Tumor cell capturing device based on magnetism

Abstract

The utility model discloses a tumor cell capturing device based on magnetism, and relates to the technical field of tumor detection equipment. Comprising a placing plate, a magnet is clamped at the top of the placing plate, a runner plate is placed on the magnet, a micro runner is arranged at the top of the runner plate, pipeline connectors used for being connected with pipelines are further arranged on the two sides of the top of the runner plate, and the pipeline connectors and the micro runner are arranged in a matched mode. Fixing cylinders with top openings are fixedly connected to the positions, located on the two sides of the runner plate, of the top of the containing plate, clamping holes are evenly formed in the inner walls of the fixing cylinders in the height direction of the fixing cylinders, the fixing cylinders are connected with adjusting cylinders, the bottom ends of the adjusting cylinders are integrally connected with arc-shaped pieces distributed annularly, and clamping blocks capable of being clamped into the clamping holes are connected to the outer walls of the arc-shaped pieces; and one side of the fixed cylinder is fixedly connected with a pipeline limiting block for limiting a pipeline. According to the tumor cell capturing device based on magnetism, the pipeline limiting block is adjusted to be at different heights, and the flow speed of liquid transmission in the pipeline can be adjusted and changed.

Description

Technical Field

[0001] This utility model relates to the field of tumor detection equipment technology, specifically a magnetic tumor cell capture device. Background Technology

[0002] Circulating tumor cells (CTCs) are cancer cells that detach from tumors and enter the circulatory system. They can detach spontaneously or through diagnostic and therapeutic procedures from solid tumor lesions and enter the systemic circulation. Most CTCs undergo apoptosis or are phagocytosed after entering the peripheral blood, but a few can escape and anchor in tissues or organs outside the lesion, thus developing into metastatic lesions and increasing the risk of death for patients with malignant tumors. These cells can be detected through simple blood tests and can serve as biological markers of cancer, indicating the presence of tumors in the body, as well as their genetic status and drug sensitivity. Unlike surgical intervention, CTCs are compatible with longitudinal studies and can effectively guide treatment. CTC detection can be effectively applied to early in vitro diagnosis, prognostic evaluation, personalized treatment, tumor recurrence monitoring, and the development of new cancer drugs. Currently, routine CTC detection involves two steps: CTC enrichment (or capture) and CTC analysis.

[0003] When detecting extremely small amounts of CTCs (circulating tumor cells) in the blood of cancer patients, microfluidic chips are often used for CTC enrichment. However, existing circulating tumor cell enrichment devices cannot easily control the blood flow rate. Summary of the Invention

[0004] This invention provides a magnetically based tumor cell capture device to solve the problems in the prior art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a magnetic tumor cell capture device, comprising a placement plate, a magnet clamped at the top of the placement plate, a flow channel plate placed on the magnet, a micro-flow channel at the top of the flow channel plate, and pipe interfaces for connecting pipes on both sides of the top of the flow channel plate, the pipe interfaces cooperating with the micro-flow channels, a fixed cylinder with a top opening fixedly connected to both sides of the top of the placement plate located on the flow channel plate, a locking hole evenly opened along the height direction of the inner wall of the fixed cylinder, an adjusting cylinder connected to the fixed cylinder, an arc-shaped piece integrally connected to the bottom end of the adjusting cylinder in a ring distribution, a locking block that can be locked into the locking hole connected to the outer wall of the arc-shaped piece, and a pipe limiting block for limiting the pipe fixedly connected to one side of the fixed cylinder.

[0006] Furthermore, the top of the adjusting cylinder is provided with a screw hole through which the adjusting cylinder passes, and the screw hole is threadedly connected to an adjusting screw whose end can extend into the annular arc-shaped plate.

[0007] Furthermore, the inner wall of the arc-shaped piece is provided with threads that cooperate with the adjusting screw.

[0008] Furthermore, guide blocks are fixedly connected to the top of both sides of the fixed cylinder, and the top of the guide blocks has an opening that communicates with the inner cavity of the fixed cylinder.

[0009] Furthermore, a through groove is provided on one side of the top of the pipe limiting block, and a limiting groove in the shape of an L-shaped through groove is provided on one side of the pipe limiting block.

[0010] Furthermore, an L-shaped limiting plate is fixedly connected to the top of the placement plate, and a limiting screw is threadedly connected to the top of the limiting plate.

[0011] Compared with the prior art, the present invention provides a magnetic tumor cell capture device with the following advantages: the magnetic tumor cell capture device allows the adjusting cylinder to adjust its height relative to the fixed cylinder, thereby adjusting the overall height of the pipe limiting block. When the pipe for transporting blood is suspended on the pipe limiting block, adjusting the pipe limiting block to different heights can adjust and change the flow rate of the liquid transported inside the pipe. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of this utility model;

[0013] Figure 2 This is a schematic diagram of the structure of the adjusting cylinder of this utility model;

[0014] Figure 3 This is a schematic diagram of the planar structure of the adjusting cylinder of this utility model;

[0015] Figure 4 This is an enlarged schematic diagram of point A of this utility model.

[0016] In the diagram: 1. Placement plate; 2. Magnet; 3. Flow channel plate; 4. Miniature flow channel; 5. Pipe interface; 6. Fixing cylinder; 7. Adjusting cylinder; 8. Pipe limiting block; 9. Clip hole; 10. Arc-shaped piece; 11. Clip block; 12. Adjusting screw; 13. Guide block; 14. Through groove; 15. Limiting groove; 16. Limiting plate; 17. Limiting screw. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Please see Figure 1-4 This utility model discloses a magnetic tumor cell capture device, including a placement plate 1, a magnet 2 clamped on the top of the placement plate 1, a flow channel plate 3 placed on the magnet 2, a micro-flow channel 4 on the top of the flow channel plate 3, and pipe interfaces 5 for connecting pipes on both sides of the top of the flow channel plate 3. The pipe interfaces 5 are configured to cooperate with the micro-flow channels 4. The top of the placement plate 1 is fixedly connected to both sides of the flow channel plate 3 with top-opening fixing cylinders 6. The inner wall of the fixing cylinder 6 is evenly provided with locking holes 9 along its height direction. The fixing cylinder 6 is connected to an adjusting cylinder 7. The bottom end of the adjusting cylinder 7 is integrally connected to an arc-shaped piece 10 distributed in a ring. The outer wall of the arc-shaped piece 10 is connected to a locking block 11 that can be locked into the locking hole 9. A pipe limiting block 8 for limiting the pipe is fixedly connected to one side of the fixing cylinder 6.

[0019] When the locking block 11 on the outer wall of the arc-shaped piece 10 is locked in the locking hole 9 at different heights on the inner wall of the fixed cylinder 6, the pipe limiting block 8 connected to the outer wall of the adjusting cylinder 7 is at different heights. When the pipe for transmitting blood is suspended on the pipe limiting block 8, the flow rate of the liquid inside the pipe is different due to the different heights of the pipe limiting block 8.

[0020] The flow plate 3, which has micro-flow channels 4 and pipe interfaces 5 at the top, is a conventional microfluidic chip.

[0021] When a blood sample with a targeted magnetic adsorbent is delivered through a tube to a microfluidic chip, the magnet 2 is positioned to enrich circulating tumor cells.

[0022] Specifically, the top of the adjusting cylinder 7 is provided with a screw hole through which the adjusting cylinder 7 passes, and the screw hole is threadedly connected to an adjusting screw 12 whose end can extend into the annular arc-shaped piece 10.

[0023] The inner wall of the arc-shaped plate 10 is provided with threads that cooperate with the adjusting screw 12.

[0024] In this embodiment, the arc-shaped sheet 10 is made of elastic plastic material and has elastic deformation capability.

[0025] There is a notch between the connected arc-shaped pieces 10. When the adjusting cylinder 7 is inserted into the inner cavity of the fixed cylinder 6 and the adjusting screw 12 extends into the area enclosed by the arc-shaped pieces 10, the bottom end of the arc-shaped pieces 10 will tilt outward because the arc-shaped pieces 10 cannot be limited by the adjusting screw 12. Since the arc-shaped pieces 10 are located in the inner cavity of the fixed cylinder 6 and are restricted by the inner wall of the fixed cylinder 6, the locking block 11 on the outer wall of the arc-shaped pieces 10 can be locked in the corresponding locking hole 9 to complete the fixation.

[0026] Specifically, guide blocks 13 are fixedly connected to the top of both sides of the fixed cylinder 6, and the top of the guide blocks 13 has an opening that communicates with the inner cavity of the fixed cylinder 6.

[0027] In this embodiment, the guide block 13 with an opening at the top can guide the guide block 13 during the process of the adjusting cylinder 7 being inserted into the inner cavity of the fixed cylinder 6.

[0028] Specifically, a through groove 14 is provided on one side of the top of the pipe limiting block 8, and a limiting groove 15 that is L-shaped with the through groove 14 is provided on one side of the pipe limiting block 8.

[0029] In this embodiment, the tube for delivering blood samples can pass through the through groove 14 and move into the limiting groove 15 so as to be suspended on the tube limiting block 8.

[0030] Specifically, the top of the placement plate 1 is fixedly connected to a limiting plate 16 that is L-shaped in shape, and the top of the limiting plate 16 is threadedly connected to a limiting screw 17.

[0031] In this embodiment, a clamping groove is formed between the limiting plate 16 and the top of the placement plate 1. When placing the flow channel plate 3, one end of the flow channel plate 3 is inserted into the clamping groove, and the limiting screw 17 is turned so that the end of the limiting screw 17 can press on the flow channel plate 3, thereby limiting the flow channel plate 3.

[0032] In summary, this magnetically based tumor cell capture device allows the adjusting cylinder 7 to adjust its height relative to the fixed cylinder 6, thereby adjusting the overall height of the pipe limiting block 8. When a blood-transmitting pipe is suspended on the pipe limiting block 8, adjusting the pipe limiting block 8 to different heights can change the flow rate of the liquid inside the pipe.

[0033] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A magnetic based tumor cell capturing device comprising a placement plate (1), characterized in that: The top of the placement plate (1) is clamped with a magnet (2), and a flow channel plate (3) is placed on the magnet (2). The top of the flow channel plate (3) has a micro flow channel (4). The top two sides of the flow channel plate (3) are also provided with pipe interfaces (5) for connecting pipes. The pipe interfaces (5) are configured to cooperate with the micro flow channels (4). The top of the placement plate (1) is fixedly connected to the two sides of the flow channel plate (3) with top openings of fixed cylinders (6). The inner wall of the fixed cylinder (6) is evenly provided with locking holes (9) along its height direction. The fixed cylinder (6) is connected to an adjusting cylinder (7). The bottom end of the adjusting cylinder (7) is integrally connected to an arc-shaped piece (10) distributed in a ring. The outer wall of the arc-shaped piece (10) is connected to a locking block (11) that can be inserted into the locking hole (9). The side of the fixed cylinder (6) is fixedly connected to a pipe limiting block (8) for limiting pipes.

2. The magnetic based tumor cell capturing device of claim 1, wherein: The top of the adjusting cylinder (7) is provided with a screw hole through which the adjusting cylinder (7) passes. The screw hole is threadedly connected to an adjusting screw (12) whose end can extend into the annular arc-shaped piece (10).

3. The magnetic based tumor cell capturing device of claim 2, wherein: The inner wall of the arc-shaped piece (10) is provided with a thread that mates with the adjusting screw (12).

4. The magnetic based tumor cell capturing device of claim 1, wherein: Guide blocks (13) are fixedly connected to the top of both sides of the fixed cylinder (6), and the top of the guide blocks (13) has an opening that communicates with the inner cavity of the fixed cylinder (6).

5. The magnetic based tumor cell capturing device of claim 1, wherein: The top side of the pipe limiting block (8) is provided with a through groove (14), and the side of the pipe limiting block (8) is provided with a limiting groove (15) that is L-shaped with the through groove (14).

6. The magnetic based tumor cell capturing device of claim 1, wherein: The top of the placement plate (1) is fixedly connected to a limiting plate (16) that is L-shaped in shape, and the top of the limiting plate (16) is threadedly connected to a limiting screw (17).

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