A urine metabolite detector suitable for multiple scenes

Abstract

The utility model discloses a urine metabolite detector suitable for multiple scenes, including flexible sensor patch, the flexible sensor patch is connected with the circuit board in the detector through the flexible flat cable, the flexible sensor patch includes the insulating layer, electrode layer, flexible base layer, double -faced adhesive layer and separation layer who sets gradually from top to bottom, wherein, electrode layer includes a plurality of working electrode and one counter electrode, the outer periphery of working electrode and counter electrode is set around hydrophobic layer, the outer periphery of flexible sensor patch is set around antibacterial layer, the utility model solves the shortcoming that the traditional urine detection equipment of prior art exists and is operated complicated, is easily polluted, and the universality is poor, cannot be applicable to the urine detection in paper diaper and urine detection of closestool, and the urine detector can be carried personally, also can be installed in paper diaper interlayer and closestool inner wall, greatly promotes the universality and use portability of urine metabolite rapid detection instrument.

Description

Technical Field

[0001] This utility model belongs to the technical field of urine detection devices, specifically relating to a urine metabolite detector applicable to multiple scenarios. Background Technology

[0002] The statements herein provide only background information related to this invention and do not necessarily constitute prior art.

[0003] Currently, urine testing primarily relies on routine urinalysis equipment in hospitals and traditional urine test strips. Routine urinalysis requires a trip to the hospital, specialized medical personnel, and results can take several hours to obtain. While urine test strips provide faster results, the colorimetric method makes accurate interpretation difficult, and the strips are easily contaminated or damaged. Many chronic and metabolic diseases require frequent hospital visits, consuming significant time and energy; therefore, rapid and accurate home-based health monitoring is crucial. With the rapid development of electronic information technology and the Internet of Things (IoT), the demand for intelligent health monitoring devices is increasing, and integrating health monitoring devices into home life is a future trend.

[0004] Existing intelligent urine detection devices generally include a substrate layer, a sensing layer, an encapsulation layer, and an adhesive layer. They mainly detect various components in urine by setting up multiple sensor circuits on the sensing layer. However, existing intelligent urine detection devices with this structure suffer from contamination and interference in real urine during the detection process, which affects the accuracy and precision of the detection. Furthermore, they lack installation structures for various application scenarios, making it difficult to achieve multi-scenario applications. Utility Model Content

[0005] The purpose of this invention is to provide a urine metabolite detector applicable to multiple scenarios, which can solve the problem of contamination and interference in real urine during the detection process of existing devices; in addition, this urine detector can be carried around and can also be installed in the lining of diapers and the inner wall of toilets, which greatly improves the versatility and portability of the rapid urine metabolite detector.

[0006] To achieve the above objectives, this utility model is implemented through the following technical solution: In a first aspect, embodiments of this utility model provide a urine metabolic substance detector applicable to multiple scenarios, including a flexible sensor patch. The flexible sensor patch is connected to a circuit board inside the detector via a flexible flat cable. The flexible sensor patch includes, from top to bottom, an insulating layer, an electrode layer, a flexible substrate layer, a double-sided adhesive layer, and a separation layer. The electrode layer includes multiple working electrodes and a counter electrode, and a hydrophobic layer is arranged around the outer periphery of the working electrodes and the counter electrode. An antibacterial layer is arranged around the outer periphery of the flexible sensor patch.

[0007] As a further technical solution, the wire circuits of the working electrode and the counter electrode correspond one-to-one with the wires in the flexible flat cable, and the flexible flat cable and the flexible sensor patch are packaged together by hot pressing.

[0008] As a further technical solution, the insulating layer covers the wire portion extending from the working electrode and the counter electrode, and the insulating layer is formed by screen printing insulating ink onto the surface of the electrode wire.

[0009] As a further technical solution, the working electrodes include glucose working electrodes, uric acid working electrodes, nitrite working electrodes, ascorbic acid working electrodes, urinary ketone body working electrodes, urinary bilirubin working electrodes, urinary calcium working electrodes, and urinary pH working electrodes.

[0010] As a further technical solution, the antibacterial layer is a polydimethylsiloxane film coated with an antibacterial agent.

[0011] As a further technical solution, the hydrophobic layer is prepared by chemical modification or by processing micro / nano structures.

[0012] As a further technical solution, the separation layer is made by covering the surface of the double-sided layer with release paper.

[0013] As a further technical solution, the flexible substrate layer is a thin film made of polystyrene, polyethylene terephthalate, or polydimethylsiloxane.

[0014] As a further technical solution, the detector's housing is equipped with a fixing suction cup, and the flexible sensor patch is attached to the corresponding urine detection position via a double-sided adhesive layer.

[0015] As a further technical solution, the flexible sensor patch is attached between the leak-proof layer and the absorbent layer of the diaper using a double-sided adhesive layer; or, the flexible sensor patch is attached to the inner wall of the toilet using a double-sided adhesive layer.

[0016] The beneficial effects of the above-described embodiments of this utility model are as follows: This invention significantly reduces the risk of bacterial contamination of the electrodes by placing an antibacterial layer around the outer periphery of the flexible sensor patch, through physical isolation and chemical sterilization. By surrounding the electrodes with a hydrophobic layer and using micro-nano structures or chemical modification to form a superhydrophobic surface, it avoids detection drift caused by urine residue. This invention solves the problem that urine metabolite detectors are easily contaminated and interfered with during the detection of real human urine.

[0017] This invention enables rapid adhesion and peeling through the design of a double-sided adhesive layer and a release layer. Combined with the deformation capability of the flexible substrate, it perfectly fits curved surfaces, overcoming the limitations of rigid sensor installation and enabling applications in various scenarios. In addition, by incorporating a flexible cable and a fixed suction cup, it solves the application problem of urine metabolic substance detectors on diapers and toilets. Attached Figure Description

[0018] The accompanying drawings, which form part of this specification, are used to provide a further understanding of this utility model. The illustrative embodiments of this utility model and their descriptions are used to explain this utility model and do not constitute an improper limitation of this utility model.

[0019] Figure 1 This is a schematic diagram of the overall structure of the urine metabolite detector applicable to multiple scenarios of this utility model; Figure 2 This is a schematic diagram of the layered structure of the flexible sensor patch of this utility model; Figure 3 This is a schematic diagram of the electrode layer of the flexible sensor patch of this utility model; Figure 4 This is a schematic diagram of the flexible sensor patch of this utility model applied to a diaper. Figure 5 This is a schematic diagram of the flexible sensor patch of this utility model applied to a toilet.

[0020] The diagram is for illustrative purposes only. The components include: 1. Flexible sensor patch; 2. Flexible flat cable; 3. Detector housing; 4. Fixing suction cup; 11. Electrode layer; 12. Insulating layer; 13. Hydrophobic layer; 14. Antibacterial layer; 15. Flexible substrate; 16. Double-sided adhesive layer; 17. Separation layer; 111. Counter electrode; 112. Glucose working electrode; 113. Uric acid working electrode; 114. Nitrite working electrode; 115. Ascorbic acid working electrode; 116. Urine ketone body working electrode; 117. Urine bilirubin working electrode; 118. Urine calcium working electrode; 119. Urine pH working electrode; 51. Skin-friendly layer; 52. Diversion layer; 53. Water-absorbing layer; 54. Leak-proof layer; 55. Bottom film. Detailed Implementation

[0021] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0022] Example 1 In a typical embodiment of this utility model, such as Figure 1 As shown, a urine metabolite detector applicable to multiple scenarios is provided, including a flexible sensor patch 1. The flexible sensor patch 1 is connected to the circuit board inside the detector via a flexible flat cable 2. The flexible sensor patch 1 includes, from top to bottom, an insulating layer 12, an electrode layer 11, a flexible substrate layer 15, a double-sided adhesive layer 16, and a separation layer 17. The electrode layer 11 includes multiple working electrodes and a counter electrode. A hydrophobic layer 13 is disposed around the outer periphery of the working electrodes and the counter electrode. An antibacterial layer 14 is disposed around the outer periphery of the flexible sensor patch 1.

[0023] The aforementioned urine metabolite detector applicable to multiple scenarios significantly reduces the risk of bacterial contamination of the electrodes by placing an antibacterial layer 14 around the outer periphery of the flexible sensor patch 1 through physical isolation and chemical sterilization. A hydrophobic layer 13 surrounds the electrodes, forming a superhydrophobic surface using micro-nano structures or chemical modification to prevent detection drift caused by urine residue. Simultaneously, the design of the double-sided adhesive layer 16 and the separation layer 17 enables rapid adhesion and peeling. Combined with the deformation capability of the flexible substrate 15 (PDMS, etc.), it perfectly conforms to curved surfaces, overcoming the limitations of rigid sensor installation and enabling applications in various scenarios. In this embodiment, the wire circuits of the working electrode and the counter electrode 111 correspond one-to-one with the wires in the flexible flat cable 2, and the flexible flat cable 2 is packaged together with the flexible sensor patch 1 by hot pressing.

[0024] Understandably, the working electrode and the wires of the flexible flat cable 2 are aligned one by one and then thermo-pressed for sealing. The thermo-pressing process avoids the risk of solder corrosion or poor soldering, ensuring the synchronous and high-fidelity transmission of the channel's electrochemical information. In addition, the flexible flat cable 2 is used to connect the working electrode to the detector, which has good bending performance and maintains a stable connection during diaper folding or toilet flushing vibration, resulting in a lower failure rate than traditional plug-in methods.

[0025] In this embodiment, the insulating layer 12 covers the wire portion extending from the working electrode and the counter electrode. The insulating layer 12 is coated with insulating ink on the surface of the electrode wire by screen printing. By covering the electrode wire with the insulating layer 12, urine is completely isolated from contact with the wire, preventing urine from covering the wire area during urine detection and causing errors in the detection results, thus ensuring the accuracy of electrochemical detection.

[0026] In this embodiment, as Figure 3 As shown, the working electrodes include a glucose working electrode 112, a uric acid working electrode 113, a nitrite working electrode 114, an ascorbic acid working electrode 115, a urinary ketone body working electrode 116, a urinary bilirubin working electrode 117, a urinary calcium working electrode 118, and a urinary pH working electrode 119.

[0027] It is understood that the electrode layer 11 in this embodiment includes eight working electrodes and one counter electrode. The working electrodes are modified with sensitive materials for detecting glucose, uric acid, nitrite, ascorbic acid, urinary ketones, urinary bilirubin, urinary calcium, and urinary pH, forming an electrochemical detection system. When the urine contains the corresponding analyte, the current of the corresponding working electrode will increase, and the change in current signal will be transmitted to the circuit board, captured by the circuit board, and the concentration of the analyte will be calculated by the microcontroller processor in the circuit board. The flexible sensor patch 1 can simultaneously detect glucose, uric acid, nitrite, ascorbic acid, urinary ketones, urinary bilirubin, urinary calcium, and urinary pH in real urine.

[0028] The preparation method of the sensitive layer of the glucose working electrode is as follows: Prussian blue dielectric layer is deposited on the urinary glucose working electrode, the surface of the urinary glucose working electrode with Prussian blue dielectric layer deposited is cleaned, and glucose oxidase and chitosan-carbon nanotube viscous solution are mixed at a volume ratio of 1:1 and dripped onto the surface of the urinary glucose working electrode to form the sensitive layer of the urinary glucose working electrode. The chitosan-carbon nanotube viscous solution contains 1%-2% chitosan by mass and 1%-2% carbon nanotube by mass.

[0029] The preparation method of the sensitive layer of the uric acid working electrode is as follows: a suspension of graphene oxide-hexadecyltrimethylammonium bromide is obtained by centrifugation, with the mass ratio of graphene oxide to hexadecyltrimethylammonium bromide being 1:1-3. The precipitate after centrifugation is collected, the precipitate is washed, and the precipitate is redispersed in a mixed solution of multi-walled carbon nanotubes-chitosan-acetic acid. The mixed solution is then dripped onto the surface of the uric acid working electrode to form the sensitive layer of the uric acid working electrode.

[0030] The preparation method of the sensitive layer of the urinary bilirubin working electrode is as follows: Prussian blue medium layer is precipitated onto the urinary bilirubin working electrode. After washing the urinary bilirubin working electrode with the Prussian blue medium layer deposited, the process of adding 90 U / ml-110 U / ml bilirubin oxidase solution and refrigerating and drying is repeated multiple times to form a multilayer bilirubin oxidase layer. Then, the surface of the urinary bilirubin working electrode is covered with 1%-2% Nafion solution to form the sensitive layer of the urinary bilirubin working electrode. The preparation method of the sensitive layer of the urinary ketone body working electrode is as follows: Prussian blue dielectric layer is deposited on the urinary ketone body working electrode. A mixed solution of multi-walled carbon nanotubes and chitosan is dropped onto the surface of the urinary ketone body working electrode with the Prussian blue dielectric layer deposited. The mass fraction of multi-walled carbon nanotubes is 0.1-0.2%, and the mass fraction of chitosan is 1%-2%. After drying, a mixed solution containing 90 U / ml-110 U / ml 3-hydroxy dehydrogenase, 9 mg / ml-11 mg / ml nicotinamide adenine dinucleotide, and 4 mg / ml-6 mg / ml bovine serum albumin is dropped onto the surface of the urinary ketone body working electrode. Then, it is placed in a glutaraldehyde volatilization environment for crosslinking for a set time. After rinsing, the surface of the urinary ketone body working electrode is covered with 1%-2% Nafion solution to form the sensitive layer of the urinary ketone body working electrode.

[0031] The preparation method of the nitrite working electrode and the sensitive layer of the urinary ascorbic acid detection motor is as follows: a mixed solution of graphene oxide, ethanol and deionized water is prepared, wherein the mass-volume ratio of graphene oxide, ethanol and water is 5-7:1.5-2.5:2.5-3.5 mg / ml. Then, the mixture is stirred to form a mixed suspension of graphene oxide-ethanol-deionized water. The mixed suspension of graphene oxide-ethanol-deionized water is mixed with PEDOT:PSS solution at a volume ratio of 1:1 to form a mixed solution. The mixed solution is dropped onto the surface of the cleaned urinary nitrite working electrode, and after refrigeration and drying, the corresponding sensitive layer is formed.

[0032] The method for preparing the sensitive layer of the urine pH working electrode is as follows: polyaniline is deposited on the surface of the urine pH working electrode, rinsed, dried and stored for a set time to form the sensitive layer of the urine pH working electrode.

[0033] It should be noted that those skilled in the art can set the number of working electrodes and the functions to be detected by the working electrodes as needed. The detection principles and preparation methods of the working electrodes and counter electrodes with corresponding functions are all existing technologies. In addition, the circuit board structure inside the detector and the data processing method of the circuit board can also be directly implemented using existing technologies.

[0034] In this embodiment, the antibacterial layer 14 is made of PU-silver nanoparticle coating, PEG coating or fluoride coating, and is used to isolate and kill bacteria.

[0035] In this embodiment, the hydrophobic layer 13 is prepared by chemical modification or by processing micro / nano structures. The hydrophobic layer is prepared by laser processing technology to create micro / nano hydrophobic structures on flexible substrates such as PET or PI, or by chemical fluorination and chemical reaction to prepare a hydrophobic coating. The hydrophobic layer 13 can prevent urine residue from remaining on the surface of the flexible sensor patch 1 after urine detection.

[0036] In this embodiment, the release layer 17 is a release paper covering the surface of the double-sided adhesive layer 16. The release layer 17 is a thin layer of release paper covering the surface of the double-sided adhesive layer 16, used to protect the double-sided adhesive layer 16 when not in use. The release layer 17 can be removed before use. The double-sided adhesive layer 16 is fixed to the back of the flexible substrate 15, used to fix the flexible sensor patch 1 in the application scenario, such as diapers and toilets.

[0037] In this embodiment, the flexible substrate 15 layer is a thin film made of polystyrene, polyethylene terephthalate, or polydimethylsiloxane. An electrode layer 11 is printed on the flexible substrate 15.

[0038] In this embodiment, a suction cup 4 is provided on the outer shell of the detector, and the flexible sensor patch 1 is attached to the corresponding urine detection position via a double-sided adhesive layer 16. The suction cup 4 is used to fix the detector to the inner wall of the toilet or other areas.

[0039] The circuit board is equipped with a clip for mounting the flexible flat cable 2. An outlet for the flexible flat cable 2 is provided on the left side, allowing it to extend out of the outer casing after connecting to the circuit board inside the detector housing 3. One end of the flexible flat cable 2 connects to the circuit board inside the housing, and the other end connects to the flexible sensor patch 1 used for multi-channel urine metabolite detection. The wire circuits of the flexible flat cable 2 and the flexible sensor patch 1 are aligned, and the flexible flat cable 2 and the flexible sensor patch 1 are encapsulated together using a thermoforming method.

[0040] In use, the flexible sensor patch 1 is attached between the leak-proof layer and the absorbent layer of the diaper via a double-sided adhesive layer 16; or, the flexible sensor patch 1 is attached to the inner wall of the toilet via a double-sided adhesive layer 16.

[0041] Specifically, such as Figure 4As shown, a typical diaper includes a skin-friendly layer 51, a diversion layer 52, an absorbent layer 53, a leak-proof layer 54, and a bottom film 55. When this rapid urine metabolite detector is used for urine detection in diapers, the flexible sensor patch 1 is attached between the leak-proof layer and the absorbent layer. The separation layer 17 is removed, and the double-sided adhesive layer 16 is attached to the surface of the leak-proof layer. When urine enters the diaper, it flows through the working electrode of the flexible sensor patch 1. Part of the flexible flat cable 2 is encapsulated inside the diaper, and the other part extends out of the diaper and connects to the detector housing 3, transmitting the detected electrochemical signal to the circuit board. At this time, the detector housing 3 does not need to be fixed.

[0042] like Figure 5 As shown, when the rapid urine metabolite detector is used to detect urine in the toilet, the fixed suction cup 4 connected to the detector housing 3 is installed on the outer wall of the toilet, and the double-sided adhesive layer 16 is pasted on the inner wall of the toilet.

[0043] It should be noted that the materials and preparation methods used in all layers of the flexible sensor patch 1 in this embodiment are existing technologies. Those skilled in the art can choose according to their needs, as long as the corresponding functions can be achieved.

[0044] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A urine metabolite detector applicable to multiple scenarios, characterized in that, The device includes a flexible sensor patch, which is connected to a circuit board inside the detector via a flexible flat cable. The flexible sensor patch includes, from top to bottom, an insulating layer, an electrode layer, a flexible substrate layer, a double-sided adhesive layer, and a release layer. The electrode layer includes multiple working electrodes and a counter electrode, and a hydrophobic layer is disposed around the outer periphery of the working electrodes and the counter electrode. An antibacterial layer is disposed around the outer periphery of the flexible sensor patch.

2. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The wire circuits of the working electrode and the counter electrode correspond one-to-one with the wires in the flexible flat cable, and the flexible flat cable is packaged together with the flexible sensor patch by hot pressing.

3. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The insulating layer covers the wire portions extending from the working electrode and the counter electrode, and the insulating layer is formed by screen printing insulating ink onto the surface of the electrode wires.

4. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The working electrodes include glucose working electrode, uric acid working electrode, nitrite working electrode, ascorbic acid working electrode, urinary ketone body working electrode, urinary bilirubin working electrode, urinary calcium working electrode, and urinary pH working electrode.

5. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The antibacterial layer is a polydimethylsiloxane film coated with an antibacterial agent.

6. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The hydrophobic layer is prepared by chemical modification or by fabricating micro / nano structures.

7. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The separation layer is made by covering the surface of the double-sided layer with release paper.

8. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The flexible substrate layer is a thin film made of polystyrene, polyethylene terephthalate, or polydimethylsiloxane.

9. The urine metabolite detector applicable to multiple scenarios as described in claim 1, characterized in that, The detector has a suction cup on its outer casing, and the flexible sensor patch is attached to the corresponding urine detection position by a double-sided adhesive layer.

10. The urine metabolite detector applicable to multiple scenarios as described in claim 9, characterized in that, The flexible sensor patch is attached between the leak-proof layer and the absorbent layer of the diaper using a double-sided adhesive layer; or, the flexible sensor patch is attached to the inner wall of the toilet using a double-sided adhesive layer.

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