An organoid droplet transfer device

Abstract

This utility model relates to an organoid droplet transfer device, comprising: a device body; a first transfer portion disposed at the lower end of the device body; a second transfer portion slidably connected to the device body, the second transfer portion abutting against the first transfer portion to form an organoid droplet transfer cavity; and an elastic reset member disposed within the device body, one end of the elastic reset member being connected to the device body and the other end being connected to the second transfer portion. Compared with the prior art, this utility model provides an organoid droplet transfer device in which the first transfer portion and the second transfer portion form an organoid droplet transfer cavity through abutment, ensuring that the organoid droplet is stably encapsulated during the transfer process, preventing the droplet from falling off or shifting due to shaking or external force; moreover, the elastic reset member allows the second transfer portion to automatically reset, facilitating the next organoid droplet transfer operation.

Description

Technical Field

[0001] This utility model relates to a transfer device, specifically an organoid droplet transfer device. Background Technology

[0002] Organoids are multicellular three-dimensional structures with microscopic anatomical features of their source organs, cultured in vitro. 48-well plates are commonly used organoid culture plates in clinical practice; however, due to the small pore size of the wells in 48-well plates, it is difficult to completely remove the organoid droplets cultured in the wells for further experiments. Utility Model Content

[0003] The purpose of this invention is to overcome at least one of the defects of the prior art and provide an organoid droplet transfer device.

[0004] The objective of this utility model can be achieved through the following technical solutions:

[0005] An organoid droplet transfer device, comprising:

[0006] device body;

[0007] A first transfer section is provided at the lower end of the device body;

[0008] A second transfer section is slidably connected to the main body of the device, and the second transfer section abuts against the first transfer section to form an organoid droplet transfer cavity;

[0009] An elastic reset member is provided inside the device body, with one end connected to the device body and the other end connected to the second transfer part.

[0010] Furthermore, the first transfer section includes a first arc-shaped segment connected to the lower end of the device body and a first shovel connected to the side of the first arc-shaped segment opposite to the device body.

[0011] Furthermore, grooves are provided on both sides of the first arc-shaped segment.

[0012] Furthermore, the thickness of the side of the first shovel blade that abuts against the organoid droplet decreases sequentially from the inside out.

[0013] Furthermore, the second transfer part includes a sliding seat fitted on the device body, a second arc-shaped segment connected to the lower end of the sliding seat, and a second shovel connected to the side of the second arc-shaped segment opposite to the device body.

[0014] Furthermore, the sliding seat has a force-applying protrusion on its side to facilitate sliding of the sliding seat on the device body.

[0015] Furthermore, the force-applying protrusion is provided with anti-slip texture.

[0016] Furthermore, the second arc-shaped segment has grooves on both sides.

[0017] Furthermore, the thickness of the side of the second shovel that abuts against the organoid droplet decreases sequentially from the inside out.

[0018] Furthermore, the elastic reset element is a spring.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] (1) This utility model provides an organoid droplet transfer device. The first transfer part and the second transfer part of the device form an organoid droplet transfer cavity through abutment, which ensures that the organoid droplet is stably wrapped during the transfer process and avoids the droplet from falling off or shifting due to shaking or external force. Moreover, the setting of the elastic reset member allows the second transfer part to automatically reset, which facilitates the next organoid droplet transfer operation.

[0021] (2) This utility model provides an organoid droplet transfer device, wherein the first arc-shaped segment and the second arc-shaped segment of the device are provided with grooves on both sides, which facilitates the observation of organoid droplets.

[0022] (3) This utility model provides an organoid droplet transfer device. The device selects a spring as an elastic reset element so that the second transfer part can be automatically reset after operation, which simplifies the operation process, improves the efficiency of repeated use, and reduces human reset error. Attached Figure Description

[0023] Figure 1 This is one of the schematic diagrams of the organoid droplet transfer device in the embodiments;

[0024] Figure 2 This is a second schematic diagram of the organoid droplet transfer device in the embodiments;

[0025] The numbers in the figure indicate: 1-device body, 2-elastic reset component, 3-sliding seat, 4-force-applying protrusion, 5-second arc-shaped segment, 6-first arc-shaped segment, 7-first shovel, 8-second shovel, 9-sample loading hole of the well plate, 10-organoid droplet. Detailed Implementation

[0026] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. These embodiments are implemented based on the technical solution of the present invention, providing detailed implementation methods and specific operating procedures. However, the scope of protection of the present invention is not limited to the following embodiments.

[0027] Example 1

[0028] To facilitate the complete removal of organoid droplets cultured in the wells of a plate, this embodiment provides an organoid droplet transfer device, see [link to device]. Figure 1-2 It includes a device body 1, a first transfer part, a second transfer part, and an elastic reset member;

[0029] The first transfer part is located at the lower end of the device body 1, and the second transfer part is slidably connected to the device body 1. When the second transfer part abuts against the first transfer part, an organoid droplet transfer cavity is formed. The elastic reset member 2 is located inside the device body 1, with one end connected to the device body 1 and the other end connected to the second transfer part.

[0030] Please see again. Figure 1-2 The first transfer section includes a first arc-shaped segment 6 connected to the lower end of the device body 1 and a first shovel 7 connected to the side of the first arc-shaped segment 6 opposite to the device body 1.

[0031] Please see again. Figure 1-2 The second transfer part includes a sliding seat 3 sleeved on the device body 1, a second arc-shaped segment 5 connected to the lower end of the sliding seat 3, and a second shovel 8 connected to the side of the second arc-shaped segment 5 opposite to the device body 1.

[0032] In this embodiment, grooves are provided on both sides of the first arc-shaped segment 6 and the second arc-shaped segment 5, so that when the first arc-shaped segment 6 and the second arc-shaped segment 5 abut against each other, there is still an area that can be used to observe organoid droplets.

[0033] In this embodiment, the thickness of the side of the first shovel 7 that abuts against the organoid droplet decreases sequentially from the inside to the outside; the thickness of the side of the second shovel 8 that abuts against the organoid droplet also decreases sequentially from the inside to the outside. That is, the first shovel 7 and the second shovel 8 are provided with cutting edges, which can reduce physical damage when cutting into the droplet.

[0034] To facilitate one-handed operation and improve control precision, the sliding seat 3 is provided with a force-applying protrusion 4 on its side. The force-applying protrusion 4 provides a clear force-applying point, which facilitates the sliding seat 3 sliding on the device body 1.

[0035] To enhance operational stability and prevent accidental opening or closing of the transfer cavity due to slippage, anti-slip textures can be provided on the force-applying protrusion 4.

[0036] Please see again. Figure 1 The elastic reset element 2 is a spring, which is inexpensive and easy to replace, while providing a stable reset force.

[0037] Working principle:

[0038] In the initial state, the elastic reset member 2 is in a naturally extended state, pushing the sliding seat 3 of the second transfer part to slide outward, keeping the first spatula 7 and the second spatula 8 separated. When it is necessary to transfer the organoid droplets cultured in the well plate sample loading well, the operator presses the force application protrusion 4 with one thumb to overcome the spring force and make the sliding seat 3 slide inward, causing the second arc-shaped segment 5 to abut against the first arc-shaped segment 6. At this time, the groove area of ​​the two sets of arc-shaped segments forms an observation window, and the cutting edges of the first spatula 7 and the second spatula 8 together form a closed organoid droplet transfer cavity. During the process of the spatula cutting into the culture well, the cutting edge design of the two spatulas, which gradually thins from the inside to the outside, can accurately cut into the bottom of the droplet, effectively reducing shear damage to the droplet structure. After the transfer is completed, the force application protrusion 4 is released, and the elastic reset member 2 automatically resets, causing the transfer cavity to open, thus realizing the precise transfer of organoid droplets.

[0039] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of this utility model without departing from its technical solution shall still fall within the protection scope of this utility model.

Claims

1. An organoid gel droplet transfer device, characterized by, include: Device body(1); A first transfer section is provided at the lower end of the device body (1); A second transfer section is slidably connected to the device body (1), and the second transfer section abuts against the first transfer section to form an organoid droplet transfer cavity; An elastic reset member (2) is provided in the device body (1), with one end of the elastic reset member (2) connected to the device body (1) and the other end connected to the second transfer part.

2. The organoid droplet transfer device according to claim 1, characterized in that, The first transfer unit includes a first arc-shaped segment (6) connected to the lower end of the device body (1) and a first shovel (7) connected to the side of the first arc-shaped segment (6) away from the device body (1).

3. The organoid droplet transfer device according to claim 2, characterized in that, The first arc-shaped segment (6) has grooves on both sides.

4. The organoid droplet transfer device according to claim 2, characterized in that, The thickness of the first shovel (7) on the side that abuts against the organoid droplet decreases sequentially from the inside out.

5. The organoid droplet transfer device according to claim 1, characterized in that, The second transfer part includes a sliding seat (3) sleeved on the device body (1), a second arc-shaped segment (5) connected to the lower end of the sliding seat (3), and a second shovel (8) connected to the side of the second arc-shaped segment (5) away from the device body (1).

6. The organoid droplet transfer device according to claim 5, characterized in that, The sliding seat (3) has a force-applying protrusion (4) on its side to facilitate the sliding of the sliding seat (3) on the device body (1).

7. The organoid droplet transfer device according to claim 6, characterized in that, The force-applying protrusion (4) is provided with anti-slip texture.

8. The organoid droplet transfer device according to claim 5, characterized in that, The second arc-shaped segment (5) has grooves on both sides.

9. The organoid droplet transfer device according to claim 5, characterized in that, The thickness of the second shovel (8) on the side that abuts against the organoid droplet decreases sequentially from the inside out.

10. The organoid droplet transfer device according to claim 1, characterized in that, The elastic reset element (2) is a spring.

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