Research and development experiment device for biological detection chip

Abstract

The utility model discloses a research and development experiment device for a biological detection chip, which belongs to the field of biological detection chip production and comprises a support frame, an experiment table is fixed at the top of the support frame, an experiment mechanism is arranged at the top of the experiment table, and a limiting mechanism for fixing the chip is further arranged at the top of the experiment table. A cleaning mechanism is arranged on the supporting frame and comprises a connecting frame arranged above the experiment table, a rotating pipe is rotationally arranged on the connecting frame through a bearing, the bottom end of the rotating pipe is communicated with a circular shell, and micro nozzles are communicated with the inner wall of the circular shell in a linear array mode. Through the arrangement of the cleaning mechanism, the effect of automatically and efficiently cleaning the detection probe is achieved, a liquid suction pump conveys cleaning liquid in a liquid storage cylinder to a circular shell through a hose, the cleaning liquid is sprayed out through a micro nozzle, the height of a connecting frame is adjusted in cooperation with a second electric push rod, the detection probe can be washed in all directions without being manually disassembled, and the detection efficiency is improved. The cleaning efficiency is greatly improved, and the manual operation cost is reduced.

Description

Technical Field

[0001] This utility model relates to the field of biological detection chip manufacturing technology, and in particular to a research and development experimental device for biological detection chips. Background Technology

[0002] In the field of life science and medical research, biochips have become key tools in disease diagnosis, gene analysis, and drug development due to their advantages of high throughput, high sensitivity, and rapid detection. In the research and development of biochips, the detection probe, as the core component for acquiring biological sample information, directly affects the validity of experimental results due to its accuracy and reliability. It is crucial to clean the detection probe promptly and thoroughly after each experiment. This not only avoids cross-contamination caused by sample residues but also extends the lifespan of the probe and ensures the accuracy of subsequent experimental data.

[0003] However, existing biodetection chip research and development experimental devices have many shortcomings in probe cleaning. Traditional cleaning methods mostly rely on manual operation. Experimenters need to manually remove the probe from the device and then clean it by soaking, rinsing and other methods. The whole process is cumbersome and time-consuming, which seriously affects experimental efficiency. Utility Model Content

[0004] The purpose of this invention is to solve the problem that in the existing technology, the cleaning method mostly relies on manual operation. Experimenters need to manually disassemble the probe from the device and then clean it by soaking, rinsing and other methods. The whole process is cumbersome and time-consuming, which seriously affects the experimental efficiency. Therefore, this invention proposes a research and development experimental device for biological detection chips.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A research and development experimental device for bio-detection chips includes a support frame, an experimental stage fixed to the top of the support frame, an experimental mechanism on the top of the experimental stage, a limiting mechanism for fixing the chip on the top of the experimental stage, a cleaning mechanism on the support frame, the cleaning mechanism including a connecting frame above the experimental stage, a rotating tube rotatably mounted on the connecting frame via bearings, the bottom end of the rotating tube connected to a circular shell, the inner wall of the circular shell being connected to micro-nozzles in a linear array, a liquid aspiration pump fixed to the support frame, a liquid storage cylinder fixed to the support frame, the inlet end of the liquid aspiration pump connected to the liquid storage cylinder via a first flexible tube, the outlet end of the liquid aspiration pump connected to a second flexible tube, the end of the second flexible tube away from the liquid aspiration pump connected to the rotating tube via a rotary joint.

[0007] Preferably, the cleaning mechanism further includes a mounting bracket fixed to the top wall of the support frame, on which an electric push rod II is mounted, and the bottom end of the extension rod of the electric push rod II is fixedly connected to the connecting frame.

[0008] Preferably, the connecting frame is provided with an adjustment mechanism, the adjustment mechanism includes a motor fixed on the connecting frame, a drive gear fixed to the output shaft end of the motor, a driven gear meshing with the outer surface of the drive gear, and the driven gear fixed to the outer surface of the rotating tube.

[0009] Preferably, the experimental mechanism includes a detection slot on the top of the experimental platform, a cylinder is fixed inside the detection slot, a detection probe is installed inside the cylinder, and the detection probe is electrically connected to an external biosignal analyzer.

[0010] Preferably, the outer surface of the cylinder is connected to a liquid outlet pipe, and a valve is installed on the liquid outlet pipe.

[0011] Preferably, the limiting mechanism includes a mounting block fixed to the top of the experimental platform, an electric push rod is fixed to the top of the mounting block, and a pressure plate is fixed to the bottom end of the extension rod of the electric push rod.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. The cleaning mechanism enables automated and efficient cleaning of the detection probes. The suction pump delivers the cleaning solution from the storage tank to the circular shell through a hose, and then sprays it out through a micro nozzle. With the help of the electric push rod to adjust the height of the connecting frame, the detection probes can be rinsed in all directions without manual disassembly, which greatly improves cleaning efficiency and reduces manual operation costs.

[0014] 2. By adjusting the mechanism, the cleaning range and angle can be flexibly adjusted. The motor drives the active gear to rotate, which in turn drives the driven gear and the rotating tube to rotate, so that the circular shell and the micro nozzle spray the cleaning fluid at different angles and trajectories. This allows for personalized cleaning of detection probes of different specifications and shapes, ensuring that there are no dead angles in the cleaning, improving the cleaning effect and the applicability of the experimental device. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural schematic diagram of a research and development experimental device for a biological detection chip proposed in this utility model;

[0016] Figure 2 This is a front view of the overall structure of an experimental device for the research and development of biological detection chips proposed in this utility model.

[0017] Figure 3 This invention proposes a research and development experimental device for biodetection chips. Figure 2 Enlarged view of the structure at point A in the middle;

[0018] Figure 4 This is a top view of the experimental platform structure of a research and development experimental device for biological detection chips proposed in this utility model.

[0019] Figure 5 This invention proposes a research and development experimental device for biodetection chips. Figure 4 Enlarged view of the structure at point B in the middle;

[0020] Figure 6 This is an internal view of the circular shell structure of a research and development experimental device for biological detection chips proposed in this utility model.

[0021] In the diagram: 1. Support frame; 2. Experimental table; 31. Detection tank; 32. Cylinder; 33. Detection probe; 34. Liquid outlet pipe; 35. Valve; 41. Mounting block; 42. Electric actuator one; 43. Pressure plate; 50. Liquid storage cylinder; 51. Mounting frame; 52. Electric actuator two; 53. Connecting frame; 54. Rotary tube; 55. Circular shell; 56. Miniature nozzle; 57. Liquid suction pump; 58. Hoses one; 59. Hoses two; 61. Motor; 62. Driving gear; 63. Driven gear. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0023] Example 1

[0024] Reference Figures 1-6 A research and development experimental device for biological detection chips includes a support frame 1, an experimental platform 2 fixed to the top of the support frame 1, an experimental mechanism on the top of the experimental platform 2, and a limiting mechanism for fixing the chip on the top of the experimental platform 2. A cleaning mechanism is provided on the support frame 1, including a connecting frame 53 above the experimental platform 2. A rotating tube 54 is rotatably mounted on the connecting frame 53 via a bearing. The bottom end of the rotating tube 54 is connected to a circular shell 55. The inner wall of the circular shell 55 is connected to a linear array of micro-nozzles 56. A liquid suction pump 57 is fixed on the support frame 1, and a liquid storage cylinder 50 is also fixed on the support frame 1. The inlet end of the liquid suction pump 57 is connected to the liquid storage cylinder 50 via a first hose 58, and the outlet end of the liquid suction pump 57 is connected to a second hose 59. The end of the second hose 59 away from the liquid suction pump 57 is connected to the rotating tube 54 via a rotary joint.

[0025] Furthermore, the cleaning mechanism also includes a mounting bracket 51 fixed to the top wall of the support frame 1. An electric push rod 52 is mounted on the mounting bracket 51, and the bottom end of the extension rod of the electric push rod 52 is fixedly connected to the connecting frame 53.

[0026] Furthermore, the experimental apparatus includes a detection slot 31 located on the top of the experimental platform 2, a cylinder 32 fixed inside the detection slot 31, a detection probe 33 installed inside the cylinder 32, and the detection probe 33 electrically connected to an external biosignal analyzer.

[0027] Furthermore, the outer surface of the cylinder 32 is connected to a liquid outlet pipe 34, and a valve 35 is installed on the liquid outlet pipe 34.

[0028] Furthermore, the limiting mechanism includes a mounting block 41 fixed to the top of the experimental table 2, an electric push rod 42 fixed to the top of the mounting block 41, and a pressure plate 43 fixed to the bottom end of the extension rod of the electric push rod 42.

[0029] Place the biological detection chip to be tested on the top of the experimental platform 2, activate the limiting mechanism, extend the electric push rod 42 on the top of the mounting block 41, and drive the pressure plate 43 at the bottom to descend, firmly pressing the chip on the experimental platform 2 to prevent the chip from shifting during the experiment and to ensure the accuracy of the experimental data.

[0030] After the chip is fixed, the detection experiment begins. The detection probe 33 is installed in the inner cylinder 32 of the detection tank 31 and is electrically connected to external detection equipment, such as a biosignal analyzer or a fluorescence detector. Biological samples are added to the designated area of ​​the chip. The external detection equipment establishes an electrical signal connection with the chip through the detection probe 33 to detect and analyze the biological samples on the chip and detect the binding reaction of biomolecules. Waste liquid generated during the detection process can be discharged by opening the valve 35 on the outlet pipe 34 connected to the outer surface of the cylinder 32. After the experiment is completed.

[0031] When the cleaning mechanism is activated, the electric push rod 52 on the mounting bracket 51 extends, causing the connecting bracket 53 to descend, bringing the circular shell 55 and the micro-nozzle 56 closer to the detection probe 33 and adjusting them to a suitable cleaning position. The liquid pump 57 starts, drawing the cleaning solution from the storage cylinder 50 through the first hose 58, then through the second hose 59 and the rotary joint to the rotating tube 54, and finally into the circular shell 55. The cleaning solution is then sprayed at high speed through the linear array of micro-nozzles 56 on the inner wall of the circular shell 55, rinsing the detection probe 33 in all directions. After cleaning, the electric push rod 52 retracts, causing the connecting bracket 53 to rise and reset, moving the cleaning mechanism away from the experimental area so that the next chip experiment can be conducted or the chip that has completed the experiment can be removed.

[0032] Based on Example 1, Example 2:

[0033] Reference Figures 1-6 ,

[0034] Furthermore, the connecting frame 53 is provided with an adjustment mechanism, which includes a motor 61 fixed on the connecting frame 53. The output shaft end of the motor 61 is fixed with a drive gear 62, and the outer surface of the drive gear 62 meshes with a driven gear 63. The driven gear 63 is fixed on the outer surface of the rotating tube 54.

[0035] During cleaning, the adjustment mechanism starts working, the motor 61 on the connecting frame 53 starts, the output shaft of the motor 61 drives the drive gear 62 to rotate, the drive gear 62 meshes with the driven gear 63, thereby driving the rotating tube 54 to rotate. The rotating tube 54 drives the circular shell 55 and the micro nozzle 56 to rotate at different angles and trajectories, realizing the cleaning of the detection probe 33 at different positions and angles, ensuring that there are no dead corners in the cleaning, and thoroughly removing the biological samples and reagents remaining on the probe surface. The setting of the rotary joint ensures that the second tube 59 will not affect the rotation of the rotating tube 54.

[0036] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A research and development experimental device for biodetection chips, comprising a support frame (1), characterized in that, An experimental platform (2) is fixed to the top of the support frame (1). An experimental mechanism is provided on the top of the experimental platform (2). A limiting mechanism for fixing the chip is also provided on the top of the experimental platform (2). A cleaning mechanism is provided on the support frame (1). The cleaning mechanism includes a connecting frame (53) located above the experimental platform (2). A rotating tube (54) rotates on the connecting frame (53) via a bearing. The bottom end of the rotating tube (54) is connected to a circular shell (55). The inner wall of the circular shell (55) is connected to a linear array of micro nozzles (56). A liquid suction pump (57) is fixed on the support frame (1). A liquid storage cylinder (50) is also fixed on the support frame (1). The inlet end of the liquid suction pump (57) is connected to the liquid storage cylinder (50) through a first hose (58). The outlet end of the liquid suction pump (57) is connected to a second hose (59). The end of the second hose (59) away from the liquid suction pump (57) is connected to a rotating tube (54) through a rotary joint.

2. The experimental apparatus for the research and development of biological detection chips according to claim 1, characterized in that, The cleaning mechanism also includes a mounting bracket (51) fixed to the top wall of the support frame (1), on which an electric push rod (52) is mounted, and the bottom end of the extension rod of the electric push rod (52) is fixedly connected to the connecting frame (53).

3. The experimental apparatus for the research and development of biological detection chips according to claim 1, characterized in that, An adjustment mechanism is provided on the connecting frame (53). The adjustment mechanism includes a motor (61) fixed on the connecting frame (53). A drive gear (62) is fixed to the output shaft end of the motor (61). A driven gear (63) meshes with the outer surface of the drive gear (62). The driven gear (63) is fixed to the outer surface of the rotating tube (54).

4. The experimental apparatus for the research and development of biological detection chips according to claim 1, characterized in that, The experimental apparatus includes a detection slot (31) located on the top of the experimental table (2), a cylinder (32) fixed inside the detection slot (31), a detection probe (33) installed inside the cylinder (32), and the detection probe (33) electrically connected to an external biosignal analyzer.

5. The experimental apparatus for the research and development of biological detection chips according to claim 4, characterized in that, The outer surface of the cylinder (32) is connected to a liquid outlet pipe (34), and a valve (35) is installed on the liquid outlet pipe (34).

6. The experimental apparatus for the research and development of biological detection chips according to claim 1, characterized in that, The limiting mechanism includes a mounting block (41) fixed to the top of the experimental table (2), an electric push rod (42) is fixed to the top of the mounting block (41), and a pressure plate (43) is fixed to the bottom end of the extension rod of the electric push rod (42).

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