A transfer device for microspheres

Abstract

The utility model provides a kind of microsphere drug-loading transfer device, including valve body, puncture needle, first syringe connector and medicine bottle connecting shell;Second syringe connector is connected to the first syringe connector, and detachably provided with protective cap on second syringe connector;Valve core is rotatably installed in the valve cavity of valve body, and valve core has the first flow passage and the second flow passage of cross arrangement;First flow passage and second flow passage are used to connect puncture needle and first syringe connector, and one end of second flow passage is provided with liquid medicine filter membrane;Valve core can be rotated and switched between multiple operating positions, so that puncture needle and first syringe connector are not communicated, or communicated through first flow passage or communicated through second flow passage;The utility model uses microsphere drug-loading transfer device to replace injection needle to connect medicine bottle and No. 1 syringe, which can effectively improve the stability of connection, avoid the risk of breaking injection needle during the flushing process of medicine bottle, reduce the disassembly steps of No. 1 syringe, and improve the drug loading efficiency.

Description

Technical Field

[0001] This utility model belongs to the technical field of microsphere drug delivery devices, specifically relating to a transferor for microsphere drug delivery. Background Technology

[0002] In the medical field, drug delivery is often achieved in the form of drug-loaded microspheres to achieve targeted drug delivery and / or slow release of drugs. Currently, drug-loaded microspheres are mainly used in percutaneous transarterial chemoembolization (TACE). The core of this procedure is to inject drug-loaded microspheres into the tumor-feeding artery through a catheter, allowing the microspheres to continuously and slowly release chemotherapy drugs within the tumor. This continuously kills the tumor while reducing the blood supply to the tumor-feeding artery.

[0003] The conventional method for preparing drug-loaded microspheres is as follows: Microsphere solution is drawn from an inverted vial using an inverted syringe (No. 1); after the microspheres settle, some of the supernatant is pushed back into the vial for rinsing and re-aspiration to avoid residual microspheres; this step is repeated 2-3 times; syringe (No. 1) is left to stand in an inverted state for about 1 minute; then, the needle of syringe (No. 1) is replaced with a filter needle, and the filter needle is removed after the supernatant is drained; syringe (No. 1) and syringe (No. 2) containing the first drug are connected using a three-way connector to transfer the first drug from syringe (No. 2) to syringe (No. 1), thus loading the first drug onto the microspheres; syringe (No. 1) and syringe (No. 3) containing the second drug are connected using a three-way connector to transfer the second drug from syringe (No. 3) to syringe (No. 1), thus loading the second drug onto the microspheres. In this way, multiple drugs can be loaded onto microspheres to form drug-loaded microspheres. However, the above operation has the following problems:

[0004] Since syringe #1 is connected to the vial containing the microsphere solution only through the needle of syringe #1, repeatedly pulling and pushing the plunger of syringe #1 to flush the vial wall can easily cause the needle to break and injure the operator due to improper operation, posing a certain safety hazard. In addition, after transferring the microspheres by connecting syringe #1 to the vial containing the microsphere solution, it needs to be disassembled for the installation and removal of the filter needle before connecting it to other syringes containing drugs, which presents a complicated technical problem. Utility Model Content

[0005] In view of the shortcomings of the prior art, the purpose of this utility model is to provide a microsphere drug delivery transfer device, which can not only avoid the safety risks caused by needle breakage, but also reduce the removal steps of syringe No. 1 during the microsphere drug delivery process and improve drug delivery efficiency.

[0006] To achieve the above and other related objectives, this utility model provides a microsphere-loaded drug transfer device, comprising a valve body, a puncture needle located above the valve body, and a first syringe connector located below the valve body; the valve body is provided with a drug vial connecting shell coaxially sleeved around the puncture needle; a second syringe connector is connected to the outer wall of the first syringe connector, and a protective cap is detachably provided on the second syringe connector; a valve core is rotatably installed in the valve cavity of the valve body, and the valve core has a first flow channel and a second flow channel arranged in a cross pattern; both the first and second flow channels are used to connect the puncture needle and the first syringe connector, and one end of the second flow channel is provided with a drug solution filter membrane; the valve core can rotate and switch between multiple operating positions, so that the puncture needle and the first syringe connector are either not connected to each other, or connected through the first flow channel, or connected through the second flow channel. When microsphere loading is required, first, install the vial containing the microspheres onto the vial connector of the drug transfer device so that the puncture needle can be inserted into the vial. Then, connect syringe #1 to the first syringe connector and rotate the valve core to connect syringe #1 to the vial through the first flow channel. In this state, perform microsphere transfer, subsequent sedimentation, and vial rinsing to ensure that all microspheres in the vial are transferred to syringe #1. Subsequently, rotate the valve core to connect syringe #1, after sedimentation, to the vial through the second flow channel to drain the supernatant from syringe #1. Finally, rotate the valve core to connect syringe #1 to the vial through the second flow channel. The first syringe is not connected to the vial, and the protective cap on the second syringe connector is removed. Then, the second syringe containing the drug is connected to the second syringe connector to transfer the drug into the first syringe, completing the drug loading of the microspheres. Repeating this step allows multiple drugs to be loaded onto the microspheres. Since the first syringe does not need to be repeatedly disassembled and reassembled during the drug loading process, the number of steps in the drug loading process is greatly reduced, improving the drug loading efficiency. In addition, the drug transfer device eliminates the need for the first syringe to puncture the vial with a puncture needle, thus avoiding the risk of needle breakage during subsequent vial rinsing and improving operational safety.

[0007] Preferably, an annular boss is formed inside the valve cavity, and an annular groove that mates with the annular boss is provided on the outer wall of the valve core; through the cooperation of the annular boss and the annular groove, the valve core can only be rotated and cannot be moved while installed in the valve cavity of the valve body, thereby avoiding the occurrence of the valve core accidentally detaching from the valve body.

[0008] Preferably, the valve core is provided with an indicator for indicating the angular position of the first flow channel and / or the angular position of the second flow channel, so that the user can accurately know the orientation of the corresponding flow channel in the valve cavity.

[0009] Preferably, the indicator includes a radially extending indicator handle and an indicator rib; one of the indicator handle and the indicator rib is used to indicate the angular position of the first flow channel, and the other is used to indicate the position of the second flow channel; in addition to indicating the angular position of the corresponding flow channel, the indicator handle is also easy for the user to grip, thereby improving the ease of operation.

[0010] Preferably, a positioning mechanism is provided between the valve body and the valve core. The positioning mechanism is used to position the valve core when it is rotated to the operating position. This makes it easier for the operator to quickly and accurately determine whether the valve core has been rotated into place, thus improving the operating experience. In addition, since the valve core is positioned and held at the operating position, the operator is less likely to accidentally rotate the valve core out of place when performing subsequent fluid transfer, ensuring that the fluid transfer at the operating position can be completed smoothly.

[0011] Preferably, the positioning mechanism includes a first positioning element disposed on the valve cavity and a second positioning element disposed on the outer wall of the valve core; one of the first positioning element and the second positioning element is a positioning protrusion, and the other is a positioning groove that engages or disengages with the positioning protrusion; when the positioning protrusion enters the positioning groove, a "click" sound will be made to remind the operator that it has been rotated into place; at the same time, when the positioning protrusion engages with the positioning groove, a jamming sensation will be produced to provide a secondary reminder to the operator.

[0012] Preferably, the groove wall of the positioning groove is an arc-shaped groove to reduce wear when the positioning protrusion enters or leaves the positioning groove.

[0013] Preferably, the positioning mechanism includes a first friction surface disposed on the valve core and a second friction surface disposed on the valve body; when the valve core is rotated to the operating position, the second friction surface contacts the second friction surface to generate a frictional force that restricts the rotation of the valve core. This frictional force can both increase the difficulty of rotation for the operator to remind the operator that the syringe has been rotated into place, and also position and hold the syringe connector to prevent it from being accidentally displaced during fluid transfer.

[0014] Preferably, the medicine bottle connecting shell has a stop device that abuts against the top of the medicine bottle to limit the depth of the puncture needle into the medicine bottle and prevent the medicine bottle from tilting during installation.

[0015] Preferably, the outer wall of the puncture needle near the puncture end is formed with a drainage port that communicates with the inside of the puncture needle, so that when the vial is inverted, the residual fluid below the puncture end can flow out through the drainage port, avoiding waste of the medication.

[0016] As described above, the microsphere drug delivery transfer device of this utility model has the following beneficial effects:

[0017] This invention utilizes a drug transfer device to connect syringe 1, a vial containing microspheres, and syringe 2 containing medication. By rotating the valve core, syringe 1 sequentially connects to the vial through the first and second flow channels, facilitating microsphere transfer, vial rinsing, and supernatant discharge. Subsequently, rotating the valve core blocks the connection between syringe 1 and the vial, ensuring syringe 1 is only connected to the connector of syringe 2, thus facilitating medication transfer to syringe 1 and completing microsphere drug loading. Since syringe 1 does not need to be repeatedly disassembled and reassembled during microsphere drug loading, the number of steps involved is greatly reduced, improving loading efficiency.

[0018] The positioning mechanism of this invention can position and hold the syringe connector at each operating position, and provide auditory and / or tactile feedback at the operating position so that the operator can accurately perceive the position of the valve core and improve the operator's experience; at the same time, the valve core positioned and held at the operating position is less likely to be accidentally rotated, ensuring that the fluid transfer at that operating position can be completed smoothly. Attached Figure Description

[0019] Figure 1 This is a three-dimensional view of a drug transfer device for microspheres.

[0020] Figure 2 This is a three-dimensional exploded view of a microsphere-loaded drug transfer device.

[0021] Figure 3 for Figure 1 The diagram shows a main cross-sectional view of a microsphere-loaded drug transfer device.

[0022] Figure 4 for Figure 1 The image shows an isometric cross-section of the microsphere drug-carrying transferor after the valve core has been removed.

[0023] Figure 5 3D view of a valve core with a handle

[0024] Figure 6 for Figure 5 Isometric cross-section.

[0025] Figure 7 This is a schematic diagram of a positioning mechanism that positions the valve core to a specific operating position.

[0026] Figure 8 This is a schematic diagram illustrating the process of transferring microspheres from a vial to syringe No. 1 using a microsphere-loaded transfer device.

[0027] Figure 9 This is a schematic diagram illustrating the process of using a microsphere-loaded drug transfer device to drain excess supernatant from syringe #1 back into the vial.

[0028] Figure 10 This is a schematic diagram illustrating the process of transferring medication from syringe #2 to syringe #1 using a microsphere-loaded drug transfer device.

[0029] Explanation of reference numerals in the attached figures

[0030] Medicine bottle 01, syringe 1 02, syringe 2 03, valve body 100, valve chamber 110, first rotating chamber 110a, second rotating chamber 110b, annular boss 111, valve core 200, first rotating shaft 200a, second rotating shaft 200b, first flow channel 210a, second flow channel 210b, annular groove 220, indicator handle 230, indicator rib 240, puncture needle 300, medicine bottle connecting shell 400, elastic retainer 410, stop 420, first syringe connector 510, second syringe connector 520, protective cap 600, medicine filter membrane 700, positioning protrusion 810, positioning groove 820, first friction surface 830. Detailed Implementation

[0031] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification.

[0032] Please see Figures 1 to 10 It should be understood that the structures, proportions, sizes, etc., illustrated in the accompanying drawings are merely for illustrative purposes to aid those skilled in the art and are not intended to limit the scope of this invention. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and purpose of this invention, should still fall within the scope of the disclosed technical content. Furthermore, the terms "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and not intended to limit the scope of this invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of this invention.

[0033] like Figures 1 to 3 As shown, the microsphere drug transfer device provided by this utility model includes a valve body 100 having a valve cavity 110 and a valve core 200 rotatably installed in the valve cavity 110.

[0034] Specifically, the outer wall of the valve body 100 is provided with a puncture needle 300, a medicine bottle connecting shell 400 and a first syringe connector 510; wherein, the puncture needle 300 and the first syringe connector 510 are both connected to the valve cavity 110, and the medicine bottle connecting shell 400 is coaxially arranged with the puncture needle 300; a second syringe connector 520 is connected to the outer wall of the first syringe connector 510, and the second syringe connector 520 is detachably provided with a protective cap 600 by means of snap-fit ​​or threaded connection.

[0035] The valve core 200 has a first flow channel 210a and a second flow channel 210b arranged in a cross manner; both the first flow channel 210a and the second flow channel 210b are used to connect the puncture needle 300 and the first syringe connector 510, and one end of the second flow channel 210b is provided with a drug solution filter membrane 700; when the valve core 200 rotates in the valve cavity 110, the valve core 200 can rotate and switch between multiple operating positions so that the puncture needle 300 and the first syringe connector 510 are not connected to each other, or are connected through the first flow channel 210a or through the second flow channel 210b.

[0036] It should be noted that the liquid filtration membrane 700 is existing technology, and it is made of liquid filtration materials such as polypropylene.

[0037] In this embodiment, both the first injection connector 510 and the second injection connector 520 are Luer female connectors to mate with Luer male connectors on conventional syringes; at this time, the protective cap 600 includes a conical sealing head and / or a threaded cap to achieve a sealed connection with the second syringe connector 520.

[0038] In this embodiment, as Figure 3 As shown, the first flow channel 210a and the second flow channel 210b are both radial flow channels, and the center line of each radial flow channel intersects perpendicularly with the center line of the valve core 200.

[0039] When drug loading on microspheres is required, such as Figure 8 As shown, first, an empty syringe 02 (No. 1) is installed on the first syringe connector 510 of the microsphere drug transfer device, and a vial 01 containing the microsphere solution is attached to the vial connector 400 of the microsphere drug transfer device. The puncture needle 300 pierces the cap of the vial 01, completing the connection between the puncture needle 300 and the vial 01. Then, the valve core 200 is rotated to connect the vial 01 and syringe 02 through the first flow channel 210a, and the microsphere solution in the vial 01 is drawn out through syringe 02. After the microspheres in syringe 01 settle, a portion of the supernatant is pushed back into the vial 01 for rinsing and back-drawing to avoid residual microspheres in the vial 01. This step is repeated 2-3 times. Figure 9As shown, rotating the valve core 200 connects the medicine bottle 01 and syringe 02 through the second flow channel 210b with the medicine filter membrane 700. After the microspheres in syringe 02 settle, the excess supernatant in syringe 02 is discharged. The medicine filter membrane 700 effectively prevents the microspheres in syringe 02 from being discharged. Figure 10 As shown, rotate the valve core 200 to disconnect the drug bottle 01 and syringe 02. Then, remove the protective cap 600 from the second syringe connector 520 and install syringe 03 containing the drug solution (such as doxorubicin) on the second syringe connector 520 to transfer the drug solution into syringe 02 for microsphere loading. When other drugs (such as contrast agents) need to be loaded, simply install syringe 03 containing the corresponding drug solution on the second syringe connector 520 and transfer the drug solution into syringe 02. After all drugs are loaded, an empty syringe 3 (not shown in the figure) can be installed on the second syringe connector 520 to extract the drug-loaded microspheres (i.e., the drug-loaded microspheres).

[0040] This application uses a microsphere-loaded drug transfer device to replace the injection needle to connect the vial 01 and syringe 02, which can effectively improve the connection stability and avoid the risk of injection needle breakage due to improper operation during the flushing of vial 01. At the same time, since the microsphere-loaded drug transfer device can switch between the vial 01 and syringe 02 through the rotating valve core 200, the two states are connected through the first flow channel 210a, connected through the second flow channel 210b with drug solution filter membrane 700, and disconnected, the transfer of microspheres, discharge of supernatant and transfer of drug solution can be completed smoothly without the need for repeated disassembly and assembly of syringe 02. This effectively reduces the number of drug loading operation steps and improves drug loading efficiency.

[0041] It should be noted that the models of the aforementioned syringes No. 1, No. 2, and No. 3 (such as 20ml, 1ml, 5ml, etc.) are selected according to the actual situation and are not limited thereto.

[0042] In this application, for ease of description, the height direction of the valve core 200 in a horizontal state in the microsphere drug delivery transferor is defined as the up-down direction, the axial direction of the valve core 200 in a horizontal state is defined as the front-back direction, and the direction perpendicular to both the up-down and front-back directions is defined as the left-right direction. Based on this, in Figure 3 In the diagram, the top and bottom sides of the paper represent the up and down directions, the outer and inner sides represent the front and back directions, and the left and right sides represent the left and right directions.

[0043] When loading microspheres with a microsphere drug transfer device, the valve core 200 needs to be rotated to switch the puncture needle 300 and the first syringe connector 510 between state one (connected through the first flow channel 210a), state two (connected through the second flow channel 210b), and state three (not connected). In order to facilitate the operator to determine whether the valve core 200 has been rotated to the corresponding operating position, an indicator for indicating the angle position of the first flow channel and / or the angle position of the second flow channel needs to be provided on the valve core 200.

[0044] Specifically, such as Figure 5 As shown, the indicator includes a radially extending indicator handle 230 and an indicator rib 240; one of the indicator handle 230 and the indicator rib 240 is used to indicate the angular position of the first flow channel 210a, and the other is used to indicate the position of the second flow channel 210b; at this time, the indicator handle 230 can also be gripped by the user to improve the ease of operation.

[0045] It should be noted that when the included angle between the first flow channel 210a and the second flow channel 210b is known (e.g., 90°), only the indicator handle 230 needs to be provided. The indicator handle 230 is used to indicate the angular position of the first flow channel 210a or the second flow channel 210b.

[0046] Furthermore, the indicator handle 230 is also equipped with anti-slip pads, anti-slip textures and other anti-slip components to prevent slipping when gripping.

[0047] In a preferred embodiment, a positioning mechanism is also provided between the valve body 100 and the valve core 200. The positioning mechanism positions and holds the valve core 200 when it is rotated to the operating position, so as to prevent the valve core 200 from accidentally rotating and deviating from the corresponding operating position, interrupting the drug transfer step and affecting the smooth progress of drug loading on microspheres.

[0048] It is understandable that positioning mechanisms come in a variety of structural forms, including but not limited to the following two.

[0049] Structural Form 1:

[0050] like Figure 4 , Figure 5 and Figure 7As shown, the positioning mechanism includes a first positioning element disposed on the wall of the valve cavity 110 and a second positioning element disposed on the outer wall of the valve core 200. One of the first and second positioning elements is a positioning protrusion 810, and the other is a positioning groove 820 that engages or disengages with the positioning protrusion 810. When the positioning protrusion 810 engages with the positioning groove 820, a "click" sound is produced, providing a tactile feedback of engagement, thus enhancing the operator's experience through both sound and touch. Furthermore, since the positioning protrusion 810 requires considerable force to disengage from the positioning groove 820, the engagement of the two elements also provides auxiliary positioning for the valve core 200, preventing accidental rotation of the valve core 200 during syringe operation.

[0051] It should be noted that there are multiple first positioning elements and multiple second positioning elements, and the multiple first positioning elements are evenly distributed on the cavity wall of the valve cavity 110, and the multiple second positioning elements are evenly distributed on the outer wall of the valve core 200, so as to ensure the stability of the force when the valve core 200 rotates; the setting position of each first positioning element and the second positioning element can be determined according to the setting orientation of the first syringe connector 510, the first flow channel 210a and the second flow channel 210b, as long as at least one set of positioning protrusions 810 and positioning grooves 820 are engaged at each operating position.

[0052] In a preferred embodiment, the positioning groove 820 is an arc-shaped groove (i.e., the cross-section is arc-shaped) or a spherical groove to reduce wear during the engagement or disengagement process of the positioning protrusion 810 and the positioning groove 820.

[0053] Structural Form Two:

[0054] like Figure 2 and Figure 5 As shown, the positioning mechanism includes a first friction surface 830 disposed on the valve core 200 and a second friction surface (not shown) disposed on the valve body 100. The number and orientation of the first friction surface 830 and the second friction surface are determined according to the orientation of the first syringe connector 510, the first flow channel 210a and the second flow channel 210b. As long as the valve core 200 is rotated to any operating position, at least one of the first friction surfaces 830 can contact the second friction surface to generate a frictional force that restricts the rotation of the valve core 200. This frictional force will cause the operator to feel a jamming sensation. In addition, when the first friction surface 830 contacts the second friction surface, the operator needs to apply a large force to disengage the first friction surface 830 from the second friction surface. Therefore, when the two are used together, they can also provide auxiliary positioning for the valve core 200, preventing the valve core 200 from rotating accidentally during the transfer of the liquid.

[0055] It is understandable that when the first friction surface 830 is misaligned with the second friction surface, the valve core 200 can rotate freely without jamming under the action of a small force. When the first friction surface 830 is aligned with the second friction surface, a jamming sensation will occur, causing the valve core 200 to require a larger force to rotate. Whether the operator feels a jamming sensation when passing through the valve core 200 can be used to judge whether the valve core 200 has rotated to the correct position.

[0056] The above two structural forms can be used alone or in combination, as long as the valve core 200 can be positioned and have a tactile feedback when rotated to any operating position; in this embodiment, the preferred approach is to use a combination of the two structural forms.

[0057] like Figures 4 to 6 As shown, the valve cavity 110 includes a cylindrical first rotating cavity 110a and a second rotating cavity 110b. The diameter of the first rotating cavity 110a is smaller than the diameter of the second rotating cavity 110b, and the cavity wall of the first rotating cavity 110a is provided with through holes that communicate with the puncture needle 300 and the first syringe connector 510, respectively. The valve core 200 includes a first rotating shaft 200a and a second rotating shaft 200b connected sequentially from front to back. Both b are cylindrical, and the first flow channel 210a and the second flow channel 210b are both formed on the first rotating shaft 200a. An annular groove 220 is formed on the outer wall of the first rotating shaft 200a, and an annular protrusion 111 is formed on the cavity wall of the first rotating cavity 110a. When the valve core 200 is inserted into the valve cavity 110, the annular groove 220 can engage with the annular protrusion 111 on the cavity wall of the valve cavity 110, so that the valve core 200 can only rotate and cannot move axially within the valve cavity 110. The first rotating shaft 200a and the first rotating cavity 110a are always rotated in a sealed state to prevent fluid leakage.

[0058] At this time, the first positioning element is set on the cavity wall of the second rotating cavity 110b, and the second positioning element is set on the outer wall of the second rotating shaft 200b.

[0059] In this application, the outer wall of the puncture needle 300 near the puncture end is formed with a drainage port that communicates with the inside of the puncture needle, so that when the medicine bottle 01 is inverted, the residual liquid below the puncture end can flow out along the drainage port, avoiding residual medicine in the medicine bottle 01 and causing waste.

[0060] Since the vial 01 containing the microsphere solution is a vial or vial-like structure, the vial connecting shell 400 and the vial 01 are connected by a snap-fit ​​method.

[0061] Specifically, such as Figure 4 and Figure 8As shown, the vial connecting shell 400 includes a plurality of elastic retaining members 410 evenly arranged around the puncture needle 300; when the vial 01 is inserted into the vial connecting shell 400, each elastic retaining member 410 bends and deforms outward under the pressure of the vial 01; when the vial 01 is inserted into place, each elastic retaining member 410 will automatically reset to form an anti-dislodgement component that abuts against the bottom of the vial 01 or the bottom of the cap, so as to prevent the vial 01 from detaching from the vial connecting shell 400 and ensure the stability of the connection between the two.

[0062] To prevent the medicine bottle 01 from tilting after being inserted into the medicine bottle connecting shell 400, the medicine bottle connecting shell 400 is provided with a stop device that abuts against the top of the medicine bottle 01. The stop device is an annular stop ring coaxially arranged with the puncture device 300 or multiple stop members 420 symmetrically arranged about the puncture device 300. The stop member 420 can be any stop structure with a flat stop surface, such as a plate structure or a T-shaped structure, and there is no limitation on this.

[0063] Because this application uses a microsphere-loaded drug transfer device to replace the injection needle in connecting the vial 01 and syringe 02, it can effectively improve the stability of the connection between the vial 01 and syringe 02, thereby avoiding the risk of injection needle breakage due to improper operation during the rinsing process of the vial 01. At the same time, because the microsphere-loaded drug transfer device can switch between the vial 01 and syringe 02 in three states—one connected through the first flow channel 210a, two connected through the second flow channel 210b with the drug solution filter membrane 700, and three not connected—by rotating the valve core 200, the transfer of microspheres, discharge of supernatant, and transfer of drug solution can be completed smoothly without the need for repeated disassembly and assembly of syringe 02, effectively reducing the number of drug loading steps and improving drug loading efficiency.

[0064] In summary, this utility model effectively overcomes the various shortcomings of the prior art and has high industrial application value.

[0065] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.

Claims

1. A microsphere drug delivery transfer device, characterized in that, The device includes a valve body (100), a puncture needle (300) located above the valve body (100), and a first syringe connector (510) located below the valve body (100). The valve body (100) has a vial connector (400) coaxially sleeved around the puncture needle (300). A second syringe connector (520) is connected to the outer wall of the first syringe connector (510), and a protective cap (600) is detachably mounted on the second syringe connector (520). A valve core (200) is rotatably mounted within the valve cavity (110) of the valve body (100). (200) has a first flow channel (210a) and a second flow channel (210b) arranged in a cross configuration; both the first flow channel (210a) and the second flow channel (210b) are used to connect the puncture needle (300) and the first syringe connector (510), and one end of the second flow channel (210b) is provided with a drug filter membrane (700); the valve core (200) can be rotated and switched between multiple operating positions so that the puncture needle (300) and the first syringe connector (510) are not connected to each other or are connected through the first flow channel (210a) or through the second flow channel (210b).

2. The microsphere drug delivery transferor according to claim 1, characterized in that, The valve cavity (110) is formed with an annular boss (111), and the outer wall of the valve core (200) is provided with an annular groove (220) that mates with the annular boss (111).

3. The microsphere drug delivery transferor according to claim 1 or 2, characterized in that, The valve core (200) is provided with an indicator for indicating the angular position of the first flow channel and / or the angular position of the second flow channel.

4. The microsphere drug delivery transferor according to claim 3, characterized in that, The indicator includes a radially extending indicator handle (230) and an indicator rib (240); one of the indicator handle (230) and the indicator rib (240) is used to indicate the angular position of the first flow channel (210a), and the other is used to indicate the position of the second flow channel (210b).

5. The microsphere drug delivery transferor according to claim 1 or 2, characterized in that, A positioning mechanism is provided between the valve body (100) and the valve core (200), which is used to position the valve core (200) when it is rotated to the operating position.

6. The microsphere drug delivery transferor according to claim 5, characterized in that, The positioning mechanism includes a first positioning element disposed on the valve cavity (110) and a second positioning element disposed on the outer wall of the valve core (200); one of the first positioning element and the second positioning element is a positioning protrusion (810), and the other is a positioning groove (820) that engages or disengages with the positioning protrusion (810).

7. The microsphere drug delivery transferor according to claim 6, characterized in that, The groove wall of the positioning groove (820) is an arc-shaped groove.

8. The microsphere drug delivery transferor according to claim 5, characterized in that, The positioning mechanism includes a first friction surface (830) disposed on the valve core (200) and a second friction surface disposed on the valve body (100); when the valve core (200) rotates to the operating position, the first friction surface (830) contacts the second friction surface to generate a frictional force that restricts the rotation of the valve core (200).

9. The microsphere drug delivery transferor according to claim 1 or 2, characterized in that, The medicine bottle connecting shell (400) has a stop device that abuts against the top of the medicine bottle.

10. A microsphere drug delivery transferor according to claim 1 or 2, characterized in that, The puncture needle (300) has a drainage port formed on the outer wall near the puncture end, which is connected to the inside of the puncture needle.

Images