Sampling equipment for biological medicine production

Abstract

The utility model discloses sampling equipment for biological medicine production, which comprises a sampling tube, a connecting rod extending into the sampling tube is arranged in the middle of the top of the sampling tube, a piston attached to the inside of the sampling tube is arranged at the bottom of the connecting rod, and a mounting hole is formed in the side wall of the sampling tube. Through the structural design of a limiting sleeve block, a sleeve ring, a second spring, a mounting rod, a second L-shaped needle head, a fixing sleeve block, a fixing rod, a connecting pipe and a first L-shaped needle head, the second L-shaped needle head, the connecting pipe and the first L-shaped needle head can be conveniently detached and replaced by an operator at the same time, so that the operator can conveniently achieve the sampling function of different drugs in the same equipment in the later period; the sampling device is simple in structure and convenient to use, sampling multifunctionality and convenience of operators in the later period are improved, the disassembly and assembly mode of the structural design is convenient and fast, the operators only need to rotate the lantern ring, and convenience and flexibility of disassembly and assembly of the second L-shaped needle head, the connecting pipe and the first L-shaped needle head in the later period are improved.

Description

Technical Field

[0001] This utility model relates to the field of sampling technology in pharmaceutical production, specifically a sampling device for biopharmaceutical production. Background Technology

[0002] Medicines are special commodities for disease prevention and treatment. In order to protect people's health and ensure the quality of medicines, it is necessary to conduct random inspections of medicines. This is an effective tool for drug supervision. Medicines have a special status in national economic and social development and play an indispensable and irreplaceable role. Therefore, it is necessary to design a sampling device for biopharmaceutical production.

[0003] The patent application number "202022159827.0" describes "a sampling device for biopharmaceutical production, including a tube body, a sealing ring at the top of the tube body, an air groove inside the tube body, and a push-pull rod penetrating the sealing ring inside the air groove, a drain port penetrating the outer wall of the tube body on one side of the bottom of the air groove, and a drain plug at the end of the drain port away from the air groove, a first connecting needle at the bottom of the air groove, and a second connecting needle inside the tube body on one side of the first connecting needle; this utility model effectively solves the problem of multiple rapid sampling and preservation of drugs produced in the same batch during the pharmaceutical production process, avoiding the situation of inaccurate sampling caused by drug mixing due to multiple sampling, which is conducive to improving the accuracy of experimental data, while reducing the workload of staff and improving the work efficiency of staff."

[0004] However, the applicant believes that the above-mentioned sampling device has the following problems in use. First, the device can only replace and disassemble the detachable needle, but cannot disassemble the second connecting needle. This results in some drug liquid remaining in the second connecting needle during later sampling, making it impossible to sample different drug liquids at the same time. In addition, the installation steps of the sampling bottle of the above-mentioned sampling device are cumbersome, which affects the operation steps before later sampling and the sampling efficiency. Utility Model Content

[0005] The purpose of this invention is to provide a sampling device for biopharmaceutical production, which solves the problems of existing sampling devices being inconvenient for changing sampling needles, facilitating sampling operations between different samples, and having a cumbersome sampling bottle installation method that hinders rapid installation and affects subsequent sampling efficiency.

[0006] To achieve the above objectives, a sampling device for biopharmaceutical production is provided, comprising a sampling tube, a connecting rod extending into the middle of the top of the sampling tube, a piston fitting against the interior of the sampling tube at the bottom of the connecting rod, an installation hole in the side wall of the sampling tube, and a sampling installation groove in the bottom of the interior of the sampling tube, one end of the front of the sampling installation groove communicating with the outside of the sampling tube. A spring is provided in the middle of the bottom of the sampling installation groove, and a placement groove is installed on the top of the spring. A placement groove is placed inside the placement groove. The sampling bottle has a needle at the top center of the sampling mounting groove that communicates with the top of the sampling tube. The needle is inserted into and cooperates with the sampling bottle. An L-shaped needle two is inserted into the top of one side of the sampling mounting groove, and the bottom of the L-shaped needle two is inserted into one side of the top of the sampling bottle. A connecting tube is connected to the side of the L-shaped needle two away from the sampling tube. An L-shaped needle one is located at the bottom of the connecting tube near the sampling tube, and the L-shaped needle one is located at the middle of the bottom of the sampling tube. A disassembly assembly is located at the middle of the outer side of the sampling tube.

[0007] According to the sampling device for biopharmaceutical production, the assembly includes a fixed sleeve, a limiting sleeve, a collar, a second spring, a mounting rod, and a fixing rod. Two sets of fixed sleeves and limiting sleeves are provided. The two sets of fixed sleeves are installed at the top and bottom of the connecting tube away from the sampling tube. The two sets of limiting sleeves are installed at the middle position on both sides of the sampling tube. A collar is provided inside both sets of limiting sleeves, and the collar is fitted onto the outside of the sampling tube. A second spring connected to the limiting sleeve is fitted on the opposite ends of the collar. A mounting rod is provided at the bottom of one end of the collar near the connecting tube. A fixing rod is provided at the top and bottom of one end of the mounting rod, which is inserted into the fixed sleeve.

[0008] According to the sampling device for biopharmaceutical production, a groove is provided on the top of one side of the sampling mounting slot, and the groove is matched with an L-shaped needle.

[0009] According to the sampling device for biopharmaceutical production, the sampling tube has a sampling cavity at its inner top, and a connecting rod and a piston are installed inside the sampling cavity. The bottom of the sampling cavity has a needle extending into the sampling mounting groove.

[0010] According to the sampling device for biopharmaceutical production, the top of the sampling bottle is covered with a sealing plug, and the sealing plug is made of rubber.

[0011] According to the sampling device for biopharmaceutical production, a fixing block is provided at the middle position of both ends of the collar, and the fixing block is connected to the spring.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: Through the structural design of the limiting sleeve, collar, spring two, mounting rod, L-shaped needle two, fixing sleeve, fixing rod, connecting tube and L-shaped needle one, the operator can easily disassemble and replace L-shaped needle two, connecting tube and L-shaped needle one at the same time, so that the operator can realize the sampling function of different drugs with the same equipment, which increases the versatility and convenience of sampling for the operator. Moreover, the disassembly and assembly method of this structural design is relatively convenient, so that the operator only needs to rotate the collar, which increases the convenience and flexibility of disassembly and assembly of L-shaped needle two, connecting tube and L-shaped needle one.

[0013] Finally, the structural design of the groove, spring one, and sampling installation slot allows operators to easily place the sampling bottle. Furthermore, the elastic restoring force of spring one can also drive the sampling bottle to be inserted into the outside of the needle and L-shaped needle two, increasing the convenience and flexibility of the sampling bottle installation method and improving the sampling efficiency of the operator.

[0014] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0015] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0016] Figure 1 This is a three-dimensional structural diagram of a sampling device collar for biopharmaceutical production according to the present invention;

[0017] Figure 2 This is a three-dimensional structural diagram of a sampling device connecting tube for biopharmaceutical production according to the present invention.

[0018] Figure 3 This is a front sectional view of a sampling device for biopharmaceutical production according to the present invention.

[0019] Figure 4 This is a top view of a sampling device for biopharmaceutical production according to the present invention;

[0020] Figure 5 This is a bottom view of a sampling device for biopharmaceutical production according to the present invention;

[0021] Figure 6 This is a front view of a sampling device for biopharmaceutical production according to the present invention.

[0022] In the diagram: 1. Sampling tube; 2. Connecting rod; 3. Limiting sleeve; 4. Piston; 5. Needle; 6. Sampling bottle; 7. Placement groove; 8. Spring 1; 9. L-shaped needle 1; 10. Connecting tube; 11. Fixing rod; 12. Sampling mounting groove; 13. Fixing sleeve; 14. L-shaped needle 2; 15. Mounting rod; 16. Collar; 17. Spring 2; 18. Mounting hole. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-6 This utility model provides a technical solution: a sampling device for biopharmaceutical production, including a sampling tube 1, a connecting rod 2 extending into the middle of the top of the sampling tube 1, a piston 4 fitting against the interior of the sampling tube 1 at the bottom of the connecting rod 2, an installation hole 18 on the side wall of the sampling tube 1, and a sampling installation groove 12 at the bottom of the interior of the sampling tube 1. The installation hole 18 is located on the side wall of the sampling tube 1, allowing the sampling tube 1 to pass through the installation hole 18 and enter the interior of the sampling tube 1, thereby being placed inside the placement groove 7. The size of the installation hole 18 matches that of the sampling bottle 6, and one end of the front of the interior of the sampling installation groove 12 is connected to the outside of the sampling tube 1 through the installation hole 18. A spring 8 is located at the middle of the bottom of the sampling installation groove 12, and the placement groove 7 is installed on the top of the spring 8. The sampling bottle 6 is placed inside the placement groove 7. A needle 5 is provided at the middle position of the top of the sampling installation slot 12, which is connected to the top of the sampling tube 1. The needle 5 is inserted into the sampling bottle 6 and cooperates with it. An L-shaped needle 2 14 is inserted into the top of one side of the sampling installation slot 12, and the bottom of the L-shaped needle 2 14 is inserted into one side of the top of the sampling bottle 6. A connecting tube 10 is connected to the side of the L-shaped needle 2 14 away from the sampling tube 1. An L-shaped needle 1 9 is provided at the bottom of the connecting tube 10 near the sampling tube 1, and the L-shaped needle 1 9 is located at the middle position of the bottom of the sampling tube 1. A disassembly and assembly component is provided at the middle position of the outer side of the sampling tube 1. This solves the problem that the existing sampling equipment is not conducive to the replacement of the sampling needle tube, which is not conducive to the sampling operation between different samples in the later stage. At the same time, the installation method of the sampling bottle 6 is relatively cumbersome, which is not conducive to the rapid installation of the sampling bottle 6 in the later stage, thus affecting the sampling efficiency in the later stage.

[0025] The assembly / disassembly system includes a fixing sleeve 13, a limiting sleeve 3, a collar 16, a spring 17, a mounting rod 15, and a fixing rod 11. Both the fixing sleeve 13 and the limiting sleeve 3 have two sets. The two sets of fixing sleeves 13 are installed at the top and bottom of the connecting pipe 10 on the side away from the sampling pipe 1. The two sets of limiting sleeves 3 are installed at the middle positions on both sides of the sampling pipe 1. Both sets of limiting sleeves 3 have a collar 16 inside, which is fitted onto the outside of the sampling pipe 1. The two ends of the collar 16 are connected... On the opposite side, spring 17 connected to the limiting sleeve 3 is provided. On the back end of the collar 16, near the bottom of the connecting tube 10, there is a mounting rod 15. On the front end of the mounting rod 15, there are fixing rods 11 that are inserted into the fixing sleeve 13. Through the structural design of this component, the operator can quickly replace and disassemble the L-type needle 14, the connecting tube 10 and the L-type needle 9, which is convenient for sampling of different drugs.

[0026] A groove is provided on the top of one side of the sampling mounting slot 12, and the groove mates with the L-shaped needle 14. The groove facilitates the subsequent insertion of the L-shaped needle 14 into the sampling mounting slot 12, making it easier to connect the sampling bottle 6 to the L-shaped needle 14. A sampling cavity is provided at the top of the inner side of the sampling tube 1, and a connecting rod 2 and a piston 4 are installed inside the sampling cavity. A needle 5 extending into the sampling mounting slot 12 is provided at the bottom of the sampling cavity. The design facilitates the installation of the connecting rod 2, the limiting sleeve 3, and the needle 5, and also allows operators to easily extract air from the sampling bottle 6. The top of the sampling bottle 6 is covered with a sealing plug made of rubber, which facilitates sealing the inside of the sampling bottle 6 and allows for easy insertion of the needle 5 and the L-shaped needle 14. Fixing blocks are provided at the middle positions of both ends of the collar 16, and the fixing blocks are connected to the spring 17, which facilitates the fixed connection between the collar 16 and the spring 17.

[0027] Working principle: In use, the operator first presses the placement groove 7 down inside the sampling mounting slot 12 to compress the spring 8. Since the sampling mounting slot 12 is connected to the outside of the sampling tube 1, the operator can directly press the placement groove 7 through the sampling mounting slot 12, causing the placement groove 7 to move to the bottom of the sampling mounting slot 12. Then, the sampling bottle 6 is placed inside the placement groove 7 through the sampling mounting slot 12. Finally, the placement groove 7 is released, and the spring 8 returns to its original elastic state. The force can drive the sampling bottle 6 to move upward inside the sampling installation groove 12, and then the sampling bottle 6 will be inserted into the outside of the needle 5 and the L-shaped needle 14 when it moves upward, thus completing the installation operation of the sampling bottle 6, so as to improve the convenience and flexibility of subsequent installation and ensure the sampling efficiency. After the sampling is completed, the sampling bottle 6 can be removed by reversing the operation of the above components. The sampling installation groove 12 is used to move the sampling bottle 6 downward, and then the sampling bottle 6 can drive the placement groove 7 to move downward to install the spring 8.

[0028] Finally, by pulling the connecting rod 2, the piston 4 moves to the top of the sampling tube 1. Then, the air inside the sampling bottle 6 is drawn out by the needle 5 to form a negative pressure. Then, the negative pressure inside the sampling bottle 6 forms a suction force. Then, the pharmaceutical liquid sample can be extracted by the L-shaped needle 9, the connecting tube 10 and the L-shaped needle 14. The extracted sample can be directly stored inside the sampling bottle 6, thus completing the rapid sampling work.

[0029] When it is necessary to replace the L-shaped needle 19, connecting tube 10, and L-shaped needle 2 14 later, the operator can directly rotate the collar 16. This causes the collar 16 to rotate and move inside the limiting sleeve 3, compressing the spring 2 17. The rotation of the collar 16 also causes the mounting rod 15 and the fixing rod 11 to move simultaneously. This allows the mounting rod 15 to move the fixing rod 11 out of the fixing sleeve 13, thus releasing the fixing of the connecting tube 10, L-shaped needle 19, and L-shaped needle 2 14. Then, the operator can directly pull the connecting tube 10 to remove the L-shaped needle 19 and L-shaped needle 2 14 to the outside of the sampling tube 1, thus completing the replacement of the connecting tube 10 and the above components. This facilitates the sampling of different medical samples later. Finally, the installation and connection of the connecting tube 10 and the above components can be completed by reversing the above steps.

[0030] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A sampling device for biopharmaceutical production, comprising a sampling tube (1), characterized in that, A connecting rod (2) extending into the middle of the top of the sampling tube (1) is provided. A piston (4) fitting into the interior of the sampling tube (1) is provided at the bottom of the connecting rod (2). An installation hole (18) is provided on the side wall of the sampling tube (1). A sampling installation groove (12) is provided at the bottom of the interior of the sampling tube (1), and one end of the front of the sampling installation groove (12) is connected to the outside of the sampling tube (1). A spring (8) is provided at the middle of the bottom of the sampling installation groove (12). A placement groove (7) is installed on the top of the spring (8). A sampling bottle (6) is placed inside the placement groove (7). The top of the sampling installation groove (12)... A needle (5) is provided at the middle position and communicates with the top of the sampling tube (1). The needle (5) is inserted into the sampling bottle (6) and cooperates with it. An L-shaped needle (2) is inserted into the top of one side of the sampling installation groove (12). The bottom of the L-shaped needle (2) is inserted into one side of the top of the sampling bottle (6). A connecting tube (10) is connected to the side of the L-shaped needle (2) away from the sampling tube (1). An L-shaped needle (9) is provided at the bottom of the connecting tube (1) near the sampling tube (1). The L-shaped needle (9) is located at the middle position of the bottom of the sampling tube (1). A disassembly assembly is provided at the middle position of the outside of the sampling tube (1).

2. The sampling device for biopharmaceutical production as described in claim 1, characterized in that: The assembly / disassembly assembly includes a fixing sleeve (13), a limiting sleeve (3), a collar (16), a second spring (17), a mounting rod (15), and a fixing rod (11). Both the fixing sleeve (13) and the limiting sleeve (3) are provided in two sets. The two sets of fixing sleeves (13) are installed at the top and bottom of the connecting pipe (10) on the side away from the sampling pipe (1). The two sets of limiting sleeves (3) are installed at the middle positions on both sides of the sampling pipe (1). (3) has a collar (16) inside, and the collar (16) is fitted on the outside of the sampling tube (1). The two ends of the collar (16) are respectively fitted with springs (17) connected to the limiting sleeve (3). The bottom of the back end of the collar (16) is provided with an installation rod (15) near the connecting tube (10). The top and bottom of the front end of the installation rod (15) are respectively provided with fixing rods (11) that are inserted into the fixing sleeve (13).

3. The sampling device for biopharmaceutical production as described in claim 1, characterized in that: The top of one side of the sampling mounting groove (12) is provided with a groove, and the groove is matched with the L-shaped needle (14).

4. A sampling device for biopharmaceutical production as described in claim 1, characterized in that: The sampling tube (1) has a sampling cavity at its inner top, and a connecting rod (2) and a piston (4) are installed inside the sampling cavity. The bottom of the sampling cavity has a needle (5) that extends into the sampling mounting groove (12).

5. A sampling device for biopharmaceutical production as described in claim 1, characterized in that: The top of the sampling bottle (6) is covered with a sealing plug, and the sealing plug is made of rubber.

6. A sampling device for biopharmaceutical production as described in claim 2, characterized in that: The collar (16) is provided with a fixing block at the middle position of both ends, and the fixing block is connected to the second spring (17).

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