Medicating and stirring tank for rifamycin fermentation process
By introducing scraper agitation and UV lamp sterilization components into the mixing tank, the problems of uneven mixing and contamination by miscellaneous bacteria were solved, achieving efficient mixing and aseptic dosing during rifamycin fermentation, thus improving product quality and production efficiency.
Patent Information
- Application Number
- CN202520198561.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-08
- Publication Date
- 2026-02-13
- Estimated Expiration
- 2035-02-08
AI Technical Summary
Traditional mixing tanks are difficult to effectively mix the materials on the inner wall of the tank, and when adding agents during fermentation, it is easy to carry miscellaneous bacteria into the tank, affecting product quality.
A dosing mixing tank including a stirring component and a sterilization component was designed. A scraper is used to stir the inner wall of the tank, and a UV lamp is used to sterilize the inside of the storage tank. The aseptic dosing of the agent is achieved by the cooperation of an electric push rod and a plug.
It improves the mixing rate of materials, ensures product quality, prevents contamination by miscellaneous bacteria, and enhances the efficiency and purity of the rifamycin fermentation process.
Smart Images
Figure CN223906833U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of mixing tanks, specifically a mixing tank for adding drugs in a rifamycin fermentation process. Background Technology
[0002] Rifamycin is an important class of antibiotics widely used to treat infectious diseases such as tuberculosis. As a core component of anti-tuberculosis drugs, the production efficiency and quality of rifamycin SV directly affect the drug supply chain and patient treatment outcomes. The traditional fermentation production process for rifamycin SV uses *Amycosis thaliana* as the starting strain, undergoing pure culture and three-stage fermentation to produce rifamycin SV. With the increasing global demand for antibiotics, especially the spread of diseases like tuberculosis, the market potential for rifamycin SV is enormous.
[0003] However, traditional mixing tanks are difficult to agitate the materials on the inner wall of the tank, and when adding agents during fermentation, they can easily carry miscellaneous bacteria into the tank, affecting product quality, and urgently need improvement. Utility Model Content
[0004] The technical problem this invention aims to solve is that existing mixing tanks are difficult to mix the materials on the inner wall of the tank, and when adding agents during fermentation, it is easy to carry miscellaneous bacteria into the tank.
[0005] To solve the above problems, the technical solution of this utility model is as follows: a rifamycin fermentation process dosing and stirring tank, including a tank body, a stirring assembly installed inside the tank body, a motor for driving the stirring assembly to rotate installed at the top, a feeding port at the top of the tank body, a discharge pipe at the bottom, a sealing cap installed at the feeding port, the stirring assembly including a stirring shaft, multiple stirring blades installed on the stirring shaft, and two scrapers symmetrically installed on the stirring shaft; a drug delivery cylinder is connected to the upper side of the tank body, a drug storage tank is connected to the top of the drug delivery cylinder, an electric push rod is installed through the side, the movable end of the electric push rod is connected to a plug inside the drug delivery cylinder, a second feeding port is opened on one side of the top of the drug storage tank, a sterilization assembly is installed at the top inside, and a second sealing cap is installed at the second feeding port.
[0006] Furthermore, a protective shell is provided on the lower outer side of the tank body, and a cavity is formed between the protective shell and the tank body. An inlet pipe and an outlet pipe are provided on the upper sides of the cavity, and a drain pipe is provided at the bottom.
[0007] Furthermore, the top of the tank is equipped with an air inlet pipe and an electronic pressure relief valve.
[0008] Furthermore, the scraper is attached to the inner side and inner bottom of the tank.
[0009] Further, the inside of the medicine storage tank is rotatably provided with a stirring shaft two, and a motor two is provided on the top of the medicine storage tank for driving the stirring shaft two to rotate, a plurality of stirring blades two are provided on the stirring shaft two, the bottom of the medicine storage tank is designed in a conical shape, and a discharge pipe two is arranged at the bottom of the medicine storage tank and fixed to the medicine feeding cylinder.
[0010] Further, the bottom of the stirring shaft two is connected with a stirring rod, the stirring rod is designed in an S shape with the top being larger and the bottom being smaller, and the bottom of the stirring rod extends into the inside of the discharge pipe two.
[0011] Further, the thickness of the plug is greater than the inner diameter of the discharge pipe two.
[0012] Further, the sterilization assembly is a UV lamp.
[0013] Further, the electromagnetic valves are arranged on the air inlet pipe, the discharge pipe one and the liquid discharge pipe, and the motor one and the motor two are deceleration motors.
[0014] Compared with the prior art, the utility model has the advantages that the utility model stirs the material at the inner wall of the tank body through the scraper, improves the mixing rate of the material, the sterilization assembly sterilizes the inside of the medicine storage tank and the medicine, the sterile injection of the medicine can be realized through the cooperation of the electric push rod and the plug, and the product quality is ensured. BRIEF DESCRIPTION OF DRAWINGS
[0015] Figure 1 is the three-dimensional view of the utility model Figure 1 .
[0016] Figure 2 is the three-dimensional view of the utility model Figure 2 .
[0017] Figure 3 is the sectional view of the tank body of the utility model.
[0018] Figure 4 is the sectional view of the connecting structure of the medicine storage tank of the utility model.
[0019] As shown in the drawings: 1, tank body; 2, motor one; 3, discharge pipe one; 4, sealing cover one; 5, stirring shaft one; 6, stirring blade one; 7, scraper; 8, medicine feeding cylinder; 9, medicine storage tank; 10, electric push rod; 11, plug; 12, sterilization assembly; 13, sealing cover two; 14, protective shell; 15, input pipe; 16, output pipe; 17, liquid discharge pipe; 18, air inlet pipe; 19, electronic pressure relief valve; 20, stirring shaft two; 21, motor two; 22, stirring blade two; 23, discharge pipe two; 24, stirring rod. DETAILED DESCRIPTION
[0020] Clearly, the described embodiments are merely a part of the embodiments of the present application, but not all the embodiments; based on the embodiments in the present application, all the other embodiments obtained by those ordinarily skilled in the art without creative labor fall within the protection scope of the present application.
[0021] As shown in Figures 1 to 3 A rifamycin fermentation process dosing stirred tank, including tank body 1, the top of the tank body 1 is provided with a feeding port one, the bottom is provided with a discharge pipe one 3, the feeding port one is installed with sealing cover one 4, the top of the tank body 1 is also provided with air inlet pipe 18 and electronic pressure relief valve 19, the lower part of the tank body 1 outside is provided with protective shell 14, the protective shell 14 and the tank body 1 form a cavity, the cavity two sides upper part is provided with input pipe 15 and output pipe 16, the bottom is provided with liquid discharge pipe 17.
[0022] The input pipe 15 and the output pipe 16 are connected to the water circulation system, and the heating, constant temperature or cooling of the material in the tank body 1 can be realized by adjusting the water temperature, temperature, pressure, oxygen concentration and other sensors can be installed in the tank body 1 to monitor the environment in the tank body 1, and sterile air can be input into the tank body 1 through the air inlet pipe 18.
[0023] The tank body 1 is provided with a stirring assembly, and a motor one 2 is installed on the top for driving the stirring assembly to rotate, the stirring assembly includes a stirring shaft one 5, a plurality of stirring blades one 6 are installed on the stirring shaft one 5, and two scrapers 7 are symmetrically installed on the stirring shaft one 5, the scraper 7 is attached to the inner side and the inner bottom of the tank body 1.
[0024] The motor one 2 drives the stirring shaft one 5 to rotate, which drives the stirring blade one 6 and the scraper 7 to rotate, so as to realize the stirring of the material in the tank body 1, and the material on the inner wall of the tank body 1 is stirred by the scraper 7, which improves the mixing rate of the material.
[0025] As shown in Figure 1 And Figure 4As shown, the tank body 1 side upper part is connected with a dosing barrel 8, the top of the dosing barrel 8 is connected with a storage tank 9, the side is throughly installed with an electric push rod 10, the movable end of the electric push rod 10 is connected with a plug 11 inside the dosing barrel 8, the top of the storage tank 9 is provided with a second charging port, the inner top is installed with a sterilization assembly 12, the second charging port is installed with a sealing cover 13, the inside of the storage tank 9 is rotatably installed with a stirring shaft 20, the top is installed with a motor 21 for driving the stirring shaft 20 to rotate, a plurality of stirring blades 22 are installed on the stirring shaft 20, the bottom of the storage tank 9 is designed in a conical shape, and the bottom is provided with a discharge pipe 23, the discharge pipe 23 is fixedly connected to the dosing barrel 8, the bottom of the stirring shaft 20 is connected with a stirring rod 24, the stirring rod 24 is designed in an S shape with the top being large and the bottom being small, and the bottom of the stirring rod 24 extends into the discharge pipe 23, the thickness of the plug 11 is greater than the inner diameter of the discharge pipe 23, and the sterilization assembly 12 is a UV lamp.
[0026] The medicament is added into the storage tank 9, the UV lamp can sterilize the inside of the storage tank 9, the motor 21 is turned on, the motor 21 drives the stirring blades 22 to rotate, the sterilization of the medicament can be realized, the electric push rod 10 is retracted, the plug 11 is moved to the inside of the dosing barrel 8 away from one end of the tank body 1, at this time the medicament can enter the dosing barrel 8, the electric push rod 10 is elongated to move the plug 11 into the tank body 1, the aseptic addition of the medicament can be realized, after the addition of the medicament is completed, the electric push rod 10 is retracted to restore the original position of the plug 11, the connection between the discharge pipe 23 and the dosing barrel 8 is sealed, at this time the medicament to be added next time can be added into the storage tank 9. The S-shaped stirring rod 24 can prevent the medicament from blocking the discharge pipe 23.
[0027] In specific use, the raw materials are added into the tank body 1, and the motor 2 is turned on, so that the raw materials can be quickly mixed and fermented to promote the growth of bacteria and the synthesis of rifamycin SV. Within 40-60h of fermentation culture, the fosfomycin sodium and glutamic acid sodium are added aseptically as metabolic control factors to inhibit unnecessary metabolic pathways and promote the synthesis of 3-amino-5-hydroxybenzoic acid, a precursor of rifamycin SV. By regulating the microbial metabolic pathway, the effective yield of rifamycin SV is improved.
[0028] The fosfomycin sodium is added into the storage tank 9, the UV lamp can sterilize the inside of the storage tank 9, the motor 21 is turned on, the motor 21 drives the stirring blades 22 to rotate, the sterilization of the medicament can be realized; the electric push rod 10 is retracted to make the fosfomycin sodium enter the dosing barrel 8, the electric push rod 10 is elongated to move the plug 11 into the tank body 1, the aseptic addition of the fosfomycin sodium can be realized; the addition of the glutamic acid sodium can be realized in the same way.
[0029] The specific structure and working principle of the non-disclosed part in the utility model are not described again.
[0030] It should be noted that, in this document, relational terms such as first and second and the like can be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can also include other elements not expressly listed or inherent to such process, method, article, or apparatus.
[0031] Although the embodiments of the utility model have been shown and described, it should be understood by those of ordinary skill in the art that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirit of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.
[0032] The utility model and its implementation mode have been described above, and this description is not restrictive, and the embodiment shown in the drawings is only one of the embodiments of the utility model, and the actual structure is not limited thereto. In summary, if a person skilled in the art is inspired by it, without departing from the creative purpose of the utility model, without creative design, similar structure modes and embodiments of the technical scheme should belong to the protection scope of the utility model.
Claims
1. A rifamycin fermentation dosing and stirring tank, comprising a tank body (1), wherein a stirring assembly is installed inside the tank body (1), and a motor (2) for driving the stirring assembly to rotate is installed on the top; a feeding port is provided on the top of the tank body (1), and a discharge pipe (3) is provided on the bottom; a sealing cap (4) is installed at one of the feeding ports, characterized in that: The stirring assembly comprises a stirring shaft (5) on which a plurality of stirring blades (6) are mounted, and two scrapers (7) are symmetrically mounted on the stirring shaft (5); the side upper portion of the tank body (1) is connected with a dosing cylinder (8), the top of the dosing cylinder (8) is connected with a medicine storage tank (9), an electric push rod (10) is mounted through the side, the movable end of the electric push rod (10) is connected with a plug (11) inside the dosing cylinder (8), a second charging opening is formed on one side of the top of the medicine storage tank (9), a sterilization assembly (12) is mounted on the inner top of the medicine storage tank (9), and a second sealing cover (13) is mounted at the second charging opening.
2. A stirred tank for the addition of a drug in a process for the fermentation of rifamycin according to claim 1, characterized in that: The lower portion of the tank body (1) is provided with a protective shell (14), and a cavity is formed between the protective shell (14) and the tank body (1), input pipes (15) and output pipes (16) are arranged on the upper portions of the two sides of the cavity, and a liquid discharge pipe (17) is arranged at the bottom of the cavity.
3. A feed tank for a rifamycin fermentation process according to claim 1, characterized in that: The top of the tank body (1) is provided with an air inlet pipe (18) and an electronic pressure relief valve (19).
4. The feed tank of claim 1, wherein: The scraper (7) is attached to the inner side and the inner bottom of the tank body (1).
5. A feed tank for a rifamycin fermentation process according to claim 1, characterized in that: A stirring shaft (20) is rotatably mounted in the medicine storage tank (9), a motor (21) for driving the stirring shaft (20) to rotate is mounted on the top of the medicine storage tank (9), a plurality of stirring blades (22) are mounted on the stirring shaft (20), the bottom of the medicine storage tank (9) is designed in a conical shape, a discharge pipe (23) is arranged at the bottom of the medicine storage tank (9), and the discharge pipe (23) is fixedly connected to the dosing cylinder (8).
6. A stirred tank for the addition of a drug in a process for the fermentation of rifamycin according to claim 5, characterized in that: The stirring shaft (20) is connected with a stirring rod (24), the stirring rod (24) is designed in an S shape with the upper portion being larger and the lower portion being smaller, and the bottom of the stirring rod (24) extends into the discharge pipe (23).
7. A feed tank for a rifamycin fermentation process according to claim 5, characterized in that: The thickness of the plug (11) is greater than the inner diameter of the discharge pipe (23).
8. A stirred tank for the addition of a drug in a process for the fermentation of rifamycin according to claim 1, characterized in that: The sterilization assembly (12) is a UV lamp.