Crystallization integrated device for chenodeoxycholic acid

Abstract

The utility model relates to the technical field of pharmaceutical engineering, disclose goose deoxycholic acid crystallization integrated device, including crystallization kettle, the upper surface of crystallization kettle is connected with the crystallization kettle cover plate slidingly, the inner wall of crystallization kettle cover plate is fixedly connected with telescopic water pipe, the upper surface of crystallization kettle cover plate is fixedly connected with flange shaft sleeve, the upper surface of flange shaft sleeve is fixedly connected with connecting plate, the upper surface of connecting plate is fixedly connected with motor, the output of motor is fixedly connected with bearing, the lower surface of bearing is fixedly connected with shaft body, the output of motor is fixedly connected with paddle, the inside of crystallization kettle is provided with cleaning mechanism, in the utility model, through telescopic pipe spherical shower nozzle, telescopic rod is used as water inlet valve connection shower nozzle part, can directly to the bottom of device work, the spherical shower nozzle can be without dead angle spray in the crystallization kettle inner wall cleaning fluid, and the problem of not easy to clean is improved.

Description

Technical Field

[0001] This utility model relates to the technical field of separation and purification equipment in pharmaceutical chemistry or biochemistry, and in particular to an integrated device for chenodeoxycholic acid crystallization. Background Technology

[0002] Chenodeoxycholic acid (CDCA) is an important primary bile acid with wide applications in pharmaceuticals, health products, and cosmetics. High-purity CDCA typically requires crystallization. CDCA crystallization equipment, through precise control of crystallization kinetics, produces CDCA crystals with a single crystal form and uniform particle size, making it a key upstream material meeting the demands of the three sunrise industries of pharmaceuticals, health, and beauty. This results in significant technological barriers and market premiums.

[0003] The existing product involves adding chenodeoxycholic acid solution / solvent to a crystallization reactor, followed by heating and stirring, and then cooling to achieve a supersaturated state and maintain a constant temperature for crystallization. The reactor lid is then opened for cleaning. The existing technology has the following problems: the cleaning efficiency is too low, requiring the reactor lid to be opened to achieve the cleaning purpose; poor cleaning strength leads to poor crystal purity and blockage of the discharge port; and opening and closing the reactor lid results in poor sealing and difficulty in opening the lid. Summary of the Invention

[0004] To overcome the above shortcomings, this utility model provides an integrated chenodeoxycholic acid crystallization device, which aims to solve problems such as low crystal purity and outlet blockage caused by low cleaning power; and difficulty in opening the crystallization vessel, which leads to poor sealing after opening.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an integrated chenodeoxycholic acid crystallization device, comprising a crystallization vessel, a crystallization vessel cover plate slidably connected to the upper surface of the crystallization vessel, a telescopic water pipe fixedly connected to the inner wall of the crystallization vessel cover plate, a flange bushing fixedly connected to the upper surface of the flange bushing, a connecting plate fixedly connected to the upper surface of the connecting plate, a motor fixedly connected to the output end of the motor, a bearing fixedly connected to the lower surface of the bearing, a shaft fixedly connected to the output end of the motor, and a paddle fixedly connected to the output end of the motor; a cleaning mechanism is provided inside the crystallization vessel.

[0006] The cleaning structure includes the telescopic water pipe, with a water inlet fixedly connected to the upper end of the telescopic water pipe, a toggle switch fixedly connected to the outer surface of the water inlet, and a spherical nozzle fixedly connected to the lower surface of the telescopic water pipe.

[0007] Furthermore, the outer surfaces of the crystallization vessel and the crystallization vessel cover are provided with opening and closing mechanisms. The opening and closing mechanisms include positioning pins on the front, back, left, and right sides of the upper surface of the crystallization vessel cover, four screws rotatably connected to the top of the crystallization vessel, positioning plates rotatably connected to the upper surfaces of the screws, a connecting turntable fixed to the lower surface of the screws, and a rotating handle fixedly connected to the lower surface of the turntable.

[0008] Furthermore, a pressure relief valve is fixedly connected to the outer surface of the crystallization vessel, and a cooling copper pipe is fixedly connected to the center of the crystallization vessel jacket.

[0009] Furthermore, a feed inlet is provided on the top of the crystallization vessel cover plate, a pressure gauge is fixedly connected to the top of the crystallization vessel cover plate, and a hot and cold inlet is fixedly connected to the top of the crystallization vessel cover plate.

[0010] Furthermore, a discharge pipe is fixedly connected to the center of the bottom of the crystallization vessel, and a drain pipe is fixedly connected to the left side of the bottom of the crystallization vessel.

[0011] Furthermore, a material placement bucket is fixedly connected to one end of the feed inlet, a placement bucket valve port is fixedly connected to the lower surface of the material placement bucket, a bracket is fixedly connected to the lower surface of the material placement bucket, and a foot is fixedly connected to the bottom of the bracket.

[0012] Furthermore, the lower wall of the crystallization vessel is fixedly connected with inclined supports on all sides, and the bottom of the inclined supports is fixedly connected with inclined feet.

[0013] Furthermore, a material transport pipe is fixedly connected to one end of the feed inlet, a fixing pin is fixedly connected to the upper surface of the material transport pipe, a reinforcing pipe is provided at one end of the outer surface of the material transport pipe, a valve port flange is fixedly connected to the lower surface of the material transport pipe, and a placement tank valve pipe is fixedly connected to the upper surface of the valve port flange.

[0014] This utility model has the following beneficial effects:

[0015] 1. In this utility model, a telescopic tube spherical nozzle is used, and a telescopic rod is used as the water inlet valve to connect the nozzle part, so that the nozzle can be lowered and can work directly at the bottom of the device. The spherical nozzle can spray the cleaning liquid into the inner wall of the crystallization vessel without dead angles, which greatly improves the problem of difficult cleaning. The water inlet valve interface is improved, and the quick-plug interface makes it easy to replace the cleaning liquid. Since chenodeoxycholic acid is insoluble in water, it can also increase the cleaning efficiency.

[0016] 2. In this utility model, the traditional opening steps are cumbersome, thanks to the positioning screw sealing clamp. The new screw structure, combined with the circular turntable and rotating handle, makes it easier to open the device sealing cover. The positioning pin and clamp ensure that the sealing performance remains excellent after maintenance. Attached Figure Description

[0017] Figure 1 This is a three-dimensional structural schematic diagram of the integrated chenodeoxycholic acid crystallization device proposed in this utility model.

[0018] Figure 2 This is a three-dimensional cross-sectional view of the integrated chenodeoxycholic acid crystallization device proposed in this utility model.

[0019] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0020] Figure 4 for Figure 2 Enlarged view of section B in the middle.

[0021] Figure 5 This is a schematic diagram of the cooling pipe section of the integrated chenodeoxycholic acid crystallization device proposed in this utility model.

[0022] Legend:

[0023] 1. Motor; 2. Connecting plate; 3. Bearing; 4. Shaft; 5. Flange sleeve; 6. Pressure gauge; 7. Fixing pin; 8. Feed inlet; 9. Material transport pipe; 10. Material placement bucket; 11. Support; 12. Placement bucket valve pipe; 13. Valve flange; 14. Reinforcing pipe; 15. Foot; 16. Hot and cold inlets; 17. Water inlet; 18. Toggle switch; 19. Telescopic water pipe; 20. Spherical nozzle; 21. Paddle; 22. Cooling copper pipe; 23. Pressure relief valve; 24. Drain pipe; 25. Angled support; 26. Angled foot; 27. Positioning plate; 28. Positioning pin; 29. ​​Screw; 30. Turntable; 31. Rotating handle; 32. Discharge pipe; 33. Crystallizer; 34. Crystallizer cover plate. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Reference Figure 1-3This utility model provides an embodiment of an integrated chenodeoxycholic acid crystallization device, comprising a crystallization vessel 33, a crystallization vessel cover plate 34 slidably connected to the upper surface of the crystallization vessel 33, a telescopic water pipe 19 fixedly connected to the inner wall of the crystallization vessel cover plate 34, a flange bushing 5 fixedly connected to the upper surface of the crystallization vessel cover plate 34, a connecting plate 2 fixedly connected to the upper surface of the flange bushing 5, a motor 1 fixedly connected to the upper surface of the connecting plate 2, a bearing 3 fixedly connected to the output end of the motor 1, a shaft 4 fixedly connected to the lower surface of the bearing 3, a paddle 21 fixedly connected to the output end of the motor 1, a pressure relief valve 23 fixedly connected to the outer surface of the crystallization vessel 33, a cooling copper pipe 22 fixedly connected to the center of the jacket of the crystallization vessel 33, and a top of the crystallization vessel cover plate 34. The reactor has a feed inlet 8. A pressure gauge 6 is fixedly connected to the top of the crystallizer cover plate 34. A hot and cold inlet 16 is fixedly connected to the top of the crystallizer cover plate 34. A material placement bucket 10 is fixedly connected to one end of the feed inlet 8. A placement bucket valve pipe 12 is fixedly connected to the lower surface of the material placement bucket 10. A bracket 11 is fixedly connected to the lower surface of the material placement bucket 10. A foot 15 is fixedly connected to the bottom of the bracket 11. A material transport pipe 9 is fixedly connected to one end of the feed inlet 8. A fixing pin 7 is fixedly connected to the side of the upper surface of the material transport pipe 9. A reinforcing pipe 14 is provided at one end of the outer surface of the material transport pipe 9. A valve flange 13 is fixedly connected to the lower surface of the material transport pipe 9. The placement bucket valve pipe 12 is fixedly connected to the upper surface of the valve flange 13.

[0026] Specifically, chenodeoxycholic acid solution is added to the material placement tank 10. The chenodeoxycholic acid solution flows into the material transport pipe 9 after the placement tank valve 12 is opened. The solution is then transported to the feed inlet 8 and subsequently into the crystallization kettle 33. The motor 1 is then started. The motor 1 uses bearings 3 and shaft 4 to drive the impeller 21, which delivers hot steam to the jacket through the hot and cold inlets 16 to heat the chenodeoxycholic acid solution. Stirring ensures uniform heating of the solution. The internal pressure is monitored by the pressure gauge 6. If the pressure is too high, the pressure relief valve 23 is opened to reduce the pressure. Coolant is then introduced through the hot and cold inlets 16 into the cooling copper pipe 22 to cool the solution until it reaches a supersaturated state. Cooling continues to maintain a low temperature for crystal growth. After crystallization is complete, the motor 1 is turned off.

[0027] Reference Figure 2-3 The crystallization vessel 33 is equipped with a cleaning mechanism; the cleaning mechanism includes a telescopic water pipe 19, with an inlet 17 fixedly connected to the upper end of the telescopic water pipe 19, a toggle switch 18 fixedly connected to the outer surface of the inlet 17, and a spherical nozzle 20 fixedly connected to the lower surface of the telescopic water pipe 19.

[0028] Specifically, the inlet 17 is connected to an external water pump, which delivers the cleaning solution to the telescopic water pipe 19. Then, the toggle switch 18 is turned on, and the cleaning solution is sprayed onto the inner wall of the crystallization vessel 33 through the spherical nozzle 20. Subsequently, the waste material is discharged through the drain pipe 24. Then, the inlet 17 is connected to clean water to rinse away the residual cleaning solution. Conventional cleaning methods are inefficient, have poor cleaning effects, and are prone to clogging the outlet, resulting in poor crystallization purity. The new cleaning mechanism is convenient and has better effects, and will not cause problems such as clogging or poor crystallization purity.

[0029] Reference Figure 4-5 Both the crystallizer 33 and the crystallizer cover 34 are equipped with opening and closing mechanisms on their outer surfaces. These mechanisms include positioning pins 28 on the front, back, left, and right sides of the upper surface of the crystallizer cover 34; four screws 29 rotatably connected to the top of the crystallizer 33; positioning plates 27 rotatably connected to the upper surfaces of the screws 29; a connecting turntable 30 fixed to the lower surface of the screws 29; and a rotating handle 31 fixedly connected to the lower surface of the turntable 30.

[0030] Specifically, the positioning pin 28 ensures that each opening and closing is exactly the same as the previous one. The screw 29, together with the positioning plate 27, makes the crystallizer cover 34 fit perfectly with the crystallizer 33. The turntable 30 and the rotating handle 31 make the opening and closing mechanism easier to open and close, and facilitate inspection and maintenance.

[0031] Working principle: Add chenodeoxycholic acid solution to the material placement tank 10, open the placement tank valve pipe 12 and the chenodeoxycholic acid solution flows into the material transport pipe 9. The chenodeoxycholic acid solution is transported to the feed inlet 8 through the material transport pipe 9 and then enters the crystallization kettle 33. Then start the motor 1. The motor 1 uses the bearing 3 and shaft 4 to drive the blade 21 to rotate and stir. Hot steam is delivered to the jacket through the hot and cold inlet 16 to heat the chenodeoxycholic acid solution. Stirring makes the solution heat evenly. Observe the pressure gauge 6 to observe the internal pressure. If the pressure is found to be too high, open the pressure relief valve 23 to reduce the pressure. Then, coolant is connected to the cooling copper pipe 22 through the hot and cold inlet 16 to cool down the solution to a supersaturated state. Then, continue to cool down to maintain a low temperature for crystal growth. After crystallization is completed, motor 1 is turned off, paddle 21 stops rotating and stirring, drain pipe 24 discharges internal coolant, and then the crystal slurry is released through discharge pipe 32 for subsequent processing. After cleaning, water inlet 17 is connected to an external water pump to spray cleaning liquid from top to bottom through telescopic water pipe 19 from spherical nozzle 20. Then, water inlet 17 is connected to clean water to rinse the inner wall, cleaning away residual cleaning liquid, and then the wastewater after cleaning is discharged through discharge pipe 32.

[0032] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A device for crystallizing chenodeoxycholic acid, comprising a crystallization kettle (33), characterized in that: The crystallization vessel (33) is slidably connected to a crystallization vessel cover plate (34) on its upper surface. A telescopic water pipe (19) is fixedly connected to the inner wall of the crystallization vessel cover plate (34). A flange bushing (5) is fixedly connected to the upper surface of the crystallization vessel cover plate (34). A connecting plate (2) is fixedly connected to the upper surface of the flange bushing (5). A motor (1) is fixedly connected to the upper surface of the connecting plate (2). A bearing (3) is fixedly connected to the output end of the motor (1). A shaft (4) is fixedly connected to the lower surface of the bearing (3). A paddle (21) is fixedly connected to the output end of the motor (1). A cleaning mechanism is provided inside the crystallization vessel (33). The cleaning mechanism includes the telescopic water pipe (19), the upper end of the telescopic water pipe (19) is fixedly connected to the water inlet (17), the outer surface of the water inlet (17) is fixedly connected to the toggle switch (18), and the lower surface of the telescopic water pipe (19) is fixedly connected to the spherical nozzle (20).

2. The integrated chenodeoxycholic acid crystallization apparatus according to claim 1, characterized in that: The outer surfaces of the crystallization vessel (33) and the crystallization vessel cover plate (34) are provided with opening and closing mechanisms. The upper surface of the crystallization vessel cover plate (34) is provided with positioning pins (28) on the front, back, left and right sides. The top of the crystallization vessel (33) is rotatably connected with four screws (29). The upper surface of the screws (29) is rotatably connected with a positioning plate (27). The lower surface of the screws (29) is fixed with a connecting turntable (30). The lower surface of the turntable (30) is fixedly connected with a rotating handle (31).

3. The integrated chenodeoxycholic acid crystallization apparatus according to claim 1, characterized in that: A pressure relief valve (23) is fixedly connected to the outer surface of the crystallization vessel (33), and a cooling copper pipe (22) is fixedly connected to the center of the jacket of the crystallization vessel (33).

4. The integrated chenodeoxycholic acid crystallization apparatus according to claim 1, characterized in that: The top of the crystallizer cover plate (34) is provided with a feed inlet (8), a pressure gauge (6) is fixedly connected to the top of the crystallizer cover plate (34), and a hot and cold inlet (16) is fixedly connected to the top of the crystallizer cover plate (34).

5. The integrated chenodeoxycholic acid crystallization apparatus according to claim 1, characterized in that: The bottom center of the crystallization vessel (33) is fixedly connected to a discharge pipe (32), and the bottom left side of the crystallization vessel (33) is fixedly connected to a drain pipe (24).

6. The integrated chenodeoxycholic acid crystallization apparatus according to claim 4, characterized in that: One end of the feed inlet (8) is fixedly connected to a material placement bucket (10), the lower surface of the material placement bucket (10) is fixedly connected to a placement bucket valve pipe (12), the lower surface of the material placement bucket (10) is fixedly connected to a bracket (11), and the bottom end of the bracket (11) is fixedly connected to a foot (15).

7. The integrated chenodeoxycholic acid crystallization apparatus according to claim 3, characterized in that: The lower wall of the crystallizing vessel (33) is fixedly connected with inclined supports (25) on all sides, and the bottom of the inclined supports (25) is fixedly connected with inclined feet (26).

8. The integrated chenodeoxycholic acid crystallization apparatus according to claim 4, characterized in that: One end of the feed inlet (8) is fixedly connected to a material transport pipe (9), a fixing pin (7) is fixedly connected to the upper surface of the material transport pipe (9), a reinforcing pipe (14) is provided at one end of the outer surface of the material transport pipe (9), a valve port flange (13) is fixedly connected to the lower surface of the material transport pipe (9), and a placement barrel valve pipe (12) is fixedly connected to the upper surface of the valve port flange (13).

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