A tank device for removing organic solvents

By designing the tank device and utilizing the aeration port and the air outlet of the bent section, combined with the air inlet and vacuum port, the problem of low organic solvent removal efficiency in liposome preparation was solved, thereby improving the quality and production efficiency of liposome formulations.

CN224270245UActive Publication Date: 2026-05-26CHUANGZHI LIFE TECH (JIANGSU) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
CHUANGZHI LIFE TECH (JIANGSU) CO LTD
Filing Date
2025-05-30
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies struggle to efficiently remove organic solvents mixed in during liposome preparation, impacting the quality and efficiency of liposome formulations.

Method used

A tank device was designed with aeration ports evenly distributed on the top surface of the tank. Aeration pipes are built into the aeration ports. The ends of the aeration pipes are bent to form a bent section. Multiple air outlets are set at the bent section and the aeration ports. Combined with the air inlet, vacuum port and air inlet pipe, the removal of organic solvents is achieved through gas dispersion and vacuuming.

Benefits of technology

It achieves efficient removal of organic solvents, improves the quality and production efficiency of liposome formulations, and reduces removal time.

✦ Generated by Eureka AI based on patent content.

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Abstract

This utility model discloses a tank device for removing organic solvents, comprising a tank body, characterized in that a plurality of aeration ports are evenly distributed on the top surface of the tank body, and an aeration pipe is built into each aeration port; the aeration pipe consists of a vertical section inserted into the aeration port and a bent section formed by bending the end of the vertical section along the bottom of the tank; a plurality of first air outlet holes are evenly distributed on the side walls on both sides of the bent section; air is evenly introduced through three aeration ports, and the end pipe is bent along the bottom of the tank, with uniformly distributed small holes at the top and left and right sides for air outlet; the gas disperses in the solution, carrying away the organic solvent in the solution upwards into the gas phase space above the tank body, effectively removing the organic solvent mixed in the solution.
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Description

Technical Field

[0001] This utility model relates to the medical and health field, specifically to a tank device for removing organic solvents. Background Technology

[0002] In recent years, the application of liposome technology in drug delivery systems has become increasingly important, especially in improving drug biodistribution, reducing toxicity, and enhancing targeting. Since the successful launch of Doxil in 1995, research on liposomes has matured, with significant breakthroughs in anti-tumor, antifungal, analgesic, and gene therapy fields.

[0003] In China, the liposome formulation market officially entered a phase of rapid growth starting in 2017, with sales in the national hospital market exceeding 7 billion yuan by 2020. Liposomes can encapsulate drugs including anti-tumor chemotherapy drugs, gene therapy drugs, and antibody drugs, indicating a huge market potential.

[0004] When preparing liposomes from a mixture of lipid components, the lipids must first be dissolved and mixed in an organic solvent to ensure a homogeneous lipid mixture. Typically, this process is carried out using chloroform or a chloroform:methanol mixture. The aim is to completely mix the lipids and obtain a clear lipid solution. Once the lipids are fully mixed in the organic solvent, the solvent needs to be removed to produce a lipid film. Utility Model Content

[0005] To address the aforementioned problems, the purpose of this invention is to provide a tank device for effectively removing organic solvents mixed in a solution.

[0006] The technical solution for realizing this utility model is as follows:

[0007] A tank device for removing organic solvents includes a tank, characterized in that a plurality of aeration ports are evenly distributed on the top surface of the tank, and an aeration pipe is built into each aeration port; the aeration pipe consists of a vertical section inserted into the aeration port and a bent section formed by bending the end of the vertical section along the bottom of the tank; a plurality of first air outlet holes are evenly distributed on the side walls on both sides of the bent section.

[0008] Several second air vents are evenly distributed on the exposed end face of the bent section.

[0009] There are three aeration ports. Each of the three aeration ports contains a corresponding aeration tube.

[0010] An air inlet is provided on the tank between the two aeration ports, and an air inlet pipe is built into the air inlet. A vacuum port is provided on the tank located diagonally opposite the air inlet.

[0011] The vacuum port and air inlet are symmetrically distributed.

[0012] The air inlet is arranged tangentially along the tank wall.

[0013] Several third air outlets are evenly distributed on one side of the bent section of the tail section of the air intake pipe and on the exposed end face of the bent section.

[0014] With the above technical solution, the three aeration ports will evenly receive air, the end pipe bends along the bottom of the tank, and small holes are opened evenly on the top and left and right sides to release air. The gas disperses in the solution and carries the organic solvent in the solution upward to the gas phase space above the tank, effectively removing the organic solvent mixed in the solution. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of this utility model;

[0016] Figure 2 This is a top view of the structure of this utility model;

[0017] Figure 3 This is a schematic diagram of the first air outlet structure of this utility model;

[0018] In the attached diagram, 1 is the tank body, 2 is the aeration port, 3 is the aeration pipe, 4 is the vertical section, 5 is the bent section, 6 is the first air outlet, 7 is the second air outlet, 8 is the air inlet, 9 is the air inlet pipe, 10 is the vacuum port, and 11 is the third air outlet. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0020] A tank device for removing organic solvents includes a tank 1, characterized in that a plurality of aeration ports 2 are evenly distributed on the top surface of the tank, and an aeration pipe 3 is built into each aeration port; the aeration pipe consists of a vertical section 4 inserted into the aeration port and a bent section 5 formed by bending the end of the vertical section along the bottom of the tank; a plurality of first air outlet holes 6 are evenly distributed on the side walls on both sides of the bent section. Air is evenly introduced through three aeration ports, and the end pipe bends along the bottom of the tank, with evenly distributed small holes at the top and left and right sides for air outlet. The gas disperses in the solution, carrying away the organic solvent in the solution upwards into the gas phase space above the tank, effectively removing the organic solvent mixed in the solution.

[0021] Several second air outlet holes 7 are evenly distributed on the exposed end face of the bent section. Additional small holes for second air outlets are made on the aeration pipe.

[0022] There are three aeration ports. Each aeration port has a corresponding built-in aeration pipe and multiple air outlet channels, which improves the efficiency of removing organic solvents.

[0023] An air inlet 8 is provided on the tank between the two aeration ports, and an air inlet pipe 9 is built into the air inlet. A vacuum port 10 is provided on the tank diagonally opposite to the air inlet. Small holes are added to the aeration pipe and the side of the air inlet. The air inlets are arranged tangentially along the tank wall, which can effectively reduce the removal time of organic solvents.

[0024] The vacuum port and air inlet are symmetrically distributed. By drawing a vacuum, the organic container in the tank can be effectively sucked away. By blowing air in through the air inlet, the organic solvent can be concentrated near the vacuum port, and then the gas can be extracted by drawing a vacuum again.

[0025] The air inlet is tangentially positioned along the tank wall. This tangential arrangement of the air inlet effectively reduces the removal time of organic solvents.

[0026] Several third air outlet holes 11 are evenly distributed on one side of the bent section of the intake pipe and on the exposed end face of the bent section. A third small air outlet hole is added to the side of the intake port for air intake. The bend is designed so that the air can be blown across a surface rather than concentrated at a single point, preventing the air from being dispersed.

Claims

1. A tank device for removing organic solvents, comprising a tank, characterized in that, The top surface of the tank is evenly distributed with several aeration ports, and an aeration pipe is built into each aeration port; the aeration pipe consists of a vertical section inserted into the aeration port and a bent section formed by bending the end of the vertical section along the bottom of the tank; several first air outlet holes are evenly distributed on the side walls on both sides of the bent section.

2. The tank device for removing organic solvents according to claim 1, characterized in that, Several second air vents are evenly distributed on the exposed end face of the bent section.

3. The tank device for removing organic solvents according to claim 1, characterized in that, There are three aeration ports.

4. The tank device for removing organic solvents according to claim 1, characterized in that, An air inlet is provided on the tank between the two aeration ports, and an air inlet pipe is built into the air inlet. A vacuum port is provided on the tank located diagonally opposite the air inlet.

5. The tank device for removing organic solvents according to claim 4, characterized in that, The vacuum port and air inlet are symmetrically distributed.

6. The tank device for removing organic solvents according to claim 4, characterized in that, The air inlet is arranged tangentially along the tank wall.

7. The tank device for removing organic solvents according to claim 4, characterized in that, Several third air outlets are evenly distributed on one side of the bent section of the tail section of the air intake pipe and on the exposed end face of the bent section.