High-flux drying auxiliary device capable of preventing cross contamination of solvents

Abstract

The utility model discloses a high-flux drying auxiliary device capable of preventing cross contamination of solvents, which comprises an oscillation base, a sample disc group and an isolation cover, the sample disc group is fixedly mounted at the top of the oscillation base, and the isolation cover is fixedly mounted on the oscillation base. The isolation hood is detachably mounted at the top of the sample disc group, the sample disc group is formed by combining a plurality of sample discs, the sample discs are mutually independent, and the sample discs are used for accommodating samples. According to the utility model, different types of samples can be effectively isolated, the problem of cross contamination among solvents contained in the samples in the drying process is avoided, the drying of various types of high-flux samples in the same batch is facilitated, the samples can be oscillated during drying, the mass transfer process of the whole system is promoted, and the drying efficiency is improved. The problems that materials are agglomerated and are not easy to disperse during static drying are solved, and the drying efficiency and the product quality are improved.

Description

Technical Field

[0001] This utility model relates to the field of drug drying equipment, and in particular to a high-throughput drying auxiliary device that can prevent solvent cross-contamination. Background Technology

[0002] In drug development, screening and studying the crystalline forms of active pharmaceutical ingredients (APIs) is a crucial step. High-throughput crystallization screening technology can be used to screen APIs for their crystal forms, salt forms, and cocrystals, obtaining a series of candidate crystal forms, salt forms, and cocrystals for subsequent evaluation and development. High-throughput screening can significantly improve screening efficiency, obtaining a large number of screening samples in a short time. This process typically uses crystallization methods such as suspension, dissolution, volatilization, and cooling; however, these methods all introduce various solvents, inevitably leading to solvent residues in the solid. Therefore, efficient drying of the solid obtained from high-throughput screening is particularly important.

[0003] Drying ovens are commonly used drying equipment in laboratories, allowing for convenient adjustment of drying temperature and time, and can be connected to external vacuum pumps for vacuum drying. When used in crystallization, existing drying ovens typically involve placing sample tubes directly into a support, which is then transferred to the oven for drying. However, using ordinary supports for auxiliary drying presents several problems: First, there is the issue of solvent cross-contamination. Since high-throughput screening experiments often use multiple solvents, when samples containing different solvents are dried in the same oven, solvent vapor molecules diffuse freely within the same space, easily leading to cross-contamination. That is, a sample that should contain solvent A may contain solvent B, interfering with subsequent research and analysis. Second, vacuum ovens are a form of "static drying," where the material remains stationary and relies on conduction or radiation heat transfer, resulting in long drying times and low efficiency. Furthermore, when sample batches are large or contain significant amounts of solvent, the limited capacity of conventional supports leads to low drying efficiency and may result in incomplete drying.

[0004] Therefore, there is a need in the art for a high-throughput drying auxiliary device that can prevent cross-contamination of solvents, avoid cross-contamination between solvents contained in samples in a vacuum oven, promote the mass transfer process of the entire system, solve the problem of material agglomeration and difficulty in dispersion during static drying, and thus improve drying efficiency. Utility Model Content

[0005] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0006] A high-throughput drying auxiliary device to prevent solvent cross-contamination includes a shaking base, a sample tray assembly, and an isolation cover. The sample tray assembly is fixedly mounted on top of the shaking base, and the isolation cover is detachably mounted on top of the sample tray assembly. The sample tray assembly is composed of multiple independent sample trays, and each sample tray is used to hold samples. The sample trays and the isolation cover are made of polyethylene, polypropylene, or polytetrafluoroethylene.

[0007] In one specific embodiment, each sample tray is divided into multiple units, and each unit is provided with multiple sample slots for accommodating samples of corresponding specifications.

[0008] In one specific embodiment, the isolation cover is provided with a plurality of one-way ventilation valves, the number of which is the same as the number of units, and the one-way ventilation valves are arranged one-to-one above the units.

[0009] In one specific embodiment, the oscillation base consists of an oscillator and a base plate, with the base plate fixedly mounted on top of the oscillator and the sample tray assembly fixedly mounted on top of the base plate.

[0010] In one specific embodiment, a first annular groove is formed at the bottom of the inner wall of the isolation cover, and a sealing ring is fixedly installed in the annular groove. A second annular groove corresponding to the sealing ring is formed on the outer wall of the sample tray. The isolation cover and the sample tray are connected by the first annular groove, the second annular groove and the sealing ring.

[0011] In one specific embodiment, the number of sample trays is set to at least four.

[0012] In one specific embodiment, the number of the units is set to at least four.

[0013] In one specific embodiment, the one-way vent valve is a centrifugal suspension valve, the centrifugal suspension valve is made of polyethylene, and the gasket of the centrifugal suspension valve is made of silicone.

[0014] In one specific embodiment, the gas discharge direction of the one-way vent valve is such that gas can only flow from the sample pan to the outside of the one-way vent valve, but cannot flow from the outside of the one-way vent valve to the inside of the sample pan.

[0015] In one specific embodiment, a light-shielding material is added to the sample tray and the isolation cover, the light-shielding material being selected from black plastic, graphite coating or silicon nitride coating.

[0016] In one embodiment, the oscillator is connected to an external controller via a radio signal, the external controller being used to adjust the oscillation rate and oscillation time.

[0017] In one specific embodiment, the sample holder can be adapted to the following equipment specifications: 2mL centrifuge tubes, 2mL sample bottles, 4mL sample bottles, 8mL sample bottles, 20mL sample bottles, and 40mL sample bottles.

[0018] The beneficial effects of this utility model include:

[0019] 1. The high-throughput drying auxiliary device provided by this utility model, which can prevent solvent cross-contamination, effectively isolates different types of samples by setting up an isolation cover and a one-way vent valve, avoiding the problem of cross-contamination between solvents contained in the samples during the drying process. This is conducive to drying multiple types of high-throughput samples in the same batch, thus improving the drying efficiency.

[0020] 2. The high-throughput drying auxiliary device provided by this utility model, which can prevent cross-contamination of solvents, can oscillate the sample during drying by setting an oscillating base, thereby promoting the mass transfer process of the entire system, solving the problem of material agglomeration and difficulty in dispersion during static drying, and further improving drying efficiency and product quality. Attached Figure Description

[0021] Figure 1 A schematic diagram of the overall structure of the high-throughput drying auxiliary device that can prevent solvent cross-contamination provided by this utility model;

[0022] Figure 2 The high-throughput drying auxiliary device for preventing solvent cross-contamination provided by this utility model is shown in a perspective view through the isolation cover from a top viewpoint.

[0023] Figure 3 A perspective view from a top view of the high-throughput drying auxiliary device provided by this utility model that can prevent solvent cross-contamination.

[0024] In the diagram, 1 is the oscillator; 2 is the base plate; 3 is the sample tray assembly; 4 is the sealing ring; 5 is the one-way vent valve; 6 is the isolation cover; 7 is the sample slot; 8 is the sample tray; and 9 is the unit. Detailed Implementation

[0025] The technical solution of this utility model will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0026] Example 1

[0027] like Figures 1-3As shown in the illustration, this embodiment demonstrates a high-throughput drying auxiliary device that prevents solvent cross-contamination. It includes a shaking base, a sample tray assembly 3, and an isolation cover 6. The sample tray assembly 3 is fixedly mounted on top of the shaking base, and the isolation cover 6 is detachably mounted on top of the sample tray assembly 3. The sample tray assembly 3 is composed of multiple sample trays 8, each of which is independent of the others. The sample trays 8 are used to hold samples. The materials of the sample trays 8 and the isolation cover 6 are selected from polyethylene, polypropylene, or polytetrafluoroethylene. Light-shielding materials are added to the sample trays 8 and the isolation cover 6. These materials are selected from black plastic, graphite coating, or silicon nitride coating. The light-shielding materials allow this device to be used for drying photosensitive compounds, avoiding the degradation of photosensitive compounds caused by light exposure, thus improving the practicality of the device.

[0028] The oscillation base consists of an oscillator 1 and a base plate 2. The base plate 2 is fixedly mounted on top of the oscillator 1, and the sample tray assembly 3 is fixedly mounted on top of the base plate 2. The base plate 2 can be made of stainless steel, aluminum alloy, or other common heat-resistant insulating materials. The oscillator 1 is connected to an external controller via a radio signal, which is used to adjust the oscillation rate and oscillation time. By starting the oscillator 1, an oscillation effect is generated on the base plate 2 and its components, thereby transferring the oscillation energy to the sample in the sample tray 7, achieving continuous and stable oscillation dispersion of the sample and accelerating the sample drying process. The oscillation base can assist in oscillation during drying, making the sample more dispersed, accelerating solvent evaporation, and further improving drying efficiency.

[0029] The bottom of the inner wall of the isolation cover 6 is provided with a first annular groove, and a sealing ring 4 is fixedly installed in the annular groove. The outer wall of the sample tray 8 is provided with a second annular groove corresponding to the sealing ring 4. The isolation cover 6 and the sample tray 8 are connected by the first annular groove, the second annular groove and the sealing ring 4.

[0030] Please refer to Figure 2 The diagram shows a sample disk group 3 consisting of four sample disks 8. Within each sample disk 8, multiple units 9 can be divided. Figure 2 In this design, each sample tray 8 is divided into four units 9. Within each unit 9, multiple sample slots 7 are provided. These sample slots 7 vary in size and can accommodate samples of different specifications, such as 2mL centrifuge tubes, 2mL sample vials, 4mL sample vials, 8mL sample vials, 20mL sample vials, and 40mL sample vials. Prepared solid samples can be placed in the vials and inserted into the sample slots 7 for drying, or centrifuge tubes after centrifugation can be placed directly into the sample slots 7 for drying. The multiple sample trays 8 and multiple units 9 increase the drying throughput that can be handled in a single operation, enabling the simultaneous shaking and drying of dozens or even hundreds of samples within the entire sample tray group 3.

[0031] Please refer toFigure 3 The isolation cover 6 is equipped with multiple one-way vent valves 5, the number of which is the same as the number of units 9, and the one-way vent valves 5 are arranged one-to-one above the units 9. The one-way vent valves 5 are centrifugal suspension valves, made of polyethylene, with silicone gaskets. The gas discharge direction of the one-way vent valves 5 is such that gas can only flow from the sample tray 8 to the outside of the one-way vent valve 5, and cannot flow from the outside of the one-way vent valve 5 into the sample tray 8. The sealing ring 4 improves the sealing performance of the device. The isolation cover 6 isolates the internal space of the sample tray assembly 3 from the external environment, forming a fully sealed system. Solvent diffusion can only occur from the inside of the sample tray 8 through the one-way vent valves 5 to the external environment, preventing the volatile solvent vapor from re-entering the sample and causing sample contamination.

[0032] The working process of the high-throughput drying auxiliary device that prevents solvent cross-contamination shown in this embodiment is as follows:

[0033] The operator places the sample vials or centrifuge tubes to be dried into sample trays 8 of appropriate size, forming a sample tray group 3. The operator can place them in the sample slots 7 of different units 9 according to the different solvents they contain, thus avoiding potential contamination between different solvents. Afterwards, the operator covers the sample tray group 3 with an isolation cover 6 for sealing. Then, the operator uses the controller of the shaker 1 to set the shaking time and rate. After completing the above steps, the operator places the device in a vacuum oven, closes the oven door and vent valve, and sets the oven temperature. High-throughput drying of the samples is then achieved. Solvent vapors are discharged to the outside of the device through the one-way vent valve 5 and exit the oven through the vent valve, preventing cross-contamination of other samples.

[0034] In summary, the above embodiments are merely preferred embodiments of the present utility model and are not intended to limit the scope of protection of the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the scope of protection of the present utility model.

Claims

1. A high-throughput drying auxiliary device that can prevent solvent cross-contamination, characterized in that, The high-throughput drying auxiliary device that prevents solvent cross-contamination includes a shaking base, a sample tray assembly, and an isolation cover. The sample tray assembly is fixedly installed on the top of the shaking base, and the isolation cover is detachably installed on the top of the sample tray assembly. The sample tray assembly is composed of multiple sample trays, and each sample tray is independent of the others. The sample trays are used to hold samples.

2. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 1, characterized in that, Each sample tray is divided into multiple units, and each unit is provided with multiple sample slots for accommodating samples of corresponding specifications.

3. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 2, characterized in that, The isolation cover is equipped with multiple one-way ventilation valves, the number of which is the same as the number of units, and the one-way ventilation valves are arranged one-to-one above the units.

4. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 1, characterized in that, The oscillation base consists of an oscillator and a base plate. The base plate is fixedly installed on top of the oscillator, and the sample tray assembly is fixedly installed on top of the base plate.

5. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 1, characterized in that, The bottom of the inner wall of the isolation cover is provided with a first annular groove, and a sealing ring is fixedly installed in the annular groove. The outer wall of the sample tray is provided with a second annular groove corresponding to the sealing ring. The isolation cover and the sample tray are connected by the first annular groove, the second annular groove and the sealing ring.

6. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 1, characterized in that, The number of sample trays is set to at least 4.

7. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 2, characterized in that, The number of units is set to at least 4.

8. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 3, characterized in that, The gas discharge direction of the one-way vent valve is such that gas can only flow from the sample pan to the outside of the one-way vent valve, but cannot flow from the outside of the one-way vent valve to the inside of the sample pan.

9. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 4, characterized in that, The oscillator is connected to an external controller via a radio signal, and the external controller is used to adjust the oscillation rate and oscillation time.

10. The high-throughput drying auxiliary device for preventing solvent cross-contamination according to claim 2, characterized in that, The sample holder is compatible with the following equipment specifications: 2mL centrifuge tubes, 2mL sample bottles, 4mL sample bottles, 8mL sample bottles, 20mL sample bottles, and 40mL sample bottles.

Images