Auxiliary F ion receiving and sample loading device

Abstract

The utility model belongs to the technical field of radiopharmaceutical preparation, and particularly discloses an F ion auxiliary receiving and sample loading device which comprises a receiving bottle with a sealing structure and used for storing F ions; one end of the sample feeding pipe is connected to the receiving bottle, the other end of the sample feeding pipe is detachably connected to the F ion source device, a pipe opening in one end of the sample feeding pipe is located at the bottom of the receiving bottle, and the other end of the sample feeding pipe is detachably connected to the synthesizer; the vacuum generator is connected to the top of the receiving bottle; the controller is electrically connected with the vacuum generator and is used for controlling the working state of the vacuum generator; the first valve is arranged on the sample injection pipe; the second valve is arranged on the sample feeding pipe; wherein when the controller controls the vacuum generator to vacuumize the receiving bottle so as to perform F ion sample introduction, the first valve is in an open state and the second valve is in a closed state; during F ion sample feeding, the first valve is in a closed state, and the second valve is in an open state.

Description

Technical Field

[0001] This utility model relates to the field of radiopharmaceutical preparation technology, specifically to an F ion-assisted receiving and sample loading device. Background Technology

[0002] Radionuclides 18 F is typically manufactured using a cyclotron, and then labeled onto different chemical substrates via a chemical synthesis module to synthesize various radiopharmaceuticals for clinical use. The cyclotron uses... 18 O 18 F nuclear reaction, [ 18 O]H2O, after being continuously bombarded by a certain proton beam, produces 18 FF - .

[0003] However, when F ions in the raw solution produced by the cyclotron are transported to the hot chamber, or when the nuclide distributor distributes and transports F ions to the hot chamber, the original direct transport method has a long transport pipeline, resulting in long transport time or unsmooth transport, which wastes a lot of time. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide an auxiliary receiving and sample loading device that can quickly receive F ions. The device has a simple structure, which greatly saves the time for F ions to be transported to the hot chamber and improves the efficiency of the experiment. Moreover, the device is easy to operate and leaves little residual F ions in the device after sample loading, thus avoiding waste of resources.

[0005] The objective of this utility model is achieved through the following technical solution:

[0006] An F ion-assisted receiving and sample loading device, comprising:

[0007] A receiving bottle with a sealed structure for storing F ions;

[0008] The sample inlet tube and the sample delivery tube are provided. One end of the sample inlet tube is connected to the receiving bottle, and the other end is detachably connected to the F ion source. One end of the sample delivery tube is located at the bottom of the receiving bottle, and the other end is detachably connected to the synthesizer.

[0009] A vacuum generator is connected to the top of the receiving bottle;

[0010] The controller is electrically connected to the vacuum generator and is used to control the working state of the vacuum generator;

[0011] A first valve is installed on the injection tube; a second valve is installed on the delivery tube;

[0012] Specifically, when the controller controls the vacuum generator to evacuate the receiving bottle for F ion injection, the first valve is in the open state and the second valve is in the closed state; when F ions are delivered, the first valve is in the closed state and the second valve is in the open state.

[0013] As described above, the F-ion assisted receiving and sample loading device has a flexible tube for both the sample inlet and the sample delivery tube. The first valve and the second valve are both electromagnetic clamp valves, and both the first valve and the second valve are electrically connected to the controller.

[0014] As described above, the vacuum generator of the F-ion assisted receiving and sample loading device is provided with a gas guide tube between the vacuum generator and the receiving bottle, and the opening of the gas guide tube is located at the top of the receiving bottle.

[0015] The bottom of the receiving bottle in the F-ion assisted receiving and sample loading device described above is U-shaped or V-shaped.

[0016] The vacuum generator of the F-ion assisted receiving and sample loading device described above is a vacuum pump that can operate in both directions; the controller controls the vacuum generator to operate in reverse to pressurize and load the sample into the receiving bottle.

[0017] The F-ion assisted receiving and sample loading device described above also includes a base and a support frame disposed on the base, the support frame being used to fix the receiving bottle.

[0018] As described above, the F-ion assisted receiving and sample loading device is further provided with a protective cover on its base; both the base and the protective cover are made of radiation-resistant materials; the protective cover and the base together form a receiving space, and the receiving bottle, the sample inlet tube, the sample delivery tube, the first valve and the second valve are all located within the receiving space.

[0019] Compared with the prior art, the present invention has the following advantages:

[0020] 1. The F-ion assisted receiving and sample loading device of this utility model has a simple structure, which greatly saves the time of F-ion transmission to the hot chamber and improves the efficiency of the experiment.

[0021] 2. This invention significantly shortens the F ion transport time through a dual-drive mechanism of negative / positive pressure; the V-shaped (optimal) or U-shaped bottle bottom works synergistically with the pressurized sample loading design to reduce the amount of residual F ions and greatly reduce the waste of expensive nuclides.

[0022] 3. The vacuum generator of this utility model is a vacuum pump that can operate in both directions. The controller automatically switches the state of the first valve and the second valve and the direction of the vacuum pump through programming, realizing the convenient operation of "one-click reception" and "one-click sample loading". Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the F-ion-assisted receiving and sample loading device in an embodiment of this utility model;

[0024] Figure 2 This is a schematic diagram of the F-ion assisted receiving and sample loading device in another embodiment of the present invention. Detailed Implementation

[0025] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0026] like Figure 1 As shown, an embodiment of the present invention provides an F-ion-assisted receiving and sample loading device, comprising:

[0027] Receiving bottle 1, with a sealed structure, is used to store F ions;

[0028] Sample inlet tube 2 and sample delivery tube 3. One end of sample inlet tube 2 is connected to receiving bottle 1, and the other end is detachably connected to F ion source (such as accelerator or nuclide dispenser, not shown in the figure). One end of sample delivery tube 3 is located at the bottom of receiving bottle 1, and the other end is detachably connected to synthesizer (not shown in the figure).

[0029] Vacuum generator 4 is connected to the top of receiving bottle 1;

[0030] The controller 5 is electrically connected to the vacuum generator 4 and is used to control the working state of the vacuum generator 4.

[0031] A first valve 61 is installed on the sample inlet tube 2; a second valve 62 is installed on the sample delivery tube 3;

[0032] When the controller 5 controls the vacuum generator 4 to evacuate the receiving bottle 1 for F ion injection, the first valve 61 is in the open state and the second valve 62 is in the closed state; when F ions are delivered, the first valve 61 is in the closed state and the second valve 62 is in the open state.

[0033] In this embodiment of the invention, when drawing F ions from the accelerator or nuclide distributor to the synthesizer for experiments, the vacuum generator 4 can be turned on to pre-draw the F ions from the accelerator or nuclide distributor into the receiving bottle 1, saving the time required for subsequent F ion transport to the hot chamber for synthesis and improving experimental efficiency. Especially when used as a temporary, portable transport device within the hot chamber, the detachable tubing design shortens the length of the tubing between the F ion source and the synthesizer; it allows for faster transport of F ions to the synthesizer for experiments, improving experimental efficiency and reducing F ion residue within the tubing.

[0034] In practical applications, receiving bottle 1 and pipelines are made of radiation-resistant and corrosion-resistant materials (such as PEEK or fluorinated polymers) to ensure the stability of long-term contact with F ionic liquid.

[0035] Furthermore, in this embodiment, both the sample inlet tube 2 and the sample delivery tube 3 are flexible tubes, and both the first valve 61 and the second valve 62 are electromagnetic clamp valves. Both the first valve 61 and the second valve 62 are electrically connected to the controller 5. The controller 5 controls the opening and closing states of the first valve 61 and the second valve 62, reducing the need for manual valve operation and avoiding the harm caused by radiation from radioactive ions to the human body.

[0036] In a preferred embodiment of this invention, a gas guide tube 7 is provided between the vacuum generator 4 and the receiving bottle 1, with the opening of the gas guide tube 7 located at the top of the receiving bottle 1. This prevents the accidental extraction of F ions from the receiving bottle 1 into the vacuum generator 4 during vacuum injection.

[0037] Furthermore, the bottom 11 of the receiving bottle 1 is U-shaped or V-shaped. The bottom 11 is designed to be V-shaped (optimal) or U-shaped to reduce the residue of F ions during sample loading.

[0038] In this embodiment of the invention, the vacuum generator 4 is a vacuum pump that can operate in both directions; the controller 5 controls the vacuum generator 4 to operate in reverse to pressurize and load the sample into the receiving bottle 1. The controller 5 automatically switches the state of the first valve and the second valve 62 and the direction of the vacuum pump through programming, realizing the convenient operation of "one-click receiving" and "one-click loading".

[0039] like Figure 2 As shown, in another preferred embodiment of the present invention, the F-ion assisted receiving and sample loading device further includes a base 100 and a support frame 8 disposed on the base 100, the support frame 8 being used to fix the receiving bottle 1. The support frame 8 is used to fix the receiving bottle 1 and prevent shaking.

[0040] Specifically, a protective cover 200 is also provided on the base 100. Both the base 1 and the protective cover 200 are made of radiation-resistant materials. The protective cover 200 and the base 100 together form a receiving space, in which the receiving bottle 1, the sample inlet tube 2, the sample delivery tube 3, the first valve 61, and the second valve 62 are all located. The protective cover 200 and the base 100 completely enclose the receiving bottle 1, the tubing, and the valves, ensuring the safety of radioactive operations. Moreover, the detachable tubing and the coordinated design of the protective cover 200 and the base 100 make the F-ion assisted receiving and sample loading device easy to carry and move, thus broadening its applications.

[0041] The workflow of the F-ion-assisted receiving and sample loading device in this embodiment of the invention is as follows:

[0042] Receive F-ion mode:

[0043] Close the second valve 62 and open the first valve 61;

[0044] Controller 5 starts vacuum pump 4 to pump air in the forward direction → negative pressure is formed in receiving bottle 1 → F ions are accelerated and quickly drawn into the bottle through sample inlet tube 2.

[0045] Sample to synthesizer mode:

[0046] Close the first valve 61 and open the second valve 62;

[0047] Controller 5 switches vacuum pump 4 to reverse pressure → positive pressure is formed in receiving bottle 1 → F ionic liquid is expelled to synthesizer through sample delivery tube 3; or F ionic liquid is directly extracted by the equipment on the synthesizer.

Claims

1. An F ion-assisted receiving and sample loading device, characterized in that... include: The receiving bottle (1) has a sealed structure for storing F ions; The sample inlet tube (2) and the sample delivery tube (3) are provided. One end of the sample inlet tube (2) is connected to the receiving bottle (1), and the other end is detachably connected to the F ion source. One end of the sample delivery tube (3) is located at the bottom of the receiving bottle (1), and the other end is detachably connected to the synthesizer. A vacuum generator (4) is connected to the top of the receiving bottle (1); The controller (5) is electrically connected to the vacuum generator (4) and is used to control the working state of the vacuum generator (4); A first valve (61) is installed on the sample inlet tube (2); a second valve (62) is installed on the sample delivery tube (3); When the controller (5) controls the vacuum generator (4) to evacuate the receiving bottle (1) for F ion injection, the first valve (61) is in the open state and the second valve (62) is in the closed state; when F ions are delivered, the first valve (61) is in the closed state and the second valve (62) is in the open state.

2. The F-ion assisted receiving and loading device according to claim 1, characterized in that Both the sample inlet tube (2) and the sample delivery tube (3) are flexible tubes. The first valve (61) and the second valve (62) are electromagnetic clamp valves. Both the first valve (61) and the second valve (62) are electrically connected to the controller (5).

3. The F-ion assisted receiving and loading device according to claim 1, characterized in that A gas guide pipe (7) is provided between the vacuum generator (4) and the receiving bottle (1), and the opening of the gas guide pipe (7) is located at the top of the receiving bottle (1).

4. The F-ion assisted receiving and loading device according to claim 1, characterized in that The bottom (11) of the receiving bottle (1) is U-shaped or V-shaped.

5. The F-ion assisted receiving and loading device according to claim 1 or 2, characterized in that The vacuum generator (4) is a vacuum pump that can operate in both directions; the controller (5) controls the vacuum generator (4) to operate in reverse to pressurize and load the sample into the receiving bottle (1).

6. The F-ion assisted receiving and sample loading device according to claim 1, characterized in that... It also includes a base (100) and a support frame (8) disposed on the base (100), the support frame (8) being used to fix the receiving bottle (1).

7. The F-ion assisted receiving and loading device according to claim 6, characterized in that The base (100) is also provided with a protective cover (200); both the base (100) and the protective cover (200) are made of radiation-resistant materials; the protective cover (200) and the base (100) together form a receiving space, and the receiving bottle (1), the sample inlet tube (2), the sample delivery tube (3), the first valve (61) and the second valve (62) are all located in the receiving space.

Images