Body fluid composition change estimation system

Abstract

To provide a body fluid composition change estimation system which estimates changes in a body fluid composition using a simple configuration.SOLUTION: A body fluid composition change estimation system is provided, comprising at least one sweat sensor, and a sweat component loss estimation unit configured to estimate an amount of loss of at least one component in sweat from an output of the sweat sensor.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a system for estimating a change in a body fluid composition. [Background technology]

[0002] Human sweat contains minerals such as sodium, potassium, calcium, and magnesium. Dehydration is a condition in which the body is deficient in essential water and minerals (also called electrolytes or ions) due to loss of bodily fluids.

[0003] The mineral concentration in sweat varies depending on the sweating pattern. The salt concentration in sweat during exercise generally varies between 0.3 and 0.9% by mass. For example, if a small amount of sweat is lost, the salt is reabsorbed through the skin, so the mineral concentration in the body fluids and the salt concentration in the sweat are unlikely to decrease and increase, whereas if a large amount of sweat is lost, the salt cannot be reabsorbed through the skin in time, so the mineral concentration in the body fluids and the salt concentration in the sweat are likely to decrease and increase. As described above, since the mineral concentration in body fluids varies depending on sweating patterns, it is desirable to replenish fluids and electrolytes according to sweating patterns. In this specification, the sweat pattern refers to a change in sweating state over time.

[0004] In general, it is recommended to take electrolytes at the same time as rehydrating as a measure against heat stroke. On the other hand, excessive salt intake leads to an increase in blood pressure, which is said to be a factor in myocardial infarction and stroke. For those who need to restrict their salt intake, it is necessary to take salt restriction into consideration when rehydrating. For example, in a state where a small amount of sweating continues, as mentioned above, the amount of minerals lost from the body is relatively small, so rehydrating with fluids that do not contain sodium is preferable.

[0005] As conventional techniques, from the viewpoint of preventing dehydration, there are techniques for measuring the amount of sweat (Patent Documents 1 and 2) and a technique for measuring the salt concentration in sweat (Patent Document 3). It is possible to simultaneously grasp the amount of sweat and the salt concentration of sweat by combining Patent Documents 1 to 3; however, Patent Document 3 measures the salt concentration using a salt concentration measuring device that includes a salt sensor having a pair of comb-shaped electrodes arranged on a substrate, an electrical conductivity measuring unit that measures the electrical conductivity between the pair of electrodes, and a calculation unit that calculates the salt concentration of the sweat between the pair of electrodes based on the electrical conductivity, which makes the device configuration complicated and impractical. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Patent No. 5281848 [Patent Document 2] International Publication No. 2017 / 208650 [Patent Document 3] Patent Publication No. 2021-032738 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention has been made in consideration of the above circumstances, and has an object to provide a body fluid composition change estimation system that estimates a change in body fluid composition with a simple configuration. [Means for solving the problem]

[0008] The present invention provides the following [1] to

[14] . [1] A system for estimating a change in a composition of a bodily fluid, comprising: at least one sweat sensor; and a sweat component loss estimation unit for estimating the amount of loss of at least one component in sweat from an output of the sweat sensor. [2] The sweat component loss estimation unit estimates a concentration of the component from an output of the sweat sensor, and estimates the amount of loss using the concentration. [3] The sweat sensor outputs a sweating pattern indicating the temporal transition of the sweating state, and the system for estimating the change in body fluid composition according to [1]. [4] The sweat sensor outputs a sweating pattern indicating the temporal transition of the sweating state, and the system for estimating the change in body fluid composition according to [2]. [5] The system for estimating the change in body fluid composition according to [3], which has a total body sweating amount estimation unit that estimates the total body sweating amount from the output of the sweat sensor. [6] The system for estimating the change in body fluid composition according to [4], which has a total body sweating amount estimation unit that estimates the total body sweating amount from the output of the sweat sensor. [7] The total body sweating amount estimation unit estimates the sweating amount using personal data including at least one selected from the group consisting of the sweating pattern, body weight, heart rate, skin temperature, and physical activity amount, and the system for estimating the change in body fluid composition according to [5] or [6]. [8] When the sweating pattern of the sweat component loss amount estimation unit corresponds to any of the following (A) to (E), the system for estimating the change in body fluid composition according to [6] estimates that the concentration has changed. (A) When the sweating pattern crosses one or more thresholds (B) When the sweating pattern reaches its peak (C) When the sweating pattern turns to an increase (D) When the sweating pattern turns to a decrease (E) When a certain period of time has elapsed from at least one selected from the group consisting of (A) to (D) [9] The system for estimating the change in body fluid composition according to [6] calculates the change amount of the body fluid composition by the following formula 1. (The concentration estimated by the sweat component loss amount estimation unit) × (The sweating amount estimated by the total body sweating amount estimation unit) : Formula 1

[10] The system for estimating the change in body fluid composition according to [9], which has a display unit that displays the change in body fluid composition or guidance according to the change.

[11] The system for estimating a change in body fluid composition according to [3] or [4], wherein the sweat component loss estimation unit estimates at least one of the concentration and the loss amount using additional input data and the sweat pattern.

[12] The system for estimating changes in body fluid composition of

[11] , wherein the additional input data is at least one selected from the group consisting of the user's personal data, the season when the system is used, the temperature when the system is used, the humidity when the system is used, the concentration of components contained in sweat measured by electrochemical properties, the concentration of components contained in sweat measured by chemical properties, the concentration of components contained in sweat measured by physical properties, the concentration of components contained in sweat measured by a detection method using specific reactivity with a specific substance, the amount of water consumed, and the amount of urination.

[13] The system for estimating a change in a body fluid composition according to [1] or [2], wherein the sweat sensor is a sweat sensor that measures an amount of local sweating.

[14] The system for estimating a change in a composition of a bodily fluid according to [1] or [2], wherein the sweat sensor is at least one selected from the group consisting of the following (i) to (iv): (i) A sweat sensor having one or more sensors for measuring the amount of body water generated from the skin surface and one or more evaporation promotion mechanisms for promoting evaporation. (ii) A sweat sensor having two or more types of sensors for measuring the amount of body water generated from the skin surface (iii) One or more sensors for measuring the amount of body water generated from the skin surface, and a sweat sensor equipped with a moisture-proofing mechanism (iv) A perspiration sensor comprising: a housing capsule having an opening to be attached to a skin surface, the housing capsule having an intake hole for drawing natural air into the housing capsule; a mixing chamber communicating with the opening for dissipating sweat on the skin surface and in which the dispersed sweat and the natural air mix to form mixed air; a housing capsule having an exhaust hole for discharging the mixed air from the mixing chamber; a first humidity sensor for measuring the humidity of the natural air; and a second humidity sensor for measuring the humidity of the mixed air. Effect of the Invention

[0009] The present invention provides a body fluid composition change estimation system that estimates a change in body fluid composition with a simple configuration. [Brief description of the drawings]

[0010] [Figure 1] FIG. 1 is a diagram illustrating the configuration of a body fluid composition change estimating system in the first embodiment. [Diagram 2] FIG. 1 is a diagram illustrating an embodiment of a hardware configuration for obtaining a quantitative sweat pattern. [Diagram 3] (a) is a diagram illustrating a quantitative sweat pattern obtained using the hardware of Fig. 2. (b) is a graph showing the change over time in the total body sweat rate estimated from the sweat pattern of (a). (c) is a graph showing the change over time in the value of the loss amount of at least one component lost from the body through sweating estimated from the sweat pattern of (a). [Figure 4] FIG. 1 illustrates an embodiment of a hardware configuration for obtaining a qualitative sweat pattern. [Diagram 5] (a) is a diagram illustrating a qualitative sweat pattern obtained using the hardware of Fig. 4. (b) is a graph showing the change over time in the total body sweat rate estimated from the sweat pattern of (a). (c) is a graph showing the change over time in the value of the loss amount of at least one component lost from the body through sweating estimated from the sweat pattern of (a). [Figure 6] FIG. 13 is a diagram illustrating another embodiment of a hardware configuration for obtaining a qualitative sweat pattern. [Figure 7] FIG. 13 is a diagram illustrating yet another embodiment of a hardware configuration for obtaining a qualitative sweat pattern. [Figure 8] (a) is a diagram illustrating a qualitative sweat pattern obtained using the hardware of Fig. 7. (b) is a graph showing the change over time in the whole-body sweat rate estimated from the sweat pattern of (a). (c) is a graph showing the change over time in the value of the loss amount of at least one component lost from the body through sweating estimated from the sweat pattern of (a). [Figure 9]1 illustrates a display unit according to an embodiment. [Figure 10] FIG. 11 is a diagram illustrating the configuration of a body fluid composition change estimating system in embodiment 2. [Figure 11] FIG. 11 is a diagram illustrating the configuration of a body fluid composition change estimating system in embodiment 3. [Figure 12] FIG. 13 is a diagram illustrating a sweat pattern in the third embodiment. [Figure 13] FIG. 13 is a diagram illustrating the configuration of a body fluid composition change estimating system in embodiment 4. [Figure 14] FIG. 13 is a diagram illustrating the concept of a body fluid composition change estimating system in embodiment 5. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] Hereinafter, the body fluid composition change estimating system according to the first to fifth embodiments of the present invention will be described in detail, however, the present invention is not limited to the following embodiments.

[0012] <Embodiment 1> The body fluid composition change estimating system in one embodiment includes a sweat sensor 1 and a sweat component loss estimating unit 2. As shown in FIG. 1, the system may further include a whole-body sweat rate estimating unit 3, a body fluid composition change calculating unit 4, and a display unit 5.

[0013] (Sweat sensor 1) The perspiration sensor may be one that quantitatively outputs the amount of perspiration as a numerical value, or may be one that qualitatively outputs the state of perspiration without using a numerical value.

[0014] The perspiration sensor 1 may be a perspiration sensor that measures the amount of localized perspiration, and may be at least one selected from the group consisting of the following (i) to (iv). (i) A sweat sensor having one or more sensors for measuring the amount of body water generated from the skin surface and one or more evaporation promotion mechanisms for promoting evaporation. (ii) A sweat sensor having two or more types of sensors for measuring the amount of body water generated from the skin surface. (iii) A sweat sensor having one or more sensors for measuring the amount of body water generated from the skin surface and a moisture-proof mechanism. (iv) A perspiration sensor comprising: a housing capsule having an opening to be attached to a skin surface, the housing capsule including an intake hole for drawing natural air into the housing capsule; a mixing chamber communicating with the opening for dissipating sweat on the skin surface and mixing the dispersed sweat and the natural air to form mixed air; a housing capsule having an exhaust hole for discharging the mixed air from the mixing chamber; a first humidity sensor for measuring the humidity of the natural air; and a second humidity sensor for measuring the humidity of the mixed air.

[0015] The output of the perspiration sensor 1 may be a digital signal that represents a perspiration pattern that indicates a change in the perspiration state over time at any given time (t), or may be an analog signal that represents a perspiration pattern that continuously indicates the perspiration state. The sweat pattern may be a record of the amount of sweat per time (t). The amount of sweat may be an absolute value, a relative value, a change amount, a level, or a degree. The sweat pattern may also be an integrated amount. The sweat pattern may or may not be visible to the user.

[0016] The sweat pattern may indicate a change over time in the amount of sweat in any local area of ​​the user's body (hereinafter also referred to as local sweat amount). The sweat pattern may be a numerical value representing the amount of sweat, or may be a numerical value indicating the amount of localized sweating and showing the change in the numerical value over time.

[0017] The sweat pattern may be, for example, a quantitative sweat pattern obtained using hardware including a sweat sensor capable of outputting the amount of local sweat as a numerical value, a microprocessor, and a memory, as shown in FIG. 2, and may be a record of the total amount of local sweat for each arbitrary time (t) during a 16-hour period from 7:00 a.m. to 11:00 p.m., as shown in FIG. 3(a).

[0018] The sweat pattern may represent a transition of an optical change amount of a sheet in which the optical value changes depending on the level of local sweating. The sweat pattern may be, for example, as shown in Fig. 4, a qualitative sweat pattern obtained by using a sheet having a structure capable of absorbing moisture per arbitrary time (t) into the sheet, light receiving / emitting elements 10 and 11 for converting the change in the optical value into an electric signal, a microprocessor, and a hardware including a memory, and may be, as shown in Fig. 5(a), a record of the transition of the amount of optical change of the sheet whose optical value changes according to the total amount of local sweating during each arbitrary time (t) during 16 hours from 7:00 a.m. to 11:00 p.m. The structure capable of absorbing moisture per arbitrary time (t) into the sheet may be, for example, a structure including a moisture-proof mechanism 12 for preventing natural evaporation affected by the usage environment, and a liquid discharge means 13 for discharging all moisture contained in the sheet after recording the amount of optical change of the sheet for each arbitrary time (t). The sheet may be hardware that does not include liquid discharge means 13, as shown in Fig. 6, and the sweat pattern may record the integrated amount of sweat. In other words, the amount of sweat at any given time may be estimated from the amount of change (difference) in the optical value at any given time interval.

[0019] The sweat pattern does not necessarily have to be visible to the user. For example, as shown in FIG. 7, the sweat pattern may be a quantitative sweat pattern obtained using hardware including a first optical filter 14, a second optical filter 15, and photosensitive paper 16, and the integrated amount of reflected light may be recorded on the photosensitive paper by utilizing light that is reflected or absorbed in a moisture-specific manner. Since the reflected light correlates with the amount of sweat, for example, as shown in FIG. 8, the amount of optical change over time on the photosensitive paper 16 indicates the integrated amount of sweat from 7:00 a.m. The amount of optical change may be a color tone.

[0020] (Sweat component loss estimation part 2) The present invention focuses on the fact that the concentration of components contained in sweat changes depending on the level of sweating, i.e., the concentration of components contained in sweat changes over time, and the sweat component loss estimation unit 2 estimates the concentration of the components contained in sweat or the amount of the components contained in sweat from the output of the sweat sensor 1. The sweat component loss estimating unit 2 may estimate the concentration of at least one component lost from the body through sweating from the output of the sweat sensor 1, and estimate the amount of the component loss using the concentration.

[0021] The sweat component loss estimating section 2 may estimate that the concentration has changed when the sweat pattern corresponds to any one of the following (A) to (E). (A) When the sweat pattern crosses one or more thresholds (B) When the sweat pattern plateaus (C) When sweating patterns begin to increase (D) When sweating patterns begin to decrease (E) When a certain time has elapsed since at least one selected from the group consisting of (A) to (D)

[0022] The sweat component loss estimation unit 2 may estimate the concentration change by numerical analysis or other methods. For example, as shown in Fig. 7, a second optical filter 15 whose transmitted light characteristic changes with a threshold value for the reflected light amount (sweating pattern) correlated with the sweat amount may be used to adjust the amount of light exposed to photosensitive paper, and the estimated result of the sweat component loss may be output. At the same time, the photosensitive paper may be exposed to light that does not pass through the second optical filter 15, thereby indicating the integrated value of the sweat amount.

[0023] (Whole body sweat rate estimation part 3) The whole-body sweat rate estimator 3 may estimate the amount of sweat of the whole body from the output of the sweat sensor 1. The whole-body sweat rate estimating section 3 may estimate the whole-body sweat rate by integrating the local sweat rates detected by a sweat sensor that measures local sweat rates.

[0024] (Body fluid composition change calculation unit 4) The body fluid composition change calculation unit 4 may combine the whole-body sweat rate estimated by the whole-body sweat rate estimation unit 3 and the concentration estimated by the sweat component loss estimation unit 2, and, for example, as shown in Figures 3(b) and 5(b), represent the whole-body sweat rate for each arbitrary time interval (t) between 7:00 a.m. and 11:00 p.m., 16 hours, by using the height of a bar graph, and may represent the concentration of at least one component lost from the body through sweating during that time interval by using the color of the bar graph. As shown in FIG. 3(b), the concentration from when the sweat pattern in FIG. 3(a) reaches a plateau (A) to when the sweat pattern starts to decrease (B) can be estimated to be higher than the concentrations before and after that point, and the color of the bar graph can be changed accordingly. As shown in FIG. 5(b), the concentration during the period in which the sweat pattern in FIG. 5(a) exceeds a threshold (e.g., a threshold related to "color shade") may be estimated to be higher than those before and after that period, and the color of the bar graph may be changed.

[0025] The body fluid composition change calculation section 4 may calculate the amount of change in body fluid composition from the concentrations of the components estimated by the sweat component loss estimation section 2 and the whole body sweat rate estimated by the whole body sweat rate estimation section 3. The body fluid composition change calculation section 4 may calculate the amount of change in the body fluid composition by the following (Equation 1). Amount of change in body fluid composition=(the concentration estimated by the sweat component loss amount estimation unit)×(the amount of sweat estimated by the whole body sweat amount estimation unit) (Equation 1)

[0026] As shown in FIG. 3(c) and FIG. 5(c), the bar graphs may be superimposed on the bar graphs in FIG. 3(b) and FIG. 5(b).

[0027] (Display section 5) The display unit 5 may display the amount of change in the body fluid composition calculated by the body fluid composition change calculation unit 4, and may also display guidance according to the amount of change. The display unit 5 may display the whole-body sweat rate estimated by the whole-body sweat rate estimation unit 3, or may display a message encouraging the user to drink an amount of water equivalent to the whole-body sweat rate. The display unit 5 may include an alerting means. The alerting means may warn that the amount of water loss (amount of weight loss) relative to the amount of weight loss is 1% or more, for example. The display unit 5 may be provided with adjustment means for adjusting display data. The adjustment means may, for example, refer to the user's personal data and lower the level of the recommended salt content concentration of the beverage for users who need to limit salt intake, such as those with hypertension.

[0028] As shown in FIG. 9, the recommended water intake and the type of the recommended beverage may be displayed together. For example, until the sweating amount exceeds a predetermined value, a "beverage without electrolytes, caffeine, and alcohol" is recommended. When the sweating amount exceeds the predetermined value and the amount of salt lost along with the sweating is estimated to exceed the predetermined value, a "sports beverage" is recommended. When the sweating amount further increases and the salt loss amount also increases, an "oral rehydration solution" with a higher salt concentration may be recommended.

[0029] <Embodiment 2> The sweating sensor 1 may be provided with a function of measuring the local sweating amount and a function of measuring the total body sweating amount. The body fluid composition change estimation system in one embodiment may, as shown in FIG. 10, not have the total body sweating amount estimation unit 3, and may have the sweating sensor 1, the sweat component loss amount estimation unit 2, the body fluid composition change calculation unit 4, and the display unit 5.

[0030] <Embodiment 3> As shown in FIG. 11, as the sweating sensors, a sweating sensor 1 for measuring the local sweating amount and a second sweating sensor 6 for measuring the total body sweating amount may be used respectively.

[0031] For example, as shown in FIG. 12, the second sweating sensor 6 outputs the total body sweating amount for 16 hours from 7:00 am to 11:00 pm, and the sweating sensor 1 outputs a sweating pattern that shows, for each arbitrary time (t) within the 16 hours from 7:00 am to 11:00 pm, the change over time of the color of a sheet whose color shade changes according to the total amount of the local sweating amount for the time interval. The bodily fluid composition change calculation unit 4 may calculate the proportion of the period during which the sweat pattern exceeds a threshold (for example, a threshold related to "color shade"), and use the "amount of sweat component loss" for periods below the threshold and the "amount of sweat component loss B" for periods above the threshold, to calculate the amount of change in bodily fluid composition using the following (Equation 2). Here, the amount of sweat component loss A and the amount of sweat component loss B are both constants, and the amount of sweat component loss B is greater than the amount of sweat component loss A. Change in body fluid composition = total body sweat rate x (percentage of time over threshold) x (amount of sweat component loss A) + total body sweat rate x (percentage of time below threshold) x (amount of sweat component loss B)

[0032] <Embodiment 4> The sweat component loss estimation unit 2 may estimate at least one of the concentration and the loss amount using the additional input data and the sweat pattern, and the whole-body sweat rate estimation unit 3 may estimate the whole-body sweat rate using the sweat pattern and the additional input data. The additional input data may be at least one selected from the group consisting of the user's personal data, the season when the system is used, the temperature when the system is used, the humidity when the system is used, the concentration of components contained in sweat measured by electrochemical properties, the concentration of components contained in sweat measured by chemical properties, the concentration of components contained in sweat measured by physical properties, the concentration of components contained in sweat measured by a detection method using specific reactivity with a specific substance, water intake, and urination volume.

[0033] As shown in Fig. 13, the salt concentration lost through sweating may be estimated using the sweating pattern and the additional input data, and the whole-body sweat rate may be estimated using the sweating pattern, the additional input data, and personal data measured by a biosensor. The personal data may include at least one selected from the group consisting of body weight, heart rate, skin temperature, and physical activity level.

[0034] 13, the amount of local sweating may be measured by a sweat sensor 1, and the measured amount of local sweating may be input to a sweat component loss estimation unit 2 and a whole-body sweating amount estimation unit 3. The amount of local sweating may be the amount of sweating generated from a unit area of ​​skin per unit time. The sweat component loss estimation unit 2 determines the salt concentration of the sweat based on the level of local sweat rate, and may further correct the determination based on the subject's lifestyle habits input from the subject information input unit 7 to estimate "the salt concentration lost from the body through sweat generated from a unit area of ​​skin per arbitrary time." Here, an arbitrary time means a time consisting of one or more unit times. The whole-body sweat rate estimation unit 3 accumulates the local sweat rates, and may further estimate the "whole-body sweat rate per any given time period" by adding the subject information input from the second subject information input unit 8 and the averaged data of the skin temperature and heart rate measured by the biosensor 9. The body fluid composition change calculation unit 4 may calculate the "amount of salt loss from the whole body at any given time" based on the "salt concentration lost from the body due to sweat generated from a unit area of ​​skin per given time" estimated by the sweat component loss estimation unit 2 and the "amount of whole body sweat per given time" estimated by the whole body sweat rate estimation unit 3, or may calculate the "amount of salt loss from the whole body from the start of system use to the end of system use" by accumulating multiple "amounts of salt loss from the whole body at any given time." The subject information input unit 7 and the second subject information input unit 8 may be the same subject information input unit. The body fluid composition change calculation unit 4 may add up multiple "whole body sweat amounts per any given time period" based on the "whole body sweat amount per given time period" estimated by the whole body sweat amount estimation unit 3, and calculate the "whole body sweat amount from the start of system use to the end of system use, i.e., the amount of water lost from the whole body from the start of system use to the end of system use." The body fluid composition change calculation unit 4 may calculate the "salt concentration of the water lost from the entire body from the start of system use to the end of system use" based on the "amount of salt lost from the entire body from the start of system use to the end of system use" and the "amount of water lost from the entire body from the start of system use to the end of system use". The display unit 5 may display the calculation results obtained by the body fluid composition change calculation unit 4, and may also display guidance in accordance with the calculation results.

[0035] <Embodiment 5> As shown in Figure 14, the "whole body sweat amount per any given time period" may be estimated based on the amount of local sweating, and the estimated result may be compared with a predetermined "threshold" to determine whether it is "below the threshold" or "above the threshold." The "amount of salt loss lost from the whole body from the start of system use to the end of system use" may then be calculated using the "formula for calculating salt loss when it is below the threshold" or the "formula for calculating salt loss when it is above the threshold."

[0036] As shown in FIG. 14, a localized sweat rate may be measured by a sweat sensor 1, and the measured localized sweat rate may be input to a whole-body sweat rate estimator 3. The whole-body sweat rate estimation unit 3 may accumulate the local sweat rates, and further estimate the "whole-body sweat rate per any given time period" by adding the subject information input from the second subject information input unit 8 and personal data. The sweat component loss estimating unit 2 may include a sweating state determining means 21 and a salt loss calculating unit 22 . The sweating state determination means 21 may determine a "light sweating state" when the "whole-body sweat amount per arbitrary time (w)" estimated by the whole-body sweating rate estimation unit 3 is "less than a threshold value," and may determine a "heavy sweating state" when the "whole-body sweat amount per arbitrary time (w)" is "greater than a threshold value." The salt loss calculation unit 22 may calculate the amount of salt loss in the "light sweating state" as "LNa = W * 0.006" and the amount of salt loss in the "heavy sweating state" as "HNa = W * 0.009" depending on the judgment of the sweating state judgment means 21. The above calculations may be combined with correction by a correction means. For example, the correction may be performed by measuring the Na component as personal data of the user and reflecting it in the constant. The amount of salt loss since the start of system use may be calculated as "Na = ΣHNa + ΣLNa". [Explanation of symbols]

[0037] 1 Sweat sensor 2 Sweat component loss estimation section 21 Sweating state determination means 22 Salt loss calculation unit 3. Whole body sweat rate estimation unit 4. Body fluid composition change calculation unit 5 Display section 6 Secondary Sweat Sensor 7. Subject information input section 8 Second subject information input section 9. Biometric Sensors 10 Light emitting element 11 Photodetector 12 Moisture-proofing mechanism 13 Liquid discharge means 14 First Optical Filter 15 Second Optical Filter 16 Photosensitive paper

Claims

1. At least one sweat sensor; A body fluid composition change estimating system comprising a sweat component loss estimating unit that estimates the amount of loss of at least one component in sweat from the output of the sweat sensor.

2. The system for estimating a change in a body fluid composition according to claim 1 , wherein the sweat component loss estimating section estimates a concentration of the component from an output of the sweat sensor, and estimates the amount of loss using the concentration.

3. The system for estimating a change in a body fluid composition according to claim 1 , wherein the perspiration sensor outputs a perspiration pattern indicating a change in a perspiration state over time.

4. The system for estimating a change in a body fluid composition according to claim 2 , wherein the perspiration sensor outputs a perspiration pattern indicating a change in a perspiration state over time.

5. 4. The body fluid composition change inferring system according to claim 3, further comprising a whole-body sweat rate estimating unit that estimates the amount of sweat of the whole body from an output of the sweat sensor.

6. 5. The body fluid composition change inferring system according to claim 4, further comprising a whole-body sweat rate estimating unit that estimates the amount of sweat of the whole body from an output of the sweat sensor.

7. The body fluid composition change estimation system of claim 5 or 6, wherein the whole-body sweat rate estimation unit estimates the amount of sweat using the sweat pattern and personal data including at least one selected from the group consisting of body weight, heart rate, skin temperature, and physical activity level.

8. The body fluid composition change estimating system according to claim 6, wherein the sweat component loss estimating unit estimates that the concentration has changed when the sweat pattern falls under any of the following (A) to (E). (A) When the sweat pattern crosses one or more thresholds (B) When your sweating pattern plateaus (C) When sweating patterns begin to increase (D) When sweating patterns begin to decrease (E) When a certain period of time has elapsed since at least one of the above (A) to (D)

9. The system for estimating a change in a body fluid composition according to claim 6 , wherein the change in the body fluid composition is calculated by the following formula 1: (the concentration estimated by the sweat component loss estimation unit)×(the sweat amount estimated by the whole-body sweat amount estimation unit) : Equation 1

10. The system for estimating a change in a body fluid composition according to claim 9 , further comprising a display unit that displays a change in the body fluid composition or guidance in response to said change.

11. The system for estimating a change in a body fluid composition according to claim 4 , wherein the sweat component loss estimating section estimates at least one of the concentration and the amount of loss using additional input data and the sweat pattern.

12. The system for estimating changes in bodily fluid composition as described in claim 11, wherein the additional input data is at least one selected from the group consisting of a user's personal data, the season when the system is used, the temperature when the system is used, the humidity when the system is used, the concentration of components contained in sweat measured by electrochemical properties, the concentration of components contained in sweat measured by chemical properties, the concentration of components contained in sweat measured by physical properties, the concentration of components contained in sweat measured by a detection method using specific reactivity with a specific substance, water intake, and urination volume.

13. 3. The system for estimating a change in a body fluid composition according to claim 1, wherein the perspiration sensor is a perspiration sensor that measures an amount of localized perspiration.

14. 3. The system for estimating a change in a body fluid composition according to claim 1, wherein the sweat sensor is at least one selected from the group consisting of the following (i) to (iv): (i) A sweat sensor having one or more sensors for measuring the amount of body water generated from the skin surface and one or more evaporation promotion mechanisms for promoting evaporation. (ii) A sweat sensor having two or more types of sensors for measuring the amount of body water generated from the skin surface. (iii) One or more sensors for measuring the amount of body water generated from the skin surface, and a sweat sensor equipped with a moisture-proofing mechanism (iv) A perspiration sensor comprising: a housing capsule having an opening to be attached to a skin surface, the housing capsule having an intake hole for drawing natural air into the housing capsule; a mixing chamber communicating with the opening for dissipating sweat on the skin surface and mixing the dispersed sweat and the natural air to form mixed air; a housing capsule having an exhaust hole for discharging the mixed air from the mixing chamber; a first humidity sensor for measuring the humidity of the natural air; and a second humidity sensor for measuring the humidity of the mixed air.

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