A pharmaceutical excipient granulating apparatus

Abstract

The utility model relates to the technical field of granulator discloses a medicinal excipient granulating equipment, including granulating box and granulating roller, the inside upper portion of granulating box is longitudinally installed with two and each other is close to of granulating roller is set up, and the transmission connection of speed reducer motor installed on the outside surface of granulating box is set up with its front end granulating box, the top of granulating box is provided with the feed hopper that communicates with the inside of granulating box, and the inside of granulating box below granulating roller is longitudinally fixed with the mesh plate that is bent into the cylinder, and the top of mesh plate is provided with the upper mouth that communicates with its inboard. The utility model technical scheme is provided with the mesh plate of the cylinder below between two granulating rollers, and the excipient of flaky particle state can be through the upper mouth and fall into the inboard of mesh plate and be moved by the paddle, and the excipient of flaky particle state can be scattered in the indentation position finally after being moved by the paddle many times, ensure that flaky material is completely broken and avoid the larger force or action speed and make granule raw material be destroyed into powder again, ensure the quality of finished product.

Description

Technical Field

[0001] This utility model relates to the field of granulation machine technology, specifically to a pharmaceutical excipient granulation equipment. Background Technology

[0002] Pharmaceutical excipients are important components in pharmaceutical preparations besides the active pharmaceutical ingredient, such as fillers and binders. Their function is to improve the formability and stability of the drug, and they must meet requirements such as safety and lack of pharmacological activity. Granulation is a process of turning drug powder into granules. Its purpose is to improve the flowability and uniformity of the powder, reduce dust, facilitate subsequent tableting and filling, and control drug release. Due to its dry granulation at room temperature, lack of additional excipients, and controllable granule quality, the roller granulator has become the preferred equipment for pharmaceutical granulation and is suitable for a variety of pharmaceutical excipients and drug systems.

[0003] During granulation, when the material reaches the top of the two granulating rollers, it first flows freely. After entering the bite angle of the granulating rollers, it is squeezed between the two granulating rollers as the granulating rollers rotate. It is compressed by the huge pressure of the granulating rollers. The pressure reaches its peak when the two granulating rollers are connected at the center. At this time, the material is squeezed into complete original particles. However, due to the gap between the granulating rollers, the material is in the state of connected sheet particles. Subsequently, the sheet material falls into the crushing chamber and is crushed by the toothed rollers to form small round particles.

[0004] However, in actual operation, the serrated roller requires a high rotation speed to achieve a good crushing effect when crushing sheet materials. Due to the high intensity and high speed, the sheet material is easily compressed back into powder, and there may be some sheet material that is not completely crushed, affecting the granulation quality. Therefore, we propose a pharmaceutical excipient granulation device. Utility Model Content

[0005] The purpose of this invention is to provide a pharmaceutical excipient granulation device. By setting a cylindrical mesh plate below between two granulation rollers, the excipient in flaky granular form can fall into the inner side of the mesh plate through the upper opening and be agitated by a pusher plate. After being agitated multiple times by the pusher plate, the flaky granular excipient will eventually disperse at the indentation position, ensuring that the flaky material is completely broken up and avoiding the large force or speed that would cause the granular raw material to be broken into powder again, thus ensuring the quality of the finished product and solving the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a pharmaceutical excipient granulation device, comprising a granulation box and granulation rollers, wherein two granulation rollers are longitudinally installed close to each other inside the upper part of the granulation box, and the granulation rollers are driven by a reduction motor installed on the outer surface of the granulation box at their front ends; a feed hopper communicating with the interior of the granulation box is provided above the granulation box; a cylindrical mesh plate is longitudinally fixed inside the granulation box below the granulation rollers, and an upper opening communicating with its inner side is provided above the mesh plate, and through holes are provided on the surface of the mesh plate; a rotating rod is rotatably installed longitudinally inside the granulation box in the middle of the inner side of the mesh plate, and the rotating rod is driven by a drive motor installed on the outer surface of the granulation box at its front ends; a lever plate is fixed to the side of the rotating rod by multiple connecting plates, and two lever plates are provided close to the inner surface of the mesh plate.

[0007] By adopting the above technical solution, the powdered auxiliary material is fed into the hopper and squeezed into flake-shaped granular raw material under the action of the granulating roller. Then it falls into the inner side of the screen plate and is continuously pushed by the pusher plate to disperse into granules and discharged through the screen plate. This can avoid the raw material being destroyed into powder again by excessive speed and force, and ensure that all the granules can be broken up.

[0008] Optionally, observation windows are provided on both sides of the granulation box, and the height of the observation windows is the same as the height of the middle position of the screen.

[0009] By adopting the above technical solution, the working status of the internal mesh plate can be easily observed through the observation window during operation.

[0010] Optionally, the bottom of the granulation box is provided with a discharge port, which is connected to the inside of the granulation box.

[0011] By adopting the above technical solution, the granular raw material is finally discharged through the outlet.

[0012] Optionally, the bottom of the granulation box is provided with an inclined guide surface, and the discharge port is located at the lowest position of the bottom of the granulation box.

[0013] By adopting the above technical solution, it is easy to guide the granular raw material to the middle position and finally discharge it from the outlet.

[0014] Optionally, the bottom of the feed hopper extends into the granulation chamber, and the bottom of the feed hopper is positioned above the space between the two granulation rollers.

[0015] By adopting the above technical solution, the raw material powder is guided at the bottom of the feed hopper and falls directly between the granulation rollers on both sides.

[0016] Optionally, the granulation box is vertically supported at each of its four corners, and multiple supports are provided.

[0017] By adopting the above technical solution, the equipment is supported by multiple legs.

[0018] Compared with the prior art, the beneficial effects of the technical solution of this application are as follows:

[0019] 1. The technical solution of this application has a cylindrical screen plate set below between two granulation rollers. The flaky granular auxiliary material can fall into the inner side of the screen plate through the upper opening and be pushed by the pusher plate. After being pushed by the pusher plate multiple times, the flaky granular auxiliary material can always be dispersed at the indentation position, ensuring that the flaky material is completely broken up and avoiding the large force or speed that would cause the granular raw material to be broken into powder again, thus ensuring the quality of the finished product.

[0020] 2. The technical solution of this application provides an observation window on the side of the granulation box at the same height as the screen, which facilitates observation of the specific situation inside the granulation box during operation. Attached Figure Description

[0021] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0022] Figure 1 This is a schematic diagram of the overall structure of the pharmaceutical excipient granulation equipment of this utility model;

[0023] Figure 2 This is a schematic diagram of the internal structure of the pharmaceutical excipient granulation equipment of this utility model;

[0024] Figure 3 This is a schematic diagram of the connection structure between the dial plate and the rotating rod in the pharmaceutical excipient granulation equipment of this utility model.

[0025] In the diagram: 1. Granulation box; 11. Feed hopper; 12. Discharge port; 13. Support leg; 14. Observation window; 2. Granulation roller; 21. Gear motor; 3. Screen plate; 31. Rotating rod; 311. Connecting plate; 312. Pulley plate; 313. Drive motor; 32. Top opening. Detailed Implementation

[0026] Please see Figure 1-3 This utility model provides a technical solution: a pharmaceutical excipient granulation device, including a granulation box 1 and a granulation roller 2, wherein the bottom four corners of the granulation box 1 are vertically supported by support legs 13, and multiple support legs 13 are provided with the same height to achieve stable support for the granulation box 1 and its internal structure.

[0027] The granulating roller 2 has two rollers of the same size and specifications, which are close to each other and rotatable in the longitudinal direction. They are installed inside the granulating box 1. A geared motor 21 is installed on the outer surface of the granulating box 1 at the front end of the granulating roller 2. The granulating roller 2 is connected to the geared motor 21 at its front end. When working, the geared motors 21 on both sides are started to drive the left granulating roller 2 to rotate clockwise, while the right granulating roller 2 rotates counterclockwise.

[0028] A feed hopper 11 is provided above the granulation box 1 and communicates with the inside of the granulation box 1. The bottom of the feed hopper 11 extends into the inside of the granulation box 1 and is positioned above the two granulation rollers 2. The pharmaceutical excipients fed in can fall between the two granulation rollers 2 under the guidance of the feed hopper 11. When the granulation rollers 2 rotate, the raw material is compressed by the huge pressure of the granulation rollers 2, and the pressure reaches its peak when the two granulation rollers 2 are connected at the center. At this time, the pharmaceutical excipients are squeezed into complete original granules. Due to the gap between the granulation rollers 2, the material is in the state of connected sheet-like granules and can fall downward.

[0029] In order to break up the flaky granular raw material, a cylindrical mesh plate 3 is longitudinally fixed inside the granulation box 1 between the two granulation rollers 2, and an upper opening 32 communicating with its inner side is provided on the upper part of the mesh plate 3. The flaky granular raw material falling downward will fall into the inner side of the mesh plate 3 through the upper opening 32.

[0030] Inside the granulation box 1 on the inner side of the screen plate 3, a rotating rod 31 is rotatably mounted longitudinally. A drive motor 313 is mounted on the outer surface of the granulation box 1 at the front end of the rotating rod 31, and the rotating rod 31 is connected to the drive motor 313 at its front end. A lever plate 312 is fixed to the side of the rotating rod 31 through a connecting plate 311. There are two lever plates 312. Each lever plate 312 is connected to the rotating rod 31 by multiple connecting plates 311. The lever plate 312 is close to the inner surface of the screen plate 3. A through hole is provided on the surface of the screen plate 3. The size of the through hole is selected according to the granulation requirements. The purpose is to allow the crushed granular raw material to pass through, while the uncrushed material cannot pass through.

[0031] During operation, the flake-like granular auxiliary material can be broken up by the slow stirring action of the agitator 312. After being agitated by the agitator 312 multiple times, the flake-like granular auxiliary material will eventually disperse at the indentation position, and the dispersed particles will fall through the through holes on the surface of the mesh plate 3, ensuring that the particles can be completely broken up and avoiding being crushed into powder by additional force.

[0032] The bottom of the granulation box 1 is provided with a discharge port 12, which is connected to the inside of the granulation box 1. The bottom of the granulation box 1 is provided with an inclined guide surface. The discharge port 12 is located at the lowest position of the bottom of the granulation box 1. The falling granular raw materials are easily discharged from the discharge port 12 and collected under the guidance of the guide surface.

[0033] In addition, observation windows 14 are provided on both sides of the granulation box 1. The height of the observation windows 14 is the same as the height of the middle position of the screen plate 3, so as to facilitate observation of the specific situation inside the granulation box 1 during operation.

[0034] In use, a collection container is placed below the discharge port 12. The geared motor 21 and the drive motor 313 are both connected to the industrial control computer. The geared motors 21 on both sides are started to drive the left and right granulation rollers 2 to rotate clockwise and counterclockwise respectively. The drive motor 313 drives the rotating rod 31 and the agitator 312 to rotate slowly inside the screen plate 3. The pharmaceutical excipients are fed from the feed hopper 11 and fall between the two granulation rollers 2. They are pressed into complete original granules by the grooves on the surface of the granulation rollers 2. Due to the gap between the granulation rollers 2, the material is in the state of connected sheet-like granules. The sheet-like material falls and enters the inner side of the screen plate 3 through the upper opening 32. Under the slow stirring action of the agitator 312, the sheet-like granules of the excipients can be broken up. After being agitated by the agitator 312 multiple times, the sheet-like granules of the excipients will eventually disperse at the indentation position and fall through the through holes on the surface of the screen plate 3. Finally, they are discharged from the discharge port 12 and collected.

Claims

1. A pharmaceutical excipient granulation device, comprising a granulation box (1) and granulation rollers (2), wherein two granulation rollers (2) are arranged longitudinally and close to each other and installed above the interior of the granulation box (1), the granulation rollers (2) are connected to a geared motor (21) mounted on the outer surface of the granulation box (1) at their front end, and a feed hopper (11) communicating with the interior of the granulation box (1) is provided above the granulation box (1), characterized in that: The granulation box (1) below the granulation roller (2) has a cylindrical mesh plate (3) fixed longitudinally inside. The mesh plate (3) has an upper opening (32) that communicates with its inner side. The surface of the mesh plate (3) has through holes for the crushed granules to pass through. Inside the granulation box (1) in the middle of the inner side of the screen plate (3), a rotating rod (31) is rotatably installed longitudinally. The rotating rod (31) is connected to the drive motor (313) installed on the outer surface of the granulation box (1) at its front end. The side of the rotating rod (31) is fixed with a lever (312) through multiple connecting plates (311). There are two levers (312) and they are close to the inner surface of the screen plate (3).

2. The pharmaceutical excipient granulating apparatus according to claim 1, characterized by: The granulation box (1) is provided with observation windows (14) on both sides, and the height of the observation windows (14) is the same as the height of the middle position of the screen plate (3).

3. The pharmaceutical excipient granulating apparatus according to claim 1, characterized by: The bottom of the granulation box (1) is provided with a discharge port (12), which is connected to the inside of the granulation box (1).

4. The pharmaceutical excipient granulating apparatus according to claim 3, characterized by: The bottom of the granulation box (1) is provided with an inclined guide surface, and the discharge port (12) is located at the lowest position of the bottom of the granulation box (1).

5. The pharmaceutical excipient granulating apparatus according to claim 1, characterized by: The bottom of the feed hopper (11) extends into the granulation box (1), and the bottom of the feed hopper (11) is positioned above the two granulation rollers (2).

6. The pharmaceutical excipient granulating apparatus according to claim 1, characterized by: The granulation box (1) is vertically supported by four corners of its bottom with legs (13), and there are multiple legs (13).

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