biological tissue homogenizer

Abstract

This biological tissue homogenization and mixing device effectively solves the problems of time-consuming, labor-intensive, and poor repeatability associated with existing manual mixing methods. It includes a base block with an upper and lower axial orientation. Multiple axially distributed, circumferentially distributed receiving slots are formed on the base block, each containing a sample tube. A support column, coaxially positioned between the receiving slots, is located at the upper end of the base block. Each support column has multiple grooves corresponding to the receiving slots, with sliding rods slidably connected within these grooves. A mixing column, positioned above and insertable into the sample tube, is located at the outer end of each sliding rod. A clearance groove is formed at the lower end of the mixing column, within which a mixing head is slidably connected. The upper end of the mixing head is connected to the mixing column via a spring. A pressing plate, coaxial with the base block, is located at the upper end of the pressing plate, its upper surface gradually increasing counterclockwise. A power column is rotatably connected coaxially within the support column. A connecting plate is located at the upper end of the power column, and a pressing column, contacting the inclined surface of the pressing plate, is located at the lower end of the connecting plate. This structure is simple, innovative, easy to use, and highly practical.

Description

Technical Field

[0001] This utility model relates to the field of detection technology, and in particular to a biological tissue homogenization and stirring device. Background Technology

[0002] In biomedical research and clinical testing, tissue homogenization is a crucial pretreatment step. Its purpose is to break down tissue cells to extract target components such as proteins, nucleic acids, and metabolites. Before fine homogenization using high-speed homogenizers or grinding beads, large tissue blocks usually need to be initially broken down into appropriately sized pieces to ensure the efficiency and uniformity of subsequent homogenization.

[0003] Currently, laboratories rely heavily on manual stirring, a traditional method with significant limitations: First, its processing efficiency is extremely low and labor intensity is high, making it difficult to meet the increasing throughput demands of modern research; second, manual operation is difficult to standardize, resulting in tissue fragments of varying sizes obtained by different personnel or by the same person in different operations, leading to poor repeatability and directly affecting the accuracy and comparability of subsequent experimental results. Utility Model Content

[0004] In view of the above situation and in order to make up for the shortcomings of the existing technology, the purpose of this utility model is to provide a biological tissue homogenization and stirring device, which effectively solves the problems of time-consuming and labor-intensive manual stirring and poor repeatability.

[0005] The technical solution is as follows: This utility model includes a base block with an upper and lower axial orientation. Multiple accommodating grooves are evenly distributed along the circumference of the base block and are axially oriented. A sample tube is placed in each accommodating groove. A support column is coaxially positioned between the multiple accommodating grooves at the upper end of the base block. Multiple sliding grooves corresponding to the accommodating grooves are formed on the support column. A sliding rod is slidably connected within each sliding groove. A stirring column, positioned above the sample tube and insertable into it, is located at the outer end of the sliding rod. A clearance groove is formed at the lower end of the stirring column. A stirring head is slidably connected coaxially within the clearance groove. The upper end of the stirring head is connected to the stirring column via a spring. A pressing plate, coaxial with the base block, is located at the upper end of the pressing plate. The upper surface of the pressing plate is an inclined surface that gradually increases counterclockwise. A power column is rotatably connected coaxially within the support column. A connecting plate is located at the upper end of the power column, and a pressing column that can contact the inclined surface of the pressing plate is located at the lower end of the connecting plate.

[0006] Preferably, the base block contains a motor, and the motor output shaft is coaxially and fixedly connected to the power column.

[0007] Preferably, the slide groove is provided with a reset column that is axially connected to the slide rod and is slidably connected to the slide rod. A compression spring is fitted on the reset column between the slide rod and the support column.

[0008] Preferably, the lower end of the stirring head is provided with friction texture.

[0009] Preferably, the lower end of the base block is provided with a plurality of rectangular limiting grooves that correspond one-to-one with the sample tubes, and the lower end of the sample tubes is provided with rectangular blocks that can be inserted into the limiting grooves.

[0010] Preferably, the lower end of the base block is provided with multiple support plates.

[0011] Compared with existing technologies, the advantages of this invention are: it enables standardized and simultaneous processing of multiple biological tissue samples, greatly improving experimental efficiency and ensuring high reproducibility of results; the extrusion column extrusion drive and spring buffer design allow the stirring head to cyclically break up tissues with a constant and controllable force, effectively avoiding the problem of inconsistent tissue fragment sizes caused by uneven force during manual operation, laying a uniform foundation for subsequent fine homogenization steps, thereby ensuring the accuracy of the final extracted biomolecular data. Compared with traditional manual stirring, it is simple to operate and saves time and effort. Attached Figure Description

[0012] Figure 1 This is the main view axonometric drawing of this utility model.

[0013] Figure 2 This is a full-section left-side axonometric drawing of this utility model.

[0014] Figure 3 This is a full-section top-view axonometric drawing of this utility model.

[0015] Figure 4 This is the bottom-view axonometric drawing of this utility model.

[0016] Figure label: 1. Base block; 2. Sample cylinder; 3. Support column; 4. Slide groove; 5. Slide rod; 6. Stirring column; 7. Relief groove; 8. Stirring head; 9. Spring; 10. Extrusion plate; 11. Power column; 12. Connecting plate; 13. Extrusion column; 14. Motor; 15. Reset column; 16. Compression spring; 17. Limiting groove; 18. Rectangular block; 19. Support plate. Detailed Implementation

[0017] To make the above-mentioned objectives, features, and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a full understanding of this utility model. However, this utility model can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this utility model. Therefore, this utility model is not limited to the implementations of the base model disclosed below.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0019] The specific embodiments of this utility model will be further described in detail below with reference to the accompanying drawings.

[0020] Depend on Figures 1 to 4 The system includes a base block 1 with vertical axis. Multiple accommodating slots are evenly distributed along its circumference and vertical axis on the base block 1. Sample cylinders 2 are placed in the accommodating slots. A support column 3 is coaxially positioned at the upper end of the base block 1, located between the multiple accommodating slots. Multiple sliding grooves 4, corresponding one-to-one with the accommodating slots, are formed on the support column 3. A sliding rod 5 is slidably connected within the sliding groove 4. A stirring column 6, positioned above and insertable into the sample cylinder 2, is located at the outer end of the sliding rod 5. A clearance groove 7 is formed at the lower end of the stirring column 6. A stirring head 8 is slidably connected coaxially within the clearance groove 7. The upper end of the stirring head 8 is connected to the stirring column 6 via a spring 9. A pressing plate 10, coaxial with the base block 1, is located at the upper end of the stirring column 6. The upper surface of the pressing plate 10 is an inclined surface that gradually increases counterclockwise. A power column 11 is rotatably connected coaxially within the support column 3. A connecting plate 12 is located at the upper end of the power column 11. A pressing column 13, which can contact the inclined surface of the pressing plate 10, is located at the lower end of the connecting plate 12.

[0021] In order to make the power column 11 rotate, the base block 1 is equipped with a motor 14, and the output shaft of the motor 14 is coaxially and fixedly connected to the power column 11.

[0022] To facilitate the reset of the slide bar 5, the slide groove 4 is provided with a reset column 15 that is axially connected to the slide bar 5 and is slidably connected to it. A compression spring 16 is fitted on the reset column 15 between the slide bar 5 and the support column 3.

[0023] To enhance the mixing effect, the lower end of the mixing head 8 is provided with friction grooves.

[0024] To facilitate fixing the sample tube 2, the lower end of the base block 1 is provided with a plurality of rectangular limiting grooves 17 that correspond one-to-one with the sample tube 2, and the lower end of the sample tube 2 is provided with a rectangular block 18 that can be inserted into the limiting groove 17.

[0025] To enhance stability, the base block 1 is provided with multiple support plates 19 at its lower end.

[0026] When using this utility model, firstly, the operator places the sample tube 2 carrying biological tissue into the circumferentially distributed receiving groove of the base block 1, and fixes it by the cooperation of the rectangular block 18 at the lower end of the sample tube 2 with the limiting groove 17 on the base block 1. After the device is started, the motor 14 in the base block 1 drives the power column 11 to rotate, and the connecting plate 12 at the upper end of the power column 11 rotates accordingly, and drives the squeezing column 13 at its lower end to rotate synchronously. During rotation, the extrusion column 13 continuously presses against the inclined surface at the upper end of the extrusion plate 10. Since the inclined surface gradually rises counterclockwise, the pressure of the extrusion column 13 is converted into a downward driving force on the extrusion plate 10, thereby pushing the entire extrusion plate 10 downward. The multiple sliding rods 5 connected to the extrusion plate 10 then slide radially inward along the sliding groove 4 on the support column 3. The compression spring 16 is compressed, so that the stirring column 6 at the outer end of each sliding rod 5 is inserted downward into the corresponding sample cylinder 2. The stirring column 6 inserted into the cylinder is buffered by the action of the spring 9. The stirring head 8 at its lower end contacts the tissue and applies pressure. The friction texture on the lower surface of the stirring head 8 further enhances the crushing effect. When the extrusion column 13 passes the highest point of the inclined surface, the pressure is released, and the compression spring 16 pushes the slide rod 5 to return to its original position along the reset column 15. The stirring column 6 is then lifted to complete one stirring cycle. The continuous operation of the motor 14 makes this process repeat, realizing automated organization, stirring and crushing. This effectively overcomes the defects of low efficiency and poor repeatability of manual operation. After stirring is completed, the motor 14 is turned off, and the sample cylinder 2 is taken out for homogenization.

[0027] Compared with existing technologies, the beneficial effects of this utility model are as follows: the provided stirring column and stirring head enable standardized and simultaneous processing of multiple biological tissue samples, greatly improving experimental efficiency and ensuring high reproducibility of results; the squeezing column's squeezing transmission and spring buffer design allow the stirring head to cyclically break down the tissue with a constant and controllable force, effectively avoiding the problem of inconsistent tissue fragment sizes caused by uneven force during manual operation, laying a uniform foundation for subsequent fine homogenization steps, thereby ensuring the accuracy of the final extracted biomolecular data. Compared with traditional manual stirring, the operation is simple, time-saving, and labor-saving. This structure is simple, novel in design, easy to use, and highly practical.

[0028] It should be noted that, depending on the implementation needs, the various components described in the embodiments of this utility model can be split into more components, or two or more components or parts of components can be combined into new components to achieve the purpose of the embodiments of this utility model.

[0029] The above embodiments only illustrate several implementation methods of this utility model, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A biological tissue homogenizer, comprising a base block (1) with vertical axial direction, characterized in that, The base block (1) has multiple accommodating slots evenly distributed along its circumference and axially aligned with the vertical direction. Sample tubes (2) are placed in the accommodating slots. The upper end of the base block (1) is coaxially provided with a support column (3) located between the multiple accommodating slots. Multiple sliding grooves (4) corresponding to the accommodating slots are provided on the support column (3). A sliding rod (5) is slidably connected in the sliding groove (4). A stirring column (6) located above the sample tube (2) and insertable into the sample tube (2) is provided at the outer end of the sliding rod (5). A clearance groove (7) is provided at the lower end of the stirring column (6). A stirring head (8) is slidably connected coaxially in the slot (7). The upper end of the stirring head (8) is connected to the stirring column (6) via a spring (9). The upper end of the stirring column (6) is provided with an extrusion plate (10) coaxial with the base block (1). The upper surface of the extrusion plate (10) is an inclined surface that gradually rises counterclockwise. A power column (11) is rotatably connected coaxially in the support column (3). The upper end of the power column (11) is provided with a connecting plate (12). The lower end of the connecting plate (12) is provided with an extrusion column (13) that can contact the inclined surface of the extrusion plate (10).

2. The biological tissue homogenizer and mixing device according to claim 1, characterized in that, The base block (1) is equipped with a motor (14), and the output shaft of the motor (14) is coaxially and fixedly connected to the power column (11).

3. The biological tissue homogenizer and mixing device according to claim 1, characterized in that, The groove (4) is provided with a reset column (15) that is axially connected to the slide rod (5) and is slidably connected to the slide rod (5). A compression spring (16) is fitted on the reset column (15) between the slide rod (5) and the support column (3).

4. The biological tissue homogenizer and mixing device according to claim 1, characterized in that, The lower end of the stirring head (8) is provided with friction texture.

5. The biological tissue homogenizer and mixing device according to claim 1, characterized in that, The base block (1) has multiple rectangular limiting grooves (17) at its lower end that correspond one-to-one with the sample tube (2), and the sample tube (2) has a rectangular block (18) at its lower end that can be inserted into the limiting groove (17).

6. The biological tissue homogenizer and mixing device according to claim 1, characterized in that, The base block (1) is provided with multiple support plates (19) at its lower end.

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