Crystallization reaction device for producing medical intermediates

Abstract

The utility model relates to the technical field of medicines, and discloses a crystallization reaction device for producing medical intermediates, which comprises a bottom plate, the collecting part is arranged at the top of the bottom plate; the stirring part is arranged in the collecting part; the moving wheels are mounted at the bottom of the bottom plate; wherein the collecting part comprises a cylinder body, a plurality of connecting rods, a plurality of connecting rods and a plurality of connecting rods; the top plate is fixedly connected to the top of the barrel. A second handle is held by hand, so that a collecting box slides to the end point along the track of a limiting frame, then materials enter the barrel body from a feeding opening and are mixed and reacted under the action of a stirring part, then crystals and liquid fall onto the upper surface of a filtering plate at the same time, and then the crystals stay on the upper surface of the filtering plate; and liquid falls into the collecting box through the drainage hopper under the action of gravity, so that the purpose of solid-liquid separation is achieved, then water flow in the water tank is sprayed out under the action of the spray head, and the purpose of cleaning crystals is achieved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical technology, specifically a crystallization reaction apparatus for the production of pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are actually chemical raw materials or chemical products used in the process of drug synthesis. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain standards, they can be used in drug synthesis. In order to ensure safety and improve work efficiency during the production process, neutralization reaction vessels are often used.

[0003] The crystallization reaction equipment used in the current production of pharmaceutical intermediates generally faces the problem of inconvenient solid-liquid separation after the material has completed the crystallization reaction. More importantly, even if some equipment can perform solid-liquid separation, there are still many inconveniences in the process of cleaning the crystals after separation to remove impurities attached to the crystal surface. Utility Model Content

[0004] The purpose of this invention is to provide a crystallization reaction apparatus for the production of pharmaceutical intermediates, which solves the problem of inconvenient solid-liquid separation operation after the material has completed the crystallization reaction. More importantly, even if some apparatuses can perform solid-liquid separation, there are still many inconvenient technical problems in the process of cleaning the crystals after separation to remove impurities attached to the crystal surface. This invention aims to remove impurities and residues from the crystal surface and improve the purity and quality of the crystals.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a crystallization reaction apparatus for the production of pharmaceutical intermediates, comprising: a base plate; a collection section disposed on the top of the base plate; a stirring section disposed inside the collection section; and a moving wheel installed at the bottom of the base plate; wherein the collection section comprises: a cylinder fixedly connected to the top of the base plate; and a top plate fixedly connected to the top of the cylinder.

[0006] Preferably, the outer wall of the cylinder has an outlet and a sliding opening, the top of the top plate has a feed inlet, the feed inlets are symmetrically arranged, and an arc-shaped door panel is rotatably connected between the inner sides of the outlet, and a handle is fixedly connected to the outer wall of the arc-shaped door panel.

[0007] Preferably, a water tank is fixedly connected to the outer wall of the cylinder, and a nozzle is connected to the inner wall of the water tank. The nozzles are equidistantly arranged, with one end of each nozzle extending inward through the cylinder. A filter plate is fixedly connected to the inner wall of the cylinder, and a limit bracket is fixedly connected to the inner wall of the cylinder. The nozzles allow the water inside the water tank to be sprayed out evenly and powerfully, thoroughly cleaning the crystals remaining on the surface of the filter plate. This helps to remove impurities and residues from the crystal surface, improving the purity and quality of the crystals.

[0008] Preferably, a flow guide bucket is fixedly connected to the bottom of the filter plate, and a collection box is slidably connected between the inner sides of the limiting frame. The collection box is adapted to the sliding port one, and a handle two is fixedly connected to the outer wall of the collection box. The collection box is adapted to the flow guide bucket. Through the cleverly designed filter plate, crystals and liquids can be quickly separated. The crystals remain on the upper surface of the filter plate, while the liquid flows smoothly into the collection box through the flow guide bucket under the action of gravity, thus achieving efficient solid-liquid separation.

[0009] Preferably, the stirring part includes: a feed hopper connected to the top of the feed inlet; a motor fixedly connected to the top of the top plate; and a discharge hopper fixedly connected to the inner wall of the cylinder.

[0010] Preferably, a rotating rod is fixedly connected to the output end of the motor. The bottom end of the rotating rod extends downward through the top plate. A stirring blade is fixedly connected to the outer wall of the rotating rod. The stirring blade is equidistant from each other around the circumference. An L-shaped connecting rod is fixedly connected to the outer wall of the rotating rod. The L-shaped connecting rod is equidistant from each other around the circumference. A scraper is fixedly connected to one end of the L-shaped connecting rod. The rotating rod drives the stirring blade and the L-shaped connecting rod to rotate simultaneously, thereby mixing and reacting the material inside the cylinder.

[0011] Preferably, a transmission pipe is connected to the bottom of the hopper, and an electric valve is rotatably connected to the inner wall of the transmission pipe. The inner wall of the hopper is adapted to the scraper, and the material is discharged from the cylinder under the action of gravity and the guidance of the hopper.

[0012] This invention provides a crystallization reaction apparatus for the production of pharmaceutical intermediates. It has the following beneficial effects:

[0013] (1) This utility model allows the collection box to slide along the trajectory of the limiting frame to the end point by holding the second handle. Then, the material enters the inside of the cylinder from the feed port, and the mixing reaction is carried out under the action of the stirring part. Then, the crystals and liquid fall onto the upper surface of the filter plate at the same time. The crystals stay on the upper surface of the filter plate, while the liquid falls into the inside of the collection box through the guide bucket under the action of gravity, thereby achieving the purpose of solid-liquid separation. Then, under the action of the nozzle, the water in the water tank is sprayed out, thereby achieving the purpose of cleaning the crystals.

[0014] (2) In this utility model, the material is fed into the feed hopper and falls into the inside of the cylinder. Then, the motor is driven to rotate the rotating rod at the output end of the motor, thereby driving the stirring blade and the L-shaped connecting rod to rotate simultaneously, so as to mix the material inside the cylinder. Then, the electric valve is turned to open the transmission pipe, so that the material is discharged under the action of gravity and the drainage of the feed hopper. At the same time, the rotation of the scraper not only stirs the material but also scrapes and cleans the inside of the feed hopper. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the main structure of this utility model;

[0016] Figure 2 This is a front view of the present utility model;

[0017] Figure 3 This is a view of the collection part of this utility model;

[0018] Figure 4 This is a detailed view of the collection part of this utility model;

[0019] Figure 5 This is a view of the stirring part of the present invention.

[0020] In the diagram: 1. Base plate; 2. Collection section; 3. Mixing section; 4. Moving wheels.

[0021] 211 Cylinder body, 212 Top plate, 213 Curved door panel, 214 Handle 1, 215 Water tank, 216 Sprayer head, 217 Filter plate, 218 Drainage bucket, 219 Limiting bracket, 220 Collection box, 221 Handle 2;

[0022] 311 Feed hopper, 312 Motor, 313 Rotating rod, 314 Agitator blade, 315 L-shaped connecting rod, 316 Scraper, 317 Discharge hopper, 318 Transmission pipe, 319 Electric valve. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0025] Example 1:

[0026] Based on existing technologies, after the crystallization reaction of materials, there is a general problem of inconvenience in solid-liquid separation. More importantly, even if some devices can perform solid-liquid separation, there are still many inconveniences in the process of cleaning the crystals after separation to remove impurities adhering to the crystal surface. A preferred embodiment of the crystallization reaction apparatus for the production of pharmaceutical intermediates provided by this utility model is as follows: Figure 1-5 As shown: A crystallization reaction apparatus for the production of pharmaceutical intermediates includes: a base plate 1; a collection part 2 disposed on the top of the base plate 1; a stirring part 3 disposed inside the collection part 2; and a moving wheel 4 installed at the bottom of the base plate 1; wherein the collection part 2 includes: a cylinder 211 fixedly connected to the top of the base plate 1; and a top plate 212 fixedly connected to the top of the cylinder 211.

[0027] The outer wall of the cylinder 211 has an outlet and a sliding opening. The top of the top plate 212 has a feed inlet. The feed inlets are symmetrically arranged. An arc-shaped door panel 213 is rotatably connected between the inner sides of the outlet. A handle 214 is fixedly connected to the outer wall of the arc-shaped door panel 213.

[0028] A water tank 215 is fixedly connected to the outer wall of the cylinder 211. A nozzle 216 is connected to the inner wall of the water tank 215. The nozzles 216 are equidistantly arranged. One end of the nozzle 216 extends inward through the cylinder 211. A filter plate 217 is fixedly connected to the inner wall of the cylinder 211. A limit bracket 219 is fixedly connected to the inner wall of the cylinder 211.

[0029] A flow guide 218 is fixedly connected to the bottom of the filter plate 217, and a collection box 220 is slidably connected between the inner sides of the limiting frame 219. The collection box 220 is adapted to the sliding port 1, and a handle 221 is fixedly connected to the outer wall of the collection box 220. The collection box 220 is adapted to the flow guide 218.

[0030] Furthermore, in this embodiment, by holding the handle 221, the collection box 220 is slid along the trajectory of the limiting frame 219 to the end point. Then, the material enters the interior of the cylinder 211 from the feed port, and is mixed under the action of the stirring part 3. Then, the crystals and liquid fall onto the upper surface of the filter plate 217 at the same time. The crystals then remain on the upper surface of the filter plate 217, while the liquid falls into the interior of the collection box 220 through the guide bucket 218 under the action of gravity, thereby achieving the purpose of solid-liquid separation. Then, under the action of the nozzle 216, the water in the water tank 215 is sprayed out, thereby achieving the purpose of cleaning the crystals.

[0031] Example 2:

[0032] Based on Embodiment 1, a preferred embodiment of the crystallization reaction apparatus for the production of pharmaceutical intermediates provided by this utility model is as follows: Figure 1-5 As shown: The stirring part 3 includes: a feed hopper 311, which is connected to the top of the feed inlet; a motor 312, which is fixedly connected to the top of the top plate 212; and a discharge hopper 317, which is fixedly connected to the inner wall of the cylinder 211.

[0033] A rotating rod 313 is fixedly connected to the output end of the motor 312. The bottom end of the rotating rod 313 extends downward through the top plate 212. A stirring blade 314 is fixedly connected to the outer wall of the rotating rod 313. The stirring blade 314 is equidistantly arranged around the circumference. An L-shaped connecting rod 315 is fixedly connected to the outer wall of the rotating rod 313. The L-shaped connecting rod 315 is equidistantly arranged around the circumference. A scraper 316 is fixedly connected to one end of the L-shaped connecting rod 315.

[0034] The bottom of the hopper 317 is connected to a transmission pipe 318, and the inner wall of the transmission pipe 318 is rotatably connected to an electric valve 319. The inner wall of the hopper 317 is adapted to the scraper 316.

[0035] Furthermore, in this embodiment, the material is fed into the feed hopper 311 and falls into the interior of the cylinder 211. Then, the motor 312 is driven to rotate the rotating rod 313 at the output end of the motor 312, thereby driving the stirring blade 314 and the L-shaped connecting rod 315 to rotate simultaneously, so as to mix the material inside the cylinder 211. Then, the electric valve 319 is turned to open the transmission pipe 318, so that the material is discharged under the action of gravity and the drainage of the discharge hopper 317. At the same time, the rotation of the scraper 316 not only stirs the material but also scrapes and cleans the interior of the discharge hopper 317.

[0036] In use, first, hold handle 221 and slide the collection box 220 along the trajectory of the limiting frame 219 to the end point. Then, let the material enter the interior of the cylinder 211 through the feed inlet, where it will be mixed under the action of the stirring part 3. Subsequently, the crystals and liquid will fall onto the upper surface of the filter plate 217. The crystals will remain on the upper surface of the filter plate 217, while the liquid will fall into the collection box 220 through the guide bucket 218 under the action of gravity, thus achieving solid-liquid separation. Then, under the action of the nozzle 216, the water in the water tank 215 will be sprayed out to clean the crystals. The purpose is twofold: firstly, the material is fed into the feed hopper 311 and falls into the interior of the cylinder 211. Then, the motor 312 is driven to rotate the rotating rod 313 at the output end of the motor 312, thereby driving the stirring blade 314 and the L-shaped connecting rod 315 to rotate simultaneously, so as to mix and react the material inside the cylinder 211. Then, the electric valve 319 is turned to open the transmission pipe 318, so that the material is discharged under the action of gravity and the diversion of the discharge hopper 317. At the same time, the rotation of the scraper 316 not only stirs the material but also scrapes and cleans the interior of the discharge hopper 317.

[0037] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0038] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A crystallization reaction apparatus for the production of pharmaceutical intermediates, characterized in that, It include: bottom plate (1); The collection site (2) is arranged on the top of the bottom plate (1); The stirring site (3) is arranged inside the collection site (2); The moving wheel (4) is installed at the bottom of the bottom plate (1); Wherein, the collection site (2) includes: The cylinder (211) is fixedly connected at the top of the bottom plate (1); The top plate (212) is fixedly connected at the top of the cylinder (211).

2. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 1, characterized by: The outer wall of the cylinder (211) is provided with an outlet, the outer wall of the cylinder (211) is provided with a sliding port one, the top of the top plate (212) is provided with a feeding port, the feeding port is symmetrically arranged, the inner side of the outlet is rotatably connected with an arc-shaped door plate (213), and the outer wall of the arc-shaped door plate (213) is fixedly connected with a handle one (214).

3. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 1, characterized by: The outer wall of the cylinder (211) is fixedly connected with a water tank (215), the inner wall of the water tank (215) is communicated with a spray head (216), the spray heads (216) are equidistantly arranged, one end of the spray head (216) extends inwardly through the cylinder (211), the inner wall of the cylinder (211) is fixedly connected with a filter plate (217), and the inner wall of the cylinder (211) is fixedly connected with a limiting frame (219).

4. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 3, characterized by: The bottom of the filter plate (217) is fixedly connected with a drainage hopper (218), the inner side of the limiting frame (219) is slidably connected with a collection box (220), the collection box (220) is matched with the sliding port one, the outer wall of the collection box (220) is fixedly connected with a handle two (221), and the collection box (220) is matched with the drainage hopper (218).

5. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 1, characterized by: The stirring site (3) includes: The feeding hopper (311) is communicatedly arranged at the top of the feeding port; The motor (312) is fixedly connected at the top of the top plate (212); The discharge hopper (317) is fixedly connected to the inner wall of the cylinder (211).

6. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 5, characterized by: The output end of the motor (312) is fixedly connected with a rotating rod (313), the bottom end of the rotating rod (313) extends downwardly through the top plate (212), the outer wall of the rotating rod (313) is fixedly connected with a stirring blade (314), the stirring blades (314) are circumferentially equidistantly arranged, the outer wall of the rotating rod (313) is fixedly connected with an L-shaped connecting rod (315), the L-shaped connecting rods (315) are circumferentially equidistantly arranged, and one end of the L-shaped connecting rod (315) is fixedly connected with a scraper (316).

7. The crystallization reaction apparatus for producing a pharmaceutical intermediate according to claim 5, characterized by: The bottom of the discharge hopper (317) is communicatedly provided with a transmission pipe (318), the inner wall of the transmission pipe (318) is rotatably connected with an electric valve (319), and the inner wall of the discharge hopper (317) is matched with the scraper (316).

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