An online solid-liquid separation and collection device

Abstract

The utility model discloses an online solid -liquid separation collection device, including at least one set of fixture layer board subassembly and filter membrane, fixture layer board subassembly includes fixture layer board and support plate, and support plate is fixed on the fixture layer board, and its upper formation has multiple interval distribution's support part, and filter membrane is located one side of support plate and with support part linear contact, and support part to filter membrane linear support effect.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical equipment technology, specifically to an online solid-liquid separation and collection device. Background Technology

[0002] In the pharmaceutical industry, solid-liquid separation of feed liquids and collection of the target solid phase are core steps in the drug production process, directly affecting the purity, yield, and final drug quality of the active ingredient. Whether it is chemically synthesized drugs, biological agents (such as proteins and vaccines), or nanomedicine carriers, efficient separation technologies are required to extract the target solid components (such as crystals, cell debris, microparticles, or nanoparticles) from complex liquid matrices (such as reaction solutions, fermentation broths, extracts, or crystallization mother liquors).

[0003] Currently, the mainstream solid-liquid separation technology in the pharmaceutical industry uses clamps. However, when installing membrane packs, there is no support structure between the membrane packs. Therefore, the membrane packs are easily damaged under the impact of the liquid during use, resulting in a reduced lifespan. Furthermore, the loss of biological agents (such as target proteins) is severe after the membrane packs are damaged.

[0004] Therefore, a novel clamping structure is needed to solve the problems of easy damage to the membrane package and serious loss of the target biological agent in the existing clamps. Utility Model Content

[0005] The purpose of this invention is to provide an online solid-liquid separation and collection device that can effectively improve membrane life and the recovery rate of target biological agents.

[0006] To achieve the above objectives, this utility model proposes an online solid-liquid separation and collection device, comprising at least one set of clamping plate assemblies and a filter membrane. The clamping plate assembly includes a clamping plate and a support plate. The support plate is fixed to the clamping plate and has a plurality of spaced-apart support portions formed thereon. The filter membrane is located on one side of the support plate and is in linear contact with the support portions. The support portions provide linear support for the filter membrane.

[0007] In a preferred embodiment, the support plate is fixed to the clamping layer plate by a fixing assembly, the fixing assembly including at least one pin on the clamping layer plate and at least one slot on the support portion that engages with the pin.

[0008] In a preferred embodiment, the support plate is a corrugated plate having multiple troughs and multiple crests. The troughs and crests have opposite convex directions and are alternately distributed. The troughs or crests serve as the support and are in linear contact with the filter membrane on the corresponding side.

[0009] In a preferred embodiment, the cross-sectional shape of the support is trapezoidal, V-shaped, or rectangular.

[0010] In a preferred embodiment, the online solid-liquid separation and collection device includes multiple sets of clamping plate assemblies stacked in upper and lower layers, with a filter membrane sandwiched between two adjacent sets of clamping plate assemblies, and both sides of the filter membrane being in linear contact with the support portion of the corresponding side support plate.

[0011] In a preferred embodiment, the online solid-liquid separation and collection device further includes two clamp back plates, which are respectively disposed on the two outermost sides of one or more sets of stacked clamp layer assemblies, and a filter membrane is also clamped between the clamp back plates and the corresponding clamp layer assemblies.

[0012] In a preferred embodiment, the support plate is integrally stamped from a steel plate.

[0013] In a preferred embodiment, the thickness of the support plate is 0.6 mm to 1 mm.

[0014] In a preferred embodiment, the clamping shelf assemblies and the clamping back plate and clamping shelf assemblies are detachably connected by a structure in which positioning bosses and recesses cooperate.

[0015] In a preferred embodiment, the edge of the filter membrane is sealed to the corresponding clamping layer or clamping back plate.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] This invention adds a support plate to the existing membrane pack clamp structure to support the membrane pack. The support plate and the membrane pack are in linear contact and form a multi-point support system, which reduces the contact stress of the membrane pack, effectively avoids plastic deformation of the membrane pack, ensures the structural stability of the membrane pack during high-pressure and high-flow-rate filtration, optimizes fluid distribution, thereby extending the service life of the membrane pack, improving the recovery rate of the target biological agent, and reducing operating costs.

[0018] The clamping layer assemblies of this invention can be quickly disassembled and assembled manually without tools, making installation convenient and quick. Furthermore, the number of stacked clamping layer assemblies can be adjusted according to the volume of the liquid, thus making it suitable for filtration of different liquid volumes. Attached Figure Description

[0019] Figure 1 This is a top view of the online solid-liquid separation and collection device of this utility model;

[0020] Figure 2 for Figure 1 A cross-sectional view along the AA direction;

[0021] Figure 3 for Figure 2 A partially enlarged schematic diagram;

[0022] Figure 4 This is a structural diagram of the fixture shelf assembly;

[0023] Figure 5 for Figure 4 A cross-sectional view along the AA direction;

[0024] Figure 6 This is a schematic diagram of the corrugated plate structure;

[0025] Figure 7 This is a schematic diagram of the cross-section of the corrugated plate.

[0026] The attached figures are labeled as follows:

[0027] 10. Online solid-liquid separation and collection device, 1. Bottom clamp back plate, 2. Top clamp back plate, 3. Clamp layer assembly, 31. Clamp layer, 311. Hollow part, 32. Support plate, 321. Valley part, 322. Peak part, 33. Locking pin, 34. Filter membrane. Detailed Implementation

[0028] The specific embodiments of this utility model are described in detail below, but it should be understood that the scope of protection of this utility model is not limited to the specific embodiments.

[0029] Unless otherwise expressly stated, throughout the specification and claims, the term "comprising" or its variations such as "including" or "comprises" shall be understood to include the stated elements or components without excluding other elements or other components.

[0030] Combination Figures 1-3 As shown in the figure, an online solid-liquid separation and collection device 10 disclosed in this utility model embodiment includes a bottom clamp back plate 1, a top clamp back plate 2, and at least one set of clamp layer plate assemblies 3 located between the bottom clamp back plate 1 and the top clamp back plate 2, and the bottom clamp back plate 1, the middle clamp layer plate assembly 3 and the top clamp back plate 2 are stacked sequentially from bottom to top.

[0031] Combination Figure 4 and Figure 5 As shown, each set of clamping shelf assembly 3 includes a clamping shelf 31 and a support plate 32. The clamping shelf 31 is hollow, that is, it has a hollow portion 311 formed inside, and the support plate 32 is fixed inside the hollow portion 311. Specifically, in this embodiment, combined with Figure 6 and Figure 7As shown, the support plate 32 is a corrugated plate, specifically a V-shaped or trapezoidal plate with a wave shape. It has multiple continuously and alternately distributed troughs 321 and multiple crests 322. The convex directions of the troughs 321 and crests 322 are opposite. In this embodiment, the troughs 321 convex downwards, and the crests 322 convex upwards. Both the troughs 321 and crests 322 serve as support parts that contact and support the corresponding side membrane. In practice, the cross-sectional shape of the support parts is trapezoidal, V-shaped, or rectangular. In this embodiment, the corrugated plate is integrally stamped from high-strength AISI 316L stainless steel sheet metal. Specifically, it is formed by cold stamping the stainless steel sheet using a mold (not shown). Its thickness can be 0.6mm~1mm, preferably 0.8mm. Its surface is mirror polished (surface roughness Ra≤0.4μm) and then electrolytically polished to form a thin electrolytic layer to improve its corrosion resistance. The angle between the trough 321 and the crest is 102.9°, the wave height is 7mm, and the distance between two adjacent troughs 321 or crests is 20mm.

[0032] The support plate 32 is fixed to the clamping plate 31 by a fixing assembly. The fixing assembly specifically includes at least one latch 33 on the clamping plate 31 and at least one slot on the support plate 32 that cooperates with the latch 33. In this embodiment, multiple latches 33 are spaced apart on the upper and lower sides of the inner frame of the clamping plate 31, and the positions of the latches 33 on the upper and lower sides can be opposite or staggered. The troughs 321 and / or crests 322 on the corrugated plate serve as slots on the support plate 32. By correspondingly engaging the latches 33 on the clamping plate 31 into the troughs 321 or crests 322 of the corrugated plate, the corrugated plate can be quickly fixed into the hollow portion 311 of the clamping plate 31. During disassembly, it is only necessary to press the corrugated plate to disengage the troughs 321 or crests 322 from the latches 33, making installation and disassembly convenient and quick.

[0033] The support plate 32 of this utility model is suitable for separating the filter membranes 34 in the online solid-liquid separation and collection device, and ensures that there is sufficient space between the filter membranes 34, so that the substances intercepted by the filter membranes 34 are not easily blocked by the filter membranes 34, thereby greatly improving the efficiency of the solid-liquid separation process and increasing the yield of the solid-liquid separation process.

[0034] Unlike the hollow clamping shelf 31 of the middle clamping shelf assembly 3, the bottom clamping back plate 1 and the top clamping back plate 2 are non-hollow plate structures. They are respectively encapsulated at the bottom and top of the clamping shelf assembly 3, forming a sealed cavity inside the clamp for liquid filtration. Furthermore, the clamping back plates and the clamping shelf assembly 3, as well as the clamping shelf assemblies 3 themselves, are detachably connected via a structure that uses positioning bosses (not shown) and recesses (not shown). Specifically, if a positioning boss is provided on one side of the clamping shelf assembly 3, a corresponding recess is provided on the side of the adjacent clamping shelf assembly 3, or vice versa. This structure of positioning bosses and recesses allows for quick installation and removal of the clamping back plates and the clamping shelf assembly 3, as well as the clamping shelf assemblies 3 themselves, without the need for tools.

[0035] In addition to the bottom clamp back plate 1 and the top clamp back plate 2, a filter membrane 34 is disposed between the two support plates 32 of two adjacent clamp layer assemblies 3. The upper and lower sides of the filter membrane 34 form linear contact with the trough portion 321 of the upper support plate 32 and the crest portion 322 of the lower support plate 32, respectively, forming a multi-point support system. This ensures the structural stability of the membrane pack during high-pressure, high-flow-rate filtration, optimizes fluid distribution, thereby extending the membrane pack's service life and improving the recovery rate of the target biopharmaceutical. In implementation, each clamp layer assembly 3 fixes a filter membrane 34 to one side of the support plate 32, and its edge is sealed to the clamp layer 31. For example, silicone gel is used to form the edge of the filter membrane 34, and the silicone gel is used to seal the connection with the clamp layer 31. In this way, when adjacent clamp layer assemblies 3 are stacked, a filter membrane 34 is disposed between each of the two adjacent support plates 32.

[0036] In addition, filter membranes 34 are also clamped between the bottom clamp back plate 1 and the adjacent clamp shelf assembly 3, and between the top clamp back plate 2 and the adjacent clamp shelf assembly 3, so that a support plate 32 supports each pair of adjacent filter membranes 34.

[0037] The advantages of this invention are as follows: 1. Based on the existing membrane pack clamp structure, this invention adds a support plate to support the membrane pack. The support plate and the membrane pack are in linear contact and form a multi-point support system, which reduces the contact stress of the membrane pack, effectively avoids plastic deformation of the membrane pack, ensures the structural stability of the membrane pack during high-pressure, high-flow-rate filtration, optimizes fluid distribution, thereby extending the service life of the membrane pack, improving the recovery rate of the target biological agent, and reducing operating costs. 2. The clamp layer assemblies of this invention can be quickly disassembled and installed manually without tools, making installation convenient and quick. Furthermore, the number of stacked clamp layer assemblies can be adjusted according to the feed liquid volume, thus adapting to the filtration of different feed liquid volumes.

[0038] The foregoing description of specific exemplary embodiments of the present invention is for illustrative and explanatory purposes. These descriptions are not intended to limit the present invention to the precise forms disclosed, and it will be apparent that many changes and variations can be made in accordance with the foregoing teachings. The exemplary embodiments were chosen and described in order to explain the specific principles of the present invention and its practical application, thereby enabling those skilled in the art to implement and utilize various different exemplary embodiments of the present invention, as well as various different choices and variations. The scope of the present invention is intended to be defined by the claims and their equivalents.

Claims

1. An online solid-liquid separation and collection device, characterized in that, The device includes at least one set of clamping plate assemblies and a filter membrane. The clamping plate assembly includes a clamping plate and a support plate. The support plate is fixed to the clamping plate and has a plurality of spaced-apart support portions formed thereon. The filter membrane is located on one side of the support plate and is in linear contact with the support portions. The support portions provide linear support for the filter membrane.

2. The online solid-liquid separation and collection device as described in claim 1, characterized in that, The support plate is fixed to the clamping layer plate by a fixing assembly, the fixing assembly including at least one pin on the clamping layer plate and at least one slot on the support portion that cooperates with the pin.

3. The online solid-liquid separation and collection device as described in claim 1, characterized in that, The support plate is a corrugated plate with multiple troughs and multiple crests. The troughs and crests have opposite directions of protrusion and are alternately distributed. The troughs or crests serve as the support and are in linear contact with the filter membrane on the corresponding side.

4. The online solid-liquid separation and collection device as described in claim 1, characterized in that, The cross-sectional shape of the support is trapezoidal, V-shaped, or rectangular.

5. An online solid-liquid separation and collection device as described in any one of claims 1 to 4, characterized in that, The online solid-liquid separation and collection device includes multiple sets of clamping plate assemblies stacked in upper and lower phases. A filter membrane is clamped between two adjacent sets of clamping plate assemblies, and the two sides of the filter membrane are in linear contact with the support portion of the corresponding side support plate.

6. The online solid-liquid separation and collection device as described in claim 1, characterized in that, The online solid-liquid separation and collection device also includes two clamp back plates, which are respectively disposed on the two outermost sides of one or more sets of stacked clamp layer assemblies. A filter membrane is also clamped between the clamp back plate and the clamp layer assembly on the corresponding side.

7. An online solid-liquid separation and collection device as described in any one of claims 1 to 4, characterized in that, The support plate is integrally stamped from a single steel plate.

8. The online solid-liquid separation and collection device as described in claim 7, characterized in that, The thickness of the support plate is 0.6mm to 1mm.

9. The online solid-liquid separation and collection device as described in claim 6, characterized in that, The clamping shelf assemblies and the clamping back plate and clamping shelf assemblies are detachably connected by a structure in which positioning bosses and concave holes cooperate.

10. The online solid-liquid separation and collection device as described in claim 6, characterized in that, The edge of the filter membrane is sealed to the corresponding clamping layer or clamping back plate.

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