Extruding and filtering device convenient for lipidosome production

Abstract

The utility model relates to the technical field of lipidosome production, and discloses an extruding and filtering device convenient for lipidosome production, which comprises a filter cartridge, a punching mesh plate horizontally and fixedly arranged at the lower end in the filter cartridge, and an extruding mechanism for extruding lipidosome, and the cleaning mechanism is used for cleaning the filtering holes, and the extrusion mechanism comprises a piston. According to the lipidosome filtering device, the electric-hydraulic push rod is controlled to work, the piston can be pushed to move downwards in the filtering cylinder, lipidosome in the filtering cylinder can be extruded and filtered through the punching net plate and the filtering holes, and when the electric-hydraulic push rod drives the piston to move upwards and move out of the drying cylinder, the inverted-L-shaped adjusting rod can be pushed to move upwards, so that the lipidosome can be filtered. And the cleaning plate can be pushed to move upwards through the sliding block, so that the cleaning column is pushed to penetrate through the filtering holes of the punching net plate, impurities in the filtering holes are further automatically cleaned, and convenience and rapidness are achieved.

Description

Technical Field

[0001] This utility model relates to the field of liposome production technology, specifically to an extrusion filtration device for facilitating liposome production. Background Technology

[0002] In the production of liposomes, extrusion filtration is a crucial step. It not only ensures the quality and purity of the liposomes but also effectively removes impurities and particles, thereby improving the stability and reliability of the product.

[0003] The inventors discovered that at least the following problems remain unresolved in existing technologies: traditional extrusion filtration devices often lack efficient extrusion mechanisms, making it difficult for liposomes to be fully compressed during filtration, thus affecting filtration efficiency and product quality. Furthermore, after filtration, the filter pores are often easily clogged by impurities, requiring manual cleaning, which not only increases labor intensity but also reduces production efficiency.

[0004] Therefore, we propose an extrusion filtration device for liposome production that can effectively extrude and filter liposomes, and can automatically clean the impurities clogging the filter pores after the liposome extrusion filtration. Utility Model Content

[0005] The purpose of this invention is to provide an extrusion filtration device for liposome production, which solves the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an extrusion filtration device for facilitating liposome production, comprising a filter cylinder, wherein a perforated mesh plate is horizontally fixedly installed at the lower end inside the filter cylinder, and filter holes are uniformly opened on the upper surface of the perforated mesh plate; it also includes an extrusion mechanism for extruding liposomes and a cleaning mechanism for cleaning the filter holes; the extrusion mechanism includes a piston, and the cleaning mechanism includes a cleaning plate and two sets of adjusting rods.

[0007] As an optional solution to the technical solution of this application, the top ends of both sides of the filter cylinder are fixedly connected to the bracket by bolts, and an electro-hydraulic actuator is fixedly connected to the middle of the upper surface of the bracket. The telescopic end of the electro-hydraulic actuator is fixedly connected to the middle of the upper surface of the piston.

[0008] As an optional solution to the technical solution of this application, the piston is movably connected to the filter cylinder, and the dimensions of the piston and the filter cylinder are matched.

[0009] As an optional solution to the technical solution of this application, the cleaning plate is horizontally placed on the bottom side of the perforated mesh plate, and a cleaning column is vertically fixedly installed on the upper surface of the cleaning plate. The cleaning column corresponds to the filter hole one by one, and the cleaning column is movably connected to the filter hole. A guide groove is evenly opened on the upper surface of the cleaning plate. The guide groove is placed between two sets of cleaning columns, and the size of the guide groove matches the size of the filter hole.

[0010] As an optional solution to the technical solution of this application, the inner walls of both sides of the filter cylinder are vertically and symmetrically provided with sliding grooves, and the two ends of the cleaning plate are symmetrically installed with sliders. The sliders at both ends of the cleaning plate are slidably connected to the sliding grooves on both sides of the filter cylinder. The bottom ends of the two sets of adjusting rods are respectively fixedly connected to the sliders at both ends of the cleaning plate. The upper surface of the slider is provided with a spring, and the spring is sleeved on the outside of the adjusting rod.

[0011] As an optional solution to the technical solution of this application, an adjustment groove is vertically opened through the inner wall of the top of the slide groove, the adjustment rod is slidably connected to the adjustment groove, the adjustment rod is inverted L-shaped, the two sets of adjustment rods are symmetrically arranged, and the adjustment rod is movably connected to the piston.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: controlling the electro-hydraulic actuator to work can push the piston to move downward in the filter cylinder. Through the perforated mesh plate and filter holes, the liposomes in the filter cylinder can be squeezed and filtered. When the electro-hydraulic actuator drives the piston to move upward and move out of the drying cylinder, it can push the inverted L-shaped adjusting rod to move upward. Through the slider, it can push the cleaning plate to move upward, thereby pushing the cleaning column through the filter holes of the perforated mesh plate, and further automatically cleaning the impurities in the filter holes, which is convenient and fast. Attached Figure Description

[0013] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0014] Figure 1 This is a front view of an extrusion filtration device for facilitating liposome production according to the present invention;

[0015] Figure 2 This is a schematic diagram of part A of an extrusion filtration device for facilitating liposome production according to the present invention.

[0016] In the diagram: 1. Filter cylinder; 11. Perforated mesh plate; 12. Filter hole; 13. Piston; 14. Cleaning plate; 15. Cleaning column; 16. Feed chute; 17. Support; 18. Electro-hydraulic actuator; 2. Slide groove; 21. Sliding block; 22. Adjusting rod; 23. Spring; 24. Adjusting groove. Detailed Implementation

[0017] Please see Figures 1-2 This utility model provides a technical solution: an extrusion filtration device for liposome production, comprising a filter cylinder 1, a perforated mesh plate 11 horizontally fixedly installed at the lower end of the filter cylinder 1, filter holes 12 uniformly opened on the upper surface of the perforated mesh plate 11, an extrusion mechanism for extruding liposomes, and a cleaning mechanism for cleaning the filter holes 12. The extrusion mechanism includes a piston 13, and brackets 17 are fixedly connected to the top ends of both sides of the filter cylinder 1 by bolts. An electro-hydraulic push rod 18 is fixedly connected to the middle of the upper surface of the bracket 17. The telescopic end of the electro-hydraulic push rod 18 is fixedly connected to the middle of the upper surface of the piston 13. The piston 13 is movably connected to the filter cylinder 1, and the size of the piston 13 matches that of the filter cylinder 1.

[0018] In this technical solution, the liposomes to be filtered are introduced into the filter cylinder 1. The electro-hydraulic push rod 18 is controlled by the corresponding controller to push the piston 13 to move downward and insert into the filter cylinder 1. The piston moves downward in the filter cylinder 1 and passes through the filter holes 12 evenly distributed on the surface of the perforated mesh plate 11, which can squeeze and filter the liposomes, resulting in high filtration efficiency.

[0019] In this embodiment, the cleaning mechanism includes a cleaning plate 14 and two sets of adjusting rods 22. The cleaning plate 14 is horizontally placed on the bottom side of the perforated mesh plate 11. Cleaning columns 15 are vertically fixedly installed on the upper surface of the cleaning plate 14. The cleaning columns 15 correspond one-to-one with the filter holes 12, and the cleaning columns 15 are movably connected to the filter holes 12. The upper surface of the cleaning plate 14 is evenly provided with guide grooves 16. The guide grooves 16 are placed between the two sets of cleaning columns 15, and the dimensions of the guide grooves 16 are matched with the dimensions of the filter holes 12. The two sides of the filter cylinder 1 The inner wall is vertically and symmetrically provided with sliding grooves 2. The two ends of the cleaning plate 14 are symmetrically installed with sliders 21. The sliders 21 at both ends of the cleaning plate 14 are slidably connected to the sliding grooves 2 on both sides of the filter cylinder 1. The bottom ends of the two sets of adjusting rods 22 are respectively fixedly connected to the sliders 21 at both ends of the cleaning plate 14. The top inner wall of the sliding groove 2 is vertically provided with an adjusting groove 24. The adjusting rod 22 is slidably connected to the adjusting groove 24. The adjusting rod 22 is inverted L-shaped. The two sets of adjusting rods 22 are symmetrically arranged, and the adjusting rod 22 is movably connected to the piston 13.

[0020] In this technical solution, after the liposomes in the filter cartridge 1 have been filtered, the electro-hydraulic push rod 18 drives the piston 13 to move upward out of the filter cartridge 1. The adjusting rod 22 is in an inverted L shape. As the piston 13 moves upward, it can push the adjusting rod 22 to move upward. The slider 21 can push the cleaning plate 14 to move upward in the filter cartridge 1. As the cleaning plate 14 moves upward, it can push the cleaning column 15 through the filter hole 12 of the perforated mesh plate 11, and further automatically clean the impurities in the filter hole 12. It is convenient and fast. It should be noted that the size of the feed trough 16 is much larger than the size of the filter hole 12. When the liposomes are filtered in the filter hole 12, the cleaning plate 14 will not affect the discharge of liposomes.

[0021] In this embodiment, a spring 23 is provided on the upper surface of the slider 21, and the spring 23 is sleeved on the outside of the adjusting rod 22.

[0022] In this technical solution, when the electro-hydraulic push rod 18 pushes the piston 13 downward to separate from the adjusting rod 22, a spring 23 is provided above the piston 13. The spring force of the spring 23 can push the slider 21 to move downward in the slide groove 2, thereby pushing the cleaning plate 14 to move downward to reset, so that the cleaning column 15 is moved out of the filter hole 12, thus preventing the cleaning column 15 from affecting the filtration operation of the filter hole 12.

[0023] When using an extrusion filtration device for liposome production, the liposomes to be filtered are introduced into the filter cylinder 1. The electro-hydraulic actuator 18 is controlled by a corresponding controller to push the piston 13 downwards into the filter cylinder 1. The piston 13 moves downwards within the filter cylinder 1, passing through the evenly distributed filter holes 12 on the surface of the perforated mesh plate 11, where it is extruded and filtered. The filtered liposomes are discharged from the guide groove 16 on the surface of the cleaning plate 14. After the liposomes in the filter cylinder 1 have been filtered, the electro-hydraulic actuator 18 is controlled to move the piston 13 upwards out of the filter cylinder 1. The piston 13 moves upwards in an inverted L-shape via the adjusting rod 22. During this upward movement, the piston 13 can... Pushing the adjusting rod 22 upwards moves the cleaning plate 14 upwards within the filter cylinder 1 via the slider 21. During this upward movement, the cleaning plate 14 pushes the cleaning column 15 through the filter holes 12 of the perforated mesh plate 11, further automatically cleaning impurities within the filter holes 12. Conversely, when the electro-hydraulic push rod 18 pushes the piston 13 downwards to separate from the adjusting rod 22, a spring 23 is provided above the piston 13. The spring force of the spring 23 pushes the slider 21 downwards within the slide groove 2, thereby pushing the cleaning plate 14 downwards to reset, causing the cleaning column 15 to move out of the filter holes 12, thus preventing the cleaning column 15 from affecting the filtration operation of the filter holes 12.

Claims

1. An extrusion filtration device for facilitating liposome production comprising a filter cartridge (1), characterised in that, The lower end of the filter cylinder (1) is horizontally fixedly installed with a perforated mesh plate (11). The upper surface of the perforated mesh plate (11) is uniformly provided with filter holes (12). It also includes a squeezing mechanism for squeezing liposomes and a cleaning mechanism for cleaning the filter holes (12). The squeezing mechanism includes a piston (13), and the cleaning mechanism includes a cleaning plate (14) and two sets of adjusting rods (22).

2. The extrusion filtration device for facilitating liposome production of claim 1, wherein: The top ends of both sides of the filter cylinder (1) are fixedly connected to the bracket (17) by bolts. An electro-hydraulic push rod (18) is fixedly connected to the middle of the upper surface of the bracket (17). The telescopic end of the electro-hydraulic push rod (18) is fixedly connected to the middle of the upper surface of the piston (13).

3. The extrusion filtration device for facilitating liposome production of claim 2, wherein: The piston (13) is movably connected to the filter cylinder (1), and the piston (13) and the filter cylinder (1) are sized to match.

4. The extrusion filtration device for facilitating liposome production of claim 1, wherein: The cleaning plate (14) is horizontally placed on the bottom side of the perforated mesh plate (11). A cleaning column (15) is vertically fixed on the upper surface of the cleaning plate (14). The cleaning column (15) corresponds one-to-one with the filter hole (12), and the cleaning column (15) is movably connected to the filter hole (12). A guide groove (16) is evenly opened on the upper surface of the cleaning plate (14). The guide groove (16) is placed between two sets of cleaning columns (15), and the size of the guide groove (16) matches that of the filter hole (12).

5. The extrusion filtration device for facilitating liposome production according to claim 4, characterized in that: The filter cylinder (1) has vertically symmetrical grooves (2) on both sides of its inner wall. The cleaning plate (14) has sliders (21) symmetrically installed at both ends. The sliders (21) at both ends of the cleaning plate (14) are slidably connected to the grooves (2) on both sides of the filter cylinder (1). The bottom ends of the two sets of adjusting rods (22) are fixedly connected to the sliders (21) at both ends of the cleaning plate (14). The upper surface of the slider (21) is provided with a spring (23), which is sleeved on the outside of the adjusting rod (22).

6. The extrusion filtration device for facilitating liposome production of claim 5, wherein: The top inner wall of the slide groove (2) is vertically provided with an adjustment groove (24). The adjustment rod (22) is slidably connected to the adjustment groove (24). The adjustment rod (22) is in the shape of an inverted L. The two sets of adjustment rods (22) are symmetrically arranged, and the adjustment rod (22) is connected to the piston (13).

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