A crude peptide filter

Abstract

The application discloses a crude peptide filter, which comprises a rack, a first barrel and a second barrel arranged on the rack, and a feeding port arranged on the first barrel; an outlet end of the first barrel is provided with a filter module, which is used for separating crude peptides in a mixed solution to be filtered; the second barrel is communicated with the first barrel; a drain pipe is further arranged at the bottom of the second barrel; a plurality of vacuum extraction interfaces are arranged on the second barrel, and outlet ends of the vacuum extraction interfaces are respectively connected with external vacuum extraction devices; when in use, a pressure difference is formed between the first barrel and the second barrel through the vacuum extraction device, the crude peptides are blocked by the filter module, and the liquid solvent is forcibly extracted under the action of negative pressure and enters the second barrel; the application realizes the rapid separation of the crude peptides and the solvent through the cooperation of the vacuum negative pressure and the filter module, so that the separation efficiency of the crude peptides is improved.

Description

Technical Field

[0001] This application relates to the field of filtration equipment technology, specifically to a coarse peptide filter. Background Technology

[0002] In the production process of peptides, it is necessary to separate crude peptides from solvents through filters. In existing technologies, filters generally feed the mixture into the filter and achieve natural separation of solvents and crude peptides through gravity and filter cloth. During the filtration process, solvent evaporation not only produces an irritating odor, but also has low separation efficiency. Utility Model Content

[0003] The main objective of this application is to provide a coarse peptide filter that addresses the shortcomings of low filtration efficiency in existing technologies.

[0004] This application achieves the above objectives through the following technical solutions: A coarse peptide filter, comprising a frame; A first barrel is mounted on the frame and has a feed inlet. A filtration module is disposed at the outlet end of the first tank; the filtration module is used to separate crude peptides in the mixture to be filtered. The second tank is connected to the first tank; a drain pipe is also provided at the bottom of the second tank. A vacuum port is provided, at least one of which is connected to the second barrel body, and the outlet end of each of the vacuum ports is connected to an external vacuum device.

[0005] Optionally, the frame includes a movable frame and a base plate connected to each other, with the first barrel body disposed on the base plate; a flange plate is also provided at the bottom of the first barrel body, and a plurality of connecting bolts are provided between the base plate and the flange plate.

[0006] Optionally, the base plate is also provided with a sealing groove in an annular structure, and the sealing groove is filled with a rubber sealing ring; the flange plate is tightly fitted with the rubber sealing ring.

[0007] Optionally, the bottom of the first tank is open, and a filter tank and several liquid outlets are provided on the bottom plate. The filter module is placed in the filter tank. The inlet end of each liquid outlet is connected to the filter tank, and its outlet end is connected to the second tank through a drain pipe.

[0008] Optionally, the filtration module includes a filter cloth and several mutually separated guide plates. Each guide plate is arranged in a concentric circle structure within the filtration tank. A guide groove is formed between any two connected guide plates. A series groove for connecting each guide groove is also provided in the filtration tank along the radial direction of the guide plates. The filter cloth is spread on top of the guide plates.

[0009] Optionally, 4-7 series channels are provided, arranged radially around the axis of the filter channel; the filter channel is also provided with a number of confluence holes, each of which is connected to each of the liquid outlets; each of the confluence holes is connected to at least one of the series channels.

[0010] Optionally, each of the manifolds is further provided with a support plate, and the support plate is provided with a plurality of infusion holes; around the axis of the support plate, a plurality of support strips are provided on the outer circumferential surface of the support plate, and a diversion groove is formed between any two adjacent support strips.

[0011] Optionally, the bottom of the mobile frame is provided with several casters; the mobile frame is also provided with a support plate, and the second barrel is disposed on the support plate.

[0012] Optionally, the movable frame is provided with a plurality of connecting slide rods, and the support plate is provided with a plurality of connecting holes, each of the connecting slide rods being inserted into and connected to each of the connecting holes; each of the connecting slide rods is threadedly connected with an adjusting nut, and the support plate is respectively fitted with each of the adjusting nuts.

[0013] Optionally, a level gauge is also provided on the second tank, and detection tubes are provided at the top and bottom of the level gauge, with each detection tube communicating with the second tank.

[0014] Compared with the prior art, this application has the following beneficial effects: This application includes a frame on which a first barrel and a second barrel are mounted. The first barrel has a feed inlet. A filter module is mounted at the outlet of the first barrel for separating crude peptides from the mixture to be filtered. The second barrel is connected to the first barrel. A drain pipe is also mounted at the bottom of the second barrel. The second barrel has several vacuum ports, and the outlet of each vacuum port is connected to an external vacuum device.

[0015] During use, the mixture is fed into the first tank through the inlet, and at the same time the external vacuum device is turned on. The vacuum device creates a pressure difference between the first tank and the second tank. At this time, the crude peptide is blocked by the filter module, while the liquid solvent is forcibly drawn away under the negative pressure and enters the second tank. Compared with the natural filtration separation in the prior art, this application maximizes the force on the solvent by using vacuum negative pressure, and at the same time, it achieves rapid separation of crude peptides and solvent by using a filtration module, thereby improving the separation efficiency of crude peptides. Secondly, while the vacuum negative pressure rapidly separates the solvent and crude peptides, the feed inlet enables continuous feeding, thereby changing the intermittent feeding in the existing technology into continuous feeding and continuous separation operations, further improving the filtration and separation efficiency of crude peptides. Attached Figure Description

[0016] Figure 1 A structural diagram of a coarse peptide filter provided in an embodiment of this application; Figure 2 An exploded view of a coarse peptide filter provided in an embodiment of this application; Figure 3 A cross-sectional view of a coarse peptide filter provided in an embodiment of this application; Figure 4 This is a schematic diagram of the filter module. Reference numerals: 1-Frame, 2-First tank, 3-Inlet, 4-Filter module, 5-Second tank, 6-Drain pipe, 7-Vacuum interface, 8-Flange plate, 9-Connecting bolt, 10-Sealing groove, 11-Rubber sealing ring, 12-Filtering tank, 13-Outlet, 14-Feeding pipe, 15-Support plate, 16-Feeding hole, 17-Support rod, 18-Diverter groove, 19-Wheel caster, 20-Connecting slide bar, 21-Connecting hole, 22-Adjusting nut, 23-Level gauge, 24-Detection tube, 101-Moving frame, 102-Base plate, 103-Support plate, 401-Filter cloth, 402-Guide plate, 403-Guide groove, 404-Series groove, 405-Confluence hole.

[0017] The purpose, features, and advantages of this application will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0020] In this utility model, unless otherwise explicitly specified and limited, the terms "connection," "fixing," etc., should be interpreted broadly. For example, "fixing" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0021] Furthermore, if the embodiments of this utility model involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the meaning of "and / or" throughout the text includes three parallel solutions. Taking "robot coordinate system and / or m" as an example, it includes a robot coordinate system solution, an m solution, or a solution where both the robot coordinate system and m are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

[0022] Implementation Method 1 Reference Figures 1 to 4 This embodiment, as an optional embodiment of this application, discloses a coarse peptide filter, including a frame 1. The frame 1 includes a movable frame 101 and a base plate 102, wherein a plurality of casters 19 are provided at the bottom of the movable frame 101; and the base plate 102 is provided at the top of the movable frame 101. The filter also includes a first barrel 2 and a second barrel 5, wherein the top of the first barrel 2 is provided with a sealing cover, and the sealing cover is provided with a feed inlet 3 and a spare feed inlet 3; The bottom of the first barrel 2 is fully open, and a flange plate 8 is also provided at the bottom of the first barrel 2; The base plate 102 is also provided with a filter groove 12 and a sealing groove 10, wherein the sealing groove 10 is an annular structure, the filter groove 12 is a circular groove, the sealing groove 10 is coaxial with the filter groove 12 and along the radial direction of the filter groove 12, and the sealing groove 10 is located on the outside of the filter groove 12. The sealing groove 10 is filled with a rubber sealing ring 11; the first barrel 2 is cylindrical in shape and is placed on the bottom plate 102 and coaxial with the filter groove 12. After assembly, the bottom surface of the flange plate 8 presses the rubber sealing ring to seal the bottom of the first barrel 2. At the same time, a number of connecting bolts 9 are provided between the flange plate 8 and the bottom plate 102.

[0023] Furthermore, the filter tank 12 is also provided with a plurality of liquid outlets 13, each of which is located within the filter tank 12; and each of the liquid outlets 13 is provided with a feed pipe 14 at its outlet end. The filter also includes a second barrel 5. The movable frame 101 is provided with several connecting slide rods 20, and the support plate 103 is provided with several connecting holes 21. Each connecting slide rod 20 is inserted into and connected to each connecting hole 21. Each connecting slide rod 20 is threadedly connected with an adjusting nut 22, and the support plate 103 is fitted with each adjusting nut 22. The second barrel 5 is placed on the support plate 103, and a sealing cap is provided on the top of the second barrel 5. The outlet end of the conveying pipe 14 passes through the sealing cap and communicates with the second barrel 5. Simultaneously, a drain pipe 6 is provided at the bottom of the second barrel 5, and a regulating valve is provided on the drain pipe 6 to control its on / off state. Meanwhile, a level gauge 23 is also provided on the second tank body 5. The top and bottom of the level gauge 23 are provided with detection tubes 24, and each detection tube 24 is connected to the second tank body 5. With the above structure, users can flexibly adjust the position of the support plate 103 according to the actual situation, thereby adjusting the height of the second body to meet different usage requirements; At the same time, the liquid level in the second tank 5 can be quickly measured by the liquid level gauge 23, so that when there is too much solvent in the second tank 5, the solvent can be discharged in time through the drain pipe 6.

[0024] Furthermore, the coarse peptide filter also includes a filtration module 4, which is disposed within the filtration tank 12. The filtration module 4 includes a filter cloth 401 and several guide plates 402. Each guide plate 402 has a circular structure and a different diameter. They are arranged in a concentric circle structure. Each guide plate 402 is integrally connected to the bottom surface of the filtration tank 12 and is coaxial with the filtration tank 12. There is a circular guide groove 403 between any two adjacent guide plates 402. Along the radial direction of the guide plate 402, the filter tank 12 is also provided with a series groove 404 for connecting each of the guide grooves 403. Preferably, there are 4-7 series grooves 404. Around the axial direction of the filter tank 12, each series groove 404 is arranged radially, so as to connect all the guide grooves 403 in the radial direction. Furthermore, a plurality of confluence holes 405 are provided in the filter tank 12. The number of confluence holes 405 is the same as the number of liquid outlets 13. Each confluence hole 405 corresponds to each liquid outlet 13. The corresponding confluence holes 405 are coaxial with the liquid outlets 13. Meanwhile, each of the manifolds 405 is connected to at least one of the series channels 404, thereby guiding the filtered solvent into each outlet 13 and finally discharging it through the outlet 13. The filter cloth 401 is spread on top of the guide plate 402; The guide plate 402 can form a large number of guide channels 403 in the filter tank 12. Since the filter cloth 401 is set on the top of the guide plate 402, a large number of solvent channels can be formed on the underside of the filter cloth 401 through the guide channels 403, realizing the separation of the filter cloth 401 from the channels. This can prevent the solvent from flowing back into the filter cloth 401. At the same time, the guide channels 403 can quickly collect a large amount of solvent, which is beneficial to improving the filtration efficiency.

[0025] Secondly, the guide groove 403 can also form a stable vacuum zone under the filter cloth 401, thereby stably adsorbing and fixing the filter cloth 401 to the top of the guide plate 402, ensuring the stable operation of the entire filter module 4. Meanwhile, a support plate 15 is also provided in each of the manifolds 405, and a plurality of infusion holes 16 are provided on the support plate 15; around the axis of the support plate 15, a plurality of support strips are provided on the outer circumferential surface of the support plate 15, and a diversion groove 18 is formed between any two adjacent support strips. The support plate 15 can divert solvents in different radial directions, thereby ensuring a stable liquid flow at the inlet end of the outlet 13 and enabling rapid solvent removal. Secondly, the support plate 15 can prevent the formation of a large vacuum adsorption force at the inlet end of the outlet 13, which would cause the filter cloth 401 to collapse at the manifold 405.

[0026] Furthermore, at least one vacuum port 7 is provided on the second barrel 5. One end of the vacuum port 7 is connected to the second barrel 5, and the other end is connected to an external vacuum device, preferably a vacuum pump.

[0027] The mixture is fed into the first tank 2 through the feed port 3. At the same time, the external vacuum device is turned on. The vacuum device creates a pressure difference between the first tank 2 and the second tank 5. At this time, the crude peptide is blocked by the filter module 4, while the liquid solvent is forcibly drawn out under negative pressure and enters the second tank 5. Compared with the natural filtration separation in the prior art, this application maximizes the force on the solvent by using vacuum negative pressure, and at the same time, it achieves rapid separation of crude peptides and solvent by using a filtration module, thereby improving the separation efficiency of crude peptides. Secondly, while the vacuum negative pressure rapidly separates the solvent and crude peptides, the feed inlet can achieve continuous feeding, thereby changing the intermittent feeding in the existing technology to continuous feeding and continuous separation operation, further improving the filtration and separation efficiency of crude peptides. Finally, compared with the prior art, both the first barrel and the second barrel of this application are fully enclosed structures, and the input of raw materials and the discharge of solvents are also completed in a closed environment, so no irritating odor is produced.

[0028] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A crude peptide filter, characterized in that, Includes rack (1); The first barrel (2) is mounted on the frame (1) and has a feed inlet (3). A filtration module (4) is disposed at the outlet end of the first barrel (2); the filtration module (4) is used to separate crude peptides in the mixture to be filtered. The second barrel (5) is connected to the first barrel (2); a drain pipe (6) is also provided at the bottom of the second barrel (5); A vacuum port (7) is provided, at least one of which is provided. Each of the vacuum ports (7) is connected to the second barrel (5), and the outlet end of each of the vacuum ports (7) is connected to an external vacuum device.

2. A coarse peptide filter according to claim 1, characterized in that, The frame (1) includes a movable frame (101) and a base plate (102) connected to each other. The first barrel (2) is disposed on the base plate (102). A flange plate (8) is also disposed at the bottom of the first barrel (2). A plurality of connecting bolts (9) are disposed between the base plate (102) and the flange plate (8).

3. A coarse peptide filter according to claim 2, characterized in that, The base plate (102) is also provided with a sealing groove (10) in an annular structure, and the sealing groove (10) is filled with a rubber sealing ring (11); the flange plate (8) is tightly fitted with the rubber sealing ring (11).

4. A coarse peptide filter according to claim 3, characterized in that, The bottom of the first barrel (2) is open. The bottom plate (102) is provided with a filter tank (12) and several liquid outlets (13). The filter module (4) is placed in the filter tank (12). The inlet end of each liquid outlet (13) is connected to the filter tank (12), and its outlet end is connected to the second barrel (5) through the feed pipe (14).

5. A coarse peptide filter according to claim 4, characterized in that, The filter module (4) includes a filter cloth (401) and several mutually separated guide plates (402). Each guide plate (402) is arranged in a concentric circle structure in the filter tank (12). A guide groove (403) is formed between any two connected guide plates (402). Along the radial direction of the guide plate (402), a series groove (404) for connecting each guide groove (403) is also provided in the filter tank (12). The filter cloth (401) is spread on the top of the guide plate (402).

6. A coarse peptide filter according to claim 5, characterized in that, The series grooves (404) are provided in 4-7 rows, and are arranged radially around the axis of the filter tank (12); the filter tank (12) is also provided with a number of confluence holes (405), each of the confluence holes (405) is connected to each of the liquid outlets (13); each of the confluence holes (405) is connected to at least one of the series grooves (404).

7. A coarse peptide filter according to claim 6, characterized in that, Each of the manifolds (405) is further provided with a support plate (15), and the support plate (15) is provided with a plurality of infusion holes (16); around the axis of the support plate (15), a plurality of support strips are provided on the outer circumferential surface of the support plate (15), and a diversion groove (18) is formed between any two adjacent support strips.

8. A coarse peptide filter according to claim 2, characterized in that, The bottom of the mobile frame (101) is provided with several casters (19); the mobile frame (101) is also provided with a support plate (103), and the second barrel (5) is provided on the support plate (103).

9. A coarse peptide filter according to claim 8, characterized in that, The movable frame (101) is provided with a plurality of connecting slide rods (20), and the support plate (103) is provided with a plurality of connecting holes (21). Each of the connecting slide rods (20) is inserted into and connected to each of the connecting holes (21). Each of the connecting slide rods (20) is threadedly connected with an adjusting nut (22), and the support plate (103) is fitted with each of the adjusting nuts (22).

10. A coarse peptide filter according to claim 1, characterized in that, The second barrel (5) is also equipped with a level gauge (23), and the top and bottom of the level gauge (23) are equipped with detection tubes (24), and each detection tube (24) is connected to the second barrel (5).

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