Mixing machine for making amlodipine besylate tablets

Abstract

The utility model relates to the technical field of pharmaceutical mixing equipment, and discloses a mixing machine for manufacturing amlodipine besylate tablets, which comprises a fixed sleeve plate, a water spraying cleaning part and a stirring and mixing part, and is characterized in that a mounting opening is formed in the fixed sleeve plate. According to the utility model, components such as the mixing stirring blade, the mixing turning blade and the connecting rod in the stirring and mixing part work cooperatively, materials are stirred from different angles and layers, and the mixing stirring blade stirs the materials in the horizontal direction, so that the materials form a transverse mixed flow in the stirring barrel; mixing and turning blades are responsible for turning materials at the bottom upwards, three-dimensional mixing of the materials is achieved, a first cleaning connecting rod and a second cleaning connecting rod drive an inner wall scraping plate and an arc-shaped inner wall scraping plate to rotate, the inner wall of the stirring barrel is continuously scraped, the materials are prevented from being attached and accumulated on the inner wall, and the stirring efficiency is improved. And the materials possibly located at the stirring dead angle originally can participate in the mixing process again.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical mixing equipment technology, specifically a mixer for the production of amlodipine besylate tablets. Background Technology

[0002] In the pharmaceutical industry, amlodipine besylate is a commonly used drug for treating hypertension and angina pectoris, and the quality of its tablets directly affects the treatment effect and health safety of patients. The mixing process, as a crucial step in the production of amlodipine besylate tablets, plays a decisive role in the quality of the drug. However, traditional mixers used in the production of amlodipine besylate tablets have many problems that urgently need to be solved.

[0003] The production of amlodipine besylate tablets requires extremely high hygiene standards, as any impurities or residues can affect the quality of the drug. Traditional mixers have many blind spots in their structural design, such as the bottom inner wall and the inner wall of the mixing tank. During the mixing process, materials easily adhere to these areas and are difficult to clean thoroughly. When producing the next batch of drugs, the residues may mix into the new raw materials, causing cross-contamination, altering the composition and quality of the drug, and may even lead to serious medical accidents. Utility Model Content

[0004] The purpose of this invention is to provide a mixer for the production of amlodipine besylate tablets, which solves the technical problems of poor mixing effect and easy material residue on the inner wall of the mixing tank in traditional mixers, which are difficult to clean. It achieves the purpose of ensuring uniform mixing of amlodipine besylate tablet raw materials and facilitating equipment cleaning to avoid batch-to-batch material contamination.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a mixer for making amlodipine benzylsulfonate tablets, comprising a fixed sleeve, a water spray cleaning section, and a mixing section, characterized in that: an installation port is provided inside the fixed sleeve, a support leg is fixedly installed on the bottom outer wall of the fixed sleeve, and a support pad is fixedly installed on the bottom outer wall of the support leg; the water spray cleaning section is located inside the installation port, and the mixing section is located inside the water spray cleaning section.

[0006] Preferably, the water spray cleaning unit specifically includes: a mixing tank, fixedly installed on the inner wall of the installation port; a feed hopper, connected to one side of the outer wall of the mixing tank; a fixed cover plate, fixedly installed on the top outer wall of the mixing tank; and water inlet connectors, symmetrically arranged on the top outer wall of the fixed cover plate.

[0007] Preferably, a discharge valve pipe is provided at the bottom of the mixing tank, and water storage blocks are fixedly installed at equal intervals around the bottom outer wall of the fixed cover plate, with a water storage tank inside the water storage block.

[0008] Preferably, the other end of the water inlet connector movably penetrates the top outer wall of the fixed cover plate and extends into the interior of the mixing tank. The other end of the water inlet connector is connected to the top outer wall of the water storage block. The bottom outer wall of the water storage block is provided with cleaning nozzles at equal intervals. The water storage blocks are connected by connecting bends.

[0009] The system incorporates water storage blocks with equally spaced cleaning nozzles at their bottom. This ensures that cleaning water is evenly and widely sprayed into the mixing tank. The evenly distributed nozzles guarantee that every corner of the tank is cleaned, effectively preventing blind spots and ensuring thorough removal of any material residue. This improves cleaning efficiency and prevents contamination of the next batch of pharmaceuticals. Multiple water storage blocks are connected by a bend in the pipe and a water inlet connector. This design allows for flexible adjustment of the water flow based on actual cleaning needs, while maintaining a balanced water volume across all storage blocks. When a stronger cleaning effect is required, the water flow can be increased, allowing all nozzles to spray water at appropriate pressure for enhanced cleaning.

[0010] Preferably, the mixing section specifically includes: a motor mounting bracket, fixedly installed on the top outer wall of the fixed cover plate; a motor, disposed on the top outer wall of the fixed cover plate; a cleaning connecting rod one, circumferentially and equidistantly disposed inside the mixing tank; and a cleaning connecting rod two, circumferentially and equidistantly disposed inside the mixing tank.

[0011] Preferably, the motor is fixedly installed on the inner wall of the motor mounting bracket, the output end of the motor movably passes through the top outer wall of the fixed cover plate and extends to the outer wall of the fixed cover plate, and the output end of the motor is fixedly connected to a rotating shaft.

[0012] A motor is installed, which drives the rotating shaft to rotate, thereby rotating components such as the mixing blades and the mixing tipping blades. These components can mix materials from different angles and levels, ensuring full contact between the amlodipine besylate raw material and excipients, and ensuring uniform mixing. For example, the mixing tipping blades can turn the material at the bottom upwards, allowing the upper and lower layers of material to blend better and avoiding uneven mixing in certain areas. When the rotating shaft rotates, it drives the connected inner wall scraper and the arc-shaped inner wall scraper to move, which can clean the inner wall of the mixing tank and prevent material from adhering to the inner wall and forming mixing dead zones. In this way, all materials can participate in the mixing process, ensuring the uniformity of drug quality.

[0013] Preferably, the rotating shaft extends to the bottom of the inner wall of the mixing tank, one end of each of the cleaning connecting rod one and the cleaning connecting rod two is fixedly connected to the outer wall of the rotating shaft, an inner wall scraper is fixedly connected to the outer wall of the cleaning connecting rod one, and connecting rods are fixedly connected to the outer wall of the rotating shaft at equal intervals around its circumference.

[0014] Preferably, an arc-shaped inner wall scraper is fixedly installed at the other end of both the connecting rod and the second cleaning connecting rod. A mixing and stirring blade is fixedly installed between the first cleaning connecting rod and the second cleaning connecting rod. A fixing block is fixedly installed at equal intervals around the outer circumference of the rotating shaft. A mixing and turning blade is fixedly installed on the outer wall of the fixing block. The mixing and turning blade is located between the connecting rod and the second cleaning connecting rod.

[0015] This invention provides a mixer for the preparation of amlodipine benzyl sulfonate tablets. It has the following beneficial effects:

[0016] (1) In the production process of amlodipine besylate tablets, each batch of production has strict requirements on the purity of raw materials and the mixing precision. The water spray cleaning unit can thoroughly clean the inside of the mixing tank after the production of a batch, and clean the residual materials. This avoids the material residue of the previous batch from contaminating the next batch of products, and ensures the quality stability and purity of each batch of medicine. The cleaning nozzle can wash away impurities, dust and other impurities from the inner wall, bottom and corners of the mixing tank, and prevent these impurities from being mixed into the raw materials of the medicine in the subsequent mixing process, thereby ensuring that the quality of the final product meets the relevant standards and requirements.

[0017] (2) This utility model uses the mixing blades, mixing turning blades and connecting rods in the mixing section to work together to mix materials from different angles and levels. The mixing blades mix the materials in the horizontal direction, so that the materials form a horizontal mixing flow in the mixing tank; while the mixing turning blades are responsible for turning the materials at the bottom upwards, realizing the three-dimensional mixing of materials. The cleaning connecting rod one and the cleaning connecting rod two drive the inner wall scraper and the arc-shaped inner wall scraper to rotate, continuously scraping the inner wall of the mixing tank, preventing the material from adhering and accumulating on the inner wall, and also allowing materials that may have been in the mixing dead corner to participate in the mixing process again. Attached Figure Description

[0018] Figure 1 This is a frontal perspective view of the overall structure of this utility model;

[0019] Figure 2 This is a partial sectional view of the water spray cleaning part of this utility model;

[0020] Figure 3 This is a partial view of the connecting bend of the present invention;

[0021] Figure 4 This is a partial view of the mixing section of this utility model.

[0022] In the diagram: 1. Fixed sleeve plate, 2. Support leg, 3. Water spray cleaning section, 311. Mixing tank, 312. Feed hopper, 313. Fixed cover plate, 314. Water inlet connector, 315. Discharge valve pipe, 316. Water storage block, 317. Cleaning nozzle, 318. Connecting bend, 4. Mixing section, 411. Motor mounting bracket, 412. Motor, 413. Rotating shaft, 414. Cleaning connecting rod one, 415. Cleaning connecting rod two, 416. Mixing blade, 417. Inner wall scraper, 418. Connecting rod, 419. Mixing turning blade, 4111. Arc-shaped inner wall scraper, 4112. Fixed block. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention. Example

[0025] Addressing the problems of poor mixing efficiency and material residue on the inner wall of the mixing tank in traditional mixers, which are difficult to clean, this invention provides a preferred embodiment of a mixer for the production of amlodipine benzylsulfonate tablets, for example... Figures 1-4 As shown: A mixer for making amlodipine benzylsulfonate tablets includes a fixed sleeve plate 1, a water spray cleaning section 3, and a mixing section 4. The fixed sleeve plate 1 has an installation port inside, and a support leg 2 is fixedly installed on the bottom outer wall of the fixed sleeve plate 1. A support pad is fixedly installed on the bottom outer wall of the support leg 2. The water spray cleaning section 3 is located inside the installation port, and the mixing section 4 is located inside the water spray cleaning section 3.

[0026] The water spray cleaning unit 3 specifically includes: a mixing tank 311, which is fixedly installed on the inner wall of the installation port; a feed hopper 312, which is connected to the outer wall of one side of the mixing tank 311; a fixed cover plate 313, which is fixedly installed on the top outer wall of the mixing tank 311; and a water inlet connector 314, which is symmetrically arranged on the top outer wall of the fixed cover plate 313.

[0027] The bottom of the mixing tank 311 is connected to a discharge valve pipe 315. The bottom outer wall of the fixed cover plate 313 is fixedly installed with water storage blocks 316 at equal intervals. The water storage blocks 316 have water storage tanks inside.

[0028] The other end of the water inlet connector 314 extends through the top outer wall of the fixed cover plate 313 and into the interior of the mixing tank 311. The other end of the water inlet connector 314 is connected to the top outer wall of the water storage block 316. The bottom outer wall of the water storage block 316 is provided with cleaning nozzles 317 at equal intervals. The water storage blocks 316 are connected by connecting bends 318.

[0029] In this embodiment, cleaning water is introduced through the water inlet connector 314, which is connected to the water storage block 316 at the bottom of the fixed cover plate 313. The cleaning water enters the water storage tank of the water storage block 316. The water storage blocks 316 are connected by connecting bends 318, so that the cleaning water is evenly distributed among the water storage blocks 316. The cleaning nozzle 317 at the bottom of the water storage block 316 sprays the cleaning water into the mixing tank 311. At the same time, the motor 412 is started, which drives the rotating shaft 413 and related components to rotate. The inner wall scraper 417 and the arc-shaped inner wall scraper 4111 work together with the water spray from the cleaning nozzle 317 to thoroughly clean the inner wall of the mixing tank 311. The wastewater after cleaning is discharged through the discharge valve pipe 315. After a batch of production is completed, the inside of the mixing tank can be thoroughly cleaned to remove residual materials. This avoids the contamination of the next batch of products by the material residue of the previous batch, ensuring the quality stability and purity of each batch of medicine. Example

[0030] Please see Figures 1-4 Furthermore, based on Embodiment 1, the mixing unit 4 specifically includes: a motor mounting bracket 411, which is fixedly installed on the top outer wall of the fixed cover plate 313; a motor 412, which is disposed on the top outer wall of the fixed cover plate 313; a first cleaning connecting rod 414, which is circumferentially and equidistantly disposed inside the mixing tank 311; and a second cleaning connecting rod 415, which is circumferentially and equidistantly disposed inside the mixing tank 311.

[0031] The motor 412 is fixedly installed on the inner wall of the motor mounting bracket 411. The output end of the motor 412 moves through the top outer wall of the fixed cover plate 313 and extends to the outer wall of the fixed cover plate 313. The output end of the motor 412 is fixedly connected to the rotating shaft 413.

[0032] The rotating shaft 413 extends to the bottom of the inner wall of the mixing tank 311. One end of the first cleaning connecting rod 414 and the second cleaning connecting rod 415 are fixedly connected to the outer wall of the rotating shaft 413. An inner wall scraper 417 is fixedly connected to the outer wall of the first cleaning connecting rod 414. Connecting rods 418 are fixedly connected at equal intervals around the outer circumference of the rotating shaft 413.

[0033] The other ends of both connecting rod 418 and cleaning connecting rod 2 415 are fixedly equipped with arc-shaped inner wall scrapers 4111. A mixing and stirring blade 416 is fixedly installed between cleaning connecting rod 1 414 and cleaning connecting rod 2 415. Fixed blocks 4112 are fixedly installed at equal intervals around the outer circumference of the rotating shaft 413. A mixing and turning blade 419 is fixedly installed on the outer wall of the fixed block 4112. The mixing and turning blade 419 is located between connecting rod 418 and cleaning connecting rod 2 415.

[0034] In this embodiment, the motor 412 is started and fixed to the inner wall of the motor mounting bracket 411. The output end of the motor 412 drives the rotating shaft 413 to rotate. The rotating shaft 413 drives the cleaning connecting rod 1 414, the cleaning connecting rod 2 415, and the connecting rod 418 to rotate. The mixing and stirring blades 416 between the cleaning connecting rod 1 414 and the cleaning connecting rod 2 415 stir the material, making the material fully mixed in the horizontal direction. The mixing and turning blades 419 on the fixing block 4112 on the outer wall of the rotating shaft 413 turn the bottom material upward, realizing the mixing of the material in the vertical direction and ensuring that the material is mixed evenly in all directions. The cleaning connecting rod 1 As the inner wall scraper 417 on 414, the connecting rod 418, and the arc-shaped inner wall scraper 4111 at the end of the cleaning connecting rod 2 415 rotate, they scrape the inner wall of the mixing tank 311 to prevent material from adhering and ensure that all materials participate in the mixing, so that the materials form a transverse mixing flow in the mixing tank; while the mixing turning blade is responsible for turning the material at the bottom upward, realizing the three-dimensional mixing of materials. The cleaning connecting rod 1 and the cleaning connecting rod 2 drive the inner wall scraper and the arc-shaped inner wall scraper to rotate, continuously scraping the inner wall of the mixing tank, preventing the material from adhering and accumulating on the inner wall, and also allowing materials that may have been in the mixing dead zone to participate in the mixing process again.

[0035] Working principle: When in use;

[0036] Step 1: Check whether the bottom support leg 2 and support pad of the fixed sleeve plate 1 are stable to ensure that the mixer is placed stably. Check whether the pipe connections of the feed hopper 312, water inlet connector 314, discharge valve pipe 315 are tight and there is no leakage. Check whether the motor 412, water spray system and other equipment can operate normally.

[0037] Step 2: The raw materials and excipients required for the production of amlodipine besylate are added to the mixing tank 311 through the feed hopper 312. The feed hopper 312 is connected to the mixing tank 311 to facilitate the smooth entry of materials into the mixing tank 311.

[0038] Step 3: Start motor 412. Motor 412 is fixed to the inner wall of motor mounting bracket 411. The output end of motor 412 drives rotating shaft 413 to rotate. Rotating shaft 413 drives cleaning connecting rod one 414, cleaning connecting rod two 415, and connecting rod 418 to rotate. The mixing blades 416 between cleaning connecting rod one 414 and cleaning connecting rod two 415 stir the material, making the material fully mixed in the horizontal direction. The mixing turning blades 419 on the outer wall fixing block 4112 of rotating shaft 413 turn the bottom material upward to achieve vertical mixing of the material, ensuring that the material is mixed evenly in all directions. The inner wall scraper 417 on cleaning connecting rod one 414 and the arc-shaped inner wall scraper 4111 at the ends of connecting rod 418 and cleaning connecting rod two 415 scrape the inner wall of mixing tank 311 as they rotate, preventing material from adhering and ensuring that all materials participate in the mixing.

[0039] Step 4: Once the materials are mixed to the required consistency, open the discharge valve 315 to allow the mixed materials to be discharged from the bottom of the mixing tank 311 and proceed to the next production process.

[0040] Step 5: Introduce cleaning water through water inlet connector 314. Water inlet connector 314 is connected to water storage block 316 at the bottom of fixed cover plate 313. The cleaning water enters the water storage tank of water storage block 316. Water storage blocks 316 are connected by connecting bend pipe 318 to make the cleaning water evenly distributed among the water storage blocks 316. The cleaning nozzle 317 at the bottom of water storage block 316 sprays the cleaning water into the mixing tank 311. At the same time, the motor 412 is started to drive the rotating shaft 413 and related components to rotate. The inner wall scraper 417 and the arc-shaped inner wall scraper 4111 cooperate with the water spray from the cleaning nozzle 317 to thoroughly clean the inner wall of the mixing tank 311. The wastewater after cleaning is discharged through discharge valve pipe 315.

[0041] Step Six: After cleaning, turn off the water supply at motor 412 and water inlet connector 314, check whether there is any damage or abnormality in each part of the equipment, and prepare for the next production.

[0042] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A mixer for preparing amlodipine benzylsulfonate tablets, comprising a fixed sleeve plate (1), a water spray cleaning section (3), and a stirring and mixing section (4), characterized in that: The fixed sleeve (1) has an installation port inside, and a support leg (2) is fixedly installed on the bottom outer wall of the fixed sleeve (1). A support pad is fixedly installed on the bottom outer wall of the support leg (2). The water spray cleaning part (3) is located inside the installation port, and the stirring and mixing part (4) is located inside the water spray cleaning part (3).

2. The mixing machine for manufacturing amlodipine besylate tablet according to claim 1, wherein: The water spray cleaning unit (3) specifically includes: The mixing tank (311) is fixedly installed on the inner wall of the installation port; The feed hopper (312) is connected to the outer wall of one side of the mixing tank (311); A fixed cover plate (313) is fixedly installed on the top outer wall of the mixing tank (311); The water inlet connector (314) is symmetrically arranged on the top outer wall of the fixed cover plate (313).

3. The mixing machine for manufacturing amlodipine besylate tablet according to claim 2, wherein: The bottom of the mixing tank (311) is connected to a discharge valve pipe (315), and a water storage block (316) is fixedly installed on the bottom outer wall of the fixed cover plate (313) at equal intervals. The water storage block (316) has a water storage tank inside.

4. A mixer for preparing amlodipine benzylsulfonate tablets according to claim 3, characterized in that: The other end of the water inlet connector (314) extends through the top outer wall of the fixed cover plate (313) and into the interior of the mixing tank (311). The other end of the water inlet connector (314) is connected to the top outer wall of the water storage block (316). The bottom outer wall of the water storage block (316) is provided with cleaning nozzles (317) at equal intervals. The water storage blocks (316) are connected by connecting bends (318).

5. The mixing machine for manufacturing amlodipine besylate tablet according to claim 1, wherein: The mixing section (4) specifically includes: The motor mounting bracket (411) is fixedly installed on the top outer wall of the fixed cover plate (313); The motor (412) is mounted on the top outer wall of the fixed cover plate (313); Clean the connecting rod 1 (414), which is circumferentially and equidistantly arranged inside the mixing tank (311); Clean the connecting rod 2 (415), which is circumferentially and equidistantly arranged inside the mixing tank (311).

6. The mixing machine for manufacturing amlodipine besylate tablet according to claim 5, wherein: The motor (412) is fixedly installed on the inner wall of the motor mounting bracket (411). The output end of the motor (412) moves through the top outer wall of the fixed cover plate (313) and extends to the outer wall of the fixed cover plate (313). The output end of the motor (412) is fixedly connected to a rotating shaft (413).

7. The mixing machine for manufacturing amlodipine besylate tablet according to claim 6, wherein: The rotating shaft (413) extends to the bottom of the inner wall of the mixing tank (311). One end of the first cleaning connecting rod (414) and the second cleaning connecting rod (415) are fixedly connected to the outer wall of the rotating shaft (413). An inner wall scraper (417) is fixedly connected to the outer wall of the first cleaning connecting rod (414). Connecting rods (418) are fixedly connected to the outer wall of the rotating shaft (413) at equal intervals.

8. The mixing machine for manufacturing amlodipine besylate tablet according to claim 7, wherein: The other ends of the connecting rod (418) and the second cleaning connecting rod (415) are both fixedly equipped with arc-shaped inner wall scrapers (4111). A mixing and stirring blade (416) is fixedly installed between the first cleaning connecting rod (414) and the second cleaning connecting rod (415). A fixing block (4112) is fixedly installed at equal intervals around the outer circumference of the rotating shaft (413). A mixing and turning blade (419) is fixedly installed on the outer wall of the fixing block (4112). The mixing and turning blade (419) is located between the connecting rod (418) and the second cleaning connecting rod (415).

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