Ball-milling device for oxacillin sodium for injection

Abstract

The utility model discloses an oxacillin sodium ball-milling device for injection, which comprises a supporting platform, a rotating motor is arranged at one end of the upper surface of the supporting platform, and a supporting plate is arranged at the other end of the upper surface of the supporting platform; the cylinder cover is connected with the side face, facing the rotating motor, of the supporting plate through a rotating shaft. The barrel is arranged on the upper side of the supporting platform, a plurality of ball milling bodies are arranged in an inner cavity of the barrel, one end of the barrel is connected with a rotating shaft of the rotating motor, the other end of the barrel is detachably connected with the barrel cover, a plurality of guide convex lines are sequentially arranged on the circumferential inner wall of the barrel at intervals, and the two ends of the guide convex lines are close to the inner wall of the axial end of the barrel and the inner wall of the axial end of the barrel cover correspondingly; and the two ends of the guide convex line are inclined relative to the middle point along the rotating direction of the barrel body. The oxacillin sodium grinding device solves the problem that part of oxacillin sodium cannot be fully ground.

Description

Technical Field

[0001] This utility model relates to the field of ball milling equipment, specifically to a ball milling device for injectable oxacillin sodium. Background Technology

[0002] Oxacillin Sodium for Injection is formulated with oxacillin sodium as the main drug and disodium hydrogen phosphate as the excipient. Oxacillin Sodium (OXCL) belongs to the lactam class of semi-synthetic penicillin antibiotics. It is mainly used to treat infections caused by penicillinase-producing Staphylococcus aureus, and can also be used to treat mixed infections caused by Streptococcus pyogenes or Streptococcus pneumoniae and penicillin-resistant Staphylococcus aureus. This product is a white or off-white lyophilized powder, packaged in a soda-lime glass molded injection vial, a sterile powder for injection coated with a polyethylene-tetrafluoroethylene brominated butyl rubber stopper, and an aluminum-plastic easy-open combination cap.

[0003] In the existing technology, the production of oxacillin sodium requires the use of a ball mill to process the sodium powder. The grinding balls inside the mill grind the oxacillin sodium powder within the cylinder under the action of the cylinder, resulting in a smooth surface, good flowability, and thus better mixing. However, some problems still exist during ball milling and need to be improved:

[0004] 1. When the dryness of sodium oxacillin is insufficient or the internal humidity of the ball mill does not meet the requirements, some sodium oxacillin will adhere to the inner wall surface of the cylinder along the axial direction, resulting in wall adhesion. This is especially true during coarse grinding, when the rotation speed is usually 40 r / min-80 r / min and the cylinder rotation speed is relatively slow. The grinding media will move along the outer edge of the circumferential inner wall and the axial inner wall of the cylinder, which may result in the grinding media not being able to directly collide with the inner walls at both ends of the cylinder or the collision force being low. This causes sodium oxacillin to stick to both sides of the cylinder, resulting in some sodium oxacillin not being fully ground.

[0005] Therefore, there is an urgent need for a ball milling device that can grind oxacillin sodium more thoroughly. Utility Model Content

[0006] The technical problem to be solved by this utility model is that when some sodium oxacillin adheres to both ends of the cylinder, some sodium oxacillin cannot be fully ground. The purpose is to provide a ball milling device to solve the problem that some sodium oxacillin cannot be fully ground.

[0007] This utility model is achieved through the following technical solution:

[0008] A ball milling device for injectable oxacillin sodium, comprising

[0009] The support platform has a rotating motor at one end of its upper surface and a support plate at the other end.

[0010] The cylinder cover is connected to the side of the support plate facing the rotating motor via a rotating shaft;

[0011] The cylinder is set on the upper side of the support platform, and the inner cavity is equipped with multiple ball mill bodies. One end of the cylinder is connected to the rotating shaft of the rotating motor, and the other end is detachably connected to the cylinder cover. Multiple guide convex lines are arranged at intervals on the circumferential inner wall of the cylinder. The two ends of the multiple guide convex lines are respectively close to the inner wall of one end of the cylinder in the axial direction and the inner wall of one end of the cylinder cover in the axial direction. Both ends of the guide convex lines are inclined relative to the midpoint along the rotation direction of the cylinder.

[0012] In some embodiments, the two ends of the guide convex line are respectively equidistant from the inner wall surfaces of the two ends of the cylinder axially.

[0013] In some embodiments, the height of the guide convex line along the radial direction of the cylinder is 1 / 10 of the diameter of the ball mill body, preferably 1.5cm-3.5cm.

[0014] In some embodiments, the cross-section of the guide convex line along the radial direction of the cylinder is a circular arc surface.

[0015] In some embodiments, the inner cavity of the cylinder is provided with a removable first partition, and the first partition is disposed close to the cylinder cover;

[0016] One end of the guide convex line is close to the first partition plate. The end of the cylinder cover facing the cylinder body is provided with a cylindrical end, and the cylindrical end is coaxial with the cylinder cover. The cylindrical end is inserted into the inner cavity of the cylinder body and is threadedly connected to the cylinder body. The end face of one end of the cylindrical end abuts against and fits against the first partition plate.

[0017] In some embodiments, a first vibration cavity is provided at the cylindrical end. The first vibration cavity adopts a frustum structure, and the end with the larger diameter abuts against and fits against the first partition. The axis of the cylindrical end passes through the center of the cross-sections at both ends of the first vibration cavity, and a plurality of vibrating balls are provided inside the first vibration cavity.

[0018] In some embodiments, the inner cavity of the cylinder is provided with a second partition plate, which is disposed opposite to the first partition plate at both ends of the inner cavity of the cylinder, and the other end of the guide convex line is close to the second partition plate;

[0019] A second vibration chamber is provided between the second partition and the inner wall of the other end of the cylinder cavity, and multiple vibrating balls are provided in the second vibration chamber.

[0020] In some embodiments, the second vibration cavity adopts a frustum structure, and the side of the second partition facing the second vibration cavity is located on the same plane as the end face of the larger end of the second vibration cavity.

[0021] In some embodiments, the inner cavity of the cylinder is provided with a circumferential limiting platform, and the outer edge of the side of the first partition facing the second partition abuts against and fits against the side of the circumferential limiting platform.

[0022] In some embodiments, the side of the first partition facing the cylinder cover is provided with an elastic layer, and the side of the second partition facing away from the first partition is provided with an elastic layer.

[0023] Compared with the prior art, this utility model has the following advantages and beneficial effects:

[0024] This invention achieves more thorough and efficient ball milling of sodium oxacillin inside the cylinder by rotating the cylinder and ball milling the oxacillin inside the cylinder, with the ball milling body contacting the first or second partition under the action of the guide convex line, and the vibrating ball colliding with the first and second partitions. This causes the sodium oxacillin attached to the surfaces of the first and second partitions at both ends of the cylinder to fall off and participate in the ball milling, thus making the ball milling of sodium oxacillin more thorough and efficient. Attached Figure Description

[0025] The accompanying drawings, which are included to provide a further understanding of the embodiments of the present invention and form part of this application, do not constitute a limitation thereof. In the drawings:

[0026] Figure 1 This is a schematic diagram of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application;

[0027] Figure 2 This is a schematic diagram of the cylinder of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application;

[0028] Figure 3 This is a left-side schematic view of the cylinder of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application;

[0029] Figure 4 The second vibration chamber of the ball milling device for injectable oxacillin sodium disclosed in this application is along... Figure 2 Left view of the cross-section with the dashed line in the middle;

[0030] Figure 5 This is a schematic diagram of the cylinder cover of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application;

[0031] Figure 6 This is a right-side schematic view of the cylinder cover of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application;

[0032] Figure 7 This is a cross-sectional schematic diagram of the guide convex line of a ball milling device for injectable oxacillin sodium disclosed in an embodiment of this application.

[0033] The attached diagram shows the markings and corresponding component names:

[0034] 1-Supporting platform, 11-Supporting column, 111-Upper column, 112-Lower column

[0035] 2- Rotate the motor,

[0036] 3-Support plate,

[0037] 4-Cylinder cover, 41-Cylindrical end, 411-First vibration chamber

[0038] 5-Spindle,

[0039] 6-Cylinder body, 61-Guide convex line, 62-Second vibration chamber, 63-Circumferential limiting platform,

[0040] 7-Grinding body,

[0041] 8-First partition,

[0042] 9-Vibrating ball,

[0043] 10-Second partition,

[0044] 20 - Elastic layer. Detailed Implementation

[0045] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the embodiments and accompanying drawings. The illustrative embodiments and descriptions of this utility model are only used to explain this utility model and are not intended to limit this utility model.

[0046] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0047] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly or indirectly attached to that other component. When a component is referred to as being "connected to" another component, it can be directly or indirectly connected to that other component.

[0048] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0049] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0050] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances. Example

[0051] This embodiment provides a ball milling device for injectable oxacillin sodium, such as... Figure 1 As shown, the device includes a support platform 1, a cylinder cover 4, and a cylinder body 6, primarily used for ball milling oxacillin sodium. A rotary motor 2 is located at one end of the upper surface of the support platform 1, and a support plate 3 is located at the other end. The support platform 1 can be cylindrical, rectangular, or other structures, depending on the application requirements. In this embodiment, for ease of description, the support platform 1 adopts a rectangular structure. The rotary motor 2 is located at one end of the upper surface of the support platform 1, and the support plate 3 is located at the other end. Multiple support columns 11 are located on the lower surface of the support platform 1, spaced apart sequentially along the extension direction of two adjacent sides of the lower surface of the support platform 1, thus stably supporting the support platform 1. Each support column 11 includes an upper column 111 and a lower column 112, which are coaxially arranged. The upper surface of the upper column 111 is located on the lower surface of the support platform 1, and the diameter of the lower column 112 is larger than that of the upper column 111, thus making the support of the support column 11 on the support platform 1 more stable. Figure 3 and Figure 6As shown, both the cover 4 and the cylinder body 6 are cylindrical, and the cover 4 and the cylinder body 6 are detachably connected. The cylinder body 6 has an inner cavity for grinding oxacillin sodium, and multiple ball mills 7 are installed within the inner cavity. The number of ball mills 7 can be increased or decreased according to usage requirements. One end of the cylinder body 6 has an opening with a diameter equal to that of the inner cavity for feeding and discharging. The other end is rotatably connected to a rotary motor 2, and the rotating shaft 5 of the rotary motor 2 is coaxially arranged with the cylinder body 6, thus causing the rotary motor 2 to drive the cylinder body 6 to rotate. The cover 4 is detachably located at the open end of the cylinder body 6, and the cover 4 and the cylinder body 6 are sealed together to prevent the oxacillin sodium powder from leaking out of the cylinder body 6. The cover 4 and the cylinder body 6 can be sealed using structures such as sealing rings or sealing rubber rings, which are existing technologies and will not be elaborated further. Figure 1 As shown, the side of the cylinder cover 4 away from the cylinder body 6 is connected to the support plate 3 via a rotating shaft 5, so that the cylinder body 6 can drive the cylinder cover 4 to rotate.

[0052] In this embodiment, as Figures 1-2 As shown, the inner wall of the cylinder 6 has multiple guide convex lines 61 arranged sequentially at intervals along the circumference of the inner wall of the cylinder 6. Both ends of the guide convex lines 61 are inclined in the opposite direction of the rotation direction of the cylinder 6 relative to their midpoints. Specifically, the two ends of the guide convex lines 61 are bent relative to their midpoints, and the bending direction is opposite to the rotation direction of the cylinder 6. The two ends of the guide convex lines 61 are respectively facing the two ends of the cylinder 6. When the cylinder 6 rotates, the grinding ball 7 in the inner cavity of the cylinder 6 undergoes centrifugal motion along the inner wall of the cylinder 6. When the grinding ball 7 moves to the guide convex line 61, the bent guide convex line 61 interacts with the grinding ball 7, causing the grinding ball 7 to shift towards the two ends of the cylinder 6. This causes the grinding ball 7 to collide with the end faces of the two ends of the cylinder 6, causing some of the sodium oxacillin attached to the two ends of the cylinder 6 to fall off and participate in the grinding. This makes the grinding of sodium oxacillin more thorough and the grinding efficiency higher. The two ends of the guide convex line 61 are at the same distance from the inner wall surfaces of the two ends of the cylinder 6 along the axial direction, so that the two ends of the cylinder 6 are uniformly impacted by the ball mill body 7.

[0053] In some embodiments, the height of the guide convex line 61 along the radial direction of the cylinder 6 is 1 / 10 to 1 / 15 of the diameter of the grinding ball 7, and the cross-section of the guide convex line 61 along the radial direction of the cylinder 6 is a circular arc surface. Specifically, in this embodiment, the height of the guide convex line 61 along the radial direction of the cylinder 6 is 1 / 10, so that the guide convex line 61 can effectively apply force to the grinding ball 7, and after the grinding ball 7 rotates to a certain height, it will fall along the curved surface of the guide convex line 61, thereby avoiding the guide convex line 61 being too high, which would prevent the grinding ball 7 from grinding in the center of the inner cavity of the cylinder 6.

[0054] In some embodiments, such as Figures 1-6As shown, the inner cavity of the cylinder 6 is provided with a detachable first partition 8, and the first partition 8 is located near the cylinder cover 4. One end of the guide convex line 61 is close to the first partition 8. The cylinder cover 4 has a cylindrical end 41 facing the cylinder 6, and the cylindrical end 41 is coaxial with the cylinder cover 4. The cylindrical end 41 is inserted into the inner cavity of the cylinder 6, and the end face of one end of the cylindrical end 41 abuts and fits against the first partition 8. The cylindrical end 41 is provided with a first vibration cavity 411. The first vibration cavity 411 adopts a frustum structure, and the end with the larger diameter abuts and fits against the first partition 8. The axis of the cylindrical end 41 passes through the two end cross-sections of the first vibration cavity 411. The first vibration chamber 411 is equipped with multiple vibrating balls 9. In this embodiment, when the cylinder 6 rotates, the vibrating balls 9 in the first vibration chamber 411 undergo centrifugal motion. Since the first vibration chamber 411 adopts a frustum structure and the larger end abuts against the first partition plate 8, the vibrating balls 9 move towards the first partition plate 8 by acting on the inclined inner wall of the first vibration chamber 411, thereby causing the first partition plate 8 to vibrate. This causes some of the sodium oxacillin attached to the first partition plate 8 to fall off and participate in the grinding, thus making the grinding of sodium oxacillin more thorough and the grinding efficiency higher.

[0055] In some embodiments, such as Figures 1-3 As shown, the inner cavity of the cylinder 6 is provided with a circumferential limiting platform 63. The outer edge of the side of the first partition 8 facing the second partition 10 abuts and fits against the side of the circumferential limiting platform 63. Specifically, the center of the circumferential limiting platform 63 has a large circular channel, so that the second partition 10 can directly contact the ball milling body 7. Under the action of the cylindrical end 41, the first partition 8 and the circumferential limiting platform 63 are pressed tightly and fit together, so that the connection is tight and prevents sodium oxacillin from entering the first vibration chamber 411. In this embodiment, after grinding is completed, the cylinder cover 4 is separated from the cylinder 6. Since there is no action of the cylindrical end 41, the first partition 8 can be easily removed, so that the sodium oxacillin in the cylinder 6 can be poured out.

[0056] In some embodiments, such as Figure 1 , Figure 2 and Figure 4 As shown, the inner cavity of the cylinder 6 is provided with a second partition 10, which is disposed opposite to the first partition 8 at both ends of the inner cavity of the cylinder 6. The other end of the guide convex line 61 is close to the second partition 10, so that the ball mill 7 can collide with the second partition 10, thereby causing the sodium oxacillin attached to the second partition 10 to fall off and participate in the grinding.

[0057] In this embodiment, a second vibration cavity 62 is provided between the second partition 10 and the inner wall of the other end of the inner cavity of the cylinder 6, and a plurality of vibrating balls 9 are provided in the second vibration cavity 62. The second vibration cavity 62 adopts a frustum structure, and the side of the second partition 10 facing the second vibration cavity 62 is on the same plane as the end face of the larger end of the second vibration cavity 62. This makes the inner wall of the second vibration cavity 62 inclined towards the second partition 10. As a result, when the cylinder 6 rotates, the vibrating balls 9 of the second vibration cavity 62 collide with the second partition 10 under the action of the second vibration cavity 62 and the cylinder 6, so that some of the sodium oxacillin attached to the second partition 10 falls off and participates in the grinding.

[0058] In some embodiments, such as Figures 1-2 As shown, the first partition 8 has an elastic layer 20 on the side facing the cylinder cover 4, and the second partition 10 has an elastic layer 20 on the side away from the first partition 8. This allows the vibrating ball 9 to move in the opposite direction after colliding with the elastic layer 20, and then collide again. This avoids a large number of balls accumulating near the first partition 8 or the second partition 10, and also prevents damage to the partition.

[0059] The elastic layer 20 can be made of rubber material.

[0060] The working principle of this device is as follows: When performing ball milling of oxacillin sodium, oxacillin sodium is placed into the cylinder 6, then the first partition 8 is installed inside the cylinder 6, and multiple vibrating balls 9 are placed into the first vibration chamber 411. The cylinder cover 4 is installed at the opening of the cylinder 6, so that the cylindrical end 41 of the cylinder cover 4 abuts against the first partition 8. Then, the rotating motor 2 is started, the cylinder 6 begins to rotate, and the ball milling body 7 performs ball milling. Under the action of the guide convex line 61, the ball milling body 7 contacts the first partition 8 or the second partition 10, and the vibrating balls 9 collide with the first partition 8 and the second partition 10, thereby causing the oxacillin sodium attached to the surfaces of the first partition 8 and the second partition 10 at both ends of the cylinder 6 to fall off and participate in the ball milling, thus making the ball milling of oxacillin sodium more thorough and efficient.

[0061] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of this utility model. It should be understood that the above description is only a specific embodiment of this utility model and is not intended to limit the scope of protection of this utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the scope of protection of this utility model.

Claims

1. A ball-milling device for oxacillin sodium for injection, characterized by, include: The support platform (1) has a rotating motor (2) at one end of its upper surface and a support plate (3) at the other end; The cylinder cover (4) is connected to the side of the support plate (3) facing the rotating motor (2) via a rotating shaft (5); A cylindrical body (6) is disposed on the upper side of the support platform (1), and a plurality of ball mill bodies (7) are provided in the inner cavity. One end of the cylindrical body (6) is connected to the rotating shaft (5) of the rotating motor (2), and the other end is detachably connected to the cylinder cover (4). A plurality of guide convex lines (61) are arranged at intervals along the circumferential inner wall of the cylindrical body (6). The two ends of the plurality of guide convex lines (61) are respectively close to the inner wall of one end of the axial direction of the cylindrical body (6) and the inner wall of one end of the axial direction of the cylinder cover (4). The two ends of the guide convex lines (61) are inclined in the opposite direction of the rotation direction of the cylindrical body (6) relative to the midpoint.

2. The ball milling apparatus according to claim 1, characterized in that, The two ends of the guide convex line (61) are respectively at the same distance from the inner wall surfaces of the two ends of the cylinder (6) in the axial direction.

3. A ball mill apparatus as claimed in claim 2, wherein, The height of the guide convex line (61) along the radial direction of the cylinder (6) is 1 / 10 of the diameter of the ball mill body (7).

4. A ball mill apparatus as claimed in claim 3, wherein, The cross-section of the guide convex line (61) along the radial direction of the cylinder (6) is a circular arc surface.

5. The ball mill apparatus of claim 1, wherein, The inner cavity of the cylinder (6) is provided with a detachable first partition (8), and the first partition (8) is located close to the cylinder cover (4); One end of the guide convex line (61) is close to the first partition plate (8). The end of the cylinder cover (4) facing the cylinder body (6) is provided with a cylindrical end (41), and the cylindrical end (41) is coaxial with the cylinder cover (4). The cylindrical end (41) is inserted into the inner cavity of the cylinder body (6) and is threadedly connected to the cylinder body (6). The end face of one end of the cylindrical end (41) abuts against and fits against the first partition plate (8).

6. A ball mill apparatus as claimed in claim 5, wherein, The cylindrical end (41) is provided with a first vibration cavity (411). The first vibration cavity (411) adopts a frustum structure, and the end with a larger diameter abuts against and fits against the first partition (8). The axis of the cylindrical end (41) passes through the center of the cross-section of the two ends of the first vibration cavity (411). The first vibration cavity (411) is provided with a plurality of vibrating balls (9).

7. The ball mill apparatus of claim 5, wherein, The inner cavity of the cylinder (6) is provided with a second partition (10), which is disposed opposite to the first partition (8) at both ends of the inner cavity of the cylinder (6), and the other end of the guide convex line (61) is close to the second partition (10); A second vibration chamber (62) is provided between the second partition (10) and the inner wall of the other end of the inner cavity of the cylinder (6), and a plurality of vibrating balls (9) are provided in the second vibration chamber (62).

8. A ball mill apparatus as claimed in claim 7, wherein, The second vibration cavity (62) adopts a frustum structure, and the side of the second partition (10) facing the second vibration cavity (62) is on the same plane as the end face of the larger end of the second vibration cavity (62).

9. The ball mill apparatus of claim 7, wherein, The inner cavity of the cylinder (6) is provided with a circumferential limiting platform (63), and the outer edge of the side of the first partition (8) facing the second partition (10) abuts against and fits against the side of the circumferential limiting platform (63).

10. A ball mill apparatus as claimed in claim 9, wherein, The first partition (8) has an elastic layer (20) on its side facing the cylinder cover (4). The second partition (10) has an elastic layer (20) on the side opposite to the first partition (8).

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