Novel tumor tissue fine grinding device

Abstract

The utility model discloses a novel tumor tissue fine grinding device, and particularly relates to the field of tumor grinding, the novel tumor tissue fine grinding device comprises a processing cylinder, the left side of the top of the processing cylinder is fixedly communicated with an inlet pipe, a grinding mechanism is arranged in the processing cylinder, and the grinding mechanism comprises a motor fixedly connected to the top of the processing cylinder; the output end of the motor is fixedly connected with a rotating rod rotationally connected with the top of the inner side of the processing barrel. The output end of the motor drives the rotating rod to rotate, so that the rotating blade, the umbrella-shaped blade and the arc-shaped block are driven to rotate, if tumor tissue is large, the tumor tissue is cut into blocks by the rotating blade, and the blocky tumor tissue slides outwards along the surface of the arc-shaped umbrella body and is further cut by the rotating tool noses until the tumor block is smaller than the distance between the two adjacent tool noses. And when the tumor tissue is ground, the tumor tissue falls into the filter screen below and is impacted and rubbed into fine particles by the grinding beads rolling along the surface of the filter screen below the rotating arc-shaped block, so that the effect of quickly and finely grinding the tumor tissue is achieved.

Description

Technical Field

[0001] This utility model relates to the field of tumor grinding technology, specifically a novel device for fine grinding of tumor tissue. Background Technology

[0002] Tumor tissue grinding is a cornerstone procedure in tumor medical research and clinical testing. Grinding breaks down the cellular structure of tumor tissue, releasing intracellular biomolecules such as nucleic acids and proteins, providing a basic sample for gene sequencing and proteomic analysis. Simultaneously, it prepares high-quality single-cell suspensions, facilitating the analysis of tumor heterogeneity using cutting-edge technologies such as flow cytometry and single-cell sequencing. Its accuracy and efficiency directly affect the reliability of subsequent experiments, and are of crucial significance for research on tumor pathogenesis, targeted drug development, and clinical pathological diagnosis.

[0003] Chinese patent publication number CN216172903U discloses a novel fine grinding device for tumor tissue, filed on November 3, 2021. This patented technology utilizes a second grinding chamber with a bottom circular shape, a diameter of [number] cm, and a height of [number] cm. A tumor tissue sample measuring 1 cm x 1 cm x 1 cm can be placed inside the second grinding chamber. A rotating shaft is then inserted into the second grinding chamber, with the lower end face of the outer shell contacting the upper end face of the first grinding chamber. Pressing the start button activates a motor that drives the rotating shaft, which in turn drives the blade below to grind the tumor tissue sample inside the second grinding chamber. Because the second grinding chamber is small, the movement range of the tumor tissue sample is limited, allowing for thorough grinding of small tumor samples. However, this device relies solely on a single rotating blade to grind the tumor tissue. During processing, the blade can quickly cut the tumor, breaking it into fragments. However, the blade is insufficient to grind these fragments, resulting in a prolonged grinding time and unsatisfactory grinding results. Therefore, the inventors have provided a novel fine grinding device for tumor tissue to solve the problems mentioned in the background art. Utility Model Content

[0004] The purpose of this invention is to provide a novel device for fine grinding of tumor tissue, thereby achieving the effect of rapid and fine grinding of tumor tissue.

[0005] The objective of this utility model can be achieved through the following technical solutions:

[0006] A novel fine grinding device for tumor tissue includes a processing cylinder. An inlet pipe is fixedly connected to the top left side of the processing cylinder. A grinding mechanism is provided inside the processing cylinder. The grinding mechanism includes a motor fixedly connected to the top of the processing cylinder. A rotating rod that can be rotatably connected to the top of the inner side of the processing cylinder is fixedly connected to the output end of the motor. A rotating blade, an umbrella-shaped blade, and an arc-shaped block are fixedly connected from top to bottom on the outer side of the rotating rod. Multiple sets of grinding beads are fixedly installed at the bottom of the arc-shaped block.

[0007] As a further embodiment of this utility model: the umbrella-shaped blade includes an arc-shaped umbrella body fixedly connected to the rotating rod, and a set of blade tips arranged in a circle fixedly connected to the outer side of the arc-shaped umbrella body.

[0008] As a further improvement of this utility model: the bottom of the processing cylinder is connected to a receiving cylinder through an installation and removal mechanism, and an annular gap is opened at the bottom of the processing cylinder, and a filter screen is provided in the gap, with the filter screen in contact with the surface of the grinding beads.

[0009] As a further embodiment of this utility model: the installation and dismantling mechanism includes a connecting ring fixedly connected to the top of the receiving cylinder, and a set of positioning grooves are provided on the outer side of the connecting ring; a set of circumferentially arranged fixing grooves are provided on the outer side of the bottom notch of the processing cylinder, and a positioning block adapted to the cross section of the fixing groove is slidably connected inside the fixing groove.

[0010] As a further embodiment of this utility model: a pair of connecting posts arranged in a left-right pattern are fixedly connected to the top of the connecting ring, through holes are opened on the top left and right sides of the filter screen, and a docking groove adapted to the connecting posts is opened at the top of the bottom notch of the processing cylinder.

[0011] As a further embodiment of this utility model: a support spring is fixedly connected to the outer side of the positioning block, and the outer side of the support spring is fixedly connected to the fixing groove; a pair of vertically mirror-symmetrical annular guide rails are fixedly connected to the outer side of the processing cylinder, and a rotating ring is slidably connected inside the two annular guide rails; a connecting rope is fixedly connected to the outer side of a set of positioning blocks, and the outer side of the connecting rope passes through the fixing groove and is fixedly connected to the rotating ring.

[0012] As a further improvement of this utility model, the inner surface of the positioning block has an arc-shaped design that gradually lengthens from bottom to top.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] This novel tumor tissue fine grinding device uses a motor output to drive a rotating rod, which in turn drives a rotating blade, an umbrella-shaped blade, and an arc-shaped block to rotate. If the tumor tissue is large, it will first be cut into pieces by the rotating blade. The pieces of tumor tissue slide outward along the surface of the arc-shaped umbrella and are further cut by the rotating blade tip until the tumor piece is smaller than the distance between two adjacent blade tips. Then, it falls into the filter screen below and is impacted and rubbed into fine particles by the grinding beads rolling along the surface of the filter screen below the rotating arc-shaped block, thereby achieving the effect of rapid and fine grinding of tumor tissue.

[0015] Furthermore, during installation, this novel tumor tissue fine grinding device features a unique design. The connecting ring's boundary contacts the positioning block, and the contact force causes the positioning block to move deeper into the fixing groove, compressing the support spring until the positioning groove and positioning block are aligned. The support spring then rebounds, moving the positioning block inwards into the positioning groove, thus completing the fixed installation of the receiving cylinder and simultaneously installing the filter screen. When the receiving cylinder needs to be removed, rotating the rotating ring pulls the connecting rope, causing the positioning block to detach from the positioning groove. The processing cylinder is then lifted, disengaging the connecting column from the docking groove, separating the filter screen and receiving cylinder from the processing cylinder, and finally removing the filter screen. This design facilitates convenient installation and removal of the filter screen. Attached Figure Description

[0016] Figure 1 A schematic diagram of the overall structure of a novel fine grinding device for tumor tissue;

[0017] Figure 2 This is a schematic cross-sectional view of the overall structure of a novel tumor tissue fine grinding device.

[0018] Figure 3 This is a schematic diagram of the internal structure of the processing cylinder in a novel tumor tissue fine grinding device.

[0019] Figure 4 In a novel fine grinding device for tumor tissue Figure 2 Enlarged schematic diagram of the structure at point A in the middle.

[0020] In the diagram: 10. Processing cylinder; 11. Receiving cylinder; 12. Inlet pipe; 20. Grinding mechanism; 201. Motor; 202. Rotating rod; 203. Rotating blade; 204. Umbrella-shaped blade; 2041. Arc-shaped umbrella body;

[0021] 2042, blade tip; 205, curved block; 206, grinding bead; 207, filter screen; 30, installation / removal mechanism;

[0022] 301. Connecting ring; 302. Positioning groove; 303. Connecting post; 304. Butt joint groove; 305. Fixing groove;

[0023] 306. Support spring; 307. Positioning block; 308. Circular guide rail; 309. Rotary ring; 310. Connecting rope. Detailed Implementation

[0024] like Figures 1-4 As shown, a novel fine grinding device for tumor tissue includes a processing cylinder 10. An inlet pipe 12 is fixedly connected to the top left side of the processing cylinder 10. A grinding mechanism 20 is provided inside the processing cylinder 10. The grinding mechanism 20 includes a motor 201 fixedly connected to the top of the processing cylinder 10. A rotating rod 202, which is rotatably connected to the top of the inner side of the processing cylinder 10, is fixedly connected to the output end of the motor 201. A rotating blade 203, an umbrella-shaped blade 204, and an arc-shaped block 205 are fixedly connected from top to bottom on the outer side of the rotating rod 202. Multiple sets of grinding beads 206 are fixedly installed at the bottom of the arc-shaped block 205.

[0025] Preferably, the umbrella-shaped blade 204 includes an arc-shaped umbrella body 2041 fixedly connected to the rotating rod 202, and a set of circumferentially arranged blade tips 2042 are fixedly connected to the outer side of the arc-shaped umbrella body 2041.

[0026] Furthermore, the bottom of the processing cylinder 10 is connected to a receiving cylinder 11 via a disassembly mechanism 30. The bottom of the processing cylinder 10 has an annular opening, and a filter screen 207 is provided in the opening. The filter screen 207 is in contact with the surface of the grinding beads 206.

[0027] In use, the tumor tissue is first inserted into the processing cylinder 10 through the inlet tube 12. The tumor tissue falls onto the top of the arc-shaped umbrella body 2041. Then, the motor 201 is started by an external power supply. The output end of the motor 201 drives the rotating rod 202 to rotate, thereby driving the rotating blade 203, the umbrella-shaped blade 204, and the arc-shaped block 205 to rotate. If the tumor tissue is large, it will first be cut into blocks by the rotating blade 203. The blocks of tumor tissue slide outward along the surface of the arc-shaped umbrella body 2041 and are then fed into the rotating blade tip 2042. The tumor tissue is cut in one step until it is smaller than the distance between two adjacent blade tips 2042. When the tumor tissue falls onto the surface of the filter screen 207 below, the fragments will gather towards the center of the filter screen 207. The fragments will be impacted and rubbed into fine particles by the grinding beads 206 rolling along the surface of the filter screen 207 below the rotating arc block 205. The fragmented tumor tissue falls into the receiving cylinder 11 through the filter screen 207. The receiving cylinder 11 is then removed by the disassembly and reassembly mechanism 30.

[0028] When the above device is used, since tumor tissue needs to be screened by the filter screen 207, tumor tissue will remain on the top surface of the filter screen 207. In order to facilitate the replacement and cleaning of the filter screen 207, an installation and removal mechanism 30 is proposed.

[0029] refer to Figure 2 Figure 4 The installation and dismantling mechanism 30 includes a connecting ring 301 fixedly connected to the top of the receiving cylinder 11, and a set of positioning grooves 302 are provided on the outer side of the connecting ring 301; a set of circumferentially arranged fixing grooves 305 are provided on the outer side of the bottom notch of the processing cylinder 10, and a positioning block 307 adapted to the cross section of the fixing groove 305 is slidably connected inside the fixing groove 305.

[0030] Preferably, a pair of connecting posts 303 arranged in a left-right arrangement are fixedly connected to the top of the connecting ring 301, and through holes are respectively opened on the top left and right sides of the filter screen 207. The bottom notch of the processing cylinder 10 is provided with a docking groove 304 that is adapted to the connecting posts 303.

[0031] Specifically, a support spring 306 is fixedly connected to the outer side of the positioning block 307, and the outer side of the support spring 306 is fixedly connected to the fixing groove 305; a pair of vertically mirror-symmetrical annular guide rails 308 are fixedly connected to the outer side of the processing cylinder 10, and a rotating ring 309 is slidably connected inside the two annular guide rails 308; a connecting rope 310 is fixedly connected to the outer side of a set of positioning blocks 307, and the outer side of the connecting rope 310 passes through the fixing groove 305 and is fixedly connected to the rotating ring 309.

[0032] Preferably, the inner surface of the positioning block 307 has an arc-shaped design that gradually lengthens from bottom to top.

[0033] During installation, the filter screen 207 is first installed on the top of the receiving cylinder 11 by inserting it into the connecting post 303 through the through hole. Then, the receiving cylinder 11 is fixedly installed to the processing cylinder 10 by inserting the connecting post 303 into the docking groove 304. During installation, the boundary of the connecting ring 301 contacts the positioning block 307. The contact force causes the positioning block 307 to move deeper into the fixing groove 305 and compresses the support spring 306 until the positioning groove 302 and the positioning block 307 are aligned, thereby allowing the support spring 306 to rebound. The movable positioning block 307 moves inward and inserts into the positioning groove 302, thereby completing the fixed installation of the receiving cylinder 11 and the installation of the filter screen 207. When it is necessary to remove the receiving cylinder 11, the rotating ring 309 is rotated, which pulls the connecting rope 310, thereby causing the positioning block 307 to disengage from the positioning groove 302. Then, the processing cylinder 10 is lifted, thereby disengaging the connecting column 303 from the docking groove 304, and separating the filter screen 207 and the receiving cylinder 11 from the processing cylinder 10. Then, the filter screen 207 can be removed. This achieves the effect of convenient installation and disassembly of the filter screen 207.

[0034] The working principle of this invention is as follows: First, the tumor tissue is inserted into the processing cylinder 10 through the inlet tube 12. The tumor tissue falls on the top of the arc-shaped umbrella body 2041. Then, the motor 201 is started by an external power supply. The output end of the motor 201 drives the rotating rod 202 to rotate, thereby driving the rotating blade 203, the umbrella-shaped blade 204, and the arc-shaped block 205 to rotate. If the tumor tissue is large, it will first be cut into blocks by the rotating blade 203. The blocks of tumor tissue slide outward along the surface of the arc-shaped umbrella body 2041 and are rotated by the tip of the blade 20. 42 Further cutting until the tumor fragment is smaller than the distance between two adjacent blade tips 2042, it will fall onto the surface of the filter screen 207 below. Since the filter screen 207 is an inwardly concave arc shape, the fragments will gather towards the center of the filter screen 207 and be impacted and rubbed into fine particles by the grinding beads 206 rolling along the surface of the filter screen 207 below the rotating arc block 205. The fragmented tumor tissue falls into the receiving cylinder 11 through the filter screen 207, and then the receiving cylinder 11 is removed by the disassembly and reassembly mechanism 30.

[0035] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. A novel fine grinding device for tumor tissue, comprising a processing cylinder (10), wherein an inlet tube (12) is fixedly connected to the top left side of the processing cylinder (10), characterized in that, The processing cylinder (10) is equipped with a grinding mechanism (20). The grinding mechanism (20) includes a motor (201) fixedly connected to the top of the processing cylinder (10). The output end of the motor (201) is fixedly connected to a rotating rod (202) that can be rotatably connected to the top of the inner side of the processing cylinder (10). Rotating blades (203), umbrella-shaped blades (204), and arc-shaped blocks (205) are fixedly connected to the outer side of the rotating rod (202) from top to bottom. Multiple sets of grinding beads (206) are fixedly installed at the bottom of the arc-shaped block (205).

2. The novel tumor tissue fine grinding device according to claim 1, characterized in that, The umbrella-shaped blade (204) includes an arc-shaped umbrella body (2041) fixedly connected to the rotating rod (202), and a set of blade tips (2042) arranged in a circle are fixedly connected to the outer side of the arc-shaped umbrella body (2041).

3. The novel tumor tissue fine grinding device according to claim 1, characterized in that, The bottom of the processing cylinder (10) is connected to the receiving cylinder (11) through the installation and removal mechanism (30). The bottom of the processing cylinder (10) has an annular opening and a filter screen (207) is provided in the opening. The filter screen (207) is in contact with the surface of the grinding beads (206).

4. The novel tumor tissue fine grinding device according to claim 3, characterized in that, The installation and removal mechanism (30) includes a connecting ring (301) fixedly connected to the top of the receiving cylinder (11), and a set of positioning grooves (302) are provided on the outer side of the connecting ring (301); a set of circumferentially arranged fixing grooves (305) are provided on the outer side of the bottom notch of the processing cylinder (10), and a positioning block (307) adapted to the cross section of the fixing groove (305) is slidably connected inside the fixing groove (305).

5. The novel tumor tissue fine grinding device according to claim 4, characterized in that, The top of the connecting ring (301) is fixedly connected to a pair of connecting posts (303) arranged in a left-right pattern. The top left and right sides of the filter screen (207) are respectively provided with through holes. The bottom notch of the processing cylinder (10) is provided with a docking groove (304) that matches the connecting posts (303).

6. The novel tumor tissue fine grinding device according to claim 4, characterized in that, A support spring (306) is fixedly connected to the outer side of the positioning block (307), and the outer side of the support spring (306) is fixedly connected to the fixing groove (305); a pair of vertically mirror-symmetrical annular guide rails (308) are fixedly connected to the outer side of the processing cylinder (10), and a rotating ring (309) is slidably connected inside the two annular guide rails (308); a connecting rope (310) is fixedly connected to the outer side of a set of positioning blocks (307), and the outer side of the connecting rope (310) passes through the fixing groove (305) and is fixedly connected to the rotating ring (309).

7. The novel tumor tissue fine grinding device according to claim 6, characterized in that, The inner surface of the positioning block (307) has an arc-shaped design that gradually lengthens from bottom to top.

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