Biopharmaceutical high-pressure sterilization device

Abstract

The utility model provides a biopharmacy high-pressure sterilization device, and relates to the field of high-pressure steam sterilization, the biopharmacy high-pressure sterilization device comprises a machine body, the machine body is used for generating high pressure in the machine body, a placement assembly is arranged in the machine body, a first elastic piece is arranged in the placement assembly, and a plurality of connecting assemblies are arranged at the top end of the placement assembly; an adjusting assembly is arranged at the top end of the connecting assembly, a clamping assembly is arranged at the top end of the connecting assembly, the adjusting assembly is used for adjusting the height of the clamping assembly, and the clamping assembly is used for clamping instruments or containers needing to be sterilized. According to the sterilization device, by arranging the clamping assemblies and the placement assembly, before sterilization, a container or an instrument needing to be sterilized is clamped through the clamping assemblies, the container or the instrument is erected, the area exposed outside is increased, uneven heating and pressing are avoided, the distance between the multiple clamping assemblies can be adjusted in cooperation with the connecting assembly and the placement assembly, and the adaptability of the sterilization device is improved; meanwhile, the safety and the stability of the sterilization process are improved.

Description

Technical Field

[0001] This utility model relates to the field of high-pressure steam sterilization, and more specifically, to a high-pressure sterilization device for biopharmaceuticals. Background Technology

[0002] High-pressure steam sterilization equipment is widely used in biopharmaceutical, medical, and laboratory settings. Its core principle is to kill microorganisms using high-temperature, high-pressure saturated steam (typically 121°C, 0.1 MPa). It is used not only for sterilizing liquids such as culture media and buffer solutions, but also for sterilizing solid items such as surgical instruments, silicone tubing, and bioreactor components. However, traditional high-pressure steam sterilization equipment typically places the items to be sterilized (such as glass bottles, petri dishes, and surgical instruments) directly onto the sterilization rack or tray, without clamping the containers or objects. This allows the containers or instruments to tip over or collide due to the airflow during steam injection, the impact of airflow during depressurization, or accidental knocking during placement. Collisions can easily cause glass containers to break, resulting in equipment damage and requiring internal cleaning, thus posing a risk to the sterilization process.

[0003] For example, the Chinese invention patent (application number: 202310336303.X) discloses a "high-pressure sterilization device for biopharmaceuticals," whose specification reveals that it includes a sterilization chamber body, a power plug located at one end of the sterilization chamber body, a set of casters located at the bottom of the sterilization chamber body, a handrail located on one side of the sterilization chamber body, a storage box located at the end of the sterilization chamber body away from the handrail, and a handle located on one side of the storage box. The device is characterized by: a sealing mechanism at the top of the sterilization chamber body, a sealing cover inside the sealing mechanism, a venting mechanism at the top of the sealing cover, an automatic pressure relief mechanism at one end of the venting mechanism, a pressure gauge installed on the top of the sealing cover, a storage box inside the sterilization chamber body, a sterilization cavity inside the sterilization chamber body, and a fixed drainage mechanism installed at the bottom of the sterilization chamber body. This high-pressure sterilization device for biopharmaceuticals simplifies operation through its sealing mechanism and automatically relieves pressure, increasing the device's safety. The aforementioned patent demonstrates the deficiencies of existing technologies.

[0004] Therefore, we have made improvements to this and proposed a high-pressure sterilization device for biopharmaceuticals. Utility Model Content

[0005] The purpose of this invention is to solve the problem that current high-pressure steam sterilization devices cannot actively clamp containers or objects, resulting in an unstable sterilization process.

[0006] To achieve the above-mentioned objectives and improve the aforementioned problems, this utility model provides a biopharmaceutical high-pressure sterilization device, comprising a body for generating high pressure inside the body, a placement component inside the body, a first elastic element inside the placement component, a plurality of connecting components at the top of the placement component, an adjusting component at the top of the connecting components, and a clamping component at the top of the connecting components. The adjusting component is used to adjust the height of the clamping component, and the clamping component is used to clamp the instruments or containers to be sterilized. The connecting components are mounted on the placement component via the first elastic element. Simultaneously, under the synergistic action of the placement component and the connecting components, the spacing between the plurality of connecting components and the clamping components can be adjusted.

[0007] The connecting component includes a connecting block, with a first connecting groove at both the front and rear ends of the connecting block. A connecting plate is fixedly provided at the top of the connecting block. The clamping component includes a mounting block located above the connecting plate. A second elastic element is provided on one side of the mounting block. The two clamping components are symmetrically installed on the placement component. The container or instrument to be clamped is slid between the two second elastic elements and clamped and fixed by the elastic force of the two second elastic elements.

[0008] As a preferred technical solution of this application, the mounting component includes a mounting plate fixed inside the body, and the top of the mounting plate has a plurality of mounting slots communicating with the bottom of the mounting plate, and the plurality of mounting slots are arranged in a rectangular array.

[0009] As a preferred technical solution of this application, the first elastic element includes a first spring piece, and the first spring piece is fixedly provided at both the front and rear ends inside the mounting groove. The connecting block is located inside the mounting groove, and the first spring pieces located at the front and rear ends inside the mounting groove are respectively located inside the first connecting groove at the front and rear ends of the connecting block.

[0010] As a preferred technical solution of this application, the bottom end of the connecting block is provided with a slot, and the front and rear ends of the slot are provided with second connecting slots.

[0011] As a preferred technical solution of this application, the adjustment component includes a mounting box fixed to the top of the connecting plate, and a fixing block is slidably provided inside the mounting box, the fixing block being fixedly connected to the mounting block at the top.

[0012] As a preferred technical solution of this application, the adjustment component further includes a semi-circular block, and a plurality of adjustment slots are equally spaced on one side of the mounting box. A sliding groove is provided below the side of the mounting box closest to the adjustment slots. A spring is fixedly installed inside the sliding groove. The semi-circular block is slidably connected to the inside of the sliding groove and fixedly connected to the end of the spring.

[0013] As a preferred technical solution of this application, the second elastic element includes a second spring piece that is fixedly connected to the mounting block.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0015] In the scheme of this application:

[0016] By using clamping and placement components, the containers or instruments to be sterilized can be clamped and upright before sterilization to increase the exposed area and avoid uneven heating and pressure. In conjunction with the connecting and placement components, the spacing between multiple clamping components can be adjusted to improve adaptability. At the same time, it increases the safety and stability of the sterilization process and solves the problem that high-pressure steam sterilization devices in the prior art cannot actively clamp containers or instruments, resulting in unstable sterilization processes. Attached Figure Description

[0017] Figure 1 A schematic diagram of the biopharmaceutical autoclaving device provided in this application;

[0018] Figure 2 A schematic diagram of the internal structure of the biopharmaceutical autoclaving device provided in this application;

[0019] Figure 3 A schematic diagram of the components housed in the biopharmaceutical autoclaving device provided in this application;

[0020] Figure 4 A schematic diagram showing the disassembled structure of the mounting slot and the first spring in the biopharmaceutical autoclave provided in this application;

[0021] Figure 5 A schematic diagram of the clamping component in the biopharmaceutical autoclaving device provided in this application;

[0022] Figure 6 A side view cross-sectional structural diagram of the regulating component in the biopharmaceutical autoclave provided in this application;

[0023] Figure 7 This is a schematic diagram of the connecting components in the biopharmaceutical autoclave provided in this application.

[0024] The image shows:

[0025] 1. Body; 2. Mounting assembly; 21. Mounting plate; 22. Mounting slot; 23. No. 1 spring; 3. Connecting assembly; 31. Connecting block; 32. Slot; 33. No. 1 connecting slot; 34. No. 2 connecting slot; 35. Connecting plate; 4. Clamping assembly; 41. Mounting block; 42. No. 2 spring; 5. Adjustment assembly; 51. Mounting box; 52. Fixing block; 53. Adjustment slot; 54. Semicircular block; 55. Slide groove. Detailed Implementation

[0026] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of the present invention.

[0027] To enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0028] It should be noted that, unless otherwise specified, the embodiments and features and technical solutions in the present invention can be combined with each other.

[0029] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0030] Example 1

[0031] Please refer to Figure 1 , Figure 3 and Figure 5 A biopharmaceutical high-pressure sterilization device includes a body 1, which is used to generate high pressure inside the body to sterilize the objects inside. By controlling the valves and pumps on the body 1, steam is continuously delivered to the interior of the body 1, so that the air pressure inside the body 1 continuously increases and the temperature also continuously increases, so as to sterilize the objects or containers inside the body 1 through high temperature and high pressure.

[0032] Liquids that need to be sterilized are not poured directly into the interior of the machine body 1. Instead, they are placed in containers and then placed inside the machine body 1. Direct pouring would require frequent cleaning of the interior of the machine body 1. Furthermore, the machine body 1 not only sterilizes liquids but also medical devices or other instruments. By placing different liquids into their respective containers and then placing them inside the machine body 1, multiple liquids can be sterilized simultaneously. Objects that need to be sterilized can also be placed inside for sterilization at the same time.

[0033] The body 1 has a placement component 2 inside, and a first elastic element inside the placement component 2. The top of the placement component 2 has several connecting components 3. Two connecting components 3 form a group, and there are several groups. The top of the connecting component 3 has an adjustment component 5 and a clamping component 4. The adjustment component 5 is used to adjust the height of the clamping component 4. The clamping component 4 is used to clamp the instruments or containers that need to be sterilized. The connecting components 3 are installed on the placement component 2 through the first elastic element. At the same time, under the synergistic action of the placement component 2 and the connecting components 3, the spacing between the connecting components 3 and the clamping components 4 can be adjusted, so that the user can customize the spacing between the connecting components 3 and the clamping components 4, so that the clamping components 4 can adapt to containers or instruments of different sizes.

[0034] The connecting component 3 includes a connecting block 31. The front and rear ends of the connecting block 31 are provided with a first connecting groove 33. The connecting block 31 is inserted into the mounting groove 22, and the first spring piece 23 is squeezed to deform through elastic force. Then it slides into the first connecting groove 33 to limit and fix the connecting block 31, and facilitate disassembly and assembly. The top of the connecting block 31 is fixedly provided with a connecting plate 35. The clamping component 4 includes a mounting block 41 located above the connecting plate 35. A second elastic member is provided on one side of the mounting block 41. The two clamping components 4 are symmetrically installed on the placement component 2. The container or instrument to be clamped is slid between the two second elastic members and clamped and fixed by the elastic force of the two second elastic members.

[0035] When clamping long, narrow instruments or containers, they are held in place by clamping assembly 4, with the upper part supported by two second elastic elements, allowing them to stand upright. Since the contact area between the second elastic element and the container or instrument is small, more of its surrounding area is exposed to the outside, ensuring even pressure and heating, and improving the preheating effect. Compared to the traditional method of placing it flat, this solution allows for more even heating.

[0036] Furthermore, such as Figure 2 and Figure 3 As shown, the placement component 2 includes a mounting plate 21 fixed inside the body 1. The top of the mounting plate 21 has several mounting slots 22 that communicate with the bottom of the mounting plate 21. When the number of clamping components 4 is exhausted or when there are clamping components 4 that cannot clamp the items, the items, such as containers and instruments that need to be sterilized, can be placed directly on the mounting plate 21. Through the mounting slots 22 on the mounting plate 21, the steam above the mounting plate 21 can also be transferred to the bottom of the mounting plate 21, so that the space above and below the mounting plate 21 is connected. At the same time, the items placed on the mounting plate 21 can also expose a larger area for pressure and heat, increasing the heat on the side of their bottom that contacts the mounting plate 21. The mounting slots 22 are arranged in a rectangular array and are used to connect with the connecting component 3.

[0037] Furthermore, such as Figure 3 and Figure 4 As shown, the first elastic element includes a first spring piece 23, which is used to contact the connecting component 3. The first spring piece 23 is fixedly provided at both the front and rear ends inside the mounting groove 22. The connecting block 31 is located inside the mounting groove 22. The first spring pieces 23 located at the front and rear ends inside the mounting groove 22 are respectively located inside the first connecting groove 33 at the front and rear ends of the connecting block 31.

[0038] Furthermore, such as Figure 5 As shown, the second elastic element includes a second spring piece 42 that is fixedly connected to the mounting block 41, and the elastic force of the second spring piece 42 is used to fix the item to be clamped.

[0039] Example 2

[0040] The biopharmaceutical autoclaving device provided in Example 1 has been further optimized, specifically, as follows: Figure 5 and Figure 7 As shown, the bottom end of the connecting block 31 is provided with a slot 32, and the front and rear ends of the slot 32 are provided with second connecting grooves 34. Through the slot 32 and the second connecting grooves 34, the connecting block 31 at the bottom of the clamping component 4 can also be inserted into the position between the two mounting grooves 22. The first spring piece 23 that is close to each other inside the two mounting grooves 22 slides into the second connecting groove 34 to achieve fixation, thereby improving the accuracy of adjusting the spacing between several clamping components 4.

[0041] Furthermore, such as Figure 5 and Figure 7 As shown, the first connecting groove 33 on the connecting block 31 is located above the second connecting groove 34. The bottom edge of the connecting block 31 is chamfered. When the connecting block 31 is inserted into the mounting groove 22, the chamfer helps to guide the connecting block 31 into the mounting groove 22.

[0042] Example 3

[0043] The biopharmaceutical autoclaving apparatus provided in Examples 1 and 2 has been further optimized, such as... Figure 5 and Figure 6 As shown, the adjustment component 5 includes a mounting box 51 fixed to the top of the connecting plate 35. A fixing block 52 is slidably provided inside the mounting box 51. By grasping and moving the mounting block 41, the fixing block 52 slides inside the mounting box 51, thereby adjusting the height of the clamping component 4 and further improving flexibility. The fixing block 52 is fixedly connected to the mounting block 41 at the top.

[0044] Furthermore, such as Figure 5 and Figure 6As shown, the adjustment component 5 also includes a semi-circular block 54. Several adjustment slots 53 are equidistantly provided on one side of the mounting box 51. When the mounting block 41 is pulled to adjust to the desired position, the semi-circular block 54 slides into the corresponding adjustment slot 53. The spring force causes the semi-circular block 54 to press against the inside of the adjustment slot 53, thereby achieving the limit. A sliding groove 55 is provided on the lower side of the mounting box 51 closest to the adjustment slot 53. A spring is fixedly installed inside the sliding groove 55. The semi-circular block 54 is slidably connected to the inside of the sliding groove 55 and fixedly connected to the end of the spring.

[0045] The usage process of the biopharmaceutical high-pressure sterilization device provided by this utility model is as follows:

[0046] When sterilization of the liquid and instruments in the container is required, pull the mounting block 41 to adjust the height, so that the semicircular block 54 is springed into the corresponding adjustment groove 53 for limiting. Install the connecting component 3 onto the placement component 2 according to the required distance between the two clamping components 4, thereby accommodating containers or instruments of different sizes. The two clamping components 4 need to be symmetrically arranged. Insert the slot 32 on the connecting block 31 into the mounting groove 22 or between the two mounting grooves 22. When inserted into the mounting groove 22, one side of the mounting groove 22... The first spring piece 23 is flattened by its own elastic force, and then the connecting block 31 continues to move downward, causing the first spring piece 23 to slide into the interior of the first connecting groove 33. The elastic force of the first connecting groove 33 then rebounds, restricting the connecting block 31. When it is necessary to insert between the two mounting grooves 22, the slot 32 below the connecting block 31 is inserted into the position between the two mounting grooves 22, so that the crossbeam between the two mounting grooves 22 is located inside the slot 32. The connecting block 31 continues to move downward, causing the two first spring pieces 23 to slide into the interior of the second connecting groove 34, thereby achieving fixation.

[0047] The container or instrument to be clamped is then inserted between the two clamping components 4 with corresponding spacing, so that the item is located between the two second spring pieces 42, and clamping and fixing are achieved by the compression of the elastic force of the two second spring pieces 42.

[0048] Users can insert multiple connecting components 3 into any mounting slot 22 or between two mounting slots 22 to customize the spacing of several clamping components 4;

[0049] After installation, close the machine body 1 to ensure its internal seal. Then, start the machine body 1 and continuously inject steam into its interior, thereby increasing the internal pressure and temperature. This pressurizes and heats the container or instrument inside the clamping assembly 4. Steam fills every corner of the machine body 1. When the pressure gauge needle rises to 121°C, it is approximately 0.1 MPa. Maintain this state for about fifteen minutes to sterilize the liquid and instrument inside the container.

[0050] After sterilization is complete, slowly release the pressure. Once the pressure is released, the sterilization process is complete. Open the machine body 1 and remove the items.

[0051] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0052] Obviously, the embodiments described above are only some embodiments of this utility model, not all embodiments. The accompanying drawings show preferred embodiments of this utility model, but do not limit the patent scope of this utility model. This utility model can be implemented in many different forms; rather, the purpose of providing these embodiments is to provide a more thorough and comprehensive understanding of the disclosure of this utility model. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing specific embodiments, or make equivalent substitutions for some of the technical features. Any equivalent structures made using the content of this utility model specification and drawings, directly or indirectly applied to other related technical fields, are similarly within the patent protection scope of this utility model.

Claims

1. A biopharmaceutical autoclave apparatus, characterized by, The device includes a body (1) which is used to generate high pressure inside. The body (1) has a placement component (2) inside. The placement component (2) has a first elastic element inside. The top of the placement component (2) has several connecting components (3). The top of the connecting component (3) has an adjustment component (5). The top of the connecting component (3) has a clamping component (4). The adjustment component (5) is used to adjust the height of the clamping component (4). The clamping component (4) is used to clamp instruments or containers that need to be sterilized. The connecting component (3) is installed on the placement component (2) through the first elastic element. At the same time, under the synergistic effect of the placement component (2) and the connecting component (3), the spacing between the several connecting components (3) and the clamping component (4) can be adjusted. The connecting component (3) includes a connecting block (31), and a first connecting groove (33) is provided at both the front and rear ends of the connecting block (31). A connecting plate (35) is fixedly provided at the top of the connecting block (31). The clamping component (4) includes a mounting block (41) located above the connecting plate (35). A second elastic element is provided on one side of the mounting block (41). The two clamping components (4) are symmetrically installed on the placement component (2). The container or instrument to be clamped is slid between the two second elastic elements and clamped and fixed by the elastic force of the two second elastic elements.

2. A biopharmaceutical autoclave apparatus as claimed in claim 1, wherein, The mounting component (2) includes a mounting plate (21) fixed inside the body (1). The top of the mounting plate (21) has several mounting slots (22) that communicate with the bottom of the mounting plate (21). The several mounting slots (22) are arranged in a rectangular array.

3. A biopharmaceutical autoclave apparatus as claimed in claim 2, wherein, The first elastic element includes a first spring piece (23). The first spring piece (23) is fixedly provided at both the front and rear ends inside the mounting groove (22). The connecting block (31) is located inside the mounting groove (22). The first spring pieces (23) located at the front and rear ends inside the mounting groove (22) are respectively located inside the first connecting groove (33) at the front and rear ends of the connecting block (31).

4. A biopharmaceutical autoclave device as claimed in claim 3, wherein, The bottom end of the connecting block (31) is provided with a slot (32), and the front and rear ends of the slot (32) are provided with second connecting slots (34).

5. A biopharmaceutical autoclave device according to claim 4, characterized in that, The adjustment component (5) includes a mounting box (51) fixed to the top of the connecting plate (35), and a fixing block (52) is slidably provided inside the mounting box (51). The fixing block (52) is fixedly connected to the mounting block (41) at the top.

6. A biopharmaceutical autoclave device according to claim 5, wherein, The adjustment component (5) also includes a semi-circular block (54). Several adjustment slots (53) are equidistantly provided on one side of the mounting box (51). A sliding groove (55) is provided below the side of the mounting box (51) closest to the adjustment slots (53). A spring is fixedly provided inside the sliding groove (55). The semi-circular block (54) is slidably connected to the inside of the sliding groove (55) and fixedly connected to the end of the spring.

7. A biopharmaceutical autoclave apparatus as claimed in claim 6, wherein, The second elastic element includes a second spring piece (42) that is fixedly connected to the mounting block (41).

8. A biopharmaceutical autoclave apparatus as claimed in claim 6, wherein, The first connecting slot (33) on the connecting block (31) is located above the second connecting slot (34).

9. A biopharmaceutical autoclave apparatus as claimed in claim 6, wherein, The bottom end edge of the connecting block (31) is provided with a chamfer.

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