Medical intermediate purification device

Abstract

The utility model belongs to the technical field of purification devices, and particularly relates to a medical intermediate purification device which comprises a centrifugal extraction purification tank, a support is fixedly connected to the outer wall of the centrifugal extraction purification tank, a discharging pipe is arranged at the bottom of the centrifugal extraction purification tank, and a communicating box is fixedly connected to the side wall of the top of the centrifugal extraction purification tank. And the communicating box is connected with a raw material pipe and an extraction pipe. Through the atomization nozzles at the front ends of the raw material pipe and the extraction pipe, the contact area of the raw material and the extraction agent is increased, the extraction efficiency is improved, the unique stirring structure is adopted, the four rings of stirring blades on the stirring monomer are opposite pairwise, and the stirring diameter is sequentially increased from top to bottom, so that the materials can be fully mixed in all directions, and the mass transfer effect is enhanced; due to the conical design of the bottom of the centrifugal extraction and purification tank, materials can be conveniently gathered and discharged, stable support is provided for the stirring monomer, the whole device is reasonable in structure, the purification effect of the medical intermediate is effectively improved, and the product quality is guaranteed.

Description

Technical Field

[0001] This utility model relates to the field of purification equipment technology, specifically a purification device for pharmaceutical intermediates. Background Technology

[0002] In the pharmaceutical manufacturing industry, the purification of pharmaceutical intermediates is crucial, as their purity directly affects the quality, safety, and efficacy of the final drug. However, traditional pharmaceutical intermediate purification technologies have many drawbacks that urgently need to be addressed.

[0003] In the early days, simple filtration and crystallization methods were used to purify pharmaceutical intermediates, but they could only remove larger particulate impurities and perform preliminary separation. For impurities with similar properties or those dissolved in solution, the separation effect was very poor, making it difficult to meet increasingly stringent drug quality standards.

[0004] With technological advancements, extraction methods have become widely used, but traditional extraction devices perform poorly in terms of mass transfer efficiency. Ordinary mixing methods make it difficult for the raw materials and extractant to fully contact, resulting in long extraction times, low efficiency, and increased production costs. Furthermore, during the separation process, incomplete phase separation can lead to product loss and impurity residue, affecting product purity.

[0005] Furthermore, existing equipment has structural design flaws. Some devices have a simple stirring structure, failing to achieve comprehensive and efficient stirring, resulting in uneven mixing and further reducing extraction efficiency. Simultaneously, the equipment lacks stability, easily experiencing shaking during operation, which not only affects operational safety but also interferes with the stability of the extraction process, reducing product quality consistency.

[0006] Given the shortcomings of traditional pharmaceutical intermediate purification technologies, it is urgent to develop a purification device that can improve extraction efficiency, enhance separation effects, and ensure stable equipment operation. The pharmaceutical intermediate purification device involved in this invention is designed to solve these long-standing industry problems, aiming to improve the purification level of pharmaceutical intermediates and ensure the quality of drug production. Utility Model Content

[0007] (a) Technical problems to be solved

[0008] To address the shortcomings of existing technologies, this invention provides a pharmaceutical intermediate purification device, which solves the problems mentioned in the background section.

[0009] (II) Technical Solution

[0010] To achieve the above objectives, this utility model specifically adopts the following technical solution:

[0011] A pharmaceutical intermediate purification device includes a centrifugal extraction purification tank. A support is fixedly connected to the outer wall of the centrifugal extraction purification tank. A discharge pipe is provided at the bottom of the centrifugal extraction purification tank. A connecting box is fixedly connected to the top side wall of the centrifugal extraction purification tank. A raw material pipe and an extraction pipe are connected to the connecting box. Atomizing nozzles are connected to the front ends of the raw material pipe and the extraction pipe. The bottom of the centrifugal extraction purification tank is conical. A drive motor is connected to the top of the centrifugal extraction purification tank. The output end of the drive motor extends through the centrifugal extraction purification tank and is fixedly connected to a connecting shaft inside. Three interconnected stirring units are connected to the bottom of the connecting shaft. Stirring blades are arranged around the four sides of each stirring unit, and the bottom of each stirring unit rotates on the conical shape.

[0012] Furthermore, there are three supports in total, which are distributed circumferentially around the centrifugal extraction and purification vessel for support.

[0013] Furthermore, the raw material tube and the extraction tube are arranged vertically.

[0014] Furthermore, each of the aforementioned stirring units is provided with four rings of stirring blades.

[0015] Furthermore, the four rings of stirring blades are arranged in opposite directions.

[0016] Furthermore, the stirring diameter of the four rings of stirring blades increases sequentially from top to bottom.

[0017] (III) Beneficial Effects

[0018] Compared with the prior art, this utility model provides a pharmaceutical intermediate purification device, which has the following features:

[0019] Beneficial effects:

[0020] This invention increases the contact area between the raw material and the extractant by using atomizing nozzles at the front end of the raw material tube and the extraction tube, thereby improving extraction efficiency. Its unique stirring structure, with four opposing stirring blades on the stirring unit and a stirring diameter that increases from top to bottom, ensures thorough mixing of materials in all directions, enhancing mass transfer. The conical design at the bottom of the centrifugal extraction and purification tank facilitates material aggregation and discharge while providing stable support for the stirring unit. The overall device has a reasonable structure, effectively improving the purification effect of pharmaceutical intermediates and ensuring product quality. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the connecting structure of the communicating box of this utility model;

[0023] Figure 3This is a schematic diagram of the internal structure of the centrifugal extraction and purification tank of this utility model;

[0024] Figure 4 This is a schematic diagram of the stirring unit structure of this utility model.

[0025] In the diagram: 1. Centrifugal extraction and purification tank; 2. Support frame; 3. Discharge pipe; 4. Connecting box; 5. Raw material pipe; 6. Extraction pipe; 7. Atomizing nozzle; 8. Conical type; 9. Drive motor; 10. Connecting shaft; 11. Stirring unit; 12. Stirring blade. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Example

[0028] like Figure 1 As shown in the figure, an embodiment of the present invention provides a pharmaceutical intermediate purification device, which includes a centrifugal extraction purification tank 1.

[0029] like Figure 1 As shown, the outer wall of the centrifugal extraction and purification vessel 1 is fixedly connected to the support 2. There are three supports 2 in total, distributed circumferentially around the centrifugal extraction and purification vessel 1. This connection method provides stable support for the centrifugal extraction and purification vessel 1, ensuring that the device remains stable during operation, avoiding shaking or tipping, and ensuring the smooth progress of the extraction and purification work.

[0030] like Figure 1 As shown, the discharge pipe 3 is located at the bottom of the centrifugal extraction and purification tank 1, and is used to discharge the liquid after extraction and purification. Its connection position facilitates the collection of the mixture accumulated at the bottom of the tank, realizing the output of materials, and is the key channel for product discharge in the entire extraction and purification process.

[0031] like Figure 1-2 As shown, the connecting box 4 is fixedly connected to the top side wall of the centrifugal extraction and purification tank 1, serving as the connection hub between the raw material pipe 5 and the extraction pipe 6 and the centrifugal extraction and purification tank 1. Through the connecting box 4, the raw material and extractant can smoothly enter the centrifugal extraction and purification tank 1, providing a material input path for subsequent extraction operations.

[0032] like Figure 1-2As shown, the raw material pipe 5 and the extraction pipe 6 are connected to the connecting box 4, and an atomizing nozzle 7 is installed at the front end of each pipe. The raw material and the extractant are respectively sprayed into the connecting box 4 through the raw material pipe 5 and the extraction pipe 6, and then into the centrifugal extraction and purification tank 1 through the atomizing nozzle 7. This connection method allows the raw material and the extractant to enter the tank in an atomized form, increasing the contact area between the two phases and thus improving the extraction efficiency.

[0033] like Figure 3 As shown, the drive motor 9 is connected to the top of the centrifugal extraction and purification tank 1, and its output end passes through the centrifugal extraction and purification tank 1 and is fixedly connected to the connecting shaft 10. The drive motor 9 provides power to the entire stirring structure, and by driving the connecting shaft 10 to rotate, it causes the stirring unit 11 and the stirring blades 12 to rotate, thereby stirring and mixing the raw materials and extractant in the tank and promoting the extraction process.

[0034] like Figure 3 As shown, the bottom of the connecting shaft 10 is fixedly connected to three interconnected stirring units 11, which transmit the power of the drive motor 9 to the stirring units 11, enabling the stirring units 11 to rotate inside the centrifugal extraction and purification tank 1, thereby driving the stirring blades 12 to stir the material and enhance the mass transfer effect.

[0035] like Figure 4 As shown, stirring blades 12 are arranged around the stirring unit 11, with four rings of stirring blades 12 on each stirring unit 11. The four rings of stirring blades 12 are arranged in opposite directions and their diameters increase from top to bottom. When the stirring unit 11 rotates, the stirring blades 12 rotate accordingly. The stirring blades 12 with different directions and diameters can stir the material in the tank from multiple angles and ranges, so that the raw materials and extractant are fully mixed and the extraction effect is improved.

[0036] like Figure 3 As shown, the bottom of the stirring unit 11 is rotatably connected to the conical part 8 at the bottom of the centrifugal extraction and purification tank 1. The design of the conical part 8 not only facilitates the accumulation of materials at the bottom of the tank and makes it easy to discharge, but also provides a support and a base for the stirring unit 11 to rotate, ensuring the stability of the stirring unit 11 during the stirring process.

[0037] When this pharmaceutical intermediate purification device is in operation, the raw material and extractant are respectively sprayed into the connecting box 4 through the raw material pipe 5 and the extraction pipe 6 via the front atomizing nozzle 7, and then enter the centrifugal extraction and purification tank 1. The drive motor 9 starts, driving the connecting shaft 10 to rotate, which in turn causes the stirring unit 11 connected to its bottom to rotate. The stirring blades 12 around the stirring unit 11 stir accordingly, with each of the four rings of stirring blades moving in opposite directions and their diameters increasing from top to bottom, ensuring thorough mixing of the raw material and extractant and accelerating the distribution of the solute between the two phases. Because the bottom of the centrifugal extraction and purification tank 1 is conical 8, it facilitates the accumulation of the mixture. The mixed liquid is finally discharged from the bottom discharge pipe 3, achieving the extraction and purification of the pharmaceutical intermediate.

[0038] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A pharmaceutical intermediate purification apparatus comprising a centrifugal extraction purification tank (1), characterized in that: The outer wall of the centrifugal extraction purification tank (1) is fixedly connected with a support (2), the bottom of the centrifugal extraction purification tank (1) is provided with a discharge pipe (3), the top side wall of the centrifugal extraction purification tank (1) is fixedly connected with a communication box (4), the communication box (4) is connected with a raw material pipe (5) and an extraction pipe (6), the front ends of the raw material pipe (5) and the extraction pipe (6) are connected with an atomizing nozzle (7), the bottom of the centrifugal extraction purification tank (1) is a conical part (8), the top of the centrifugal extraction purification tank (1) is connected with a driving motor (9), the output end of the driving motor (9) extends to the inside through the centrifugal extraction purification tank (1) and is fixedly connected with a connecting shaft (10), the bottom of the connecting shaft (10) is connected with three mutually connected stirring units (11), stirring blades (12) are arranged around the stirring units (11), and the bottom of the stirring unit (11) rotates on the conical part (8).

2. A medical intermediate purification device according to claim 1, characterized in that: The support (2) is three in total and is circumferentially distributed around the centrifugal extraction purification tank (1) to support.

3. A medical intermediate purification device according to claim 1, characterized in that: The raw material pipe (5) and the extraction pipe (6) are vertically arranged.

4. A medical intermediate purification device according to claim 1, characterized in that: Four circles of stirring blades (12) are arranged on each stirring unit (11).

5. A medical intermediate purification device according to claim 4, characterized in that: The arrangement directions of the four circles of stirring blades (12) are opposite to each other.

6. A medical intermediate purification device according to claim 5, characterized in that: The stirring diameters of the four circles of stirring blades (12) gradually increase from top to bottom.

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