Gene sequencer
By introducing a sliding, removable sealing plate and mounting bracket structure into the gene sequencer, the problems of space waste and operational complexity during flow cell replacement are solved, enabling rapid flow cell replacement and optimization of instrument size.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- ZHONGDI HUANYU (CHONGQING) BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-05-07
- Publication Date
- 2026-04-10
AI Technical Summary
Existing gene sequencers suffer from wasted space or the need for additional ejection mechanisms when changing flow cells, resulting in large instrument size and complex operation.
A gene sequencer was designed, which adopts a sliding and removable cover plate and mounting frame structure. Through the cooperation of connecting blocks and inclined grooves, the flow cell can be easily and quickly replaced, reducing space waste and eliminating the need for a push-out mechanism.
It enables simple and quick replacement of flow cells in confined spaces, reducing the overall size of the instrument while maintaining the convenience of testing experiments.
Smart Images
Figure CN224105829U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the field of gene sequencing related equipment, specifically relates to a gene sequencer. BACKGROUND
[0002] The gene sequencer is the instrument for determining the base order, kind and quantity of DNA fragment, and is mainly applied to human genome sequencing, genetic diagnosis of human genetic disease, infectious disease and cancer, parentage identification and individual identification of forensic, screening of bioengineering medicine, crossbreeding of animals and plants and the like, and needs to use the flow tank in the present gene sequencer, the flow tank (FlowCell) is the core component for carrying the sequencing reaction in the gene sequencer, and its function is to fix DNA / RNA fragment and realize sequence signal capture and conversion, and a new flow tank needs to be replaced before each detection.
[0003] The present gene sequencer is mainly adopted two ways for the convenience of replacing the flow tank, one is that a large space is left above the flow tank table of the instrument, and the changer reaches in for replacement, and the other is that the flow tank table and the part of equipment below are set as slidable structure, and are pushed out to the outside of the instrument for operation when replacing, but the two ways have defects, the first way leads to much space waste, and further makes the whole volume of the instrument become large, and the second way needs an additional set of pushing mechanism, and needs to compromise and choose the part of functions of the flow tank, therefore, a new structure needs to be designed, which reduces the space waste and facilitates simple and quick replacement of the flow tank. UTILITARY MODEL CONTENT
[0004] In order to overcome the defects of the prior art, the utility model aims at providing a gene sequencer, so as to facilitate simple and quick replacement of the flow tank in a narrow space.
[0005] In order to achieve the above object, the utility model provides a gene sequencer, which comprises a sequencer body, a flow tank table is arranged in the sequencer body, further comprises a seal plate which can be slid out, the sequencer body is equipped with a sliding groove, two connecting blocks are fixed to the inner side of the seal plate, a mounting frame which can move up and down is arranged between the two connecting blocks, the mounting frame is in U shape, can be slid into the outer side of the flow tank table, and is used for carrying the flow tank.
[0006] Compared with the prior art, the utility model discloses the beneficial effect lies in: the sequencing instrument body is the existing gene sequencer, and it is the relatively mature prior art, and the model is NovaSeqTM X, including micro -fluidic chip, temperature -controlled and fluid system, signal acquisition and processing module, data generation and calculation unit, control and interface etc.; The flow groove carrier is used for placing the flow groove, and the chute is used for placing and sliding the sealing plate, the connecting block and the mounting bracket, the sealing plate is used for shielding and closing the chute, the connecting block is used for connecting the sealing plate and the mounting bracket, and the mounting bracket is used for carrying the flow groove, when needing to replace the flow groove, the mounting bracket is moved up, the used flow groove is lifted upwards to make it leave the flow groove carrier, then the sealing plate is pulled, the mounting bracket is pulled out through the connecting block, the flow groove is carried out, then the flow groove is replaced, the sealing plate is pushed, the mounting bracket is pushed back to the flow groove carrier above, then the mounting bracket is moved down, and the flow groove is placed on the flow groove carrier, and the replacement is completed, in the application, a large amount of space above the flow groove carrier need not be reserved, and the overall volume of the instrument can be effectively reduced, and simultaneously, the flow groove carrier is still fixed at the original position without the need of pushing out mechanism, so that the detection experiment is facilitated.
[0007] As the preferred implementation of the utility model, two first connecting rods are fixed on the two sides of the mounting bracket, a strip-shaped ring is sleeved on the outer side of the first connecting rod, two second connecting rods are fixed on the inner side of the two connecting blocks, the second connecting rod passes through the strip-shaped ring, and the first connecting rod and the second connecting rod can rotate relative to the strip-shaped ring; The sequencing instrument body is close to the two sides of the flow groove carrier and is provided with two inclined grooves, when the mounting bracket moves above the flow groove carrier, two strip-shaped rings slide into two inclined grooves on the same side respectively, and the mounting bracket moves downwards below the flow groove carrier.
[0008] Beneficial effects: the first connecting rod and the second connecting rod are connected through the strip-shaped ring, when two strip-shaped rings are respectively slid into two inclined grooves on the same side, the mounting frame moves downward and moves below the flow tank loading platform, so that the flow tank on the mounting frame is placed on the flow tank loading platform; when the sealing plate is pulled out, two strip-shaped rings on the two sides slide upward through the inclined grooves, drive the mounting frame to rise in height, and the flow tank is taken out from the flow tank loading platform; after the flow tank is replaced, when it is pushed back inward, two strip-shaped rings away from the sealing plate pass through the first inclined groove first, but since the rear strip-shaped ring and the mounting frame are still horizontally sliding on the sequencer body, at this time, the strip-shaped ring away from the sealing plate does not slide downward and fall into the first inclined groove; when the two rear strip-shaped rings pass through the inclined grooves, they are simultaneously turned downward and fall into the inclined grooves, and then the mounting frame moves above the flow tank loading platform before falling downward, so that the flow tank accurately falls on the flow tank loading platform.
[0009] As a preferred embodiment of the utility model, a first limiting block is fixed in the sequencer body, and the first limiting block is located on the side of the flow tank loading platform away from the sealing plate; a second limiting block is fixed on the mounting frame, and the second limiting block is located on the side of the mounting frame close to the sealing plate.
[0010] Beneficial effects: the first limiting block is used for positioning the flow tank when it slides in, and the second limiting block is used for supporting the flow tank when it slides in, and the flow tank is moved to the inside of the sliding groove, and when the flow tank abuts against the first limiting block, the flow tank is positioned by the first limiting block and falls on the flow tank loading platform.
[0011] As a preferred embodiment of the utility model, a recycling block is fixed on the two sides of the mounting frame, and the recycling block is higher than the mounting frame and is used for taking out the flow tank when it slides out.
[0012] Beneficial effects: when the strip-shaped ring moves upward through the inclined groove, since the recycling block is higher than the mounting frame, even if the mounting frame is below the flow tank loading platform, the flow tank can be taken out, so that it can be located in the mounting frame at all times and is convenient to take out along with the mounting frame.
[0013] As a preferred embodiment of the utility model, two sliding rails are fixed in the sequencer body, and the two sliding rails are respectively and slidably connected with the two connecting blocks.
[0014] Beneficial effects: the sliding rails are used for limiting and guiding the sliding of the connecting blocks, so that the mounting frame is prevented from being deviated from the flow tank loading platform.
[0015] As the preferred embodiment of the utility model, the outer side of the sealing plate is fixed with a pull rod.
[0016] Beneficial effect: the pull rod is used for conveniently pulling out the sealing plate. BRIEF DESCRIPTION OF DRAWINGS
[0017] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or the prior art, the drawings needed to be used in the embodiment or the prior art description will be briefly introduced below.
[0018] Figure 1 It is the structural schematic view of the gene sequencer embodiment of the utility model.
[0019] Figure 2 It is the sectional view of the gene sequencer embodiment of the utility model.
[0020] Figure 3 It is the perspective sectional view of the gene sequencer embodiment of the utility model.
[0021] Figure 4 It is the gene sequencer embodiment of the utility model Figure 3 The local enlarged view of detail A.
[0022] Figure 5 It is the structural schematic view of the gene sequencer embodiment of the utility model hiding the sequencer body.
[0023] The reference signs in the drawings of the specification include: 1 sequencer body, 2 flow tank platform, 3 sealing plate, 4 sliding groove, 5 connecting block, 6 mounting frame, 7 first connecting rod, 8 bar ring, 9 second connecting rod, 10 chute, 11 first limiting block, 12 second limiting block, 13 recovery block, 14 sliding rail, 15 pull rod. DETAILED DESCRIPTION
[0024] The embodiments of the utility model will be described in detail below, and the examples of the embodiments are shown in the drawings, wherein the same or similar reference signs represent the same or similar elements or elements with the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are intended to explain the embodiments of the utility model, and cannot be understood as the limitation of the utility model.
[0025] In the description of the embodiments of the utility model, it is understood that the orientation or position relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the embodiments of the utility model and simplifying the description, and therefore cannot be understood as indicating or implying that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as the limitation of the utility model.
[0026] In addition, the terms "first", "second", "third", "fourth" and the like in the description and in the claims are used for distinguishing between similar elements and not necessarily described in the described sequence of order. Terms are to be construed as limiting the claim to a given number of elements unless specifically stated otherwise.
[0027] The utility model will be described in detail below with reference to the drawings and in combination with the embodiments.
[0028] As shown in Figs. Figure 1 , Figure 3 and Figure 4 The utility model provides a gene sequencer: including sequencer body 1, be equipped with flow groove support 2 in sequencer body 1, sequencer body 1 is equipped with sliding slot 4, flow groove support 2 is located in sliding slot 4, two slide rails 14 are fixed in sequencer body 1, and two slide rails 14 are horizontally arranged in sliding slot 4.
[0029] As shown in Figs. Figures 2-4 In the embodiment, the inner side of two slide rails 14 is slidably provided with a connecting block 5, one end of two connecting blocks 5 is fixedly connected with a sealing plate 3, the sealing plate 3 is used to shield and close the sliding slot 4, the outer side of the sealing plate 3 is fixedly provided with a pull rod 15, the pull rod 15 is used to facilitate pulling out the sealing plate 3, and then the connecting block 5 is pulled out outward under the limitation of the slide rail 14.
[0030] As shown in Figs. Figure 4 and Figure 5As shown, in the embodiment, the inner side of each of the two connecting blocks 5 is fixed with two second connecting rods 9, the outer side of each of the second connecting rods 9 is sleeved with a strip-shaped ring 8, the strip-shaped ring 8 is further provided with a first connecting rod 7, the first connecting rod 7 is fixedly connected with a mounting rack 6, and the first connecting rod 7 and the second connecting rod 9 can rotate relative to the strip-shaped ring 8; in the application, the first connecting rod 7, the second connecting rod 9 and the strip-shaped ring 8 are all four, the mounting rack 6 is U-shaped, and four first connecting rods 7 are located on both sides of the U-shaped mounting rack 6; the inner side of the mounting rack 6 is provided with an L-shaped groove for placing a flow tank; the sequencing instrument body 1 is provided with two inclined grooves 10 on both sides close to the flow tank platform 2, when the two strip-shaped rings 8 are respectively slid into the two inclined grooves 10 on the same side, the mounting rack 6 moves downward and moves below the flow tank platform 2, so that the flow tank on the mounting rack 6 is placed on the flow tank platform 2; when the sealing plate 3 is pulled out, the two strip-shaped rings 8 on both sides slide upward through the inclined grooves 10, drive the mounting rack 6 to rise in height, and take out the flow tank from the flow tank platform 2; after replacing the flow tank, when being pushed back inward, the two strip-shaped rings 8 away from the sealing plate 3 first pass through the first inclined groove 10, but since the rear strip-shaped ring 8 and the mounting rack 6 are still sliding horizontally on the sequencing instrument body 1, at this time, the strip-shaped ring 8 away from the sealing plate 3 will not slide downward and fall into the first inclined groove 10; when the two strip-shaped rings 8 pass through the inclined grooves 10, they will be synchronously downward, fall into the inclined grooves 10, and then make the mounting rack 6 move above the flow tank platform 2 before falling downward, so that the flow tank falls accurately on the flow tank platform 2.
[0031] As shown in the accompanying drawings, Figure 4 As shown, in the embodiment, the inner side of each of the two connecting blocks 5 is fixed with two second connecting rods 9, the outer side of each of the second connecting rods 9 is sleeved with a strip-shaped ring 8, the strip-shaped ring 8 is further provided with a first connecting rod 7, the first connecting rod 7 is fixedly connected with a mounting rack 6, and the first connecting rod 7 and the second connecting rod 9 can rotate relative to the strip-shaped ring 8; in the application, the first connecting rod 7, the second connecting rod 9 and the strip-shaped ring 8 are all four, the mounting rack 6 is U-shaped, and four first connecting rods 7 are located on both sides of the U-shaped mounting rack 6; the inner side of the mounting rack 6 is provided with an L-shaped groove for placing a flow tank; the sequencing instrument body 1 is provided with two inclined grooves 10 on both sides close to the flow tank platform 2, when the two strip-shaped rings 8 are respectively slid into the two inclined grooves 10 on the same side, the mounting rack 6 moves downward and moves below the flow tank platform 2, so that the flow tank on the mounting rack 6 is placed on the flow tank platform 2; when the sealing plate 3 is pulled out, the two strip-shaped rings 8 on both sides slide upward through the inclined grooves 10, drive the mounting rack 6 to rise in height, and take out the flow tank from the flow tank platform 2; after replacing the flow tank, when being pushed back inward, the two strip-shaped rings 8 away from the sealing plate 3 first pass through the first inclined groove 10, but since the rear strip-shaped ring 8 and the mounting rack 6 are still sliding horizontally on the sequencing instrument body 1, at this time, the strip-shaped ring 8 away from the sealing plate 3 will not slide downward and fall into the first inclined groove 10; when the two strip-shaped rings 8 pass through the inclined grooves 10, they will be synchronously downward, fall into the inclined grooves 10, and then make the mounting rack 6 move above the flow tank platform 2 before falling downward, so that the flow tank falls accurately on the flow tank platform 2.
[0032] As shown in the accompanying drawings, Figure 5As shown, in the present embodiment, the mounting rack 6 is fixed with recovery blocks 13 on both sides, the recovery blocks 13 are higher than the mounting rack 6, and are used to take out the flow tank when sliding out. When the strip-shaped ring 8 moves upwardly and obliquely through the chute 10, since the recovery blocks 13 are higher than the mounting rack 6, the flow tank can be taken out even if the mounting rack 6 is located below the flow tank loading platform 2, and can be always located in the mounting rack 6, thereby facilitating taking out along with the mounting rack 6.
[0033] The preferred embodiments of the present application are described in detail above in combination with the drawings, and typical known structures and known common knowledge technologies are not described in detail herein. The ordinary skilled in the art can improve and implement the technical solutions of the present application based on the disclosure of the present embodiments, and some typical known structures, known methods or known common knowledge technologies should not be an obstacle for the ordinary skilled in the art to implement the present application.
[0034] The scope of protection of the present application should be subject to the content of the claims thereof, and the content recorded in the content, specific embodiments and drawings of the description should be used to explain the claims.
[0035] Within the technical concept of the present application, several modifications can be made to the specific embodiments of the present application, and the specific embodiments after the modifications should also be considered within the protection scope of the present application.
Claims
1. A gene sequencer comprising a sequencer body, wherein a flow cell stage is arranged in the sequencer body, characterized in that: Also include the slideable extraction of the sealing plate, the sequencer body is provided with a sliding groove, the inner side of the sealing plate is fixed with two connecting blocks, two connecting blocks are provided with a mounting frame that can move up and down, the mounting frame is U-shaped, can be slidably inserted into the outside of the flow tank stage, used to carry the flow tank.
2. The genetic sequencer of claim 1, wherein: Two first connecting rods are fixed on both sides of the mounting frame, a strip-shaped ring is sleeved on the outside of the first connecting rod, two second connecting rods are fixed on the inner side of the two connecting blocks, the second connecting rod passes through the strip-shaped ring, the first connecting rod and the second connecting rod can rotate relative to the strip-shaped ring; two inclined grooves are arranged on both sides of the sequencer body close to the flow tank stage, when the mounting frame moves above the flow tank stage, two strip-shaped rings are respectively slid into two inclined grooves on the same side, the mounting frame moves downward below the flow tank stage.
3. The genetic sequencer of claim 1, wherein: A first limiting block is fixed in the sequencer body, the first limiting block is located on the side of the flow tank stage away from the sealing plate; a second limiting block is fixed on the mounting frame, the second limiting block is located on the side of the mounting frame close to the sealing plate.
4. The genetic sequencer of claim 1, wherein: Recycling blocks are fixed on both sides of the mounting frame, the recycling blocks are higher than the mounting frame, used to slide out the flow tank.
5. The genetic sequencer of claim 1, wherein: Two slide rails are fixed in the sequencer body, two slide rails are respectively and two connecting blocks are in sliding connection.
6. The genetic sequencer of claim 1, wherein: A pull rod is fixed on the outside of the sealing plate.