Cosmetic composition with peptides to improve skin volume and wrinkle structure

Abstract

Cosmetic system, comprehensive (a) a serum containing a peptide signaling complex which includes at least one peptide or peptide derivative which - stimulates the differentiation, lipogenesis or proliferation of adipocytes or - modulates matrix communication between dermis and subcutis, or - both effects combined, and (b) a lamellar cream with skin-identical lipid lamellae (phosphatidylcholine, ceramides, cholesterol, free fatty acids) for fixation and transduction of the peptides applied under (a); for cosmetic use to maintain and regenerate subcutaneous adipose tissue and dermal support structure.

Description

1. Technical field

[0001] The invention relates to cosmetic and dermocosmetic compositions and their use for the non-invasive preservation and restoration of subcutaneous adipose tissue and for the structural improvement of skin architecture through peptide-mediated signaling processes between dermis and subcutis. 2. State of the art

[0002] Well-known cosmetic anti-aging preparations focus predominantly on the epidermis and dermis.

[0003] They promote collagen or elastin synthesis, improve skin hydration, or have an antioxidant effect.

[0004] The loss of subcutaneous fat pads – one of the main causes of age-related volume loss – is not addressed in these concepts.

[0005] With decreasing adipocyte count and lipid content, the dermis loses its support and collapses; wrinkles arise secondarily due to the uneven underlying surface.

[0006] A cosmetic system that specifically promotes the maintenance or regeneration of subcutaneous adipose tissue has not yet been disclosed. 3. Object of the invention

[0007] The object of the invention is to provide a cosmetic system that addresses the volume reduction of subcutaneous adipose tissue as the primary cause of skin aging and enables regeneration and stabilization of the dermal support structures through targeted activation of adipocyte signaling pathways.

[0008] This is intended to fill in skin contours, smooth wrinkles and restore the mechanical tension of the dermis. 4. Solution to the task

[0009] The task is solved by a multi-stage cosmetic system consisting of: 1. a serum containing a peptide signaling complex, 2. a lamellar cream (DMS-like structure) for fixation and transduction of the peptides and 3. optionally, instrumental, non-therapeutic stimulation (ultrasound, RF microneedling, microcurrent) for penetration and signal enhancement.

[0010] The signal complex contains at least one peptide or peptide derivative that - stimulates the differentiation, lipogenesis or proliferation of adipocytes or - modulates or the matrix communication between dermis and subcutis - both effects combined.

[0011] Suitable peptides are selected from the group including, but not limited to, Acetyl Hexapeptide-38, Acetyl Tetrapeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Acetyl Decapeptide-3, Trifluoroacetyl Tripeptide-2 or their functional analogues and derivatives. 5. Mechanism of action (non-medical)

[0012] The system activates the biological dialogue between dermis and subcutis through targeted fibro-adipo signal modulation and causes: 1. Adipogenic signal activation → Maintenance and proliferation of subcutaneous adipocytes, 2. ECM stabilization → Strengthening of the dermal matrix, 3. Secondary smoothing of the superficial skin layers by restoring deep skin contact.

[0013] The system can optionally be combined with device-based stimulation without claiming a medical purpose. 6. Justification of the novelty

[0014] The current state of the art describes cosmetic formulations that act exclusively on the epidermis or dermis. A system that specifically targets subcutaneous adipose tissue as the primary structure responsible for skin aging and promotes its maintenance and regeneration via peptide-mediated fibro-adipo signaling pathways has not been disclosed.

[0015] This represents a technical innovation compared to all previous cosmetic systems. 7. Advantages of the invention • Causal approach instead of symptomatic surface care • Volume regeneration instead of wrinkle concealment • Non-invasive, clinically-aesthetically pleasing and compatible with medical devices • Widely applicable (face, neck, hands, body, intimate area) • Open peptide definition → future drugs can be integrated 8. Typical example

[0016] Serum: Aqua, Glycerin, Acetyl-Hexapeptide-38 (0.5%), Acetyl-Tetrapeptide-2 (0.3%), Palmitoyl-Tetrapeptide-7 (0.3%), PPG-26-Buteth-26, PEG-40 HCO, Preservative.

[0017] Cream (DMS-like): Aqua, Phosphatidylcholine, Ceramide NP / AP / EOP, Cholesterol, Cetearyl Alcohol, Caprylic / Capric Triglyceride, Boswellia Extract (0.3%), pH 5.2 - 5.8. 9. Industrial Applicability

[0018] The invention is industrially manufacturable and suitable for premium cosmetic products. The system can be mass-produced and distributed worldwide.