Flexible plasmonic patch

Abstract

The utility model relates to medical instrument technical field provides a kind of flexible plasma patch, including first dielectric barrier layer, electrode layer, second dielectric barrier layer and medical film layer by upper to lower sequentially laminated settings, the electrode layer is suitable for connecting power module, for generating plasma, the medical film layer is suitable for contacting wound surface, the first dielectric barrier layer, the electrode layer, the second dielectric barrier layer and the medical film layer are all correspondingly provided with through-hole. The utility model is through setting corresponding through-hole, on the one hand make outside air pass through through-hole and enter wound surface, increase the generation amount of active particle, effectively improve the efficiency of sterilization and promote wound healing;On the other hand, the ozone generated by electrode layer discharge flows out from through-hole, thereby reducing ozone accumulation, avoiding the tissue oxidation stress caused by ozone accumulation, leading to cell membrane lipid peroxidation.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a flexible plasma patch. Background Technology

[0002] Plasma is a special state of matter containing high-energy electrons, ions, and neutral particles. Among them, low-temperature plasma, due to its low temperature and active biochemical properties, has significant advantages, especially in sterilization, promoting healing, promoting blood clotting, and killing tumor cells.

[0003] Chinese patent CN 108969889A, published on December 11, 2018, discloses a flexible plasma patch: it includes a first flexible insulating layer, an electrode and a second flexible insulating layer arranged in sequence. The first flexible insulating layer has protrusions, which form a gap with the surface to be treated.

[0004] Chinese patent CN 116600458A, published on August 15, 2023, discloses a flexible DBD micro-plasma patch and sterilization device: the patch includes a first copper foil, a dielectric tape layer and a second copper foil, wherein the second copper foil has vacancies, and micro-plasma is generated at the vacancies.

[0005] Although the aforementioned literature demonstrates that flexible plasma patches can achieve functions such as wound healing and skin disease treatment, the flexible plasma patches continuously consume working gas during operation and cannot be replenished in a timely manner, resulting in poor treatment effects. Furthermore, the ozone generated during wound treatment accumulates, and high concentrations of ozone are toxic to living cells. Long-term concentration in a certain area can easily cause tissue oxidative stress, leading to cell membrane lipid peroxidation, which in turn triggers an inflammatory response and delays the wound healing process. Utility Model Content

[0006] This invention provides a flexible plasma patch to address the aforementioned technical deficiencies in the prior art. By setting corresponding through holes, it allows outside air to enter the wound through the through holes, increasing the amount of active particles generated and effectively improving the efficiency of sterilization and wound healing. On the other hand, it allows ozone generated by the discharge of the electrode layer to flow out through the through holes, thereby reducing ozone accumulation and avoiding tissue oxidative stress caused by ozone accumulation, which leads to cell membrane lipid peroxidation.

[0007] This utility model provides a flexible plasma patch, comprising a first dielectric barrier layer, an electrode layer, a second dielectric barrier layer, and a medical film layer stacked sequentially from top to bottom. The electrode layer is adapted to connect to a power module for generating plasma, and the medical film layer is adapted to contact the wound surface. The first dielectric barrier layer, the electrode layer, the second dielectric barrier layer, and the medical film layer are all provided with corresponding through holes.

[0008] According to the flexible plasma patch provided by this utility model, the first dielectric barrier layer is provided with a first through hole at intervals, and the first through hole is provided corresponding to the gap of the electrode layer; the second dielectric barrier layer is provided with a second through hole at intervals, and the position of the second through hole corresponds to the position of the first through hole; the medical film layer is provided with a third through hole, and the position of the third through hole corresponds to the position of the second through hole.

[0009] According to the flexible plasma patch provided by this utility model, the diameters of the first through hole, the second through hole and the third through hole gradually increase along the thickness direction of the flexible plasma patch.

[0010] According to the flexible plasma patch provided by this utility model, the diameter of the first through hole is smaller than the diameter of the second through hole, and the diameter of the second through hole is smaller than the diameter of the third through hole.

[0011] According to the flexible plasma patch provided by this utility model, at least two of the first through holes form a first hole group; On the same projection plane, the layout area of ​​each group of the first holes covers the opening area of ​​the second through hole; the diameter of the third through hole is greater than or equal to the diameter of the second through hole.

[0012] According to the flexible plasma patch provided by this utility model, at least three first through holes form a first hole group, and at least two second through holes form a second hole group. The layout area of ​​each group of first holes corresponds to the layout area of ​​each group of second holes, and the number of through holes in each group of first holes is greater than the number of through holes in the corresponding second hole group. On the same projection plane, the layout area of ​​each group of second holes covers the opening area of ​​the third through hole.

[0013] According to the flexible plasma patch provided by this utility model, the electrode layer includes a substrate, a positive electrode and a negative electrode, the positive electrode and the negative electrode are coplanarly disposed on the substrate, and both the positive electrode and the negative electrode are adapted to connect to a power module.

[0014] According to the flexible plasma patch provided by this utility model, the electrode layer includes a positive electrode, an insulating dielectric layer and a negative electrode stacked sequentially.

[0015] The flexible plasma patch provided by this utility model also includes an adapter component, which is integrated with the electrode lines of the electrode layer and is adapted to connect to a power module.

[0016] The flexible plasma patch provided by this utility model has through holes throughout the entire flexible plasma patch. On the one hand, it allows outside air to enter the wound through the through holes, increasing the amount of active particles generated and effectively improving the efficiency of sterilization and wound healing. On the other hand, it allows ozone generated by the discharge of the electrode layer to flow out through the through holes, thereby reducing ozone accumulation and avoiding tissue oxidative stress caused by ozone accumulation, which leads to cell membrane lipid peroxidation. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the structure of the flexible plasma patch provided in this embodiment of the present invention.

[0019] Figure 2 This is an exploded view of the structure of the flexible plasma patch provided in this embodiment of the present invention.

[0020] Figure 3 This is an isometric sectional view of the flexible plasma patch provided in this embodiment of the present invention.

[0021] Figure 4 yes Figure 3 The diagram shows a partial schematic of the flexible plasma patch provided in this embodiment of the present invention.

[0022] Figure 5 This is a partial exploded view of the flexible plasma patch provided in an embodiment of the present invention.

[0023] Figure 6 This is a schematic diagram of the electrode layer in the flexible plasma patch provided in this embodiment of the present invention.

[0024] Figure 7 This is a top view of the flexible plasma patch provided in this embodiment of the utility model.

[0025] Figure label: 10. First dielectric barrier layer; 11. First through hole; 20. Electrode layer; 21. Positive electrode; 22. Negative electrode; 30. Second dielectric barrier layer; 31. Second through hole; 40. Medical film layer; 41. Third through hole; 50. Adapter component. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0027] In the description of the embodiments of this application, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of this application based on the specific circumstances.

[0028] In the embodiments of this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0029] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the embodiments of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0030] Figure 1 This is a schematic diagram of the structure of the flexible plasma patch provided in this embodiment of the present invention. Figure 2 This is an exploded view of the structure of the flexible plasma patch provided in this embodiment of the present invention.

[0031] See Figure 1 and Figure 2This utility model provides a flexible plasma patch, which includes a first dielectric barrier layer 10, an electrode layer 20, a second dielectric barrier layer 30 and a medical film layer 40 stacked from top to bottom.

[0032] Electrode layer 20 is suitable for connecting a power module to generate plasma, and medical film layer 40 is suitable for contact with the wound surface. First dielectric barrier layer 10 and second dielectric barrier layer 30 serve as flexible substrates, providing support and a flat working interface. Both first dielectric barrier layer 10 and second dielectric barrier layer 30 are made of the same insulating dielectric material, including but not limited to silicone rubber, silicone, gel, polyimide, and polydimethylsiloxane. First dielectric barrier layer 10 and second dielectric barrier layer 30 can also be made of polymer films, such as PET (polyethylene terephthalate), PU (polyurethane), and PVC (polyvinyl chloride), to ensure the patch has flexibility and comfort. Medical film layer 40 is suitable for contact with the wound surface and includes, but is not limited to, polyurethane, polyethylene, and polyvinyl chloride. First dielectric barrier layer 10, electrode layer 20, second dielectric barrier layer 30, and medical film layer 40 are all provided with corresponding through-holes.

[0033] In the processing of the flexible plasma patch provided in this embodiment, the dimensions, electrode pattern, dielectric thickness, and other parameters of the flexible plasma patch are first determined. Electrodes are commonly made of metal (copper, aluminum) or conductive carbon ink, while the dielectric layer uses high dielectric constant materials such as polymers. During the fabrication of the electrode layer 20, electrode patterns can be formed on the substrate using methods such as photolithography, etching, and printing. The first dielectric barrier layer 10 and the second dielectric barrier layer 30 are fabricated using coating, sputtering, or sol-gel methods to create insulating layers of the required thickness. Then, the upper and lower dielectric barrier layers are aligned with the electrode layer 20, and sealed by hot pressing, ultrasonic welding, or bonding. The medical film layer 40 can be adhered to the surface of the second dielectric barrier layer 30 using biocompatible adhesive. Finally, a driving power supply is connected to the flexible plasma patch, and a built-in chip regulates the voltage frequency and power output to ensure stable operation.

[0034] It is understood that the flexible plasma patch provided in this embodiment of the present invention has through holes throughout the entire flexible plasma patch. On the one hand, it allows outside air to enter the wound through the through holes, increasing the amount of active particles generated and effectively improving the efficiency of sterilization and wound healing. On the other hand, it allows ozone generated by the discharge of the electrode layer 20 to flow out through the through holes, thereby reducing ozone accumulation and avoiding tissue oxidative stress caused by ozone accumulation, which leads to cell membrane lipid peroxidation.

[0035] Because ozone generated during wound treatment tends to accumulate, while it can exert a certain bactericidal effect, high concentrations of ozone are toxic to living cells. Prolonged concentration in a particular area can easily cause oxidative stress in tissues, leading to cell membrane lipid peroxidation and subsequently triggering an inflammatory response, thus delaying wound healing. Furthermore, large amounts of ozone can inhibit leukocyte function, interfere with normal immune responses, and weaken the body's ability to resist infection, hindering wound defense and repair. The flexible plasma patch provided in this embodiment, through corresponding through-holes, provides an escape channel for ozone, reducing ozone accumulation at the wound site, thereby promoting wound healing and improving treatment efficiency.

[0036] Continue reading Figure 2 In some embodiments of this utility model, the first dielectric barrier layer 10 is provided with first through holes 11 at intervals, the first through holes 11 being disposed corresponding to the gaps in the electrode layer 20, and gaps being disposed between the electrodes in the electrode layer 20; the second dielectric barrier layer 30 is provided with second through holes 31 at intervals, the positions of the second through holes 31 corresponding to the positions of the first through holes 11, which is equivalent to a through hole consisting of the first through hole 11, the gaps, and the second through hole 31 being disposed through the flexible plasma patch. The medical film layer 40 is provided with a third through hole 41, the position of the third through hole 41 corresponding to the position of the second through hole 31.

[0037] Essentially, the flexible plasma patch provided in this embodiment can be encapsulated as a whole, and then have through holes uniformly provided. Alternatively, after each layer of the structure is fabricated, holes can be made individually for each layer, and the holes for each layer can be set accordingly.

[0038] In some embodiments of this utility model, a biocompatible adhesive or tape can be provided on the medical film layer 40 to fix the flexible plasma patch to the vicinity of the patient's wound, that is, to fix the flexible plasma patch to the target area, ensuring that the plasma release is stable and uniform and will not easily fall off. Even in the state of exercise or sleep, it can maintain good adhesion and reduce secondary damage caused by tearing again.

[0039] Figure 3 This is an isometric sectional view of the flexible plasma patch provided in this embodiment of the present invention. Figure 4 yes Figure 3 The diagram shows a partial schematic of the flexible plasma patch provided in this embodiment of the present invention.

[0040] See Figure 3 and Figure 4In some embodiments of this utility model, along the thickness direction of the flexible plasma patch, the apertures of the first through hole 11, the second through hole 31, and the third through hole 41 gradually increase from top to bottom, that is, along the thickness direction of the flexible plasma patch, the apertures of the first through hole 11, the second through hole 31, and the third through hole 41 gradually decrease from bottom to top.

[0041] This means that the first through hole 11, the second through hole 31, and the third through hole 41 can all be tapered or trapezoidal holes, and the diameter of the first through hole 11 gradually increases. The top dimension of the second through hole 31 is the same as the bottom dimension of the first through hole 11, and the diameter of the second through hole 31 gradually increases. The top dimension of the third through hole 41 is the same as the bottom dimension of the second through hole 31, and the diameter of the third through hole 41 gradually increases.

[0042] That is, the bottom diameter of the third through hole 41 is the largest, and the top diameter of the first through hole 11 is the smallest. This setting is equivalent to the through holes closer to the wound having larger diameters, while the through holes farther from the wound having smaller diameters, thus preventing water vapor or other liquids from entering the flexible plasma patch through the through holes.

[0043] It should be noted that the entire through-hole design of the flexible plasma patch can be precisely controlled in terms of the diameter and arrangement of the through-holes according to the specific wound condition. By utilizing the principle of capillary action, the pore size is small enough to allow liquid droplets to enter, but allows air and ozone to pass through freely.

[0044] Alternatively, a hydrophobic layer can be coated around each third through-hole 41 or on the entire surface of the medical film layer 40. Even when exposed to moisture, the medical film layer 40 is not easily wetted, preventing moisture from penetrating the flexible plasma patch. Alternatively, a moisture-absorbing material layer can be placed on the lower layer of the medical film layer 40 at the location of the third through-hole 41. This moisture-absorbing material layer quickly absorbs moisture near the electrode layer 20. Even if a small amount of liquid accidentally seeps in, it will be absorbed promptly, protecting the circuitry of the electrode layer 20 from damage.

[0045] See Figure 3 and Figure 4 In some embodiments of this utility model, the diameter of the first through hole 11 is smaller than the diameter of the second through hole 31, and the diameter of the second through hole 31 is smaller than the diameter of the third through hole 41.

[0046] Essentially, the first through-hole 11, the second through-hole 31, and the third through-hole 41 are all cylindrical straight holes. The through-holes formed by the first through-hole 11, the second through-hole 31, and the third through-hole 41 penetrating the flexible plasma patch are stepped holes. The stepped holes can accelerate the airflow in the vertical direction, which helps to replenish the working gas. At the same time, the stepped holes increase the surface area for air interaction, promote smooth airflow, and can effectively improve treatment efficiency.

[0047] In some embodiments of this utility model, at least two first through holes 11 form a first hole group; on the same projection plane, the layout area of ​​each first hole group covers the opening area of ​​the second through hole 31; the diameter of the third through hole 41 is greater than or equal to the diameter of the second through hole 31.

[0048] Since the first through hole 11 is connected to the outside air, the diameter of the first through hole 11 determines whether external contamination can enter the wound. Therefore, by opening at least two first through holes 11 of different shapes in the original position of one first through hole 11, and by reducing the size of a single first through hole 11 and increasing the number of first through holes 11 in the same area, the size of the first through hole 11 can be effectively reduced, thereby further isolating external contamination and preventing microorganisms, dust and other harmful substances from invading the wound.

[0049] In this embodiment, the diameter of the third through hole 41 is greater than or equal to the diameter of the second through hole 31, while the diameter of the first through hole 11 is always smaller than the diameter of the second through hole 31. This ensures that the through holes of the flexible plasma patch, which consist of the first through hole 11, the second through hole 31, and the third through hole 41, are also larger near the wound and smaller at the end that is far from the wound and connected to the outside air. This prevents external contamination from entering the interior of the flexible plasma patch through the first through hole 11.

[0050] In some embodiments of this utility model, at least three first through holes 11 form a first hole group, and at least two second through holes 31 form a second hole group. The layout area of ​​each first hole group corresponds to the layout area of ​​each second hole group, and the number of through holes in each first hole group is greater than the number of through holes in the corresponding second hole group. On the same projection plane, the layout area of ​​each second hole group covers the opening area of ​​the third through hole 41.

[0051] In this embodiment, by creating at least three first through holes 11 of different shapes at the location of the original single first through hole 11, the size of a single first through hole 11 is reduced, while the number of first through holes 11 in the same area is increased. Similarly, by creating at least two second through holes 31 of different shapes at the location of the original single second through hole 31, the size of a single second through hole 31 is reduced, while the number of second through holes 31 in the same area is increased. Furthermore, by always maintaining a size larger than the third through hole 41 and a size larger than the second through hole 31, the capillary action principle can be effectively utilized. This ensures that the pore size is small enough to prevent liquid droplets from entering, while allowing air and ozone to pass freely. This ensures the flexible plasma patch has a good therapeutic effect while effectively preventing contaminants from sequentially entering and contacting the wound through the various through holes.

[0052] In some embodiments of this invention, the pore walls of the through holes can also be provided with an ozone catalyst to rapidly decompose excess ozone into oxygen. The hydroxyl radicals (·OH) formed by ozone under the action of the ozone catalyst have a higher reaction rate and stronger oxidizing power with organic matter, oxidizing and decomposing large organic molecules into small molecules, making them easier to degrade, thereby improving treatment efficiency.

[0053] It should be noted that the shapes of the first through hole 11, the second through hole 31 and the third through hole 41 include, but are not limited to, circles, ovals, squares, strips, polygons, and irregular shapes, such as pentagons or hearts.

[0054] It should also be noted that the flexible plasma patch provided in this embodiment of the present invention can use computer simulation software to predict the distribution pattern of each through hole under different hole diameters and spacings according to the wound area, depth, shape, etc., so as to adapt to different wound conditions.

[0055] Figure 5 This is a partial exploded view of the flexible plasma patch provided in an embodiment of the present invention. Figure 6 This is a schematic diagram of the structure of the electrode layer 20 in the flexible plasma patch provided in this embodiment of the present invention.

[0056] See Figure 5 and Figure 6 In some embodiments of this utility model, the electrode layer 20 includes a positive electrode 21, an insulating dielectric layer, and a negative electrode 22 stacked sequentially from top to bottom. The positive electrode 21, the insulating dielectric layer, and the negative electrode 22 are stacked to form a dielectric barrier discharge structure similar to a "sandwich".

[0057] Dielectric barrier discharge (DBD discharge) does not require the electrodes to be in direct contact with the gas. Instead, it uses an insulating medium to isolate the electrodes from the gas, which can prevent electrode corrosion and extend the life of the equipment.

[0058] In some embodiments of this utility model, the electrode layer 20 may further include a substrate, a positive electrode 21 and a negative electrode 22, with the positive electrode 21 and the negative electrode 22 coplanarly disposed on the substrate, and both the positive electrode 21 and the negative electrode 22 being adapted to connect to a power module to generate plasma.

[0059] Compared to other discharge methods, coplanar electrodes can achieve stable and consistent energy transfer over a wider range, avoiding hot spot formation and ensuring uniform heating of the treatment area; they are also conducive to generating a large number of reactive oxygen species (ROS), reactive nitrogen species (RNS) and other charged particles, effectively promoting biological effects such as wound healing, anti-inflammatory and analgesic effects.

[0060] It should be noted that the discharge electrode is not limited to comb-shaped electrodes, spiral electrodes, mesh electrodes, and honeycomb electrodes.

[0061] Figure 7 This is a top view of the flexible plasma patch provided in this embodiment of the utility model.

[0062] Continue reading Figure 1 And see also Figure 7 In some embodiments of this utility model, the flexible plasma patch further includes a transition component 50, which is integrated with the electrode lines of the electrode layer 20, and the transition component 50 is adapted to connect to a power module.

[0063] The adapter component 50 facilitates the connection between the flexible plasma patch and the power module. The adapter component 50 can be equipped with standardized plugs and sockets, allowing the flexible plasma patch to be quickly connected to the power module, simplifying maintenance and connection.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A flexible plasma patch, characterized in that, It includes a first dielectric barrier layer, an electrode layer, a second dielectric barrier layer, and a medical film layer stacked sequentially from top to bottom. The electrode layer is adapted to connect to a power module for generating plasma, and the medical film layer is adapted to contact the wound surface. The first dielectric barrier layer, the electrode layer, the second dielectric barrier layer, and the medical film layer are all provided with corresponding through holes. Along the thickness direction of the flexible plasma patch, the apertures of the first through-hole on the first dielectric barrier layer, the second through-hole on the second dielectric barrier layer, and the third through-hole on the medical film layer gradually increase from top to bottom.

2. The flexible plasma patch according to claim 1, characterized in that, The first through hole is provided corresponding to the gap in the electrode layer; The position of the second through hole corresponds to the position of the first through hole; The position of the third through hole corresponds to the position of the second through hole.

3. The flexible plasma patch according to claim 2, characterized in that, The diameter of the first through hole is smaller than the diameter of the second through hole, and the diameter of the second through hole is smaller than the diameter of the third through hole.

4. The flexible plasma patch according to claim 2, characterized in that, At least two of the first through holes form a first hole group; On the same projection plane, the layout area of ​​each group of the first holes covers the opening area of ​​the second through hole; the diameter of the third through hole is greater than or equal to the diameter of the second through hole.

5. The flexible plasma patch according to claim 2, characterized in that, At least three first through holes form a first hole group, and at least two second through holes form a second hole group. The layout area of ​​each group of first holes corresponds to the layout area of ​​each group of second holes, and the number of through holes in each group of first holes is greater than the number of through holes in the corresponding second hole group. On the same projection plane, the layout area of ​​each group of second holes covers the opening area of ​​the third through hole.

6. The flexible plasma patch according to any one of claims 1 to 5, characterized in that, The electrode layer includes a substrate, a positive electrode, and a negative electrode. The positive electrode and the negative electrode are coplanarly disposed on the substrate, and both the positive electrode and the negative electrode are adapted to connect to a power module.

7. The flexible plasma patch according to any one of claims 1 to 5, characterized in that, The electrode layer comprises a positive electrode, an insulating dielectric layer, and a negative electrode stacked sequentially.

8. The flexible plasma patch according to any one of claims 1 to 5, characterized in that, It also includes an adapter component, which is integrated with the electrode lines of the electrode layer and is adapted to connect to a power module.

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