In-situ detection assembly, transfer module and nucleic acid detection device

Abstract

The utility model provides in -situ detection subassembly, transfer module and nucleic acid detection equipment, this in -situ detection subassembly includes in -situ inductor, response seat, elastic part and response bolt, response bolt swing sets up on response seat, and elastic part elastically abuts between response seat and response bolt, and the both ends of response bolt are provided with abutting portion and response portion respectively, and abutting portion protrudes response seat's first side lateral wall, and in -situ inductor sets up on response seat's second side, when abutting portion is pressed, can drive response bolt to move relative to response seat, so that response portion enters in -situ inductor's detection range and triggers in -situ inductor, this transfer module includes above -mentioned in -situ detection subassembly, this nucleic acid detection equipment includes above -mentioned transfer module, the utility model discloses through physical touch can accurate detection reaction tube whether in -situ transparent article etc.

Description

Technical Field

[0001] This utility model relates to the field of medical devices, specifically to an in-situ detection component, a transport module, and a nucleic acid detection device. Background Technology

[0002] Common transport modules in in vitro diagnostic equipment include a motor, guide rail, and slider. The motor drives the slider, fixed on the guide rail, to move back and forth along the guide rail via a drive wheel, a timing belt, and a driven wheel. The carrier for transporting items is fixedly connected to the slider, thus achieving the purpose of transporting items. For transporting multiple items along multiple different routes, multiple conventional transport modules are usually required, resulting in a bulky equipment structure.

[0003] Furthermore, in existing transfer modules, photoelectric sensors often directly emit detection light towards the location where the reaction tube is placed to detect whether the reaction tube is in place. Since the reaction tube is transparent, some of the detection light passes through the reaction tube, while the rest is reflected back by the tube wall. Whether it is a through-beam or reflective photoelectric sensor, the transparent reaction tube will adversely affect the direct detection of the photoelectric sensor and reduce the accuracy of its detection results. Utility Model Content

[0004] The primary objective of this invention is to provide an in-situ detection component that can accurately detect whether transparent items such as reaction tubes are in place through physical contact.

[0005] The second objective of this invention is to provide a transfer module that includes the aforementioned in-situ detection components.

[0006] The third objective of this invention is to provide a nucleic acid detection device that includes the aforementioned transport module.

[0007] To achieve the aforementioned first objective, this utility model provides an in-situ detection component, including an in-situ sensor, a sensing base, an elastic element, and a sensing pin. The sensing pin is movably disposed on the sensing base, and the elastic element elastically abuts against the sensing base and the sensing pin. The two ends of the sensing pin are respectively provided with an abutment portion and a sensing portion. The abutment portion protrudes from the first sidewall of the sensing base, and the in-situ sensor is disposed on the second side of the sensing base. When the abutment portion is compressed, it can drive the sensing pin to move relative to the sensing base, so that the sensing portion enters the detection range of the in-situ sensor and triggers the in-situ sensor.

[0008] As can be seen from the above scheme, with the above settings, when the contact part is compressed, the sensing pin can move backward relative to the sensing seat, causing the elastic element to compress, the sensing part to enter the detection range of the in-situ sensor and trigger the in-situ sensor, thereby determining that there is a reaction tube in the part to be detected; if the contact part is not compressed, the elastic element is not compressed, and the sensing part is at a preset distance from the detection range of the in-situ sensor, that is, the sensing part will not trigger the in-situ sensor, then it can be determined that there is no reaction tube in the part to be detected; this utility model uses physical touch to sense whether there is a reaction tube in the part to be detected, which is beneficial to improving the accuracy of the detection results and reducing the occurrence of misjudgments compared with the existing technology of directly detecting transparent reaction tubes by detecting light.

[0009] A further embodiment is that the sensor base has a stepped hole, and a first contact portion is provided in the stepped hole; the middle part of the sensor pin is inserted into the stepped hole, and an annular flange is provided at one end of the sensor pin near the abutment portion. An elastic element elastically abuts between the first contact portion and the annular flange. A second contact portion is provided at one end of the sensor pin near the sensing portion. The second contact portion is located on the outside of the stepped hole and can abut against the second side wall of the sensor base.

[0010] As can be seen from the above scheme, the installation position of the elastic element can be limited by the above settings, which helps to prevent the sensing pin from accidentally detaching from the sensing base.

[0011] A further embodiment is that the sensing pin includes a first pin and a second pin, the first pin and the second pin are detachably connected, an annular flange is fixedly disposed on the first pin, and a second contact part is fixedly disposed on the second pin; Alternatively, the sensing pin is an integral part, with the annular flange and / or the second contact portion detachably connected to the sensing pin.

[0012] As can be seen from the above scheme, the above settings facilitate the assembly of the induction pin and the induction base.

[0013] To achieve the second objective mentioned above, this utility model provides a transfer module, including a mounting frame, a transfer drive device, a transmission component, a drive wheel, a driven wheel, a fixing component, and the aforementioned in-situ detection component. The drive wheel and driven wheel are both mounted on the mounting frame. The transmission component is wound around the drive wheel and driven wheel. The fixing component is fixedly mounted on the transmission component. The transfer drive device can drive the drive wheel to rotate, thereby driving the transmission component and the fixing component to move. The fixing component includes a reaction tube seat, and a placement cavity is provided inside the reaction tube seat. The in-situ detection component is mounted on the mounting frame, and a sensing pin is correspondingly positioned with the reaction tube seat. The abutment portion can extend into the placement cavity, or the abutment portion can move to a preset height range directly above the placement cavity.

[0014] As can be seen from the above scheme, the above settings facilitate the detection of the presence of a reaction tube in the placement cavity by the in-situ detection component. The structure is simple and the detection results are highly accurate.

[0015] A further option is that the extension direction of the sensing pin is parallel to the movement direction of the fixing component, and the sensing seat is fixedly installed at the end of the movement path of the fixing component. Alternatively, the extension direction of the sensing pin intersects the movement direction of the fixing component, and the in-position detection component is movably disposed on one side of the movement path of the fixing component, and the in-position detection component can move closer to the fixing component.

[0016] As can be seen from the above scheme, with the above settings, when the extension direction of the sensing pin is parallel to one end of the fixing component, the fixing component moves towards the sensing pin, causing the contact part of the sensing pin to automatically extend into the placement cavity or move to the top of the placement cavity, thereby achieving the purpose of detecting whether the reaction tube is in place. This has the advantages of simple structure and convenient operation. When the extension direction of the sensing pin intersects with the movement direction of the fixing component, the movement of the fixing component can be paused when it reaches the detection position. At this time, the in-place detection component is controlled to move closer to the fixing component, causing the contact part of the sensing pin to extend into the placement cavity or move to the top of the placement cavity, thereby achieving the purpose of detecting whether the reaction tube is in place.

[0017] A further option is to have a detection hole on the side wall of the reaction tube seat, which is connected to the placement cavity. The detection hole is positioned opposite the sensing pin, and the abutment part can pass through the detection hole and extend into the placement cavity.

[0018] As can be seen from the above scheme, the above arrangement allows the abutting part to abut against the part of the reaction tube inserted into the placement cavity, ensuring that it can both detect whether the reaction tube is in place and prevent the reaction tube from being pushed away from the placement cavity by the abutting part.

[0019] A further design involves installing two guide rails on the mounting bracket, each extending parallel to the line connecting the central axes of the driving and driven wheels. Two or more fixing components are included, designated as a first fixing component and a second fixing component. These components are slidably connected to their respective guide rails, and both are connected to the transmission components, with the first and second fixing components moving in opposite directions. As can be seen from the above scheme, the above settings enable the fixing component to move linearly along the guide rail, ensuring that the reaction tube seat and the sensing pin are aligned, which helps to improve the accuracy of the detection results. With the above settings, when the transmission component moves, it can simultaneously drive the first fixing component and the second fixing component to move in opposite directions. On the one hand, this facilitates the transfer of at least two reaction tubes, which helps to improve the transfer efficiency. On the other hand, it saves space and reduces the occupied area and the number of parts.

[0020] A further embodiment is that the transfer module also includes an initial position detection component, which includes an initial position sensor and a baffle. One of the initial position sensor and the baffle is mounted on the mounting bracket, and the other is mounted on the transmission component and moves with the transmission component. The baffle can enter the detection range of the initial position sensor and trigger the initial position sensor.

[0021] As can be seen from the above scheme, the above settings make it easy to detect whether the fixed component has returned to its initial position.

[0022] To achieve the third objective mentioned above, this utility model provides a nucleic acid detection device, which includes the aforementioned transport module.

[0023] A further embodiment of the nucleic acid testing equipment includes a reagent module, a sample module, a pipette tip module, a pipette arm, a sample pretreatment module, an incubation and interpretation module, an auxiliary reagent module, and a waste bin. The sample pretreatment module and the sample module are both located on the first side of the transport module, the incubation and interpretation module and the pipette tip module are both located on the second side of the transport module, the auxiliary reagent module is located between the incubation and interpretation module and the pipette tip module, the reagent module is located at the end of the transport module, and the waste bin is located below the sample module. The pipette arm moves between the transport module, the reagent module, the sample module, the pipette tip module, the pipette arm, the sample pretreatment module, the incubation and interpretation module, the auxiliary reagent module, and the waste bin.

[0024] As can be seen from the above scheme, the nucleic acid detection equipment of this utility model has the advantages of compact structure and high detection efficiency through the above settings. Attached Figure Description

[0025] Figure 1 This is a cross-sectional view of the sensing pin in one state in an embodiment of the in-situ detection component of this utility model.

[0026] Figure 2 This is a cross-sectional view of another state of the sensing pin in an embodiment of the in-situ detection component of this utility model.

[0027] Figure 3 This is a structural diagram of an embodiment of the transfer module of this utility model.

[0028] Figure 4 yes Figure 3 Enlarged view of point A in the middle.

[0029] Figure 5 This is an exploded view of an embodiment of the transfer module of this utility model.

[0030] Figure 6 This is a structural diagram of an embodiment of the nucleic acid detection equipment of this utility model.

[0031] Figure 7This is a schematic diagram of the movement of the fixed component in an embodiment of the nucleic acid detection equipment of this utility model.

[0032] Explanation of reference numerals in the attached figures: 10-In-situ detection component, 101-In-situ sensor, 102-Sensing base, 1021-Stepped hole, 1022-First contact part, 103-Elastic element, 104-Sensing pin, 1041-First pin, 10411-Abutting part, 10412-Annular flange, 1042-Second pin, 10421-Sensing part, 10422-Second contact part, 105-Pin positioning piece; 20-Transfer module, 201-Mounting bracket, 202-Transfer drive device, 203-Transmission component, 204-Driving wheel, 205-Driven wheel, 206a-First fixing component, 2061-Reaction tube seat, 20611-Placement cavity, 20612-Detection hole, 2062-Sliding seat, 206b-Second fixing component, 207-Guide rail, 208-Initial position detection component, 2081-Initial position sensor, 2082-Baffle, 209-Sensing base plate; 30-Nucleic acid testing equipment, 301-Reagent module, 302-Sample module, 303-Pipette tip module, 304-Sample pretreatment module, 305-Incubation and interpretation module, 306-Auxiliary reagent module, 307-Trash can; 40-Reaction tube.

[0033] The present invention will be further described below with reference to the accompanying drawings and embodiments. Detailed Implementation

[0034] Example of an in-situ detection component: See Figures 1 to 5 The presence detection component 10 provided in this embodiment includes a presence sensor 101, a sensing base 102, an elastic member 103, a sensing pin 104, and a pin positioning piece 105. The sensing pin 104 is movably disposed on the sensing base 102. The elastic member 103 elastically abuts against the sensing base 102 and the sensing pin 104. A first end of the sensing pin 104 has an abutment portion 10411 protruding from the first sidewall of the sensing base 102. A second end of the sensing pin 104 has a sensing portion 10421. The presence sensor 101 is disposed on the second side of the sensing base 102.

[0035] When the contact part 10411 approaches the part to be detected and is pressed, it can drive the sensing pin 104 to move backward relative to the sensing base 102, causing the elastic member 103 to be compressed, so that the sensing part 10421 enters the detection range of the in-situ sensor 101 and triggers the in-situ sensor 101, then it can be determined that there is a reaction tube 40 in the part to be detected; otherwise, there is no reaction tube 40 in the part to be detected.

[0036] The sensor base 102 has a stepped hole 1021 through it. The stepped hole 1021 includes a first hole segment and a second hole segment that are connected to each other. The inner diameter of the first hole segment is larger than the inner diameter of the second hole segment, so that an annular first contact portion 1022 is formed between the first hole segment and the second hole segment.

[0037] The middle portion of the sensing pin 104 is inserted into the stepped hole 1021. An annular flange 10412 is provided at one end of the sensing pin 104 near the abutment portion 10411. An elastic member 103 elastically abuts between the first contact portion 1022 and the annular flange 10412, ensuring that the abutment portion 10411 protrudes beyond the stepped hole 1021 under normal conditions. The elastic member 103 is preferably a spring, fitted onto the sensing pin 104. The sensing portion 10421 protrudes from the second sidewall of the sensing base 102. A second contact portion 10422 is provided at one end of the sensing pin 104 near the sensing portion 10421. The second contact portion 10422 is located on the outside of the stepped hole 1021 and can abut against the sidewall of the sensing base 102 to prevent the sensing pin 104 from separating from the sensing base 102.

[0038] In one embodiment, the sensing pin 104 includes a first pin 1041 and a second pin 1042 coaxially arranged. The first pin 1041 and the second pin 1042 are detachably connected, including but not limited to threaded connection, snap-fit ​​connection, and magnetic connection. An abutment portion 10411 is disposed on the end of the first pin 1041 away from the second pin 1042. The abutment portion 10411 is spherical to avoid damaging the reaction tube 40. An annular flange 10412 is fixedly disposed between the two ends of the first pin 1041. The outer diameter of the annular flange 10412 is larger than the outer diameter of the first pin 1041. Further, the outer diameter of the annular flange 10412 is smaller than the inner diameter of the first hole segment and larger than the inner diameter of the second hole segment. A sensing portion 10421 is disposed on the end of the second pin 1042 away from the first pin 1041. The sensing portion 10421 is made of an opaque material and is used to trigger the presence sensor 101. The in-situ sensor 101 is a photoelectric sensor, and in this embodiment, it is preferably a photoelectric switch. The second contact portion 10422 is fixedly disposed on the end of the second pin 1042 near the first pin 1041.

[0039] In another embodiment, the sensing pin is integrally formed, and the annular flange and the second contact portion are detachably connected to the sensing pin. The detachable connection includes, but is not limited to, threaded connection, snap-fit ​​connection, and magnetic connection. After the sensing pin is inserted into the stepped hole, the annular flange or the second contact portion is then connected, which facilitates the installation of the sensing pin and also prevents the sensing pin from detaching from the sensing base.

[0040] Under normal conditions, the sensing part 10421 protrudes beyond the stepped hole 1021, or the sensing part 10421 is submerged within the stepped hole 1021; in this embodiment, the former is preferred. During detection, the sensing part 10421 protrudes beyond the stepped hole 1021 and extends into the detection range of the in-situ sensor 101.

[0041] This embodiment can detect the presence of a transparent reaction tube 40 within the area to be detected through physical contact. Compared with the prior art method of directly emitting detection light onto the area to be detected, this effectively reduces the occurrence of false judgments and improves the accuracy of the detection results. Moreover, in this embodiment, the position of the in-situ sensor 101 is fixed. Compared with the method of placing the sensor on a movable part and having it move with the component, this helps to avoid the power cord of the in-situ sensor 101 moving back and forth, reducing risks.

[0042] Example of a transfer module: See Figures 3 to 5 and combined Figure 1 and Figure 2 The transfer module 20 provided in this embodiment includes a mounting frame 201, a transfer drive device 202, a transmission component 203, a drive wheel 204, a driven wheel 205, a fixing component, and an in-situ detection component 10 of the above-described in-situ detection component embodiment.

[0043] Both the driving wheel 204 and the driven wheel 205 are mounted on the top plate of the mounting bracket 201. A transmission component 203 is wound around the driving wheel 204 and the driven wheel 205. The transmission component 203 can be a synchronous belt or a chain; in this embodiment, the former is preferred. Correspondingly, the driving wheel 204 and the driven wheel 205 are preferably pulleys. A fixing component is fixedly mounted on the transmission component 203 and located between the driving wheel 204 and the driven wheel 205. The transfer drive device is preferably a motor. The drive shaft of the transfer drive device is connected to the driving wheel 204 to drive the driving wheel 204 to rotate, thereby driving the fixing component to move back and forth between the driving wheel 204 and the driven wheel 205 via the transmission component 203.

[0044] The top plate of the mounting bracket 201 is also provided with two guide rails 207, the extension direction of which is parallel to the line connecting the central axis of the driving wheel 204 and the driven wheel 205. The guide rails 207 can be located on the inner or outer side of the transmission component 203.

[0045] The fixing assembly includes a reaction tube holder 2061 and a sliding seat 2062. The sliding seat 2062 is fixedly connected to the transmission component 203 and slidably connected to the guide rail 207. The reaction tube holder 2061 is disposed on the sliding seat 2062. The reaction tube holder 2061 has a placement cavity 20611 for accommodating the reaction tube 40. In this embodiment, the placement cavity 20611 is the part to be tested. The placement cavity 20611 has an upward-facing inlet and outlet. The lower part of the reaction tube 40 can be inserted into the placement cavity 20611, and the upper part of the reaction tube 40 can protrude out of the placement cavity 20611.

[0046] The presence detection component 10 is mounted on the top plate of the mounting bracket 201 via a sensing base plate 209. A sensing pin 104 is correspondingly positioned with the reaction tube seat 2061, allowing the abutment portion 10411 to extend into the placement cavity 20611, or the abutment portion 10411 to move to a preset height range directly above the placement cavity 20611. This preset height is less than or equal to the height of the reaction tube 40 protruding upwards from the inlet and outlet of the placement cavity 20611. To prevent the reaction tube 40 from being pushed away from the placement cavity 20611 during detection, this embodiment preferably detects the presence of the reaction tube 40 from inside the placement cavity 20611.

[0047] In one embodiment, the extending direction of the sensing pin 104 is parallel to the moving direction of the fixing component, and the sensing seat 102 is fixedly disposed at the end of the moving path of the fixing component. In this embodiment, the position of the in-place detection component 10 is fixed. When the fixing component moves toward the sensing pin 104, the abutment portion 10411 of the sensing pin 104 automatically extends into the fixing component to detect whether the reaction tube 40 is present in the fixing component. A detection hole 20612 is provided on the side wall of the reaction tube seat 2061. The detection hole 20612 communicates with the placement cavity 20611. The detection hole 20612 is correspondingly disposed with the sensing pin 104, and the abutment portion 10411 can be inserted into the detection hole 20612. The detection hole 20612 can be one or two. When two are provided, the two detection holes 20612 are respectively disposed on opposite sides of the reaction tube seat 2061 and are coaxially disposed.

[0048] In another embodiment, the extending direction of the sensing pin 104 intersects the moving direction of the fixing component, preferably perpendicularly. The presence detection component 10 is movably disposed on one side of the moving path of the fixing component. In this embodiment, the presence detection component 10 needs to move closer to the fixing component under the action of an external force, so that the abutting portion 10411 of the sensing pin 104 can extend into the fixing component to detect whether the reaction tube 40 is present in the fixing component.

[0049] Combination Figure 1 and Figure 4To prevent the sensing unit 10421 from shifting position during movement, the presence detection component 10 of this embodiment also includes a pin positioning piece 105. The pin positioning piece 105 is disposed between the presence sensor 101 and the sensing base 102. The pin positioning piece 105 has a through positioning hole. The end of the sensing pin 104 near the sensing unit 10421 is slidably inserted into the positioning hole. The sensing unit 10421 is disposed on the side of the pin positioning piece 105 near the presence sensor 101.

[0050] Combination Figure 3 and Figure 5 The number of fixing components is set to two or more; this embodiment uses two as an example. The two fixing components are a first fixing component 206a and a second fixing component 206b. The first fixing component 206a and the second fixing component 206b are respectively arranged on both sides of the line connecting the central shafts of the driving wheel 204 and the driven wheel 205, and both the first fixing component 206a and the second fixing component 206b are connected to the transmission component 203. The first fixing component 206a and the second fixing component 206b are respectively connected to the corresponding guide rails 207, and the moving directions of the first fixing component 206a and the second fixing component 206b are opposite.

[0051] In this embodiment, the circumference of the transmission component 203 is L. Along the extending direction of the transmission component 203, the first fixing component 206a and the second fixing component 206b are always spaced L / 2 apart, such that the first fixing component 206a and the second fixing component 206b are always distributed on both sides of the line connecting the central axes of the driving wheel 204 and the driven wheel 205. The second fixing component 206b has the same structure as the first fixing component 206a, and will not be described further here.

[0052] The transfer module 20 also includes an initial position detection component 208, which includes an initial position sensor 2081 and a baffle 2082. One of the initial position sensor 2081 and the baffle 2082 is mounted on the mounting frame 201, and the other is mounted on the transmission member 203 and moves with the transmission member 203. The baffle 2082 can enter the detection range of the initial position sensor 2081 and trigger the initial position sensor 2081. In this embodiment, the initial position sensor 2081 is fixedly mounted on the top plate of the mounting frame 201 and is located close to the in-place detection component 10. The baffle 2082 is fixedly connected to the transmission member 203, or the baffle 2082 is fixedly connected to the sliding seat 2062 of the fixed component. The initial position sensor 2081 can be a photoelectric sensor, and in this embodiment, it is preferably a photoelectric switch. In this embodiment, the initial position sensor 2081 is fixed in position. Compared with the scheme of setting the sensor on the transmission component 203 and having it move with the transmission component, this helps to avoid the power line of the initial position sensor 2081 moving back and forth, thus reducing the risk.

[0053] The transfer module 20 also includes a control component (not shown) mounted on the mounting frame 201, which is electrically connected to the in-situ sensor 101, the initial position sensor 2081 and the transfer drive device 202.

[0054] Example of nucleic acid testing equipment: See Figure 6 and Figure 7 and combined Figure 5 The nucleic acid detection device 30 provided in this embodiment includes a reagent module 301, a sample module 302, a pipette tip module 303, a pipette arm (not shown in the figure), a sample pretreatment module 304, an incubation and interpretation module 305, a trash can 307, the transport module 20 of the above embodiment, and two auxiliary reagent modules 306.

[0055] For ease of explanation, the transfer direction of the transfer module 20 is set as X-axis, the direction perpendicular to the transfer direction in the horizontal plane is set as Y-axis, and the vertical direction is set as Z-axis.

[0056] The sample pretreatment module 304 and sample module 302 are both located on the first side of the transport module 20 in the X direction; the incubation and interpretation module 305 and pipette tip module 303 are both located on the second side of the transport module 20 in the X direction; and the auxiliary reagent module 306 is located between the incubation and interpretation module 305 and the pipette tip module 303. The reagent module 301 is located at one end of the transport module 20 in the X direction, and the waste bin 307 is located below the sample module 302. This arrangement in the present embodiment has the advantages of compact structure, space saving, and improved detection efficiency.

[0057] In other embodiments, the reagent module 301, sample module 302, pipette tip module 303, pipette arm (not shown in the figure), sample pretreatment module 304, incubation and interpretation module 305, auxiliary reagent module 306, trash can 307, and the transfer module 20 of the above embodiments may be arranged in other ways, which will not be described in detail here.

[0058] The pipette arm can move between the transport module 20, reagent module 301, sample module 302, pipette tip module 303, sample pretreatment module 304, incubation and interpretation module 305, auxiliary reagent module 306, and trash can 307.

[0059] The transport module 20 is provided with an initial position 1, a sample application position, a transfer position 1, an initial position 2, and a transfer position 2 along its transport direction. Initial position 1, sample application position 1, and transfer position 1 are all located on the first side of the transmission component 203 in the X direction, while initial position 2 and transfer position 2 are both located on the second side of the transmission component 203 in the X direction. Initial position 1 is close to the reagent module 301, initial position 2 is close to the sample pretreatment module 304, transfer position 1 is close to the incubation and interpretation module 305, and transfer position 2 is close to the waste bin 307.

[0060] When the first fixing component 206a is located at initial bit one, the second fixing component 206b is located at initial bit two; when the first fixing component 206a is located at shift bit one, the second fixing component 206b is located at shift bit two.

[0061] The working principle of the nucleic acid detection device 30 in this embodiment: Initially, the first fixing component 206a is located in the initial position one, and the reaction tube A is gripped into the reaction tube seat 2061 of the first fixing component 206a by the gripper of the peripheral device (not shown in the figure); Then, the transfer drive device 202 is started, driving the first fixing component 206a to move in the positive direction of X, moving the reaction tube A to the sample loading position; Next, the pipette arm sequentially picks up the disposable pipette tip from the pipette tip module 303, aspirates the auxiliary reagent from the auxiliary reagent module 306, aspirates the sample solution from the sample tube processed by the sample pretreatment module 304, and drops the mixture of auxiliary reagent and sample solution into the reaction tube A at the sample application position. Then, the transfer drive device 202 is activated, driving the first fixed component 206a to move in the opposite direction of the X direction, moving the reaction tube A back to the initial position one; Next, the peripheral gripper grabs the reaction tube cap in reagent module 301 and places the reaction tube cap on reaction tube A in initial position one; Then or simultaneously, the reaction tube B, which has completed the incubation and interpretation operation in the incubation and interpretation module 305, is grasped by the gripper of the external device and placed into the reaction tube seat 2061 of the second fixing component 206b on the initial position 2; Next, the transfer drive device 202 is started, driving the first fixed component 206a to move in the positive direction of the X direction, moving the reaction tube A to transfer position one. At this time, the reaction tube B moves to transfer position two. Then, the peripheral gripper grabs reaction tube A at transfer position one and moves it into incubation and interpretation module 305, and the peripheral gripper grabs reaction tube B at transfer position two and moves it into trash can 307.

[0062] In summary, this invention, by providing an abutment portion 10411 of the sensing pin 104 that can extend into or move directly above the placement cavity 20611, allows the sensing pin 104 to be blocked and forced to move backward relative to the sensing seat 102. This compresses the elastic member 103, causing the sensing portion 10421 to enter the detection range of the presence sensor 101 and trigger the presence sensor 101. This indicates the presence of the reaction tube 40 within the placement cavity 20611. Furthermore, if the abutment portion 10411 extends into or moves directly above the placement cavity 20611, the invention can determine the presence of the reaction tube 40 within the placement cavity 20611. Since there is no obstruction directly above 20611, the elastic element 103 is not compressed, and the sensing part 10421 is at a preset distance from the detection range of the in-situ sensor 101. That is, the sensing part 10421 will not trigger the in-situ sensor 101, so it can be determined that there is no reaction tube 40 inside the placement cavity 20611. This utility model senses whether there is a reaction tube 40 inside the reaction tube seat 2061 by physical touch. Compared with the prior art, which directly detects the transparent reaction tube by detection light, this method is beneficial to improving the accuracy of the detection results and reducing the occurrence of misjudgments.

[0063] Finally, it should be emphasized that the above are only preferred embodiments of the present utility model and are not intended to limit the present utility model. For those skilled in the art, the present utility model can have various changes and modifications. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An in-situ detection component, characterized in that: The device includes an in-situ sensor, a sensor base, an elastic element, and a sensor pin. The sensor pin is movably mounted on the sensor base. The elastic element elastically abuts against the sensor base and the sensor pin. The two ends of the sensor pin are respectively provided with an abutment portion and a sensing portion. The abutment portion protrudes from the first sidewall of the sensor base. The in-situ sensor is disposed on the second side of the sensor base. When the abutment portion is compressed, it can drive the sensor pin to move relative to the sensor base, so that the sensing portion enters the detection range of the in-situ sensor and triggers the in-situ sensor.

2. The in-situ detection component according to claim 1, characterized in that: The induction base has a stepped hole, and a first contact part is provided in the stepped hole; The middle part of the sensing pin is inserted into the stepped hole. The sensing pin has an annular flange at one end near the abutting part. The elastic element elastically abuts between the first contact part and the annular flange. The sensing pin has a second contact part at one end near the sensing part. The second contact part is located on the outside of the stepped hole and can abut against the second side wall of the sensing seat.

3. The in-situ detection component according to claim 2, characterized in that: The sensing pin includes a first pin and a second pin, the first pin and the second pin are detachably connected, the annular flange is fixedly disposed on the first pin, and the second contact portion is fixedly disposed on the second pin; Alternatively, the sensing pin may be integrally formed, and the annular flange and / or the second contact portion may be detachably connected to the sensing pin.

4. A transfer module, characterized in that: The device includes a mounting frame, a transfer drive device, a transmission component, a drive wheel, a driven wheel, a fixing component, and the in-situ detection component as described in any one of claims 1 to 3. The drive wheel and the driven wheel are both mounted on the mounting frame. The transmission component is wound around the drive wheel and the driven wheel. The fixing component is fixedly mounted on the transmission component. The transfer drive device can drive the drive wheel to rotate, thereby driving the transmission component and the fixing component to move. The fixing component includes a reaction tube seat, and the reaction tube seat is provided with a placement cavity; The in-situ detection component is mounted on the mounting bracket, the sensing pin is correspondingly disposed with the reaction tube seat, the abutment part can extend into the placement cavity, or the abutment part can move to a preset height range directly above the placement cavity.

5. The transfer module according to claim 4, characterized in that: The extension direction of the sensing pin is parallel to the moving direction of the fixing component, and the sensing seat is fixedly disposed at the end of the moving path of the fixing component. Alternatively, the extending direction of the sensing pin intersects the moving direction of the fixing component, the in-situ detection component is movably disposed on one side of the moving path of the fixing component, and the in-situ detection component can move closer to the fixing component.

6. The transfer module according to claim 4, characterized in that: The side wall of the reaction tube seat is provided with a detection hole, which is connected to the placement cavity. The detection hole is positioned opposite to the sensing pin, and the abutment part can extend into the placement cavity through the detection hole.

7. The transfer module according to claim 4, characterized in that: The mounting bracket is provided with two guide rails, and the extension direction of each guide rail is parallel to the line connecting the central axis of the driving wheel and the driven wheel; The number of fixing components is set to two or more, wherein the two fixing components are a first fixing component and a second fixing component, the first fixing component and the second fixing component are slidably connected to the corresponding guide rails, the first fixing component and the second fixing component are both connected to the transmission component, and the first fixing component and the second fixing component move in opposite directions.

8. The transfer module according to claim 4, characterized in that: The transfer module further includes an initial position detection component, which includes an initial position sensor and a baffle. One of the initial position sensor and the baffle is disposed on the mounting frame, and the other is disposed on the transmission component and moves with the transmission component. The baffle can enter the detection range of the initial position sensor and trigger the initial position sensor.

9. A nucleic acid testing device, characterized in that: Includes the transfer module described in any one of claims 4 to 8 above.

10. The nucleic acid detection device according to claim 9, characterized in that: The nucleic acid detection device further includes a reagent module, a sample module, a pipette tip module, a pipette arm, a sample pretreatment module, an incubation and interpretation module, an auxiliary reagent module, and a waste bin. The sample pretreatment module and the sample module are both located on the first side of the transport module, the incubation and interpretation module and the pipette tip module are both located on the second side of the transport module, the auxiliary reagent module is located between the incubation and interpretation module and the pipette tip module, the reagent module is located at the end of the transport module, and the waste bin is located below the sample module. The pipette arm moves among the transport module, the reagent module, the sample module, the pipette tip module, the pipette arm, the sample pretreatment module, the incubation and interpretation module, the auxiliary reagent module, and the waste bin.

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