Chromatographic column limiting frame for simulated moving bed purification and separation equipment

Abstract

The utility model relates to chromatographic separation technical field, and disclose a kind of chromatographic column limiting frame for simulated moving bed purification separation equipment, including simulated moving bed ontology, fixed plate one and fixed plate two, fixed plate one is provided with mounting bracket between fixed plate two, the outer wall sliding connection of mounting bracket has moving stand, the outer wall of mounting bracket is opened and is limited to hole one, the outer wall of moving stand is opened and is limited to hole two, the outer wall of moving stand is inserted and is installed and is limited to pin, the outer wall of moving stand is provided with chromatographic column, the outer wall of chromatographic column is fixed and is installed and is limited to ring.This chromatographic column limiting frame for simulated moving bed purification separation equipment, by the design of guide block and guide slot, the quick positioning of mounting bracket can be realized, then cooperate with bolt one, threaded hole one and threaded hole two, the quick fixing of mounting bracket can be realized, when using or assembling, it is convenient for its quick disassembly, and higher adaptability, high practicality.

Description

Technical Field

[0001] This utility model relates to the field of chromatographic separation technology, specifically a column positioning rack for a simulated moving bed purification and separation device. Background Technology

[0002] The simulated moving bed (SMB) purification and separation equipment is a high-efficiency separation device based on chromatographic separation principles. By periodically switching the relative flow direction between the stationary phase bed and the material, it simulates the "moving" effect of the stationary phase, achieving continuous separation and purification. Its core consists of multiple tandem chromatographic columns, switching valve assemblies, a pump, and a control system, which can precisely control the flow direction and distribution of feed, eluent, target product, and waste. Compared to traditional fixed beds, SMB significantly improves stationary phase utilization and product purity, reduces eluent consumption, and enables continuous operation, lowering energy consumption and time costs associated with batch processes. It is currently widely used in the purification of sugars, chiral drugs, antibiotics, and food additives, such as the separation of glucose and fructose and the resolution of chiral compounds. It is a key piece of equipment for achieving efficient separation in the fine chemical and biopharmaceutical industries.

[0003] In the existing technology, the column limiter of the simulated moving bed purification and separation equipment has the advantages of high separation efficiency, good product purity and yield, high utilization rate of stationary phase and solvent, low energy consumption, continuous operation, strong stability, wide application scenarios and good adaptability. However, when installing the chromatographic column, no positioning structure is designed, and bolts are used directly for installation, which is relatively slow, has low practicality, and is not convenient for widespread use. Summary of the Invention

[0004] The technical problem to be solved by this utility model is to provide a column positioning frame for a simulated moving bed purification and separation device. It can effectively solve the problems of existing technologies that do not have a positioning structure and are directly installed by bolts, which is slow to install, has low practicality, and is not easy to promote and use.

[0005] The technical solution adopted by this utility model is as follows: a chromatographic column limiting frame for a simulated moving bed purification and separation device, comprising a simulated moving bed body, a fixed plate one, and a fixed plate two. A mounting frame is provided between the fixed plate one and the fixed plate two. A movable frame is slidably connected to the outer wall of the mounting frame. A limiting hole one is opened on the outer wall of the mounting frame, and a limiting hole two is opened on the outer wall of the movable frame. A limiting pin is inserted and installed on the outer wall of the movable frame. A chromatographic column is provided on the outer wall of the movable frame. A limiting ring is fixedly installed on the outer wall of the chromatographic column. A mounting base is fixedly installed on the side of the movable frame near the chromatographic column. A positioning groove and a threaded hole three are opened on the end of the mounting base near the chromatographic column. A limiting component is provided on the end of the mounting base near the chromatographic column. A positioning block is fixedly installed on the outer wall of the limiting component. A threaded hole four is opened on the outer wall of the limiting component. A bolt two is threadedly connected to the outer wall of the limiting component.

[0006] Preferably, guide blocks are fixedly installed at both the end of the mounting bracket near the first fixing plate and the end of the mounting bracket near the second fixing plate. Guide grooves and threaded holes are provided on both the side of the first fixing plate near the mounting bracket and the side of the second fixing plate near the mounting bracket. Threaded holes are provided on the outer wall of the mounting bracket, and bolts are threadedly connected to the outer wall of the mounting bracket. The guide blocks are inserted into the guide grooves, and the cross-section of the guide blocks is T-shaped.

[0007] Using the above technical solution, the staff inserts the guide block into the guide groove, so that the mounting bracket is located between the first fixed plate and the second fixed plate, which can realize the rapid positioning of the mounting bracket.

[0008] Preferably, the bolt extends through the threaded hole one into the interior of the threaded hole two, and the threaded hole one and the threaded hole two have the same diameter.

[0009] With the above technical solution, after the mounting bracket is quickly positioned, the operator can quickly fix the mounting bracket by inserting a bolt through the threaded hole and extending it into the threaded hole. This makes it easy to quickly disassemble and assemble the bracket during use or assembly.

[0010] Preferably, the limiting pin passes through the second limiting hole and the first limiting hole, and the second limiting hole and the first limiting hole have the same diameter.

[0011] Using the above technical solution, the staff slides the mobile frame on the outer wall of the mounting frame. When it slides to the appropriate position, the staff inserts the limiting pin through the limiting hole 2 and the limiting hole 1 to achieve rapid positioning of the mobile frame.

[0012] Preferably, the limiting hole 1 has multiple identical ones, and the multiple limiting holes 1 are distributed at equal intervals.

[0013] The above technical solution, through the design of multiple limiting holes, makes it easy to adjust the height of the moving frame, thereby facilitating the installation of chromatographic columns of different heights and providing high adaptability.

[0014] Preferably, two identical limiting rings are provided, the distance between the two limiting rings is the same as the height of the mounting base, and the chromatographic column is adapted to the mounting base.

[0015] Using the above technical solution, the staff inserts the chromatographic column into the interior of the mounting base, so that the limiting rings are located on both sides of the mounting base, which can achieve rapid positioning of the chromatographic column.

[0016] Preferably, the limiting member is adapted to the chromatographic column, the positioning block and the positioning groove are installed by plugging, the bolt two extends through the threaded hole four into the interior of the threaded hole three, and the threaded hole four and the threaded hole three have the same diameter.

[0017] With the above technical solution, after the chromatographic column is quickly positioned, the operator inserts the positioning block into the positioning groove so that the limiting component abuts against the outer wall of the chromatographic column. Then, the bolt two extends through the threaded hole four into the threaded hole three, which can realize the rapid positioning of the chromatographic column. After long-term use, it is convenient to repair or replace it.

[0018] Compared with the prior art, this utility model provides a column limiting rack for a simulated moving bed purification and separation device, which has the following beneficial effects: 1. The chromatographic column limiting frame of this simulated moving bed purification and separation equipment can achieve rapid positioning of the mounting frame through the design of guide blocks and guide grooves. With the cooperation of bolt one, threaded hole one and threaded hole two, the mounting frame can be quickly fixed. It is easy to quickly disassemble and assemble during use or assembly, and has high adaptability. Through the cooperation of the chromatographic column, limiting ring and mounting base, the chromatographic column can be quickly positioned. Through the cooperation of positioning block and positioning groove, limiting part and chromatographic column and bolt two, threaded hole four and threaded hole three, the chromatographic column can be quickly limited. After long-term use, it is easy to repair or replace it. 2. The column positioning frame of this simulated moving bed purification and separation equipment can achieve rapid positioning of the moving frame through the cooperation of the positioning pin, positioning hole two, and positioning hole one. The design of multiple positioning holes one makes it easy to adjust the height of the moving frame, thus facilitating the installation of chromatographic columns of different heights and adapting to different working conditions. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram of the three-dimensional structure of the chromatographic column of this utility model; Figure 3 This is a schematic diagram of the installation structure of the mobile frame of this utility model; Figure 4 This is a schematic diagram of the mounting structure of the mounting bracket of this utility model; Figure 5 This is a schematic diagram of the chromatographic column installation structure of this utility model.

[0020] The components are: 1. Simulated moving bed body; 2. Fixed plate one; 3. Fixed plate two; 4. Mounting frame; 5. Guide block; 6. Guide groove; 7. Threaded hole one; 8. Threaded hole two; 9. Bolt one; 10. Moving frame; 11. Limiting hole one; 12. Limiting hole two; 13. Limiting pin; 14. Chromatographic column; 15. Limiting ring; 16. Mounting base; 17. Positioning groove; 18. Threaded hole three; 19. Limiting component; 20. Positioning block; 21. Threaded hole four; 22. Bolt two. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Example 1: like Figure 1-5 As shown, the present invention provides a chromatographic column limiting frame for a simulated moving bed purification and separation device, comprising a simulated moving bed body 1, a first fixed plate 2, and a second fixed plate 3. A mounting frame 4 is provided between the first fixed plate 2 and the second fixed plate 3. A movable frame 10 is slidably connected to the outer wall of the mounting frame 4. A limiting hole 11 is provided on the outer wall of the mounting frame 4, and a limiting hole 12 is provided on the outer wall of the movable frame 10. A limiting pin 13 is inserted and installed on the outer wall of the movable frame 10. A chromatographic column 14 is provided on the outer wall of the movable frame 10. A limiting ring 15 is fixedly installed on the outer wall of the chromatographic column 14. A mounting base 16 is fixedly installed on the side of the movable frame 10 near the chromatographic column 14. A positioning groove 17 and a threaded hole 18 are provided at the end of the mounting base 16 near the chromatographic column 14. A limiting component 19 is provided at the end of the mounting base 16 near the chromatographic column 14. A positioning block 20 is fixedly installed on the outer wall of the limiting component 19. A threaded hole 21 is provided on the outer wall of the limiting component 19, and a bolt 22 is threadedly connected to the outer wall of the limiting component 19.

[0023] Specifically, guide blocks 5 are fixedly installed at both the end of the mounting bracket 4 near the first fixing plate 2 and the end of the mounting bracket 4 near the second fixing plate 3. Guide grooves 6 and threaded holes 8 are provided on both the side of the first fixing plate 2 near the mounting bracket 4 and the side of the second fixing plate 3 near the mounting bracket 4. Threaded holes 7 are provided on the outer wall of the mounting bracket 4, and bolts 9 are threadedly connected to the outer wall of the mounting bracket 4. The guide blocks 5 and guide grooves 6 are inserted into each other, and the cross-section of the guide blocks 5 has a "T" shape. The advantage is that when the operator inserts the guide blocks 5 into the guide grooves 6, the mounting bracket 4 is positioned between the first fixing plate 2 and the second fixing plate 3, enabling rapid positioning of the mounting bracket 4.

[0024] Specifically, bolt 9 extends through threaded hole 7 into threaded hole 8, with threaded hole 7 and threaded hole 8 having the same diameter. The advantage is that after quickly positioning the mounting bracket 4, the operator can quickly fix the mounting bracket 4 by extending bolt 9 through threaded hole 7 into threaded hole 8, facilitating quick assembly and disassembly during use or assembly.

[0025] Specifically, the limiting pin 13 passes through the second limiting hole 12 and the first limiting hole 11, and the second limiting hole 12 and the first limiting hole 11 have the same diameter. The advantage is that when the operator slides the movable frame 10 on the outer wall of the mounting frame 4, and when it slides to the appropriate position, the operator then inserts the limiting pin 13 through the second limiting hole 12 and the first limiting hole 11, which can quickly limit the movement of the movable frame 10.

[0026] Example 2: like Figure 2-5 As shown, as an improvement on the previous embodiment, to further facilitate the installation of chromatographic columns 14 of different heights, specifically, multiple identical limiting holes 11 are provided, and the multiple limiting holes 11 are distributed at equal intervals. The advantage is that the design of multiple limiting holes 11 makes it easy to adjust the height of the moving frame 10, thereby facilitating the installation of chromatographic columns 14 of different heights and providing high adaptability.

[0027] Specifically, two identical limiting rings 15 are provided, and the distance between the two limiting rings 15 is the same as the height of the mounting base 16, so that the chromatographic column 14 is adapted to the mounting base 16. The advantage is that when the operator inserts the chromatographic column 14 into the interior of the mounting base 16, so that the limiting rings 15 are located on both sides of the mounting base 16, the chromatographic column 14 can be quickly positioned.

[0028] Specifically, the limiting component 19 is adapted to the chromatographic column 14, the positioning block 20 and the positioning groove 17 are plug-in installed, and the bolt 22 extends through the threaded hole 21 to the inside of the threaded hole 18. The threaded hole 21 and the threaded hole 18 have the same diameter. The advantage is that after the chromatographic column 14 is quickly positioned, the operator inserts the positioning block 20 into the positioning groove 17, so that the limiting component 19 abuts against the outer wall of the chromatographic column 14, and then extends the bolt 22 through the threaded hole 21 to the inside of the threaded hole 18, which can achieve rapid positioning of the chromatographic column 14. After long-term use, it is convenient to inspect or replace it.

[0029] Working principle: During installation, the operator inserts the guide block 5 into the guide groove 6, positioning the mounting bracket 4 between the first fixing plate 2 and the second fixing plate 3, enabling rapid positioning of the mounting bracket 4. After positioning the mounting bracket 4, the operator inserts bolt 9 through threaded hole 7 into threaded hole 8, quickly fixing the mounting bracket 4 for easy disassembly and assembly during use or assembly. The operator then slides the movable bracket 10 along the outer wall of the mounting bracket 4. When it reaches the desired position, the operator inserts the limiting pin 13 through limiting hole 12 and limiting hole 11, quickly limiting the movable bracket 10. Finally, the operator inserts the chromatographic column... Insert the 14 into the mounting base 16 so that the limiting ring 15 is located on both sides of the mounting base 16, which can realize the rapid positioning of the chromatographic column 14. After the chromatographic column 14 is quickly positioned, the operator inserts the positioning block 20 into the positioning groove 17 so that the limiting member 19 abuts against the outer wall of the chromatographic column 14. Then, the bolt 22 is inserted through the threaded hole 21 and extended into the threaded hole 3 18, which can realize the rapid positioning of the chromatographic column 14. After long-term use, it is convenient to repair or replace it. During use, the design of multiple limiting holes 11 makes it easy to adjust the height of the moving frame 10, thus facilitating the installation of chromatographic columns 14 of different heights, with high adaptability.

[0030] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A column positioning frame for a simulated moving bed purification and separation device, comprising a simulated moving bed body (1), a first fixing plate (2), and a second fixing plate (3), characterized in that: A mounting bracket (4) is provided between the first fixing plate (2) and the second fixing plate (3). A movable frame (10) is slidably connected to the outer wall of the mounting bracket (4). A limiting hole (11) is provided on the outer wall of the mounting bracket (4), and a limiting hole (12) is provided on the outer wall of the movable frame (10). A limiting pin (13) is inserted and installed on the outer wall of the movable frame (10). A chromatographic column (14) is provided on the outer wall of the movable frame (10). A limiting ring (15) is fixedly installed on the outer wall of the chromatographic column (14). A mounting base (16) is fixedly installed on the side of the frame (10) near the chromatographic column (14). The mounting base (16) near the chromatographic column (14) has a positioning groove (17) and a threaded hole (18). A limiting member (19) is provided on the side of the mounting base (16) near the chromatographic column (14). A positioning block (20) is fixedly installed on the outer wall of the limiting member (19). A threaded hole (21) is provided on the outer wall of the limiting member (19). A bolt (22) is threadedly connected to the outer wall of the limiting member (19).

2. The column positioning rack for a simulated moving bed purification and separation device according to claim 1, characterized in that: Guide blocks (5) are fixedly installed on one end of the mounting bracket (4) near the first fixing plate (2) and the other end of the mounting bracket (4) near the second fixing plate (3). Guide grooves (6) and threaded holes (8) are provided on the side of the first fixing plate (2) near the mounting bracket (4) and the side of the second fixing plate (3) near the mounting bracket (4). Threaded holes (7) are provided on the outer wall of the mounting bracket (4). Bolts (9) are threadedly connected to the outer wall of the mounting bracket (4). The guide block (5) and the guide groove (6) are installed by insertion. The cross section of the guide block (5) is a "T" shaped structure.

3. The column positioning rack for a simulated moving bed purification and separation device according to claim 2, characterized in that: The bolt one (9) extends through the threaded hole one (7) into the interior of the threaded hole two (8), the threaded hole one (7) and the threaded hole two (8) having the same diameter.

4. The column positioning rack for a simulated moving bed purification and separation device according to claim 1, characterized in that: The limiting pin (13) passes through the limiting hole two (12) and the limiting hole one (11), and the limiting hole two (12) and the limiting hole one (11) have the same diameter.

5. The column positioning rack for a simulated moving bed purification and separation device according to claim 1, characterized in that: The limiting hole (11) has multiple identical holes, and the multiple limiting holes (11) are distributed at equal intervals.

6. The column positioning rack for a simulated moving bed purification and separation device according to claim 1, characterized in that: Two identical limiting rings (15) are provided, and the distance between the two limiting rings (15) is the same as the height of the mounting base (16). The chromatographic column (14) is adapted to the mounting base (16).

7. The column positioning rack for a simulated moving bed purification and separation device according to claim 1, characterized in that: The limiting member (19) is adapted to the chromatographic column (14), the positioning block (20) and the positioning groove (17) are plugged in, the bolt two (22) extends through the threaded hole four (21) to the inside of the threaded hole three (18), and the threaded hole four (21) and the threaded hole three (18) have the same diameter.

Images