Low-residual-oxygen medicine filling and sealing box body
By designing a low residual oxygen drug filling chamber and utilizing components such as oxygen and nitrogen valves, oxygen detection components, and pressure gauges, the residual oxygen content during drug filling is precisely controlled, solving the problem of difficult control of residual oxygen content during drug filling and ensuring drug quality and shelf life.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-19
- Publication Date
- 2026-03-31
AI Technical Summary
Existing technologies make it difficult to precisely control the amount of residual oxygen at the top of the filling bottle during the drug filling process, which affects drug quality and shelf life.
Design a low residual oxygen drug filling box, which forms a sealed cavity through the sealing body and the door panel with sealing hinges. Equipped with oxygen and nitrogen inlet valves, oxygen detection components, pressure gauges and circulating fan components, it can achieve precise control of oxygen concentration and pressure in the sealed cavity.
It provides a stable low-oxygen environment to ensure precise control of residual oxygen during drug filling and sealing, meet the needs of drug quality assessment, and extend the shelf life of drugs.
Smart Images
Figure CN224061574U_ABST
Abstract
Description
[Technical Field]
[0002] This application belongs to the field of pharmaceutical manufacturing technology, specifically relating to a low residual oxygen drug filling box. [Background Technology]
[0004] Drug oxidation is a critical quality control issue in drug research and development and manufacturing. The residual oxygen level in a drug directly affects its stability and shelf life, especially for oxygen-sensitive drugs such as amino acid products. Currently, the industry standard for residual oxygen concentration in the bottle space after filling and sealing is typically below 5%, as lower residual oxygen levels help reduce changes in drug transmittance and extend shelf life. However, traditional drug filling and sealing are usually carried out in open or semi-open environments, making it difficult to accurately control the amount of residual oxygen at the top of the bottle in practice. Therefore, it is impossible to accurately evaluate the impact of the residual oxygen content at the top on product quality. [Utility Model Content]
[0006] To address the problem of inaccurate control of residual oxygen levels during drug filling processes in existing technologies, this application provides a low residual oxygen drug filling box.
[0007] This application is achieved through the following technical solution:
[0008] A low residual oxygen drug filling box includes a sealing body and a door panel that is sealed and hinged to the sealing body. The sealing body and the door panel cooperate to form a sealed cavity for accommodating filling bottles. The sealing body is provided with an operating port and an oxygen inlet valve for external oxygen and a nitrogen inlet valve for external nitrogen. A sealing glove facing the sealed cavity is sealed and connected to the operating port.
[0009] The low residual oxygen drug filling box described above also includes an oxygen detection component for measuring the oxygen concentration in the sealed cavity.
[0010] As described above, in a low residual oxygen drug filling box, the oxygen detection component includes two oxygen concentration probes, a first oxygen concentration probe and a second oxygen concentration probe, respectively arranged diagonally along the sealed cavity.
[0011] The low residual oxygen drug filling box described above also includes a pressure gauge for measuring the atmospheric pressure inside the sealed cavity.
[0012] The low residual oxygen drug filling box as described above further includes a circulating fan assembly that connects to the sealed cavity. The circulating fan assembly includes circulating pipes with both ends connected to opposite sides of the sealing box body, and a circulating fan disposed on the circulating pipes.
[0013] The low residual oxygen drug filling box described above also includes a control module electrically connected to the pressure gauge, and an automatic exhaust valve electrically connected to the control module.
[0014] As described above, a low residual oxygen drug filling box is provided with a door handle on the door panel.
[0015] As described above, in a low residual oxygen drug filling box, a sealing ring is provided at the joint between the door panel and the main body of the box.
[0016] In the low residual oxygen drug filling box described above, when the door panel is sealed relative to the main body of the box for filling operations, the atmospheric pressure of the sealed cavity is 2-5 Pa.
[0017] Compared with the prior art, this application has the following advantages:
[0018] This application discloses a low-residual-oxygen drug filling chamber. By combining the main body of the chamber with a hinged door to form a sealed cavity, it effectively isolates the entry of outside air, providing a stable filling environment. Oxygen and nitrogen inlet valves on the main body allow the operator to precisely adjust the oxygen concentration within the sealed cavity as needed, thereby controlling the residual oxygen level at the top of the filling bottle. A sealed glove connected to the operating port not only facilitates filling operations within the sealed cavity but also prevents the introduction of external oxygen during operation. This design meets the requirements for a low-oxygen environment and allows for the assessment of the impact of different oxygen levels on drug quality by adjusting the oxygen concentration, providing reliable experimental conditions and strong technical support for drug research and development. [Attached Image Description]
[0020] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0021] Figure 1 This is a three-dimensional perspective view of the sealed state in the embodiments of this application;
[0022] Figure 2 yes Figure 1 Internal perspective view;
[0023] Figure 3 yes Figure 1 Left side view;
[0024] Figure 4 This is a three-dimensional perspective view of the open state in the embodiments of this application.
Detailed Implementation Methods
[0026] To make the technical problems solved by this application, the technical solutions, and the beneficial effects clearer, this application will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of this application and are not intended to limit this application.
[0027] Please see Figures 1 to 4 A low residual oxygen drug filling box includes a sealing body 1 and a door panel 2 that is sealed and hinged to the sealing body 1. The sealing body 1 and the door panel 2 cooperate to form a sealed cavity 3 for accommodating filling bottles. The sealing body 1 is provided with an operation port 4 and an oxygen inlet valve 5 for external oxygen and a nitrogen inlet valve 6 for external nitrogen. A sealing glove 7 is sealed and connected to the operation port 4 and is positioned towards the sealed cavity 3.
[0028] This application discloses a low-residual-oxygen drug filling chamber. By combining the main body of the chamber with a hinged door panel to form a sealed cavity, it effectively isolates the entry of outside air, providing a stable filling environment. Oxygen and nitrogen inlet valves on the main body allow the operator to precisely adjust the oxygen concentration within the sealed cavity as needed, thereby controlling the residual oxygen level at the top of the filling bottle. A sealed glove connected to the operating port not only facilitates filling operations within the sealed cavity but also prevents the introduction of external oxygen during operation. This design meets the requirements for a low-oxygen environment and allows for the assessment of the impact of different oxygen levels on drug quality by adjusting the oxygen concentration, providing reliable experimental conditions and strong technical support for drug research and development.
[0029] Furthermore, as a preferred embodiment of this solution and not a limitation thereof, it also includes an oxygen detection component 8 for measuring the oxygen concentration in the sealed cavity 3.
[0030] In this embodiment, the real-time monitoring capability of the oxygen concentration within the sealed cavity 3 of the low residual oxygen drug filling box is improved. Its working principle is based on high-sensitivity oxygen sensor technology, which can quickly and accurately reflect changes in the oxygen content within the cavity. Common oxygen detection sensor models include SGA-700-O2, AO-09, and RC-KQ1.
[0031] Furthermore, as a preferred embodiment of this solution and not a limitation thereof, the oxygen detection component 8 includes two oxygen concentration probes 81 and 82 arranged diagonally along the sealed cavity 3.
[0032] In this embodiment, two probes are positioned diagonally along the sealed cavity, effectively detecting oxygen concentrations at different locations within the cavity and ensuring the comprehensiveness and accuracy of the measurement data. This arrangement not only allows for real-time monitoring of oxygen concentration changes but also enables verification of the uniformity of gas distribution within the sealed cavity by comparing the data from the two probes. This is particularly important for low-residual-oxygen drug filling chambers, as the oxygen concentration control requirements during drug filling are extremely stringent; even minute differences in oxygen concentration can affect the quality and shelf life of the drug.
[0033] Furthermore, as a preferred embodiment of this solution and not a limitation thereof, a pressure gauge 9 for measuring the atmospheric pressure value inside the sealed cavity 3 is also included.
[0034] In this embodiment, the pressure changes within the sealed cavity can be accurately measured and the data displayed in real time on the pressure gauge. By observing the pressure gauge reading, the operator can promptly understand the pressure status within the sealed cavity and ensure it remains within the set range, typically a positive pressure of 2-5 Pa. This positive pressure environment helps prevent the infiltration of outside air, thereby maintaining the stability of the low-oxygen environment within the sealed cavity. It provides intuitive feedback on the pressure status within the sealed cavity, allowing the operator to adjust the opening of the oxygen inlet valve 5 and the nitrogen inlet valve 6 in a timely manner to maintain the required pressure level. Secondly, by monitoring pressure changes, potential leaks or other factors that may affect the stability of the environment within the sealed cavity can be detected promptly, and corresponding measures can be taken for repair or adjustment. Furthermore, the pressure gauge 9 can also serve as part of a safety protection device; when the pressure within the sealed cavity exceeds a set safety threshold, it can trigger the automatic vent valve 12 to vent, preventing damage to equipment or pharmaceuticals due to excessive pressure. The pressure gauge 9 can be further integrated with the control system to achieve automatic adjustment and alarm functions for the pressure within the sealed cavity. For example, when the pressure gauge detects an abnormal pressure, it can automatically close the oxygen and nitrogen inlet valves and activate the automatic exhaust valve to vent the gas, ensuring the safety of the equipment and medicines. Simultaneously, the control system can automatically adjust the opening of the inlet valves according to a preset pressure curve to achieve precise control of the pressure within the sealed chamber.
[0035] Furthermore, as a preferred embodiment of this solution and not a limitation, it also includes a circulating fan assembly 10 that connects to the sealed cavity 3. The circulating fan assembly 10 includes a circulating pipe 101 with its two ends respectively connected to two opposite sides of the sealing body 1, and a circulating fan 102 disposed on the circulating pipe 101.
[0036] In this embodiment, the circulating fan 102 generates airflow, causing the gas within the sealed cavity 3 to circulate continuously in the circulating pipe 101, thereby achieving gas mixing and uniform distribution. This design effectively eliminates potential dead zones or concentration gradients within the sealed cavity, ensuring consistent oxygen concentration at all locations. This is particularly important for drug filling processes that require precise control of residual oxygen levels, as uniform oxygen distribution reduces variations in drug quality caused by localized differences in oxygen concentration.
[0037] Furthermore, as a preferred embodiment of this solution and not a limitation, it also includes a control module electrically connected to the pressure gauge 9, and an automatic exhaust valve 12 electrically connected to the control module.
[0038] In this embodiment, based on sensor data acquisition and automatic control technology: pressure gauge 9 monitors the atmospheric pressure inside the sealed cavity 3 in real time and transmits the data to the control module; the control module determines whether pressure adjustment is needed based on a preset pressure threshold and controls the opening or closing of the automatic exhaust valve 12 accordingly. This achieves real-time monitoring and automatic adjustment of the pressure inside the sealed cavity, ensuring that the pressure is always maintained within a safe and stable range, typically a positive pressure of 2-5 Pa. This not only helps prevent the infiltration of outside air and maintain the stability of the low-oxygen environment, but also avoids damage to equipment or pharmaceuticals due to excessive pressure. Furthermore, through the intelligent control of the automatic exhaust valve 12, it can respond promptly to abnormal pressure conditions, such as automatically opening the exhaust valve to reduce pressure when the pressure exceeds a set threshold, thereby improving the safety and reliability of the equipment.
[0039] Furthermore, as a preferred embodiment of this solution and not a limitation, the door panel 2 is provided with a door handle 13.
[0040] This embodiment provides a convenient door opening and closing operation method, enhancing the practicality of the device and the user experience. Operators can easily open or close the door panel by gripping and rotating the handle, thereby achieving rapid opening or closing of the sealing cavity 3.
[0041] Furthermore, as a preferred embodiment of this solution and not a limitation, a sealing ring 14 is provided at the joint between the door panel 2 and the sealing body 1.
[0042] In this embodiment, the airtightness of the sealed cavity 3 is ensured, thereby maintaining the stability of the internal low-oxygen environment. Based on the sealing properties of elastic materials such as rubber or silicone: when the door panel is closed and pressed, the sealing ring 14 is deformed under pressure, filling the tiny gap between the door panel and the main body of the box, forming an effective sealing barrier to prevent the infiltration of outside air and the leakage of internal gas.
[0043] Furthermore, as a preferred embodiment of this solution and not a limitation, when the door panel 2 is sealed relative to the sealing body 1 for filling operation, the atmospheric pressure of the sealing cavity 3 is 2-5 Pa.
[0044] In this embodiment, by maintaining the air pressure inside the sealed cavity at 2-5 Pa, it is possible to effectively prevent outside air from seeping into the sealed cavity due to pressure difference, thereby maintaining the stability of the internal low-oxygen environment. This provides an additional protective barrier for the sealed cavity, significantly reducing the risk of outside air infiltration and ensuring precise control of oxygen concentration. This is crucial for oxygen-sensitive drugs (such as amino acid products), as even a small oxygen leak can lead to changes in drug quality; maintaining a positive pressure state also helps reduce the growth of dust and microorganisms inside the sealed cavity, providing a cleaner storage environment for the drugs.
[0045] The working principle of this embodiment is as follows:
[0046] This application discloses a low-residual-oxygen drug filling chamber. By combining the main body of the chamber with a hinged door to form a sealed cavity, it effectively isolates the entry of outside air, providing a stable filling environment. Oxygen and nitrogen inlet valves on the main body allow the operator to precisely adjust the oxygen concentration within the sealed cavity as needed, thereby controlling the residual oxygen level at the top of the filling bottle. A sealed glove connected to the operating port not only facilitates filling operations within the sealed cavity but also prevents the introduction of external oxygen during operation. This design meets the requirements for a low-oxygen environment and allows for the assessment of the impact of different oxygen levels on drug quality by adjusting the oxygen concentration, providing reliable experimental conditions and strong technical support for drug research and development.
[0047] The above are implementation methods provided in conjunction with specific content, and it is not intended that the specific implementation of this application is limited to these descriptions. Any methods or structures that are similar to those of this application, or any technical deductions or substitutions made based on the concept of this application, should be considered within the scope of protection of this application.
Claims
1. A low residual oxygen pharmaceutical filling enclosure, characterized in that, The application relates to a sealed box for filling bottles, which comprises a box body (1) and a door plate (2) sealed and hinged to the box body (1), the box body (1) and the door plate (2) cooperatively form a sealed cavity (3) for accommodating filled bottles, the box body (1) is respectively provided with an operation port (4), an oxygen inlet valve (5) for connecting with external oxygen and a nitrogen inlet valve (6) for connecting with external nitrogen, a sealed glove (7) is sealed and connected to the operation port (4) and faces the sealed cavity (3).
2. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, The sealed box further comprises an oxygen detection assembly (8) for measuring the oxygen concentration in the sealed cavity (3).
3. The low residual oxygen pharmaceutical fill-chamber of claim 2, wherein, The oxygen detection assembly (8) comprises two first oxygen concentration probes (81) and two second oxygen concentration probes (82) which are arranged along the diagonal lines of the sealed cavity (3) respectively.
4. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, The sealed box further comprises a pressure gauge (9) for measuring the atmospheric pressure in the sealed cavity (3).
5. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, The sealed box further comprises a circulating fan assembly (10) which communicates with the sealed cavity (3), the circulating fan assembly (10) comprises a circulating pipeline (101) which is connected to two opposite sides of the box body (1) respectively, and a circulating fan (102) arranged on the circulating pipeline (101).
6. The low residual oxygen pharmaceutical fill-chamber of claim 4, wherein, The sealed box further comprises a control module electrically connected to the pressure gauge (9) and an automatic exhaust valve (12) electrically connected to the control module.
7. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, The door plate (2) is provided with a door handle (13).
8. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, The door plate (2) is provided with a sealing rubber ring (14) at the joint with the box body (1).
9. The low residual oxygen pharmaceutical fill-chamber of claim 1, wherein, When the door plate (2) is sealed relative to the box body (1) for filling operation, the atmospheric pressure in the sealed cavity (3) is 2-5 Pa.