Lotus active peptide multifunctional medicine and food digital regulation and control intelligent manufacturing equipment

Abstract

The utility model relates to the technical field of food and medicine processing, in particular to lotus active peptide multifunctional medicine food digital regulation and control intelligent manufacturing equipment which comprises a raw material pretreatment device, an enzymolysis reaction device, a separation and purification device, an intelligent blending device and a sterile filling device which are sequentially connected through a conveying pipeline. The separation and purification device at least comprises a membrane separation unit and a chromatographic purification unit which are arranged in parallel, and is provided with an automatic valve group for switching fluid paths. By arranging the raw material pretreatment device, the enzymolysis reaction device, the separation and purification device, the intelligent blending device, the sterile filling device and the like, the raw material pretreatment device can be used for pretreating raw materials and then conveying the pretreated raw materials to the enzymolysis reaction device for reaction; when materials are purified and separated, a set of system can replace a plurality of traditional production lines through the separation and purification device with switchable modes and the flexible allocation device, so that the investment and the space are greatly saved, and the market change can be quickly responded.

Description

A multifunctional intelligent manufacturing equipment for the digital regulation of lotus active peptides in medicine and food Technical Field

[0001] This utility model relates to the field of food and pharmaceutical processing technology, specifically to a digitally controlled intelligent manufacturing equipment for lotus active peptide multifunctional pharmaceutical food. Background Technology

[0002] Lotus active peptides are a class of small molecule protein fragments extracted from various parts of the lotus. They have attracted attention due to their various potential health-promoting properties. Lotus active peptides represent a deep exploration of traditional medicinal and edible plants by modern science. With their high absorption rate and diverse biological activities, they have shown great application potential in the health industry and cosmetics field, especially in anti-oxidation, immune regulation, and anti-fatigue. Among them, lotus active peptides have a wide range of physiological functions, and their applications span both pharmaceutical and functional food fields.

[0003] However, existing production equipment has obvious limitations: pharmaceutical production lines focus on the extraction of high-purity single components, with large equipment investment, high energy consumption, and rigid processes, making them difficult to use for producing food products that emphasize the synergistic effects of multiple components; while food production lines are usually more extensive, lacking precise process monitoring and online quality inspection equipment, and cannot achieve targeted enrichment and precise control of specific functional components. Summary of the Invention

[0004] To address the aforementioned shortcomings of existing technologies, this invention provides a digitally controlled intelligent manufacturing equipment for lotus active peptides in pharmaceuticals and foods. This equipment effectively solves the problems of existing production lines that focus on the extraction of high-purity single components, resulting in large equipment investments, high energy consumption, and rigid processes, making it difficult to use for production emphasizing the synergistic effects of multiple components.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] This utility model provides a multifunctional drug and food digital control intelligent manufacturing equipment for lotus active peptides, including a raw material pretreatment device, an enzymatic reaction device, a separation and purification device, an intelligent blending device, and an aseptic filling device connected in sequence through a conveying pipeline. The separation and purification device is an integrated device with switchable working modes, including at least a membrane separation unit and a chromatography purification unit arranged in parallel, and is equipped with an automatic valve group for switching fluid paths. The intelligent blending device integrates at least one drug-food homology factor addition unit, which includes a precision metering pump and a raw material silo connected to it.

[0007] Furthermore, it also includes a central control platform, which includes a human-computer interaction interface, a data storage module, and a built-in association model.

[0008] Furthermore, it also includes a quality monitoring device, which includes an online peptide spectrum analyzer located at the outlet of the enzymatic hydrolysis reaction device and an online ultraviolet detector located at the outlet of the separation and purification device.

[0009] Furthermore, the enzymatic hydrolysis device is a dynamic enzymatic hydrolysis tank equipped with multiple independent enzyme solution addition ports, an online pH sensor, and an online temperature sensor.

[0010] Furthermore, the association model is a prediction model trained based on machine learning algorithms. Its input is connected to the historical process database in the data storage module, and its output is used to output the predicted value of the yield or activity of the target active ingredient.

[0011] Furthermore, the membrane separation unit is an ultrafiltration membrane module or a nanofiltration membrane module, the chromatography purification unit is a chromatography column system, and the automatic valve group is controlled by the central control platform to guide the material flow to the membrane separation unit or the chromatography purification unit according to the purity requirements of the target product.

[0012] Furthermore, the medicinal and edible homology factor adding unit comprises multiple units, each used to hold synergistic factors with different effects. The synergistic factors include at least one of hawthorn flavonoids, Ganoderma lucidum polysaccharides, Ginkgo biloba extract, and Astragalus polysaccharides.

[0013] Furthermore, it also includes a CIP (Clean-in-Place) online cleaning device, which is connected to each physical production unit via a cleaning pipe with spray balls.

[0014] The technical solution provided by this utility model has the following advantages compared with the known prior art:

[0015] I. This utility model, by setting up components such as a raw material pretreatment device, an enzymatic reaction device, a separation and purification device, an intelligent blending device, and an aseptic filling device, allows the raw materials to be pretreated by the raw material pretreatment device and then transported to the enzymatic reaction device for reaction. The materials are then separated by the separation and purification device, and the materials are processed by blending the material components before filling. During the purification and separation of materials, the system can replace multiple traditional production lines through the switchable separation and purification device and the flexible blending device, which can greatly save investment and space and respond quickly to market changes.

[0016] II. This utility model incorporates components such as a quality monitoring device, an addition port, an online pH sensor, and an online temperature sensor. Multiple independent enzyme addition ports allow for the addition of different types of enzymes in stages and as needed, simulating optimal enzymatic hydrolysis kinetics. Combined with online pH and temperature sensors, it enables real-time monitoring and automatic adjustment of the two most critical parameters affecting enzyme activity. An online peptide spectrum analyzer installed at the outlet of the enzymatic hydrolysis device can analyze the peptide distribution and molecular weight of the hydrolysis products in real time. An online ultraviolet detector can monitor the concentration and purity of the final product in real time. The online temperature sensor can detect the temperature of the material, ensuring that the temperature curves of each batch are completely identical. This greatly guarantees a high degree of consistency in the peptide composition and yield of the hydrolysis products between different batches. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 is a schematic diagram of the enzymatic hydrolysis reaction device of this utility model;

[0020] Figure 3 is a schematic diagram of the separation and purification device of this utility model.

[0021] Figure reference numerals: 1. Raw material pretreatment device; 2. Enzymatic hydrolysis reaction device; 21. Addition port; 22. Online pH sensor; 23. Online temperature sensor; 3. Separation and purification device; 31. Membrane separation unit; 32. Chromatographic purification unit; 33. Automatic valve group; 4. Intelligent mixing device; 41. Addition unit; 5. Aseptic filling device; 61. Online peptide spectrum analyzer; 62. Online ultraviolet detector; 7. CIP online cleaning device; 8. Central control platform. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0023] The present invention will be further described below with reference to the embodiments.

[0024] Referring to Figures 1-3, a multifunctional pharmaceutical and food digital control intelligent manufacturing equipment for lotus active peptides includes a raw material pretreatment device 1, an enzymatic hydrolysis reaction device 2, a separation and purification device 3, an intelligent blending device 4, and an aseptic filling device 5, connected sequentially via conveying pipelines. The separation and purification device 3 is an integrated device with switchable working modes, including at least a membrane separation unit 31 and a chromatography purification unit 32 arranged in parallel, and equipped with an automatic valve group 33 for switching fluid paths. The intelligent blending device 4 integrates at least one medicinal and food homologous factor addition unit 41, which includes a precision metering pump and a raw material silo connected thereto. The raw material pretreatment device 1 can perform preparatory work such as cleaning, crushing, homogenizing, sterilizing, or temperature control on the initial raw materials, so that the enzymatic hydrolysis reaction device 2 can utilize enzymes... As a biocatalyst, it can directionally decompose raw materials into the desired small molecules, allowing materials to flow through different pathways such as membrane separation or chromatography, greatly enhancing the flexibility and versatility of the production line. A precision metering pump accurately extracts and adds specific amounts of medicinal and edible homologous ingredients from the raw material silo, ensuring the stability of the composition, dosage, and efficacy of each batch of products. Aseptic filling device 5 is then used for filling. Through a switchable separation and purification device 3 and a flexible blending device, one system can replace multiple traditional production lines, significantly saving investment and space, and enabling rapid response to market changes. The central control platform 8 is also connected to a display terminal for displaying a three-dimensional virtual model of the physical system, allowing real-time display of equipment operating status and achieving virtual-real synchronization.

[0025] Referring to Figure 1, it also includes a central control platform 8, which includes a human-machine interface, a data storage module, and a built-in correlation model. It can continuously and stably record and save historical and real-time data from all sensors and devices, and present complex system information in a graphical and chart-based intuitive way. The correlation model is specifically a component-process-activity correlation model, which is the core of the intelligence of the central control platform 8. It can analyze the massive information in the data storage module and identify patterns, correlations, and trends that are difficult for the human eye to detect.

[0026] Referring to Figures 1-3, the device also includes a quality monitoring system. The quality monitoring system includes an online peptide spectrometer 61 located at the outlet of the enzymatic hydrolysis device 2 and an online ultraviolet detector 62 located at the outlet of the separation and purification device 3. The online peptide spectrometer 61, located at the outlet of the enzymatic hydrolysis device 2, can monitor the composition, molecular weight distribution, and characteristic spectra of peptides in the product after the enzymatic hydrolysis reaction. It can accurately determine whether the enzymatic hydrolysis reaction has reached the expected level, avoid insufficient or excessive reaction, and thus accurately control the reaction process to ensure product activity. The online ultraviolet detector 62, located at the outlet of the separation and purification device 3, can detect the concentration and purity of the target component in the purified product.

[0027] Furthermore, the correlation model is a predictive model trained based on machine learning algorithms. Its input is connected to the historical process database in the data storage module, and its output is used to output the predicted value of the yield or activity of the target active ingredient. The peptide spectrum data and ultraviolet absorption data generated in real time by the online peptide spectrum analyzer 61 and the online ultraviolet detector 62 are automatically transmitted to the data storage module of the central control platform 8, becoming valuable production big data. The model inputs real-time quality data and corresponding process parameters into the correlation model through optimization and self-learning. The model will continuously learn and optimize, and can automatically fine-tune the process parameters of the previous process based on the online detection results and the target value set by the model, forming a fully automatic quality detection closed loop.

[0028] Referring to Figures 1-3, the membrane separation unit 31 is an ultrafiltration membrane module or a nanofiltration membrane module, the chromatography purification unit 32 is a chromatography column system, and the automatic valve group 33 is controlled by the central control platform 8. The automatic valve group 33 acts as a physical switch for the material flow, receiving instructions from the central control platform 8 and dynamically guiding the material to the most suitable purification path. It is used to guide the material flow to the membrane separation unit 31 or the chromatography purification unit 32 according to the purity requirements of the target product. The membrane separation unit 31 can use ultrafiltration or nanofiltration membranes to quickly perform preliminary separation, desalting, and concentration of materials according to molecular size. It can efficiently remove most macromolecular impurities or small molecule salts, with large processing capacity, fast speed, and relatively low cost, laying a solid foundation for subsequent purification. The chromatography purification unit 32 can use the chromatography column system to achieve high-resolution and high-precision separation based on the slight differences in physicochemical properties between the target product and impurities. This is a key step in obtaining ultra-high purity products, especially suitable for separating substances with similar structures.

[0029] Referring to Figure 1, there are multiple medicinal and edible homology factor addition units 41, each used to hold synergistic factors with different effects. The synergistic factors include at least one of hawthorn flavonoids, Ganoderma lucidum polysaccharides, Ginkgo biloba extract, and Astragalus polysaccharides. Through the independent design and control of multiple addition units 41, the system can accurately calculate and add one or more specific synergistic factors according to different product design goals. This allows for rapid switching between the production of products with different effects on the same production system, greatly enhancing the flexibility of the production line and enabling rapid response to changes in market demand.

[0030] Referring to Figure 1, the system also includes a CIP online cleaning device 7. The CIP online cleaning device 7 is connected to each physical production unit through a cleaning pipe with spray balls. The CIP online cleaning device 7 uses cleaning agents, disinfectants, and pure water to perform a comprehensive and thorough automated cleaning of the inner surfaces of equipment such as enzymatic hydrolysis tanks, separation and purification units, and mixing tanks through a preset program. This completely eliminates the blind spots and uncertainties that may exist in manual cleaning, effectively prevents cross-contamination, and ensures that every batch of products meets the highest hygiene standards.

[0031] Working principle: After being cleaned and crushed by the raw material pretreatment device 1, the raw materials are sent to the enzymatic hydrolysis reaction device 2. The device is equipped with multiple enzyme solution addition ports 21, which can add different proteases according to a preset time sequence under the control of the central control platform 8. The online pH sensor 22 and the online temperature sensor 23 monitor the reaction environment in real time.

[0032] The enzymatic hydrolysate is then pumped into the separation and purification unit 3. When producing food-grade products, the digital twin system control platform 8 will instruct the automatic valve group 33 to open the pipeline leading to the membrane separation unit 31 and close the pipeline leading to the chromatography purification unit 32 for efficient and low-cost separation. When producing pharmaceutical-grade products, the valve group will switch the flow path, allowing the material to enter the chromatography purification unit 32 for fine purification to obtain a high-purity single component.

[0033] The purified lotus active peptides enter the intelligent mixing device 4. The medicinal and edible homology factor addition unit 41 integrated in the intelligent mixing device 4 takes out the synergistic factor from the specific raw material warehouse according to the instructions of the central control platform 8, and adds it to the tank in the optimized ratio through a precision metering pump to mix with the lotus active peptides.

[0034] Finally, the product is packaged by the aseptic filling device 5. Throughout the process, the online peptide spectrum analyzer 61 and online ultraviolet detector 62 of the quality monitoring device provide real-time quality data to the digital twin model central control platform 8 for process optimization and feedback control. The CIP online cleaning device 7 ensures hygiene and safety when switching between different products. The central control platform 8 is the control terminal of the entire system. Its built-in correlation model continuously learns from the data storage module. When the operator sets the product effect through the human-machine interface, the model can quickly calculate the optimal enzymatic hydrolysis, purification and formulation parameters and control the physical equipment to execute them. The three-dimensional virtual model displays the equipment operating status in real time on the display terminal, realizing virtual-real synchronization.

[0035] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the protection scope of the technical solutions of the embodiments of this utility model.

Claims

1. A multifunctional pharmaceutical and food digital control intelligent manufacturing equipment for lotus active peptides, comprising a raw material pretreatment device (1), an enzymatic hydrolysis reaction device (2), a separation and purification device (3), an intelligent blending device (4), and an aseptic filling device (5) connected sequentially via a conveying pipeline, characterized in that: The separation and purification device (3) is an integrated device with switchable working modes, including at least a membrane separation unit (31) and a chromatography purification unit (32) arranged in parallel, and is equipped with an automatic valve group (33) for switching fluid paths. The intelligent dispensing device (4) integrates at least one medicinal and edible homology factor addition unit (41), and the addition unit (41) includes a precision metering pump and a raw material silo connected thereto.

2. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 1, characterized in that, It also includes a central control platform (8), which includes a human-computer interaction interface, a data storage module and a built-in association model.

3. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 1, characterized in that, It also includes a quality monitoring device, which includes an online peptide spectrum analyzer (61) located at the outlet of the enzymatic hydrolysis reaction device (2) and an online ultraviolet detector (62) located at the outlet of the separation and purification device (3).

4. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 1, characterized in that, The enzymatic hydrolysis device (2) is a dynamic enzymatic hydrolysis tank equipped with multiple independent enzyme solution addition ports (21), an online pH sensor (22), and an online temperature sensor (23).

5. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 2, characterized in that, The correlation model is a prediction model trained based on machine learning algorithms. Its input is connected to the historical process database in the data storage module, and its output is used to output the predicted value of the yield or activity of the target active ingredient.

6. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 2, characterized in that, The membrane separation unit (31) is an ultrafiltration membrane module or a nanofiltration membrane module, the chromatography purification unit (32) is a chromatography column system, and the automatic valve group (33) is controlled by the central control platform (8) to guide the material flow to the membrane separation unit (31) or the chromatography purification unit (32) according to the purity requirements of the target product.

7. The intelligent manufacturing equipment for the digital control of lotus active peptides in pharmaceuticals and foods according to claim 1, characterized in that, The food-medicine homology factor addition unit (41) consists of multiple units, each used to hold synergistic factors with different effects. The synergistic factors include at least one of hawthorn flavonoids, Ganoderma lucidum polysaccharides, Ginkgo biloba extract, and Astragalus polysaccharides.

8. The intelligent manufacturing equipment for the digital control of lotus active peptide multifunctional pharmaceuticals and foods according to claim 1, characterized in that, It also includes a CIP online cleaning device (7), which is connected to each physical production device through a cleaning pipe with spray balls.

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