic connection device for a bioreactor according to claim 1, characterized in that: The surface of the sliding frame (202) is provided with a pressing mechanism (3). The pressing mechanism (3) includes a pressing frame (301) fixedly connected to the upper surface of the sliding frame (202). An electric push rod (302) is fixedly installed on the inner wall of the pressing frame (301). One end of the electric push rod (302) is fixedly connected to a pressing plate (303).

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