Tumor electric field treatment device and electrode plate

Abstract

The utility model provides a tumor electric field treatment device and an electrode slice, the electrode slice comprises an electrode array, and the electrode array comprises a plurality of electrode units. The plurality of electrode units are divided into a plurality of peripheral electrode units and a plurality of central electrode units enclosed by the plurality of peripheral electrode units in spatial arrangement, every two adjacent central electrode units are connected with each other through a corresponding connecting part, and each peripheral electrode unit is only connected with the closest central electrode unit through a corresponding connecting part; the electrode array is provided with a plurality of grounding traces, a plurality of signal traces and an AC signal trace, in circuit connection, the grounding ends of the electrode units located in the same row are connected to the same grounding trace, the signal ends of the electrode units located in the same column are connected to the same signal trace, and the electrode units are connected to the same AC signal trace. According to the tumor electric field treatment device and the electrode plate thereof, the temperature can be accurately measured, the number of the conductive traces can be reduced, and the layout scheme of the conductive traces is simplified.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a tumor electric field treatment device and an electrode sheet. BACKGROUND

[0002] Tumor electric field treatment is a tumor treatment method that interferes with the mitotic process of tumor cells through a low-intensity, medium-high frequency, alternating electric field generated by a special electric field generator. Studies have shown that electric field treatment has a significant effect in treating diseases such as glioblastoma, non-small cell lung cancer, and malignant pleural mesothelioma. The electric field applied by this treatment method can affect the aggregation of tubulin, prevent spindle formation, inhibit the mitotic process, and induce apoptosis of cancer cells. A tumor electric field treatment device mainly includes an electric field generator, an adapter, and multiple pairs of electrode sheets. The electric field generator generates an alternating electric signal, which is transmitted to the electrode sheets through the adapter. The electrode sheets are attached to the body surface on opposite sides of the tumor area of the patient, and an alternating current signal is applied between each pair of electrode sheets to non-invasively apply a tumor treatment electric field to the tumor area.

[0003] During electric field treatment, heat is generated at the attachment site of the electrode sheet, and the temperature also rises accordingly. Therefore, it is necessary to monitor the temperature at the attachment site, and when the temperature is too high, the electric field strength needs to be adjusted in time to reduce the risk of skin burns caused by excessively high temperature. The electrode sheet usually has multiple electrode units, and even if the same alternating current signal is applied to each electrode unit, the heat generated on each electrode unit will be different due to the different positions, i.e., the temperature of each electrode unit on the electrode sheet will not be completely uniform, and there may be a situation where the temperature of a certain electrode unit exceeds the temperature threshold while the temperatures of other electrode units are normal. Therefore, it is necessary to set a temperature sensor on each electrode unit to detect the temperature of each electrode unit to effectively avoid the risk of burns caused by excessively high temperature of a single electrode unit. The existing electrode sheet separately sets a conductive trace for transmitting temperature detection signals for each electrode unit, and when the number of electrode units is large, the number of conductive traces on the electrode sheet also increases, resulting in a complex wiring scheme and affecting the flexibility of the electrode sheet, which leads to poor attachment.

[0004] Therefore, it is necessary to provide an improved tumor electric field treatment device and electrode sheet to overcome the problems existing in the prior art. CONTENT OF THE INVENTION

[0005] The present application provides an electrode sheet and a tumor electric field treatment device that can accurately detect the temperature of each electrode unit on the electrode sheet and simplify the layout scheme of the conductive traces.

[0006] Specifically, the application is realized by the following technical scheme: an electrode sheet comprising an electrode array, the electrode array comprising a plurality of electrode units and a plurality of connecting portions connecting adjacent two electrode units, the plurality of electrode units being divided into a plurality of peripheral electrode units and a plurality of central electrode units surrounded by the plurality of peripheral electrode units in spatial arrangement, adjacent two central electrode units being connected to each other by a corresponding connecting portion, and each peripheral electrode unit being connected to the closest central electrode unit by a corresponding connecting portion; the electrode array being provided with a plurality of ground traces, a plurality of signal traces and an AC signal trace, in circuit connection, the plurality of electrode units being arranged in multiple rows and multiple columns, the ground ends of the electrode units in the same row being connected to the same ground trace, the signal ends of the electrode units in the same column being connected to the same signal trace, and the plurality of electrode units being connected to the same AC signal trace.

[0007] According to an embodiment of the application, each electrode unit is provided with a temperature sensor, the temperature sensor being provided with a ground end and a signal end, in circuit connection, the ground ends of the temperature sensors of the electrode units in the same row being connected to the same ground trace, and the signal ends of the temperature sensors of the electrode units in the same column being connected to the same signal trace.

[0008] According to an embodiment of the application, the electrode array is provided with thirteen electrode units, the electrode array being provided with four ground traces, three of which are connected to the ground ends of three electrode units respectively, and the other one being connected to the ground ends of the remaining four electrode units; the electrode array is also provided with four signal traces, three of which are connected to the signal ends of four electrode units respectively, and the other one being connected to the signal end of the remaining one electrode unit.

[0009] According to one embodiment of the utility model, thirteen electrode units are arranged as five rows and five columns in space, two electrode units are arranged in each of the first and fifth rows, three electrode units are arranged in each of the middle three rows, the three electrode units in each of the middle three rows are arranged as three columns and are located in the first, third and fifth columns respectively, the two electrode units in each of the first and fifth rows are arranged as two columns and are located in the second and fourth columns respectively; the ground terminals of the two electrode units in the first row and any electrode unit in the fifth row are connected to one ground trace; the ground terminals of the three electrode units in the second row are connected to another ground trace; the ground terminals of the three electrode units in the third row are connected to still another ground trace; the ground terminals of the three electrode units in the fourth row and the remaining electrode unit in the fifth row are connected to the last ground trace.

[0010] According to one embodiment of the utility model, the signal terminals of any electrode unit in the fifth row are connected to one signal trace; the signal terminals of the three electrode units in the third column and the remaining electrode unit in the fifth row are connected to another signal trace; the signal terminals of the three electrode units in the first column and any electrode unit in the first row are connected to still another signal trace; the signal terminals of the three electrode units in the fifth column and the remaining electrode unit in the first row are connected to the last signal trace.

[0011] According to one embodiment of the utility model, a diode is connected in series between the ground terminal of the electrode unit and the corresponding ground trace.

[0012] According to one embodiment of the utility model, the electrode array is provided with a flexible circuit board, most of the traces in the plurality of ground traces and the plurality of signal traces are arranged on the back of the flexible circuit board, and the AC signal trace is arranged on the front of the flexible circuit board.

[0013] According to one embodiment of the utility model, the electrode array is provided with a wiring part, the front and back of the wiring part are respectively provided with a plurality of gold fingers, the ends of each ground trace penetrate through the wiring part and are connected to the corresponding gold finger on the front of the wiring part, and the ends of each signal trace are connected to the corresponding gold finger on the back of the wiring part.

[0014] The application also provides the following technical scheme: a tumor electric field treatment device, which comprises an electric field generator and a plurality of pairs of the electrode sheet, and the electrode sheet is electrically connected to the electric field generator.

[0015] According to one embodiment of the utility model, still include a plurality of grounding switch and a plurality of acquisition channel, a plurality of ground traces are respectively with corresponding grounding switch one-to-one corresponding series ground;A plurality of signal traces are respectively with corresponding acquisition channel one-to-one connection.

[0016] The tumor electric field treatment device and the electrode sheet thereof according to the present application, the plurality of electrode units of the electrode sheet share the signal trace, and the plurality of electrode units are grouped by the common ground trace to be conducted in batches, so that the plurality of electrode units of the common signal trace transmit signals in time, which can reduce the number of conductive traces and simplify the layout scheme of the conductive traces.

[0017] It should be understood that the foregoing general description and the following detailed description are only exemplary and explanatory, and cannot limit the present application. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a framework diagram of the tumor electric field treatment device according to one embodiment of the present application;

[0019] Figure 2 It is a perspective view of the electrode sheet of the tumor electric field treatment device according to the present application;

[0020] Figure 3 It is Figure 2 A partial perspective exploded view of the electrode sheet shown;

[0021] Figure 4 It is Figure 3 A plan view of the electrode array of the electrode sheet shown;

[0022] Figure 5 It is Figure 4 A perspective exploded view of the electrode array shown;

[0023] Figure 6 It is Figure 5 A wiring diagram of the ground trace on the front of the flexible circuit board of the electrode array shown;

[0024] Figure 7 It is Figure 5 A wiring diagram of the ground trace on the back of the flexible circuit board of the electrode array shown;

[0025] Figure 8 It is Figure 5 A wiring diagram of the signal trace on the back of the flexible circuit board of the electrode array shown;

[0026] Figure 9 It is a circuit connection schematic diagram of one electrode sheet and adapter of the tumor electric field treatment device.

[0027] REFERENCE NUMERALS:

[0028] Tumor electric field therapy device 100, electric field generator 10, adapter 20, controller 21, analog-to-digital conversion module 22, communication unit 23, voltage dividing resistor 24, ground switch 25, power supply module 26, AC line 27, electrode sheet 30, electrode array 31, electrode unit 310, central electrode unit 310A, peripheral electrode unit 310B, connection portion 311, wiring portion 312, gold finger 3121, flexible circuit board 313, main body portion 314, conductive disc 3141, ground pad 3142, signal pad 3143, dielectric element 315, through hole 3151, temperature sensor 316, ground terminal 3161, signal terminal 3162, reinforcing plate 317, conductive trace 318, AC signal trace 318A, ground trace 318B, first ground trace 318B-1, second ground trace 318B-2, third ground trace 318B-3, fourth ground trace 318B-4, signal trace 318C, first signal trace 318C-1, second signal trace 318C-2, third signal trace 318C-3, fourth signal trace 318C-4, diode 319, backing 32, support 33, through hole 331, adhesive 34, connector 40. DETAILED DESCRIPTION

[0029] The exemplary embodiments will be described in detail herein with reference to the accompanying drawings. In the following description, unless otherwise indicated, like numbers in the different drawings represent similar or analogous elements. The embodiments described in the following exemplary embodiments are not meant to represent all embodiments consistent with the present disclosure. Rather, they are merely examples of apparatuses, systems, devices, and methods consistent with some aspects of the present disclosure.

[0030] Reference Figure 1 As shown, tumor electric field therapy device 100 includes electric field generator 10, adapter 20, and a plurality of pairs of electrode sheets 30, with adapter 20 electrically connecting electric field generator 10 and each electrode sheet 30. Electric field generator 10 generates an AC signal that meets the requirements of the treatment, and adapter 20 receives the AC signal output from electric field generator 10 and transmits the AC signal to electrode sheet 30. The pairs of electrode sheets 30 are attached to the body surface of the corresponding tumor area of the patient, and the AC signal is applied to the tumor area of the patient to interfere with or prevent mitosis of the tumor cells of the patient, thereby achieving the purpose of treating the tumor.

[0031] Reference Figure 2 and Figure 3As shown, the electrode sheet 30 comprises an electrode array 31, a backing 32, a plurality of supports 33 and a plurality of adhesive members 34. The electrode array 31 is adhered to the backing 32 and electrically connected to the adapter 20 by wires (not shown). The electrode array 31 is provided with thirteen electrode units 310 arranged in multiple rows and columns. The supports 33 are provided corresponding to each row of electrode units 310. The supports 33 are provided with a plurality of through holes 331 and are adhered to the backing 32 in a manner that each through hole 331 surrounds each electrode unit 310 in the corresponding row. The supports 33 can support and protect the electrode units 310. The adhesive members 34 are also provided corresponding to each row of electrode units 310 and cover each row of electrode units 310 and the corresponding supports 33. The electrode sheet 30 is attached to the patient's body surface in a manner that the side of the electrode sheet 30 with the adhesive members 34 exposed faces the patient. Herein, the side of the electrode sheet 30 facing the patient is defined as the front side, and the opposite side is defined as the back side. The backing 32 is a mesh non-woven fabric coated with a biocompatible adhesive (not shown) on the front side for tightly attaching the backing 32 to the patient's body surface. The supports 33 are made of foam material. The adhesive members 34 are double-sided adhesive and preferably conductive gel that can keep the skin surface moist and avoid causing skin problems.

[0032] Reference Figure 4 As shown, the thirteen electrode units 310 of the electrode array 31 are arranged in five rows and five columns in a spatial structure. The first and fifth rows are each provided with two electrode units 310, and the middle three rows are each provided with three electrode units 310. The electrode units 310 in the middle three rows are arranged in three columns and located in the first, third and fifth columns of the electrode array 31. The two electrode units 310 in the first and fifth rows are arranged in two columns and located in the second and fourth columns of the electrode array 31. The electrode units 310 in the middle of the electrode array 31 are defined as central electrode units 310A, which include the three electrode units 310 in the third column (also referred to as the central column) of the electrode array 31 and in the middle three rows. The other electrode units 310 are located in the periphery of the electrode array 31 and are defined as peripheral electrode units 310B. All peripheral electrode units 310B are located around all central electrode units 310A.

[0033] The electrode array 31 further comprises a plurality of connecting portions 311 connecting two adjacent electrode units 310. The connecting portions 311 are arranged to connect the electrode array 31 as a whole in structure, and to meet the wiring requirements of each electrode unit 310 to ensure that each electrode unit 310 can transmit corresponding electrical signals. The connecting portions 311 make the electrode array 31 as a whole in the shape of an axis-symmetrical fishbone, wherein the middle column is the symmetry axis of the electrode array 31 and also the main stem, and the other columns are branches extending laterally from the main stem. That is, the three central electrode units 310A in the third column are connected to each other along the column direction, and each peripheral electrode unit 310B is connected to only one corresponding central electrode unit 310A along the row direction or obliquely. In this way, the connecting portions 311 have less constraint on each peripheral electrode unit 310B, and each peripheral electrode unit 310B has greater freedom, which can avoid wrinkles around the peripheral electrode unit 310B during the application. In order to further improve the freedom of each peripheral electrode unit 310B, the backing 32 can also be selectively slotted along the branches of the electrode array 31.

[0034] Specifically, the three central electrode units 310A are respectively located in the second, third and fourth rows of the electrode array 31 and are all located in the third column, and are connected to each other along the column direction by the corresponding connecting portions 311, and are located on the symmetry axis of the electrode array 31 to form the main stem of the electrode array 31; the peripheral electrode unit 310B in the first row is connected to the central electrode unit 310A in the second row by the corresponding connecting portion 311 arranged in the shape of an oblique line, the peripheral electrode unit 310B in the second row is connected to the central electrode unit 310A in the second row by the corresponding connecting portion 311 arranged in the row direction, the peripheral electrode unit 310B in the third row is connected to the central electrode unit 310A in the third row by the corresponding connecting portion 311 arranged in the row direction, the peripheral electrode unit 310B in the fourth row is also connected to the central electrode unit 310A in the fourth row by the corresponding connecting portion 311 arranged in the row direction, and the peripheral electrode unit 310B in the fifth row is connected to the central electrode unit 310A in the fourth row by the corresponding connecting portion 311 arranged in the shape of an oblique line. In addition, the electrode array 31 is not provided with other redundant connecting portions 311. The electrode units 310 of the electrode array 31 are connected by the minimum number of connecting portions 311, and each peripheral electrode unit 310B is connected to only one corresponding central electrode unit 310A, and the peripheral electrode units 310B are not connected to each other, so that greater freedom can be obtained, which facilitates flexible movement during the application and avoids wrinkles around the peripheral electrode unit 310B during the application.

[0035] The electrode array 31 further comprises a wiring portion 312 located on the symmetry axis of the electrode array 31, which is arranged to extend outwardly along the column direction from the central electrode unit 310A in the fourth row. The front and back surfaces of the wiring portion 312 are respectively provided with a plurality of gold fingers 3121 for electrical connection with wires (not shown).

[0036] Reference Figure 5 As shown in the figure, the electrode array 31 comprises a plurality of main body parts 314 arranged corresponding to each electrode unit 310, and a plurality of connecting parts 311 connecting adjacent two main body parts 314. The plurality of main body parts 314, the plurality of connecting parts 311 and the aforementioned wiring part 312 jointly constitute a flexible circuit board 313 of the electrode array 31. The electrode array 31 further comprises a plurality of dielectric elements 315, a plurality of temperature sensors 316 and a plurality of reinforcing plates 317. The front surface of the main body part 314 is provided with a conductive disc 3141, and the dielectric element 315 is arranged on the front surface of the main body part 314 in a one-to-one correspondence manner and is welded to the conductive disc 3141. The center of the dielectric element 315 is provided with a through hole 3151, and the temperature sensor 316 is arranged on the front surface of the main body part 314 in a one-to-one correspondence manner and is located in the through hole 3151 of the dielectric element 315. The reinforcing plate 317 is arranged on the back surface of the main body part 314 in a one-to-one correspondence manner, and the main body part 314, the dielectric element 315 and the reinforcing plate 317 are arranged in a central overlapping manner to jointly constitute the corresponding electrode unit 310. In this embodiment, the dielectric element 315 is a ceramic sheet, and the dielectric element 315 can also be in other forms, for example, a high polymer dielectric layer with high dielectric constant and low dielectric loss made of thin film material with non-fixed crystal direction, high flexibility and high toughness. The high polymer dielectric layer can be formed on the main body part 314 by evaporation, sputtering or ion plating gas deposition, printing, spraying or casting. In addition, the reinforcing plate 317 is selectively arranged.

[0037] Reference Figures 6 to 8 As shown in the figure, the front surface and the back surface of the flexible circuit board 313 are further provided with a plurality of conductive traces 318, wherein the conductive traces 318 on the front surface are mainly an AC signal trace 318A, and one of the plurality of gold fingers 3121 of the wiring part 312 is used for transmitting an alternating current signal. The AC signal trace 318A extends from the gold finger 3121 along each connecting part 311 to each main body part 314 and is electrically connected to the conductive disc 3141 of each main body part 314 to transmit an alternating current signal to each electrode unit 310. Each connecting part 311 is provided with two parallel AC signal traces 318A to ensure the stability of the alternating current signal transmission.

[0038] In this embodiment, each main body part 314 is provided with one temperature sensor 316 corresponding to each electrode unit 310 to detect the temperature of each electrode unit 310, so as to realize accurate temperature measurement and avoid causing low-temperature burns on the patient's skin. Each main body part 314 is provided with a ground pad 3142 and a signal pad 3143 at the center of the conductive disc 3141. In combination with Figure 9As shown, the temperature sensor 316 has a ground terminal 3161 and a signal terminal 3162. The ground terminal 3161 is soldered to the ground pad 3142, and the signal terminal 3162 is soldered to the signal pad 3143. The ground terminal 3161 of each temperature sensor 316 is the ground terminal of the corresponding electrode unit 310, and the signal terminal 3162 of each temperature sensor 316 is the signal terminal of the corresponding electrode unit 310.

[0039] refer to Figure 7 and Figure 8 As shown, the conductive traces 318 on the back of the flexible circuit board 313 also include several ground traces 318B and several signal traces 318C. The ground traces 318B extend from a corresponding gold finger 3121 along the corresponding connection portion 311 to the ground pads 3142 on the corresponding multiple main body portions 314, to be electrically connected to the ground terminal 3161 of the corresponding temperature sensor 316, for grounding the ground terminal 3161 of the corresponding temperature sensor 316; the signal traces 318C extend from a corresponding gold finger 3121 along the corresponding connection portion 311 to the signal pads 3143 on one or more corresponding main body portions 314, to be electrically connected to the signal terminal 3162 of the corresponding temperature sensor 316, for transmitting DC signals to the corresponding temperature sensor 316 to detect the temperature at the corresponding electrode unit 310, and transmitting the detected temperature signal to the adapter 20 or the electric field generator 10.

[0040] The flexible circuit board 313 also has a diode 319 on each main body 314. The diode 319 is connected in series between the ground terminal 3161 of the temperature sensor 316 and the corresponding ground trace 318B. Specifically, the anode of the diode 319 is electrically connected to the ground terminal 3161 of the corresponding temperature sensor 316, and the cathode of the diode is electrically connected to the corresponding ground trace 318B. Each main body 314 also has an anode pad (unlabeled) and a cathode pad (unlabeled) at the center of the conductive pad 3141 corresponding to the diode 319. The anode pad (unlabeled) is electrically connected to the ground pad 3142 through a corresponding pad trace (unlabeled). The diode 319 prevents reverse current flow, thus preventing temperature detection signals from other electrode units 310 from affecting the temperature sensor 316.

[0041] In the present embodiment, in order to obtain the temperature detection signals of the thirteen temperature sensors 316, four ground traces 318B and four signal traces 318C are provided on the flexible circuit board 313, and the corresponding temperature sensors 316 in the plurality of electrode units 310 can share the corresponding ground traces 318B and the corresponding signal traces 318C, and the temperature detection signals of each temperature sensor 316 are obtained in batches by means of the ground traces 318B being grounded in turn, and the control method will be described in detail later. Compared with the mode of providing independent signal traces for each temperature sensor 316, this wiring mode reduces the total number of conductive traces 318, reduces the wiring difficulty of the flexible circuit board 313, simplifies the manufacturing process of the flexible circuit board 313, and also improves the flexibility of the flexible circuit board 313 and the adhesion during application. The wiring part 312 is provided with ten gold fingers 3121, four of which are respectively and correspondingly connected with the four ground traces 318B; four of which are respectively and correspondingly connected with the four signal traces 318C; one of which is connected with the AC signal trace 318A; and one of which is connected with the shielding layer (not shown) of the wire (not shown) and grounded to prevent signal interference.

[0042] Returning to Figures 6 to 9 As shown, the wiring scheme of the ground traces 318B and the signal traces 318C will be described in detail below. In terms of spatial structure, the thirteen electrode units 310 are labeled as electrode units M1 to M13 from top to bottom and from left to right according to their positions. Specifically, the two electrode units 310 in the first row are electrode units M1 and M2, respectively; the three electrode units 310 in the second row are electrode units M3, M4 and M5, respectively; the three electrode units 310 in the third row are electrode units M6, M7 and M8, respectively; the three electrode units 310 in the fourth row are electrode units M9, M10 and M11, respectively; and the two electrode units 310 in the fifth row are electrode units M12 and M13, respectively. The four ground traces 318B are first ground trace 318B-1, second ground trace 318B-2, third ground trace 318B-3 and fourth ground trace 318B-4, respectively; and the four signal traces 318C are first signal trace 318C-1, second signal trace 318C-2, third signal trace 318C-3 and fourth signal trace 318C-4, respectively.

[0043] For emphasis Figure 7 As shown, the wiring scheme of the four ground traces 318B is as follows:

[0044] The ground terminals 3161 of the temperature sensors 316 of the electrode units M1, M2, and M13 are connected in parallel to a first ground trace 318B-1, the three electrode units 310 are located at the two end edges of the electrode sheet 30 in the spatial structure, and are all peripheral electrode units 310B. The specific routing of the first ground trace 318B-1 is as follows: extending upwards from the wiring portion 312 and branching into two branches near the electrode unit M10, one branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M13 through the corresponding connecting portion 311, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M1 through the corresponding connecting portion 311 after sequentially passing through the electrode units M10, M7, and M4, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M2 through the corresponding connecting portion 311.

[0045] The ground terminals 3161 of the temperature sensors 316 of the electrode units M3, M4, and M5 are connected in parallel to a second ground trace 318B-2, the three electrode units 310 are located in the second row of the electrode sheet 30 in the spatial structure, and are adjacent to each other. The specific routing of the second ground trace 318B-2 is as follows: extending upwards from the wiring portion 312 and connecting to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M4 through the corresponding connecting portion 311 after sequentially passing through the electrode units M10, M7, and M4, and simultaneously branching into two branches to the left and right sides, one branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M3 through the corresponding connecting portion 311, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M5 through the corresponding connecting portion 311.

[0046] The ground terminals 3161 of the temperature sensors 316 of the electrode units M6, M7, and M8 are connected in parallel to a third ground trace 318B-3, the three electrode units 310 are located in the third row of the electrode sheet 30 in the spatial structure, and are adjacent to each other. The specific routing of the third ground trace 318B-3 is as follows: extending upwards from the wiring portion 312 and connecting to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M7 through the corresponding connecting portion 311 after sequentially passing through the electrode units M10 and M7, and simultaneously branching into two branches to the left and right sides, one branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M6 through the corresponding connecting portion 311, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M8 through the corresponding connecting portion 311.

[0047] The ground terminals 3161 of the temperature sensors 316 of the electrode units M9, M10, M11, M12 are connected in parallel to the fourth ground trace 318B-4, and the four electrode units 310 are located in the fourth and adjacent fifth rows of the electrode sheet 30 in the spatial structure and adjacent to each other. The fourth ground trace 318B-4 is routed as follows: extending upward from the wiring portion 312 and being divided into two branches near the electrode unit M10, one branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M12 through the corresponding connecting portion 311, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M10, and then simultaneously divided into two branches to the left and right, one branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M9 through the corresponding connecting portion 311, and the other branch is connected to the ground pad 3142 corresponding to the ground terminal 3161 of the temperature sensor 316 of the electrode unit M11 through the corresponding connecting portion 311.

[0048] The ends of the four ground traces 318B on the wiring portion 312 are respectively connected to the four corresponding gold fingers 3121 arranged on the front face of the wiring portion 312 after penetrating the corresponding positions of the wiring portion 312. When the electrode units 310 are respectively provided with a diode 319 corresponding to each temperature sensor 316, the corresponding ground trace 318B needs to be electrically connected to the ground pad 3142 corresponding to the ground terminal 3161 of the corresponding temperature sensor 316 through the corresponding diode 319, anode pad (not numbered) and cathode pad (not numbered).

[0049] For emphasis Figure 8 As shown, the routing scheme of the four signal traces 318C is as follows:

[0050] The signal terminal 3162 of the temperature sensor 316 of the electrode unit M12 is connected to the first signal trace 318C-1, and the first signal trace 318C-1 is routed as follows: extending upward from the wiring portion 312 and then connected to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M12 through the corresponding connecting portion 311.

[0051] The signal terminals 3162 of the temperature sensors 316 of the electrode units M1, M3, M6, M9 are connected in parallel to the second signal trace 318C-2, and the four electrode units 310 are located on the left side of the symmetry axis of the electrode array 31 in the spatial structure. Figure 8The specific routing of the second signal trace 318C-2 is as follows: extending upward from the connection portion 312, connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M9 after passing through the electrode units M10, M9 and the corresponding connection portion 311, then returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M6 after passing through the electrode units M10, M7, M6 and the corresponding connection portion 311, then returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M3 after passing through the electrode units M7, M4, M3 and the corresponding connection portion 311, and finally returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M1 after passing through the electrode unit M4 and the corresponding connection portion 311, without branching in the middle.

[0052] The signal terminals 3162 of the temperature sensors 316 of the electrode units M2, M5, M8 and M11 are connected in parallel to the third signal trace 318C-3, and these four electrode units 310 are all located on the right side of the symmetry axis of the electrode array 31 in the spatial structure Figure 8 The specific routing of the third signal trace 318C-3 is as follows: extending upward from the connection portion 312, connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M11 after passing through the electrode units M10, M11 and the corresponding connection portion 311, then returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M8 after passing through the electrode units M10, M7, M8 and the corresponding connection portion 311, then returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M5 after passing through the electrode units M7, M4, M5 and the corresponding connection portion 311, and finally returning and connecting to the signal pad 3143 corresponding to the signal terminal 3162 of the temperature sensor 316 of the electrode unit M2 after passing through the electrode unit M4 and the corresponding connection portion 311, without branching in the middle.

[0053] The signal ends 3162 of the temperature sensors 316 of the electrode units M4, M7, M10, M13 are connected in parallel to the fourth signal trace 318C-4, and the four electrode units 310 are located on the symmetry axis of the electrode array 31 in a spatial structure, three of which are located on the symmetry axis, and the other is close to the symmetry axis. The fourth signal trace 318C-4 is routed as follows: it is divided into two branches at the connection part 312, one branch extends upward along the symmetry axis, and when passing through the electrode units M10, M7, M4 and the corresponding connection parts 311, it is connected to the signal pads 3143 corresponding to the signal ends 3162 of the temperature sensors 316 of the electrode units M10, M7, M4, respectively. The other branch is connected to the signal pads 3143 corresponding to the signal ends 3162 of the temperature sensor 316 of the electrode unit M13 through the corresponding connection part 311.

[0054] The ends of the four signal traces 318C on the connection part 312 are connected one by one to the four corresponding gold fingers 3121 provided on the back of the connection part 312. It can be understood that although the ground trace 318B and the signal trace 318C are mostly arranged on the back of the flexible circuit board 313, the ground trace 318B needs to pass through the corresponding part of the flexible circuit board 313 and be electrically connected to the corresponding ground pad 3142 on the front of the flexible circuit board 313. In addition, the four ground traces 318B and the four signal traces 318C are arranged in parallel on the back of the flexible circuit board 313 and do not interfere with each other, but the ground trace 318B and the signal trace 318C will inevitably cross at some places on the flexible circuit board 313 due to wiring requirements. In order to avoid interference, the ground trace 318B or the signal trace 318C at the crossing part will pass through the corresponding part of the flexible circuit board 313 to the front of the flexible circuit board 313 for jumper connection, and then pass back to the back of the flexible circuit board 313 for further arrangement. Therefore, there will also be shorter parts of the ground trace 318B and the signal trace 318C on the front of the flexible circuit board 313, and the ground trace 318B and the signal trace 318C on the front of the flexible circuit board 313 do not interfere with each other.

[0055] The following will be described in detail Figure 9As shown, the lead wires (not shown) of the electrode sheet 30 are plugged into the connectors 40 of the adapter 20 to achieve the electrical connection between the electrode sheet 30 and the adapter 20. In the electrical connection, the thirteen electrode units 310 are arranged in four rows and four columns, the four ground traces 318B are respectively connected to the ground ends 3161 of the plurality of temperature sensors 316, and the signal ends 3162 of the plurality of temperature sensors 316 connected to each ground trace 318B are respectively connected to different signal traces 318C, i.e. the thirteen temperature sensors 316 are divided into four row groups, and the signal ends 3162 of the temperature sensors 316 in each row group are respectively connected to different signal traces 318C; that is, the four signal traces 318C are respectively connected to the signal ends 3162 of the plurality of temperature sensors 316, and the ground ends 3161 of the plurality of temperature sensors 316 connected to each signal trace 318C are respectively connected to different ground traces 318B.

[0056] The adapter 20 includes a controller 21, a plurality of analog-to-digital conversion modules 22, a communication unit 23, a plurality of voltage division resistors 24, a plurality of ground switches 25, and a power supply module 26, wherein the power supply module 26 provides a direct current power VCC for the controller 21, the analog-to-digital conversion modules 22, and the communication unit 23. The plurality of analog-to-digital conversion modules 22, the plurality of voltage division resistors 24, and the plurality of ground switches 25 are respectively arranged one-to-one corresponding to each electrode sheet 30. The analog-to-digital conversion modules 22 provide four acquisition channels A, B, C, and D for the electrode sheet 30, and the controller 21 controls the on-off of each acquisition channel in the corresponding group of analog-to-digital conversion modules 22 and each ground switch in the corresponding group of ground switches 25.

[0057] The adapter 20 is also provided with an AC line 27 for transmitting AC signals, and the AC signal traces 318A of the electrode sheet 30 are connected to the AC line 27 to transmit AC signals. The four ground traces 318B-1, 318B-2, 318B-3 and 318B-4 of the electrode sheet 30 are respectively connected to the ground switches 25-1, 25-2, 25-3 and 25-4 on the adapter 20 for grounding, and the four signal traces 318C-1, 318C-2, 318C-3 and 318C-4 of the electrode sheet 30 are respectively connected to the A, B, C and D acquisition channels of the analog-to-digital conversion module 22 of the adapter 20. In terms of circuit arrangement, the thirteen electrode units 310 are arranged in a two-dimensional array on the flexible circuit board 313, and are arranged in four rows and four columns. Specifically, the first row has three electrode units 310, which are electrode units M1, M2 and M13 from left to right, and these three electrode units 310 are arranged in the second column to the fourth column; the second row has three electrode units 310, which are electrode units M3, M5 and M4 from left to right, and these three electrode units 310 are arranged in the second column to the fourth column; the third row has three electrode units 310, which are electrode units M6, M8 and M7 from left to right, and these three electrode units 310 are arranged in the second column to the fourth column; and the fourth row has four electrode units 310, which are electrode units M12, M9, M11 and M10 from left to right, and these four electrode units 310 are arranged in the first column to the fourth column. The ground ends 3161 of the temperature sensors 316 of the electrode units 310 in the same row are connected in parallel to the same ground trace 318B, and the signal ends 3162 of the temperature sensors 316 of the electrode units 310 in the same column are connected in parallel to the same signal trace 318C and then connected to the same acquisition channel.

[0058] Specifically, the ground ends 3161 of the temperature sensors 316 of the three electrode units M1, M2 and M13 in the first row are connected in parallel to the first ground trace 318B-1, the ground ends 3161 of the temperature sensors 316 of the three electrode units M3, M5 and M4 in the second row are connected in parallel to the second ground trace 318B-2, the ground ends 3161 of the temperature sensors 316 of the three electrode units M6, M8 and M7 in the third row are connected in parallel to the third ground trace 318B-3, and the ground ends 3161 of the temperature sensors 316 of the four electrode units M12, M9, M11 and M10 in the fourth row are connected in parallel to the fourth ground trace 318B-4.

[0059] The signal end 3162 of the temperature sensor 316 of the single electrode unit M12 in the first column is connected to the first signal trace 318C-1, the signal ends 3162 of the temperature sensors 316 of the four electrode units M1, M3, M6, M9 in the second column are connected in parallel to the second signal trace 318C-2, the signal ends 3162 of the temperature sensors 316 of the four electrode units M2, M5, M8, M11 in the third column are connected in parallel to the third signal trace 318C-3, and the signal ends 3162 of the temperature sensors 316 of the four electrode units M13, M4, M7, M10 in the fourth column are connected in parallel to the fourth signal trace 318C-4.

[0060] In short, the signal ends 3162 of the temperature sensors 316 of the electrode units 310 in the same row are connected to the adapter 20 through the respective corresponding signal traces 318C, respectively, and the ground ends 3161 of the temperature sensors 316 of the electrode units 310 in the same row are shorted to ground through the same ground trace 318B. The ground ends 3161 of the temperature sensors 316 of the electrode units 310 in the same column are grounded through the respective corresponding ground traces 318B, respectively, and the signal ends 3162 of the temperature sensors 316 of the electrode units 310 in the same column are connected to the adapter 20 through the same signal trace 318C. The signal ends 3162 of the temperature sensors 316 of the electrode units 310 in different rows and different columns are connected to the adapter 20 through different signal traces 318C, respectively, and the ground ends 3161 of the temperature sensors 316 of the electrode units 310 in different rows and different columns are grounded through different ground traces 318B, respectively.

[0061] When it is necessary to apply an AC signal to each electrode unit 310 of the corresponding electrode sheet 30, the corresponding four ground switches 25 are all turned off, the electric field generator 10 outputs an AC signal to the corresponding AC line 27 in the adapter 20, and applies the AC signal to the dielectric element 315 of each electrode unit 310 through the AC signal trace 318A connected to the AC line 27.

[0062] When collecting the temperature detection signals of the temperature sensors 316 on each electrode sheet 30, the four-way signal trace 318C is always turned on, the ground switch 25-1 is first closed, and the other ground switches 25-2 to 25-4 are all disconnected, so that the B, C and D three collection channels of the analog-digital conversion module 22 can simultaneously obtain the temperature detection signals of the electrode units M1, M2, M13; then the ground switch 25-2 is closed, and the other ground switches 25-1, 25-3 and 25-4 are all disconnected, so that the B, C and D three collection channels of the analog-digital conversion module 22 can simultaneously obtain the temperature detection signals of the electrode units M3, M5, M4; then the ground switch 25-3 is closed, and the other ground switches 25-1, 25-2 and 25-4 are all disconnected, so that the B, C and D three collection channels of the analog-digital conversion module 22 can simultaneously obtain the temperature detection signals of the electrode units M6, M8, M7; finally, the ground switch 25-4 is closed, and the other ground switches 25-1, 25-2 and 25-3 are all disconnected, so that the A, B, C and D four collection channels of the analog-digital conversion module 22 can simultaneously obtain the temperature detection signals of the electrode units M12, M9, M11, M10. In this way, the temperature detection signals of all the temperature sensors 316 can be collected.

[0063] The communication unit 23 is controlled by the controller 21 and serially transmits the digital signals converted by the analog-digital conversion module 22, and sends the digital signals to the electric field generator 10. When any one of the multiple digital signals received by the electric field generator 10 exceeds the preset threshold value set in the controller 21, at this time, the voltage or current or power of the alternating current signal output by the electric field generator 10 can be appropriately reduced to avoid that the temperature of a certain electrode unit 310 is too high, causing a low-temperature burn to the skin of the patient.

[0064] The above is only a preferred embodiment of the present application, and is not used to limit the present application, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An electrode sheet comprising an electrode array, the electrode array including a plurality of electrode units and a plurality of connecting portions connecting adjacent electrode units, characterized in that: The electrode units are spatially arranged into several peripheral electrode units and several central electrode units surrounded by the peripheral electrode units. Adjacent central electrode units are connected to each other through corresponding connecting parts. Each peripheral electrode unit is connected only to its nearest central electrode unit through the corresponding connecting part. The electrode array is provided with several ground traces, several signal traces and an AC signal trace. In terms of circuit connection, the electrode units are arranged in multiple rows and columns. The ground terminals of each electrode unit in the same row are connected to the same ground trace. The signal terminals of each electrode unit in the same column are connected to the same signal trace. All electrode units are connected to the same AC signal trace.

2. The electrode sheet according to claim 1, characterized in that: Each of the electrode units is provided with a temperature sensor, which has a ground terminal and a signal terminal. In terms of circuit connection, the ground terminals of the temperature sensors of the electrode units located in the same row are connected to the same ground trace, and the signal terminals of the temperature sensors of the electrode units located in the same column are connected to the same signal trace.

3. The electrode sheet according to claim 1, characterized in that: The electrode array has thirteen electrode units and four grounding traces. Three of the grounding traces are connected to the grounding terminals of the three electrode units respectively, and the other grounding trace is connected to the grounding terminals of the remaining four electrode units. The electrode array also has four signal traces. Three of the signal traces are connected to the signal terminals of the four electrode units respectively, and the other signal trace is connected to the signal terminal of the remaining electrode unit.

4. The electrode sheet according to claim 3, characterized in that: The thirteen electrode units are arranged in five rows and five columns. The first and fifth rows each have two electrode units, and the middle three rows each have three electrode units. The three electrode units in each of the middle three rows are arranged in three columns, located in the first, third, and fifth columns respectively. The two electrode units in each of the first and fifth rows are arranged in two columns, located in the second and fourth columns respectively. The grounding terminals of the two electrode units in the first row and any one electrode unit in the fifth row are each connected to one grounding trace. The grounding terminals of the three electrode units in the second row are each connected to another grounding trace. The grounding terminals of the three electrode units in the third row are each connected to yet another grounding trace. The grounding terminals of the three electrode units in the fourth row and the remaining electrode unit in the fifth row are each connected to the last grounding trace.

5. The electrode sheet according to claim 4, characterized in that: The signal terminal of any of the electrode units located in the fifth row is connected to one of the signal traces; the signal terminals of the three electrode units located in the third column and the remaining electrode unit in the fifth row are each connected to another of the signal traces; the signal terminals of the three electrode units located in the first column and any of the electrode units located in the first row are each connected to yet another of the signal traces; the signal terminals of the three electrode units located in the fifth column and the remaining electrode unit in the first row are each connected to the last of the signal traces.

6. The electrode sheet according to any one of claims 1-3, characterized in that: A diode is connected in series between the ground terminal of the electrode unit and the corresponding ground trace.

7. The electrode sheet according to claim 1, characterized in that: The electrode array is provided with a flexible circuit board. Most of the ground traces and signal traces are arranged on the back side of the flexible circuit board, and the AC signal traces are arranged on the front side of the flexible circuit board.

8. The electrode sheet according to claim 7, characterized in that: The electrode array is provided with a wiring section, and a plurality of gold fingers are provided on the front and back sides of the wiring section respectively. The end of each grounding trace passes through the wiring section and is connected to the corresponding gold finger located on the front side of the wiring section. The end of each signal trace is connected to the corresponding gold finger located on the back side of the wiring section.

9. A tumor electric field therapy device, characterized in that: It includes an electric field generator and a plurality of electrode plates as described in any one of claims 1 to 8, the electrode plates being electrically connected to the electric field generator.

10. The tumor electric field therapy device according to claim 9, characterized in that: It also includes several grounding switches and several acquisition channels. Each of the grounding traces is connected in series with the corresponding grounding switch and then grounded. Each of the signal traces is connected to the corresponding acquisition channel.

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