KERATINOUS MATERIAL TREATMENT MASK

Abstract

KERATINOUS MATERIAL CARE MASK The present invention relates to a keratinous material care mask, comprising, A) a water-insoluble substrate layer, and B) a water-soluble layer disposed on the water-insoluble substrate layer, the water-soluble layer comprising (i) at least one hyaluronic acid (HA) or a salt thereof, and (ii) polydatin, wherein the hyaluronic acid or a salt thereof has a weight-average molecular weight between 20,000 and 60,000 Daltons. The present invention also relates to a non-therapeutic process for caring for keratinous materials. Figure for abstract: none

Description

Title of the invention: KERATINOUS MATERIAL TREATMENT MASK technical field

[0001] The present invention relates to a product for the care of keratinous materials. In particular, the present invention relates to a mask for the care of keratinous materials. The present invention also relates to a non-therapeutic process for the care of keratinous materials. STATE OF THE ART

[0002] The ultimate goal of the cosmetics industry has always been to deliver highly effective products to consumers that offer skin benefits such as hydration, whitening, cleansing, and others.

[0003] Masks are popular with many consumers because they can put the masks on their face for a certain time and then remove them, without massaging them onto their face during application.

[0004] The nanofiber mask is a new type of sheet mask because of its instant solubility in water and the reduction of formula waste, which is different from the classic fabric mask made with non-woven fibers.

[0005] Electrospinning is the existing technology for manufacturing nanofiber sheets from a spinning solution. Generally, the spinning solution consists of a polymer, a solvent, and an optional functional active ingredient.

[0006] In this field, commonly used polymers include oxidized polyethylene (PEO), polyvinyl alcohol (PVA), polyacrylonitrile (PAN), etc. The solvent can be water and organic solvents such as ethanol and N,N-dimethylformamide (DMF).

[0007] In the field of cosmetics, some companies have developed spinning solutions containing sodium hyaluronate as a matrix. However, some of the proposed combinations may not be environmentally friendly.

[0008] In addition, a certain spinning solution can create a noodle-like effect on the skin after use, particularly at a high dose of certain active ingredients.

[0009] It is therefore desirable to have a low risk of a noodle-like transformation effect on the skin after use.

[0010] It is also desirable to have uniform nanofiber membranes for nanofiber masks.

[0011] We therefore seek to develop a treatment mask for keratinous materials, which includes a uniform and ecological layer of nanofibers in the mask, capable of being rapidly dissolved on contact with water with a low risk of a transformation effect into noodles on the skin after use. Summary of the invention

[0012] An objective of the present invention is to provide a mask with a uniform, ecological nanofiber layer, capable of being rapidly dissolved on contact with water with a low risk of a noodle-like effect on the skin after use.

[0013] Another objective of the present invention is to propose a non-therapeutic process for the care of keratinous materials.

[0014] In a first aspect, the present invention proposes a treatment mask for keratinous materials, comprising: A. a layer of substrate insoluble in water, and B. a water-soluble layer disposed on the water-insoluble substrate layer, wherein the water-soluble layer comprises (i) at least one hyaluronic acid (HA) or a salt thereof, and (ii) polydatin,

[0015] wherein the hyaluronic acid or a salt thereof has a weight-average molecular weight between 10,000 and 80,000 Daltons.

[0016] Due to the presence of hyaluronic acid (HA) or a salt thereof and polydatin, the mask according to the present invention can be used for the care of keratinous materials.

[0017] In a second aspect, the present invention proposes a non-therapeutic process for the treatment of keratinous materials, comprising the steps of: i. application of the mask according to the present invention on keratinous materials with the water-soluble layer in contact with the keratinous materials; ii. adding water to the mask to dissolve the water-soluble layer; iii. removal of the water-insoluble substrate from keratinous materials; and iv. the act of leaving the water-soluble layer dissolved on the keratinous materials.

[0018] Other features and advantages of the invention will become clearer upon reading the description and examples that follow. DETAILED DESCRIPTION OF THE INVENTION

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as that commonly understood by a person skilled in the art in the field relevant to the present invention. When the definition of a term in this If the invention conflicts with the meaning commonly understood by a person skilled in the art in the field covered by the present invention, the definition described in the present invention shall apply.

[0020] In what follows and unless otherwise indicated, the limits of a range of values ​​are included in that range, in particular in the expressions "between...and..." and "from...to...".

[0021] Furthermore, the expression "at least one" used in this description is equivalent to the expression "one or more".

[0022] Throughout this application, the term "comprising" shall be interpreted as encompassing all the specifically mentioned features as well as any optional, additional, and unspecified features. As used herein, the use of the term "comprising" also discloses the embodiment in which no features other than the specifically mentioned features are present (i.e., "consisting of").

[0023] Unless otherwise stated, all numerical values ​​expressing a quantity of ingredients and the like used in the description and claims should be understood as modified by the term "approximately". Accordingly, unless otherwise stated, the numerical values ​​and parameters described herein are approximate values ​​that may be changed according to the desired purpose, if applicable.

[0024] As used here, a uniform layer means that the layer does not exhibit agglomerations, knots or breaks when touched by hand.

[0025] As used here, nanofibers means that the fibers have a diameter of nanometric size.

[0026] For the purposes of the present invention, the term "keratinous material" is understood to refer to the covering of human skin. Facial skin is considered in particular according to the present invention.

[0027] In the present invention, all percentages refer, unless otherwise indicated, to a percentage by weight. Mask

[0028] According to the first aspect, the present invention proposes a treatment mask for keratinous materials, comprising:

[0029] A) a layer of substrate insoluble in water, and

[0030] B) a water-soluble layer disposed on the water-insoluble substrate layer, wherein the water-soluble layer comprises (i) at least one hyaluronic acid (HA) or a salt thereof, and (ii) polydatin,

[0031] wherein hyaluronic acid or a salt thereof has a weight average molecular weight between 10,000 and 80,000 Daltons. Water-insoluble substrate layer

[0032] According to the first aspect, the mask according to the present invention comprises a layer of substrate insoluble in water.

[0033] For the purposes of the invention, the expression "insoluble in water" means that the substrate layer is not soluble in water and does not disintegrate when immersed in water.

[0034] A person skilled in the art can choose an appropriate substrate layer and the weight ratio between the substrate layer used and the water-soluble layer according to the desired cosmetic benefits.

[0035] The substrate layer may be a woven, knitted, or non-woven fabric made of natural fibers such as cotton, paper pulp, bamboo, and cellulose fibers, semi-natural fibers such as viscose rayon fibers, and synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers, and polypropylene fibers. Two or more fibers selected from the above may be used in combination.

[0036] The substrate layer may consist of one or more sub-layers, in which the material of each sub-layer may be identical or different.

[0037] The substrate layer can have a wide variety of shapes, depending on the desired use and the characteristics of the mask.

[0038] The substrate layer is typically designed to adapt to the area of ​​skin on which topical application is desired. For example, when the mask is applied to the face, the substrate layer is designed to conform to the shape of the face, avoiding, if necessary, the areas of the eyes, nostrils, and mouth.

[0039] A person skilled in the art can determine the thickness and texture of the substrate layer according to its intended use. In particular, the thickness and texture of the substrate layer are selected so that water can penetrate through the substrate to come into contact with the water-soluble layer. Water-soluble layer

[0040] According to the first aspect, the mask according to the present invention comprises a water-soluble layer disposed on the water-insoluble substrate layer, wherein the water-soluble layer comprises (i) at least one hyaluronic acid (HA) or a salt thereof, and (ii) polydatin.

[0041] For the purposes of the invention, the expression "water-soluble layer" means that the layer is soluble in water when it is in contact with water. Hyaluronic acid (HA) or a salt thereof

[0042] Hyaluronic acid is a non-sulfated linear glycosaminoglycan composed of repeated motifs of D-glucuronic acid and N-acetyl-D-glucosamine.

[0043] The hyaluronic acid salt can be chosen from alkali salts such as sodium and potassium salts or other salts, for example, zinc salts, silver salts and mixtures thereof.

[0044] Preferably, the hyaluronic acid salt is chosen from alkali salts, other salts or mixtures thereof; preferably chosen from sodium, potassium, zinc, silver salts and mixtures thereof; more preferably chosen from sodium and potassium salts.

[0045] More preferably, the water-soluble layer comprises a hyaluronic acid salt, more preferably sodium hyaluronate.

[0046] The inventors discovered that hyaluronic acid or its salts have a weight average molecular weight (WM) between 10,000 and 80,000 Daltons, which is beneficial for the formation of uniform nanofibers.

[0047] Preferably, hyaluronic acid or its salts have a weight average molecular weight (WM) between 20,000 and 60,000 Daltons, preferably between 25,000 and 55,000 Daltons, more preferably between 30,000 and 50,000 Daltons.

[0048] For example, sodium hyaluronate may be sold by BLOOMAGE BIOTECHNOLOGY under the trade name HYBLOOM ™ LOW MOLECULAR WEIGHT SODIUM HYALURONATE (HA-TLM).

[0049] Advantageously, hyaluronic acid (HA) or a salt thereof is present in the water-soluble layer in an amount ranging from 25% by weight to 85% by weight, preferably from 40% by weight to 80% by weight, more preferably from 50% by weight to 75% by weight, relative to the total weight of the water-soluble layer. Polydatene

[0050] According to the first aspect, the water-soluble layer of the present invention comprises polydaten.

[0051] Polydatin is a polyphenol belonging to the stilbenoid chemical family, which is also called piceide. Polydatin can be extracted from the root and rhizome of Polygonum cuspidatum and can also be found in a variety of other sources, such as grapes, peanuts, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products, and many everyday food products.

[0052] Polydatin includes trans-polydatin and cis-polydatin. Trans-polydatin will be isomerized to cis-polydatin.

[0053] Preferably, the polydatin used in the water-soluble layer according to the present invention is chosen from trans-polydatin, cis-polydatin and their combination.

[0054] Trans-polydatin is a 3,4',5-trihydroxystibene-3-[3-mono-D] glucoside, a stilbenoid which is a trans-resveratrol substituted at position 3 by a [>-D-glucosyl] residue, and has the following structure: OH OH

[0055] Examples of commercial polydaten products include those sold under the name POLYGONUM CUSPIDATUM ROOT EXTRACT by GUILIN LAYN NATURAL INGREDIENTS.

[0056] Advantageously, polydatin is present in the water-soluble layer in an amount ranging from 1% by weight to 22% by weight, preferably from 2% by weight to 21% by weight, more preferably from 3% by weight to 15% by weight, relative to the total weight of the water-soluble layer.

[0057] Advantageously, the weight ratio between hyaluronic acid or its salt and polydatin present in the water-soluble layer is 20:1 to 3:1, preferably 15:1 to 4:1.

[0058] In some embodiments, the water-soluble layer consists of at least one hyaluronic acid or its salt as described above and polydatin. Other active cosmetic ingredients

[0059] The water-soluble layer of the present invention may comprise one or more other cosmetic active ingredients in addition to hyaluronic acid (HA) or a salt thereof and polydatin.

[0060] It is easy for a person skilled in the art to adjust the quantity of additional cosmetic active ingredients according to the final use of the mask according to the present invention. Additional adjuvants or additives

[0061] The water-soluble layer of the present invention may also include conventional cosmetic adjuvants or additives, for example perfumes, a hydrotrope, preservatives, pH regulators and combinations thereof.

[0062] In some embodiments, the water-soluble layer comprises at least one conventional cosmetic adjuvant or additive, preferably at least one hydrotrope.

[0063] Examples of hydrotropics include niacinamide and caffeine.

[0064] Preferably, the water-soluble layer comprises at least one hydrotrope selected from niacinamide, caffeine and their combinations.

[0065] A person skilled in the art can choose the quantity of additional adjuvants or additives so as not to have a negative impact on the final use of the composition according to the present invention.

[0066] In some embodiments, the water-soluble layer comprises at least one hyaluronic acid or its salt, polydatin, and at least one compound selected from the group comprising perfumes, hydrotropes, preservatives, pH regulators and their combinations.

[0067] Preferably, the water-soluble layer comprises sodium hyaluronate, polydatin, niacinamide and caffeine.

[0068] Preferably, the weight ratio between the water-insoluble substrate layer and the water-soluble layer ranges from 15:1 to 1:1.

[0069] More preferably, the weight ratio between the water-insoluble substrate layer and the water-soluble layer ranges from 8:1 to 2:1.

[0070] According to a particular preferred embodiment, the present invention provides a treatment mask for keratinous materials, comprising: A. a layer of substrate insoluble in water, and A. a water-soluble layer disposed on the water-insoluble substrate layer, the water-soluble layer comprising (i) sodium hyaluronate having a weight-average molecular weight between 20,000 and 60,000 Daltons, and (ii) polydatin,

[0071] in which the weight ratio between sodium hyaluronate having a weight average molecular weight between 20,000 and 60,000 and polydatin present in the water-soluble layer is from 15:1 to 4:1. Preparation and use

[0072] The mask according to the present invention can be prepared by forming the water-soluble layer on the water-insoluble substrate layer by electrospinning.

[0073] The spinning solution for electrospinning comprises at least one hyaluronic acid (HA) or a salt thereof as described above, polydatin as described above, optionally other cosmetic active ingredients, and optionally cosmetic adjuvants or additives, in a solvent such as water.

[0074] The content of hyaluronic acid (HA) or its salt in the spinning solution can affect the structure of the nanofibers and the quality of the film, which affects the performance of the mask.

[0075] When the hyaluronic acid (HA) or hyaluronic acid salt content is too low, the polymer chain breaks before reaching the collector, and the spinning solution can decomposing into droplets without forming fibers, or broken filaments, may also occur.

[0076] When the content of hyaluronic acid (HA) or its salt is too high, the spinning solution will not have good fluidity, the electrostatic charges may not be strong enough to stretch the solution to form a nanofiber, and defective or pearly nanofibers may be obtained.

[0077] Preferably, the hyaluronic acid content or its salt in the spinning solution is 2% to 30% by weight, preferably 5% to 20% by weight, more preferably 10% to 15% by weight, relative to the total weight of the spinning solution.

[0078] Advantageously, polydaten is present in the spinning solution in an amount ranging from 0.01% to 10% by weight, preferably from 0.1% to 5% by weight, more preferably from 0.1% to 1% by weight, relative to the total weight of the spinning solution.

[0079] Advantageously, the weight ratio between hyaluronic acid or its salt and polydatin present in the spinning solution is 20:1 to 3:1, preferably 15:1 to 4:1.

[0080] The mask according to the present invention can be used for the care of keratinous materials due to the presence of hyaluronic acid (HA) or a salt thereof and polydatin, and optionally other cosmetic active ingredients.

[0081] The mask according to the present invention is a dry mask.

[0082] Here, dry mask means that there is no solvent in the mask.

[0083] According to the second aspect, the present invention proposes a non-therapeutic process of keratinous material care, including the steps of: i. application of the mask according to the present invention on keratinous materials with the water-soluble layer in contact with the keratinous materials; i. adding water to the mask to dissolve the water-soluble layer; ii. removal of the water-insoluble substrate from keratinous materials; and iii. the act of leaving the water-soluble layer to remain on the keratinous materials.

[0084] Optionally, gentle massage with the fingers can be used for better absorption capacity.

[0085] It is not necessary to rinse the keratinous materials after using the mask.

[0086] Preferably, keratinous materials such as skin are not rinsed after removal of the water-insoluble substrate of keratinous materials.

[0087] Keratinous materials can be, in particular, the skin of the face and / or the skin of the eyes.

[0088] The mask as defined above is applied to at least one area of ​​the skin.

[0089] In particular, the mask as defined above is applied to the skin of the face and / or on the skin of the eyes. EXAMPLES

[0090] The following examples serve to illustrate the present invention without, however, being limiting in nature.

[0091] The main raw materials used, trade names and their suppliers are listed in Table 1.

[0092] [Tables 1] INCI name Trade name Supplier Sodium hyaluronate (PM = 20K-60 K Daltons) HYBLOOM ™ LOW MOLECUL AR WEIGHT SODIUM HYAL URONATE (HA-TLM) BLOOMAGE BIOTEC HNOLOGY Sodium hyaluronate (PM>100 K Daltons) HYBLOOM™ SODIUM HYAL URONATE (HA-T) BLOOMAGE BIOTEC HNOLOGY Hydrolyzed sodium hyaluronate (PM = <5 K Daltons) SUPER ACTIVE HYALURON IC ACID BLOOMAGE BIOTEC HNOLOGY Oxidized polyethyl ene OXIDIZED POLYETHYLENE AMOCHEM QINGDAO Polydatin POLYGONUM CUSPIDATUM ROOT EXTRACT GUILIN LAYN NAT URAL INGREDIENTS Niacinamide NIACINAMIDE VEER CHEMIE & A ROMATICS Caffeine NATURAL ANHYDROUS CAFFEINE POWDER (EX COFFEE) TESTA

[0093] Examples of the Invention 1 to 3 and Comparative Examples 1 to 4

[0094] The mask of the examples of the invention (El) 1 to 3 and of the comparative examples (EC) 1 to 5 has been prepared.

[0095] First, the spinning solutions of the examples of the invention (El) 1 to 3 and of the comparative examples (EC) 1 to 4 were prepared on the basis of the components given in Table 2. The quantities in Table 2 are given as % by weight of active ingredient relative to the total weight of the spinning solution.

[0096] [Tables2] Components ELI EI.2 EL3 EC. 1 EC. 2 EC. 3 EC. 4 Sodium hyaluronate (MW = 20K-60K Daltons) 11 8 10 11 11 0 0 Sodium hyaluronate (MW > 100K Daltons) 0 0 0 0 0 11 0 Hydrolyzed sodium hyaluronate (MW = < 5K Daltons) 0 0 0 0 0 0 11 Oxidized polyethylene 0 0 0 1 0 0 0 Polydatin 0.8 0.6 2 0 0 0.8 0.8 Niacinamide 3.75 3.75 3.75 3.75 3.75 3.75 3.75 3.75 Caffeine 1.6 1.6 1.6 1.6 1.6 1.6 1.6 Water QS1 00 QS1 00 QS1 00 QS1 00 QS1 00 QS1 00 QS1 00

[0097] Next, water-soluble layers were formed by electrospinning with spinning solutions of the examples of the invention (El) 1 to 3 and the comparative examples (EC) 1 to 4 according to Table 2 on a water-insoluble substrate layer consisting of polyester fibers, the weight ratio between the water-insoluble substrate layer and the water-soluble layer being 4:1.

[0098] The water-soluble layer obtained in the examples of the invention (El) 1 to 3 and the comparative examples (EC) 1 to 4 comprise components listed in Table 3. The quantities in Table 3 are given as % by weight of active ingredient relative to the total weight of the water-soluble layer.

[0099] [Tables3] Components El. 1 El. 2 El. 3 EC. 1 EC. 2 EC. 3 EC. 4 Sodium hyaluronate (MW = 20K-60 K) 64.14 57.35 57.64 63.40 67.28 0 0 Sodium hyaluronate (MW > 100 K) 0 0 0 0 0 64.14 0 Hydrolyzed sodium hyaluronate (MW = < 5 K) 0 0 0 0 0 0 64.14 Oxidized polyethylene 0 0 0 5.76 0 0 0 Polydatin 4.66 4.30 11.53 0 0 4.66 4.66 Niacinamide 21.87 26.88 21.61 21.61 22.94 21.87 21.87 Caffeine 9.33 11.47 9.22 9.22 9.79 9.33 9.33 Assessment Nanofiber structure

[0100] The structure of the water-soluble layers obtained in the examples of the invention (El) 1 to 3 and the comparative examples (EC) 1 to 4 was observed by scanning electron microscopy.

[0101] It has been discovered that sheets of nanofibers have formed in the water-soluble layer obtained in Examples of the Invention (E1) 1 to 3 and Comparative Example (CE) 1, which are relatively uniform without clumps, knots, or breaks. The average diameter of the nanofibers is approximately 150 to 250 nm. In contrast, no uniform sheets of nanofibers have formed in Comparative Examples (CE) 2 to 4. Risk of turning into noodles

[0102] The risk of each prepared composition turning into noodles was assessed by a sensory expert on 6 volunteers using a special gesture as described below: 1. Apply the mask to be evaluated to one half of each volunteer's face; 2. Add water to the mask to dissolve the water-soluble layer; 3. Remove the water-insoluble layer and slide the joints of fingers on the faces of the volunteers, applying slight pressure; 4. Assign a score to the phenomenon of the transformation into noodles on the face of each volunteer according to the following standard. Phenomenon Note No noodle transformation occurs 0 A slight noodle transformation occurs 1 A slight to moderate noodle transformation occurs 2 A moderate noodle transformation occurs 3 A moderate to high noodle transformation occurs 4 A high noodle transformation occurs 5 A very high noodle transformation occurs 6

[0103] The average score of the noodle transformation phenomenon is summarized in Table 4.

[0104] [Tables4] ELI EL 2 EI.3 EC. 1 EC. 2 EC. 3 EC. 4 Noodle processing score 0 0.2 0.5 4.5 N / AN / AN / A

[0105] N / A means that the risk of transformation into noodles has not been assessed because there was no uniform sheet of nanofibers formed on the water-insoluble layer.

[0106] It can be seen that the masks obtained in examples of the invention 1 to 3 comprise a water-soluble layer of a uniform and environmentally friendly nanofiber structure with a low risk of a noodle-like transformation effect on the skin after use.

Claims

Demands

1. Keratinous material treatment mask, comprising: A) a water-insoluble substrate layer, and B) a water-soluble layer disposed on the water-insoluble substrate layer, wherein the water-soluble layer comprises (i) at least one hyaluronic acid (HA) or a salt thereof, and (ii) polydatin, wherein the hyaluronic acid or a salt thereof has a weight-average molecular weight between 10,000 and 80,000 Daltons, and wherein the weight ratio of the hyaluronic acid or its salt to the polydatin present in the water-soluble layer is 20:1 to 3:1, the mask being prepared by forming the water-soluble layer on the water-insoluble substrate layer by electrospinning.

2. Mask according to claim 1, wherein the hyaluronic acid salt is selected from alkali salts, other salts, or mixtures thereof; preferably selected from sodium, potassium, zinc, silver salts, and mixtures thereof; more preferably selected from sodium and potassium salts.

3. Mask according to claim 2, wherein the water-soluble layer comprises sodium hyaluronate.

4. Mask according to any one of claims 1 to 3, wherein the hyaluronic acid or its salts has a weight average molecular weight (WM) between 20,000 and 60,000 Daltons, preferably between 25,000 and 55,000 Daltons, more preferably between 30,000 and 50,000 Daltons.

5. Mask according to any one of claims 1 to 4, wherein polydatin is selected from trans-polydatin, cis-polydatin and their combination.

6. A mask according to any one of claims 1 to 5, wherein the weight ratio of hyaluronic acid or its salt to polydatin present in the water-soluble layer is 15:1 to 4:1

7. H-.

1. Mask according to any one of claims 1 to 6, wherein the water-soluble layer comprises at least one conventional cosmetic adjuvant or additive, preferably at least one hydrotropic.

8. Mask according to any one of claims 1 to 7, wherein the water-soluble layer comprises at least one hydrotrope selected from niacinamide, caffeine and their combinations.

9. A mask according to claim 1, comprising: A) a water-insoluble substrate layer, and B) a water-soluble layer disposed on the water-insoluble substrate layer, wherein the water-soluble layer comprises (i) sodium hyaluronate having a weight-average molecular weight between 20,000 and 60,000 Daltons, and (ii) polydatin, wherein the weight ratio of the sodium hyaluronate having a weight-average molecular weight between 20,000 and 60,000 Daltons and the polydatin present in the water-soluble layer is 15:1 to 4:1

10. H-.

1. Non-therapeutic process for the care of keratinous materials, comprising the steps of: (i) applying the mask according to any one of claims 1 to 9 on the keratinous materials with the water-soluble layer in contact with the keratinous materials; (ii) adding water to the mask to dissolve the water-soluble layer; (iii) removing the water-insoluble substrate from the keratinous materials; and (iv) leaving the water-soluble layer dissolved on the keratinous materials.