Matching attachment structure for lipidosome production filtering device

Abstract

The utility model discloses a matching attachment structure for a lipidosome production filtering device, which comprises a base, a tank body and a membrane cylinder, the tank body is arranged on the base, the membrane cylinder is arranged in the tank body, and the lower end of the membrane cylinder is arranged in the base and is movably connected with the base. According to the utility model, the base, the tank body, the membrane cylinder, the attachment device, the box body, the locking assembly, the linkage piece, the control piece, the elastic sealing ring, the clamping groove and the limiting block are matched for use, so that the problem that when the membrane cylinder of the existing microfiltration membrane filter is connected with the base, a small end distance of the lower end of the membrane cylinder is generally inserted into the base, and the membrane cylinder is not easily separated from the base is solved to a certain extent. Through simple insertion, the lower end of the membrane cylinder cannot bear a better acting point, and is lack of effective acting points and adhesive strength, so that the problems that the membrane cylinder is very easy to incline and deviate, the liquid is not uniformly distributed in the filtering process, the filtering efficiency is reduced, the filter membrane is possibly damaged, and the service life of the filter membrane is influenced are solved.

Description

Technical Field

[0001] This invention belongs to the field of liposome production technology, and particularly relates to a cooperating attachment structure for a liposome production filtration device. Background Technology

[0002] In liposome production, filtration is a crucial step in ensuring product quality and purity, and microporous membrane filters are an indispensable core device in this process. Through their precise membrane structure, microporous membrane filters can efficiently trap tiny particles, unencapsulated free drugs, and impurities in the liposome solution. When used in conjunction with other filtration devices such as ultrafiltration systems and tangential flow filtration systems, microporous membrane filters can further optimize the particle size distribution of liposomes, improving product uniformity and stability, thus providing a solid guarantee for the safety and efficacy of liposomal drugs.

[0003] The problem with existing technology is that when connecting the membrane cartridge to the base, the lower end of the membrane cartridge is usually inserted into the base with a small gap. This simple insertion does not provide a good point of force for the lower end of the membrane cartridge, resulting in a lack of effective force and adhesion strength. This can easily cause the membrane cartridge to tilt and shift, leading to uneven liquid distribution during filtration, reduced filtration efficiency, and potential damage to the filter membrane, affecting its service life. Utility Model Content

[0004] To address the problems existing in the prior art, this utility model provides a matching attachment structure for a liposome production filtration device. This structure enables rapid connection and fixation of the membrane cartridge during installation, enhancing the adhesion strength at the lower end of the membrane cartridge. This improves upon or solves, to some extent, the problems of existing microporous membrane filters where the membrane cartridge is typically only inserted into the base with a small portion of its lower end. This simple insertion results in the lower end of the membrane cartridge not receiving a good point of adhesion, lacking effective adhesion and strength. This easily leads to membrane cartridge tilting and shifting, causing uneven liquid distribution during filtration, reducing filtration efficiency, and potentially damaging the filter membrane, thus affecting its service life.

[0005] This invention is implemented as follows: a mating attachment structure for a liposome production filtration device includes a base, a tank, and a membrane tube. The tank is disposed on the base and fixedly connected to the base. The membrane tube is disposed inside the tank, with its lower end disposed inside the base and movably connected to the base. An attachment device is disposed at the lower end of the membrane tube, and the attachment device is fixedly connected to the upper side of the base. The membrane tube is movably connected to the base through the attachment device. An elastic sealing ring that mates with the base is fixedly connected to the lower end of the membrane tube.

[0006] The preferred attachment device of this utility model includes a box body, locking components, linkage components, and control components. The box body is fixedly connected to the upper side of the base and corresponds to and is adapted to the lower end of the membrane tube. There are three locking components, which are evenly arranged around the inside of the box body. The linkage components are arranged at the lower ends of the three locking components. The control components are sleeved on the surface of the box body. By setting the attachment device, the adhesion between the membrane tube and the base is increased, and the lower end of the membrane tube can be quickly attached and fixed to the base, which avoids the membrane tube from tilting or shifting to a certain extent.

[0007] The preferred locking assembly of this utility model includes positioning rods, lock heads, push springs, and pressure rods. There are two positioning rods, both located on the right side inside the box, with their left and right ends fixedly connected to the left and right inner walls of the right side of the box, respectively. The lock head is sleeved on the left end surface of the two positioning rods and slidably connected to them. The left end of the lock head extends out of the box and is movably connected to it. There are two push springs, each sleeved on the surface of one of the two positioning rods, with their left and right ends fixedly connected to the right surface of the box and the right side of the lock head, respectively. The pressure rod is fixedly connected to the right side of the lower surface of the lock head. By providing the locking assembly, it engages with the slot, enabling quick locking and fixing of the lower end of the membrane tube during installation, thus increasing the strength of the lower end of the membrane tube.

[0008] The preferred linkage component of this utility model includes a turntable and movable slots. The turntable is sleeved on the inner wall of the box and rotatably connected to the box. There are three movable slots, which are evenly distributed around the upper surface of the turntable and all penetrate the turntable. The lower ends of the three pressure rods extend into the three movable slots and are movably connected to the movable slots. By setting the linkage component, it is used to drive the locking components, which has the function of driving the three locking components to move synchronously, which facilitates the release of the fixation when the membrane cylinder is disassembled.

[0009] The preferred control component of this utility model includes a knob and a connector. The knob is sleeved on the surface of the housing and rotatably connected to the housing. There are two connectors, which are respectively fixedly connected to the front and rear ends of the upper surface of the turntable. The ends of the two connectors that are far apart from each other extend out of the housing and are movably connected to the housing. They are also fixedly connected to the front and rear inner surfaces of the knob. By setting the control component, the linkage component can be rotated, which facilitates the rotation of the linkage component during operation.

[0010] As a preferred embodiment of this invention, three slots are evenly provided on the circumference of the lower end of the membrane tube. The positions of the three slots correspond to and are adapted to the positions of the three locking heads. By evenly providing three slots on the circumference of the lower end of the membrane tube, the three locking components are engaged and locked together, thereby improving the force point at the lower end of the membrane tube and achieving better adhesion and fixation.

[0011] As a preferred embodiment of this invention, each of the three pressure rods extends into a movable groove at its lower end, and each is fixedly connected to a limiting block. By fixing the limiting block to the lower end of each of the three pressure rods, the pressure rod and the turntable are limited, preventing the pressure rod from detaching from the movable groove.

[0012] 1. This utility model, through the coordinated use of a base, tank, membrane cartridge, attachment device, box, locking assembly, positioning rod, lock head, push spring, pressure rod, linkage component, turntable, movable groove, control component, button ring, connecting component, elastic sealing ring, slot, and limiting block, improves or solves to a certain extent the problem of existing microporous membrane filters. When the membrane cartridge is connected to the base, it is usually inserted into the base with only a small distance at the bottom. This simple insertion does not provide a good point of force for the bottom of the membrane cartridge, resulting in a lack of effective force and adhesion strength. This can easily cause the membrane cartridge to tilt and shift, leading to uneven liquid distribution during filtration, reduced filtration efficiency, and potential damage to the filter membrane, affecting its service life. Attached Figure Description

[0013] Figure 1 This is a three-dimensional structural diagram of a microporous membrane filter provided in an embodiment of the present invention;

[0014] Figure 2 This is an exploded three-dimensional structural diagram of a microporous membrane filter provided in an embodiment of the present invention;

[0015] Figure 3 This is a three-dimensional structural diagram of the slot in the microporous membrane filter provided by an embodiment of the present invention;

[0016] Figure 4 This is a three-dimensional structural schematic diagram of the attachment device in a microporous membrane filter provided by an embodiment of the present invention;

[0017] Figure 5 This is an exploded three-dimensional structural diagram of the attachment device in the microporous membrane filter provided in this embodiment of the utility model.

[0018] In the diagram: 1. Base; 2. Tank; 3. Membrane tube; 4. Attachment device; 41. Box; 42. Locking assembly; 421. Positioning rod; 422. Lock head; 423. Push spring; 424. Pressure rod; 43. Linkage component; 431. Turntable; 432. Movable groove; 44. Control component; 441. Button ring; 442. Connecting component; 5. Elastic sealing ring; 6. Slot; 7. Limit block. Detailed Implementation

[0019] To further understand the invention content, features and effects of this utility model, the following embodiments are provided, and detailed descriptions are given in conjunction with the accompanying drawings.

[0020] The structure of this utility model will now be described in detail with reference to the accompanying drawings.

[0021] like Figures 1 to 5 As shown in the figure, the attachment structure for the liposome production filtration device provided in this embodiment of the present invention includes a base 1, a tank 2 and a membrane tube 3. The tank 2 is disposed on the base 1 and is fixedly connected to the base 1. The membrane tube 3 is disposed inside the tank 2, and its lower end is disposed inside the base 1 and is movably connected to the base 1. An attachment device 4 is provided at the lower end of the membrane tube 3. The attachment device 4 is fixedly connected to the upper side of the base 1. The membrane tube 3 is movably connected to the base 1 through the attachment device 4. An elastic sealing ring 5 that cooperates with the base 1 is fixedly connected to the lower end of the membrane tube 3.

[0022] refer to Figure 2 , Figure 3 and Figure 4 The attachment device 4 includes a box body 41, a locking component 42, a linkage component 43, and a control component 44. The box body 41 is fixedly connected to the upper side of the base 1 and corresponds to and is adapted to the lower end of the membrane tube 3. There are three locking components 42, which are evenly arranged around the inside of the box body 41. The linkage component 43 is arranged at the lower end of the three locking components 42. The control component 44 is sleeved on the surface of the box body 41.

[0023] The above solution is adopted: by setting up the attachment device 4, the adhesion between the membrane tube 3 and the base 1 is increased, and the lower end of the membrane tube 3 can be quickly attached and fixed to the base 1, which avoids the membrane tube 3 from tilting or shifting to a certain extent.

[0024] refer to Figure 3 , Figure 4 and Figure 5The locking assembly 42 includes a positioning rod 421, a lock head 422, a push spring 423, and a pressure rod 424. There are two positioning rods 421, both of which are located inside the right side of the box body 41, and their left and right ends are fixedly connected to the left and right inner walls of the right side of the box body 41, respectively. The lock head 422 is sleeved on the left end surface of the two positioning rods 421 and is slidably connected to the positioning rods 421. The left end of the lock head 422 extends out of the box body 41 and is movably connected to the box body 41. There are two push springs 423, which are respectively sleeved on the surface of the two positioning rods 421, and their left and right ends are fixedly connected to the right surface of the box body 41 and the right side of the lock head 422, respectively. The pressure rod 424 is fixedly connected to the right side of the lower surface of the lock head 422.

[0025] The above solution involves setting a locking component 42 to engage with the slot 6, which enables quick and secure locking of the lower end of the membrane tube 3 during installation, thereby increasing the strength of the lower end of the membrane tube 3.

[0026] refer to Figure 4 and Figure 5 The linkage component 43 includes a turntable 431 and a movable groove 432. The turntable 431 is fitted on the inner wall of the box body 41 and is rotatably connected to the box body 41. There are three movable grooves 432, which are evenly opened around the upper surface of the turntable 431 and all penetrate the turntable 431. The lower ends of the three pressure rods 424 extend into the three movable grooves 432 respectively and are movably connected to the movable grooves 432.

[0027] The above solution is adopted: by setting the linkage component 43, it is used to drive the locking component 42, which has the function of driving the three locking components 42 to move synchronously, which facilitates the release of the fixation when the membrane tube 3 is disassembled.

[0028] refer to Figure 3 , Figure 4 and Figure 5 The control component 44 includes a button ring 441 and a connector 442. The button ring 441 is sleeved on the surface of the box body 41 and is rotatably connected to the box body 41. There are two connectors 442, which are respectively fixedly connected to the front and rear ends of the upper surface of the turntable 431. The ends of the two connectors 442 that are far apart from each other extend out of the box body 41 and are movably connected to the box body 41, and are respectively fixedly connected to the front and rear sides of the inside of the button ring 441.

[0029] The above solution is adopted: by setting up a control component 44, the linkage component 43 is rotated, which facilitates the rotation of the linkage component 43 during operation.

[0030] refer to Figure 2 and Figure 3 Three slots 6 are evenly distributed around the lower end of the membrane tube 3. The positions of the three slots 6 correspond to and are compatible with the positions of the three lock heads 422.

[0031] The above solution is adopted: three slots 6 are evenly provided on the circumference of the lower end of the membrane tube 3 to engage the three locking components 42, thereby increasing the force point at the lower end of the membrane tube 3 and achieving better adhesion and fixation.

[0032] refer to Figure 5 Each of the three pressure rods 424 extends into a movable groove 432 at its lower end, and each is fixedly connected to a limit block 7.

[0033] The above solution is adopted: by fixing limit blocks 7 to the lower ends of the three pressure rods 424, the pressure rods 424 and the turntable 431 are limited to prevent the pressure rods 424 from detaching from the movable groove 432.

[0034] During installation, the lower end of the membrane tube 3 is inserted normally into the base 1. As it is inserted downwards, the lower end of the membrane tube 3 will press against the end of the three locking heads 422 that extends into the box body 41. This causes the locking heads 422 to be pressed against the surface of the positioning rod 421 and move into the box body 41. At the same time, the push spring 423 is pressed. After the membrane tube 3 is fully inserted, it is rotated. When the slot 6 corresponds to the locking head 422, the locking head 422 is no longer pressed, and the push spring 423 will rebound, pushing the locking head 422 out of the box body 41 from the surface of the positioning rod 421. This allows the locking head 422 to be inserted into the slot 6, thereby raising the point of force at the lower end of the membrane tube 3 and fixing it.

[0035] During subsequent disassembly, the button ring 441 is rotated. The rotation of the button ring 441 drives the turntable 431 to rotate inside the box 41 through the connector 442. At the same time as the turntable 431 rotates, it drives the three movable slots 432 to rotate. The rotation of the three movable slots 432 simultaneously squeezes and moves the three pressure rods 424 inside. The pressure rods 424 are squeezed and moved, which drives the lock head 422 to move from the surface of the positioning rod 421 into the box 41. The lock head 422 moves out of the slot 6 to release the fixation. Then the membrane cylinder 3 can be pulled out upwards.

[0036] When the lower end of the membrane tube 3 is inserted normally into the base 1, it will compress the elastic sealing ring 5 to a certain extent to achieve a seal.

[0037] In summary, the attachment structure for the liposome production filtration device, through the coordinated use of a base 1, tank 2, membrane cartridge 3, attachment device 4, box 41, locking assembly 42, positioning rod 421, lock head 422, push spring 423, pressure rod 424, linkage 43, turntable 431, movable groove 432, control component 44, button ring 441, connecting component 442, elastic sealing ring 5, slot 6, and limiting block 7, improves or solves, to a certain extent, the problem of existing microporous membrane filters where, when connecting the membrane cartridge to the base, the lower end of the membrane cartridge is usually inserted into the base with a small gap. This simple insertion does not provide a good point of force for the lower end of the membrane cartridge, resulting in a lack of effective force and adhesion strength. This easily leads to tilting and displacement of the membrane cartridge, causing uneven liquid distribution during filtration, reducing filtration efficiency, and potentially damaging the filter membrane, affecting its service life.

[0038] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0039] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A fitting structure for a filtration device for liposome production, comprising a base (1), a tank (2), and a membrane cartridge (3), wherein the tank (2) is disposed on the base (1) and fixedly connected to the base (1), and the membrane cartridge (3) is disposed inside the tank (2), with its lower end disposed inside the base (1) and movably connected to the base (1), characterized in that: The film cylinder (3) is provided with an attachment device (4) at the lower end, the attachment device (4) is fixedly connected to the upper side of the base (1), the film cylinder (3) is movably connected to the base (1) through the attachment device (4), and the lower end of the film cylinder (3) is fixedly connected with an elastic sealing ring (5) matched with the base (1).

2. The fitting attachment structure for a liposome production filter device according to claim 1, wherein: The attachment device (4) comprises a box body (41), a locking assembly (42), a linkage (43) and a control member (44), the box body (41) is fixedly connected to the upper side of the base (1) and corresponds to the lower end of the film cylinder (3), the number of the locking assembly (42) is three, and they are uniformly arranged around the inside of the box body (41), the linkage (43) is arranged at the lower end of the three locking assemblies (42), and the control member (44) is sleeved on the surface of the box body (41).

3. The fitting attachment structure for a liposome production filter device according to claim 2, wherein: The locking assembly (42) comprises a positioning rod (421), a lock head (422), a push spring (423) and a pressing rod (424), the number of the positioning rod (421) is two, and they are arranged on the right side of the inside of the box body (41), and the left and right ends are fixedly connected to the left and right side inner walls of the right end of the inside of the box body (41), the lock head (422) is sleeved on the surface of the left end of the two positioning rods (421) and is slidably connected with the positioning rods (421), the left end of the lock head (422) extends out of the inside of the box body (41) and is movably connected with the box body (41), the number of the push spring (423) is two, and they are sleeved on the surface of the two positioning rods (421), and the left and right ends are fixedly connected to the right surface of the inside of the box body (41) and the right side of the lock head (422), and the pressing rod (424) is fixedly connected to the right side of the lower surface of the lock head (422).

4. The fitting attachment structure for a liposome production filter device according to claim 3, wherein: The linkage (43) comprises a rotating disc (431) and a movable groove (432), the rotating disc (431) is sleeved on the inner wall of the box body (41) and is rotatably connected with the box body (41), the number of the movable groove (432) is three, and they are uniformly arranged around the upper surface of the rotating disc (431) and penetrate the rotating disc (431), and the lower ends of the three pressing rods (424) extend into the three movable grooves (432) and are movably connected with the movable grooves (432).

5. The fitting attachment structure for a liposome production filter device according to claim 4, wherein: The control member (44) comprises a knob ring (441) and a connecting piece (442), the knob ring (441) is sleeved on the surface of the box body (41) and is rotatably connected with the box body (41), the number of the connecting piece (442) is two, and they are fixedly connected to the front and rear ends of the upper surface of the rotating disc (431), and the ends of the two connecting pieces (442) away from each other extend out of the box body (41) and are movably connected with the box body (41), and are fixedly connected to the front and rear inner side surfaces of the knob ring (441).

6. The fitting attachment structure for a liposome production filter device according to claim 3, wherein: The lower end of the film cylinder (3) is uniformly provided with three clamping grooves (6) around the surface, and the positions of the three clamping grooves (6) correspond to and match the positions of the three lock heads (422).

7. The fitting attachment structure for a liposome production filter apparatus according to claim 4, wherein: The lower end of each of the three pressing rods (424) extends a movable slot (432), and is fixedly connected with a limiting block (7).

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