Liquid oral composition

Abstract

To provide a liquid oral composition having a moist and mild sensation during use.SOLUTION: A liquid oral composition comprises: (A) glycerin; (B) an O / W emulsion in which a polyvalent alcohol and water are used as the dispersion medium, the dispersoid is an oily component being fat or oil in liquid state at 25°C, and the emulsifier is a nonionic surfactant; and (C) one or more selected from saccharin, saccharin sodium, and sucralose.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a liquid oral composition having a moist and mild feeling of use.

Background Art

[0002] With the increasing awareness of oral care, rinsing with a liquid type mouthwash has become popular. In recent years, there has been a demand for a mouthwash with a moist and mild feeling of use.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] In view of the above circumstances, the present invention has been made, and an object thereof is to provide a liquid oral composition having a moist and mild feeling of use.

Means for Solving the Problems

[0005] As a result of intensive studies to achieve the above object, the present inventors have found that the above problems can be solved by combining (A) glycerin with a specific O / W type emulsion, and thus have arrived at the present invention.

[0006] That is, in the present invention, the component (A) is glycerin, (B) a polyhydric alcohol and water as a dispersion medium, an oily component in which the dispersoid is an oil and fat that is liquid at 25°C, and an O / W type emulsion in which the emulsifier is a nonionic surfactant, and (C) one or more selected from saccharin, sodium saccharin, and sucralose are combined to obtain a moist and mild feeling of use.

[0007] Accordingly, the present invention provides the following liquid oral composition. 1. (A) Glycerin, (B) A polyhydric alcohol and water as a dispersion medium, an oily component in which the dispersoid is an oil and fat that is liquid at 25°C, and an O / W type emulsion in which the emulsifier is a nonionic surfactant, and (C) A liquid oral composition containing at least one selected from saccharin, sodium saccharin, and sucralose. 2. The liquid oral composition according to 1, wherein the amount of the oily component, which is an oil and fat that is liquid at 25°C, is 20 to 50% by mass of the whole (B) emulsion, and the amount of the nonionic surfactant is 5 to 20% by mass of the whole (B) emulsion. 3. The liquid oral composition according to 1 or 2, wherein the oily component is at least one selected from glyceryl tri-fatty acids having 6 to 12 carbon atoms in the fatty acid carbon chain. 4. The liquid oral composition according to any one of 1 to 3, wherein the average particle diameter of the emulsion particles is 30 to 300 nm.

Effect of the Invention

[0008] According to the present invention, a liquid oral composition with a moist and mild feeling of use can be provided.

Mode for Carrying Out the Invention

[0009] Hereinafter, the present invention will be described in detail. The liquid oral composition of the present invention is an O / W type emulsion containing (A) glycerin, (B) a polyhydric alcohol and water as a dispersion medium, an oily component in which the dispersoid is an oil and fat that is liquid at 25°C, and an emulsifier is a nonionic surfactant, and (C) at least one selected from saccharin, sodium saccharin, and sucralose.

[0010] [Component (A)] Component (A) of the present invention is glycerin. Glycerin is not particularly limited as long as it is used in an oral composition. The blending amount of (A) glycerin is preferably 1 to 40% (mass%, the same hereinafter) of the whole composition including the (B) emulsion described later, and more preferably 2 to 20%. By setting it within such a range, a moist and mild feeling in use can be obtained more easily.

[0011] [(B) component] Component (B) of the present invention is an O / W type emulsion in which a polyhydric alcohol and water are used as a dispersion medium, the dispersed substance is an oily component which is an oil and fat that is liquid at 25°C, and the emulsifier is a nonionic surfactant. By combining with the above (A) component, a moist and mild feeling in use can be obtained. By blending the O / W type emulsion into the liquid oral composition, oil droplet particles of the O / W type emulsion are dispersed in the liquid oral composition, and the above dispersion medium is mixed with the aqueous phase of the liquid oral composition and exists as an O / W type emulsion.

[0012] Examples of the polyhydric alcohol include polyhydric alcohols such as glycerin and dipropylene glycol, and they can be used alone or in combination of two or more.

[0013] Examples of the oily component which is an oil and fat that is liquid at 25°C include liquid oils and fats such as olive oil, camellia oil, and castor oil, and glyceryl tri-fatty acid having a carbon chain length of 6 to 12, and they can be used alone or in combination of two or more. Examples of glyceryl tri-fatty acid include glyceryl tricaprylate, glyceryl tricaprate, and glyceryl tri(caprylate / caprate). Among the above oils and fats, glyceryl tri-fatty acid, especially glyceryl tri(caprylate / caprate), is suitable because it is less likely to discolor due to oxidation and is also stable.

[0014] The amount of the oily component in the emulsion is preferably 10 to 60% of the whole emulsion including the dispersion medium, more preferably 20 to 50%. The amount of the oily component is adjusted according to the average particle size of the emulsion particles. As the average particle size becomes smaller, the amount of the oily component is decreased, thereby improving the stability of the emulsion. If it is 10% or more, the emulsion can be formed more sufficiently. If it is 60% or less, it is suitable for preventing the separation of the oily component and the impairment of the appearance stability.

[0015] Examples of the emulsifier which is a nonionic surfactant include nonionic surfactants such as glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ether, and they can be used alone or in combination of two or more. Among them, those having an HLB value of 10 to 16 are preferable. Examples of the glycerin fatty acid ester include decaglyceryl monomyristate and decaglyceryl monolaurate which are decaglycerin mono-fatty acid esters having 12 to 16 carbon atoms in the fatty acid. The average added mole number of ethylene oxide of the polyoxyethylene hydrogenated castor oil is preferably 10 to 100 moles, more preferably 20 to 60 moles. The average added mole number of ethylene oxide of the polyoxyethylene alkyl ether is preferably 4 to 20 moles, more preferably 6 to 15 moles. Among these, from the viewpoint of the stability of the emulsion, decaglyceryl monomyristate and polyoxyethylene hydrogenated castor oil are preferable.

[0016] The amount of the nonionic surfactant in the emulsion is preferably 5 to 30% of the whole emulsion including the dispersion medium, more preferably 5 to 20%. The addition amount of the nonionic surfactant is adjusted according to the average particle size of the emulsion particles to be formed. As the average particle size becomes smaller, the stability of the emulsion is improved by increasing the content of the emulsifier. If it is 5% or more, the oily component does not separate, and if it is 30% or less, it is suitable for suppressing gelation.

[0017] The above emulsion preferably has an average particle diameter of the emulsion particles of 30 to 300 nm, more preferably 40 to 250 nm. When the average particle diameter is within the above range, a moist and mild feeling of use and a feeling of retention in the oral cavity can be obtained more easily.

[0018] In addition, the method for measuring the average particle diameter of the emulsion particles is to dilute the emulsion 1,000 times with purified water, put it in a cell, and measure the average particle diameter at 25 °C with a light scattering photometer. Examples of the light scattering photometer include the Dynamic Light Scattering Photometer DLS-8000 manufactured by Otsuka Electronics Co., Ltd.

[0019] A known method can be adopted as the method for preparing the emulsion. For example, a predetermined amount of nonionic surfactant, polyhydric alcohol as a dispersion medium, and half the amount of water are stirred with a homomixer, then an oily component is added to form an emulsion, and finally the remaining water is added to prepare an O / W type emulsion. Thereafter, the average particle diameter of the prepared emulsion can be adjusted using a high-pressure homogenizer. In emulsification by a high-pressure homogenizer, the average particle diameter is adjusted due to the difference in shear force. When the emulsified particles are atomized, the stability over time is further improved. Examples of the high-pressure homogenizer include Microfluidizer (manufactured by Microfluidics International CO), Gorin homogenizer (manufactured by Rannie Gorin), Altimizer (manufactured by Sugino Machine), etc., but are not limited to these models, and any model may be used as long as it has a similar mechanism. The pressure during emulsification (high-pressure emulsification) is usually 30 MPa or more, preferably 30 to 100 MPa. The introduction of the oil phase into the water phase and the emulsification operation are preferably carried out under temperature conditions of about 25 to 50 °C.

[0020] In the present invention, as the (B) emulsion, the emulsion prepared by the above method can be added and blended, but commercially available products can also be used. For example, NET-TE-50 manufactured by Nikko Chemicals Co., Ltd. can be used.

[0021] (B) The blending amount of the emulsion (including the dispersion medium) is preferably 0.1 to 4% of the whole composition, more preferably 0.2 to 1.0%. By setting it within such a range, a moist and mild feeling of use and a feeling of retention in the oral cavity can be obtained more effectively. In addition, the content of the oily component contained in the emulsion particles of (B) the emulsion is preferably 0.02 to 1.0% of the whole composition, more preferably 0.05 to 0.5%.

[0022] [Component (C)] Component (C) of the present invention is a high-intensity sweetener and can be used alone or in combination of two or more. By using component (C) in combination, the unpleasant aftertaste caused by combining the above components (A) and (B) can be improved. (B) As the high-intensity sweetener, a sweetener having a sweetness of preferably 5 or more, more preferably 10 or more, and still more preferably 50 or more when sucrose is set to 1 can be used.

[0023] Examples of the high-intensity sweetener include sucralose, sodium saccharin, stevia, acesulfame potassium, aspartame, thaumatin, licorice, glycyrrhizin, etc. From the viewpoint of the effect of improving the unpleasant aftertaste, saccharin, sodium saccharin, and sucralose are preferred. Also, commercially available products can be used, specifically, sucralose manufactured by San-Ei Gen F.F.I., Inc. can be used.

[0024] (C) The blending amount of the high-intensity sweetener is preferably 0.00001 to 1% of the whole composition, more preferably 0.0005 to 0.05%. By setting it to 0.00001% or more, a moist and mild feeling of use and a feeling of retention in the oral cavity can be obtained more effectively. By setting it to 1% or less, the flavor expressiveness can be ensured sufficiently.

[0025] The liquid oral composition of the present invention is prepared as a mouthwash, liquid dentifrice, etc. In addition to the above components, various components commonly used in liquid oral compositions can be blended as needed within a range that does not impair the effects of the present invention. Examples of the various components that can be blended include surfactants, thickeners, humectants, solvents, active ingredients, sugar alcohols, sweeteners, fragrances, pH adjusters, preservatives, colorants, suspending agents, and the like. Each of them can be used alone or in combination of two or more in appropriate amounts. The above components (A) to (C) can also be blended other than in emulsions.

[0026] Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, and the like. Examples of the nonionic surfactant include the nonionic surfactants described as the emulsifier of the above emulsion (B).

[0027] Examples of the anionic surfactant include alkyl sulfates, acyl amino acid salts, acyl taurine salts, dodecylbenzene sulfonates, α-sulfo fatty acid alkyl ester salts, alkyl phosphate ester salts, and the like. As the salt, alkali metal salts such as sodium salts and potassium salts are preferable.

[0028] Examples of the cationic surfactant include alkyl ammonium salts, alkyl benzyl ammonium salts, and the like.

[0029] Examples of the amphoteric surfactant include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine, imidazoline-type amphoteric surfactants such as N-fatty acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts, and amino acid-type surfactants such as N-fatty acyl-L-alginate salts.

[0030] The blending amount of the surfactant including the emulsifier in the (B) emulsion is preferably 0.05 to 10% of the whole composition, more preferably 0.1 to 8%, and even more preferably 0.15 to 6%.

[0031] Examples of the thickener include xanthan gum, sodium alginate, alginate esters such as propylene glycol alginate, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinyl pyrrolidone, sodium polyacrylate, sodium polyglutamate (natto gum), and the like. When the thickener is blended, the amount thereof is preferably 0.01 to 3% of the whole composition, more preferably 0.03 to 2%.

[0032] Examples of the wetting agent include glycerin, propylene glycol, ethylene glycol, polyethylene glycol, and the like. The blending amount of the wetting agent including the polyhydric alcohol of the component (A) and the emulsion (B) is preferably 1 to 50% of the whole composition, more preferably 2 to 30%, and still more preferably 3 to 20%.

[0033] As the solvent, water or a lower monohydric alcohol having 2 to 4 carbon atoms such as ethanol can be used.

[0034] The liquid oral composition of the present embodiment is preferably an aqueous liquid oral composition in which water is a solvent, and the balance of the content of each component can be water. In the case of the aqueous liquid oral composition, the total blending amount of water including the water of the emulsion (B) is preferably 50 to 98% of the whole composition, more preferably 65 to 98%, and still more preferably 70 to 95%.

[0035] When the solvent is a lower monohydric alcohol, the blending amount of the lower monohydric alcohol is preferably 0.5 to 20% of the whole composition, more preferably 2 to 10%, and still more preferably 4 to 8%.

[0036] Examples of the active ingredient include fluoride, enzyme, anti-inflammatory agent, bactericide, calculus preventive agent, blood circulation promoter, amino acids, and the like. Examples of the fluoride include sodium fluoride, sodium monofluorophosphate, stannous fluoride, and the like. Examples of the enzyme include dextranase, amylase, protease, mutanase, and the like. Examples of the anti-inflammatory agent include tranexamic acid, epsilon-aminocaproic acid, allantoin, aluminum chlorohydroxyallantoin, azulene, glycyrrhizinate, glycyrrhetinate, sodium chloride, vitamins, and the like. Examples of the bactericide include isopropylmethylphenol (4-isopropyl-3-methylphenol), copper chlorophyll, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, lysozyme chloride, and the like. Among them, isopropylmethylphenol is preferable from the viewpoint of high biofilm bactericidal power. Examples of the calculus preventive include pyrophosphates, polyphosphates, zeolite, and the like. Examples of the blood circulation promoter include vitamin E, and the like. Examples of the amino acids include alanine, glycine, proline, and the like. When the active ingredient is formulated, the amount can be an effective amount within a range that does not interfere with the effects of the present invention. For example, 0.01 to 1% of the whole composition is preferable, 0.02 to 0.6% is more preferable, and 0.03 to 0.4% is even more preferable. When the blending amount of the active ingredient is not less than the above lower limit value, the effect of preventing dental caries and periodontal disease can be enhanced more. When the content of the active ingredient is not more than the above upper limit value, the liquid oral composition is easier to hold in the mouth, and the usability can be enhanced more.

[0037] The liquid oral composition of the present invention preferably contains a sugar alcohol. By containing a sugar alcohol, the liquid oral composition has a refreshing sweetness and excellent usability. The sugar alcohol is not particularly limited as long as it can be formulated in the liquid oral composition. Examples of the sugar alcohol include xylitol, sorbitol, mannitol, maltitol, erythritol, and the like. When formulating a sugar alcohol, the amount thereof is preferably 0.5 to 10%, more preferably 1 to 8%, and even more preferably 1 to 6% of the entire composition. When the content of the sugar alcohol is at least the above lower limit, it is easier to hold the liquid oral composition in the mouth and the usability can be further enhanced.

[0038] Examples of the sweetening agent include saccharin, sodium saccharin, stevioside, stevia extract, glycyrrhizin, thaumatin, and the like. When formulating a sweetening agent, the amount thereof is preferably 0.001 to 0.2%, more preferably 0.003 to 0.1% of the entire composition. When the content of the sweetening agent is at least the above lower limit, it is easier to hold the liquid oral composition in the mouth and the usability can be further enhanced. When the content of the sweetening agent is at most the above upper limit, the effect of preventing dental caries and periodontal disease can be further enhanced.

[0039] As the fragrance, natural fragrances such as peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, perilla oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, oregano oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil, pomelo oil, iris concrete, absolute peppermint, absolute rose, orange flower, and fragrances obtained by processing these natural fragrances (such as cut of the fore fraction, cut of the back fraction, fractional distillation, liquid-liquid extraction, essence formation, powder fragrance formation, etc.), and menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octyl aldehyde, citral, pregeone, carvyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexanepropionate, methyl anthranilate, ethyl methylphenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and other single-component fragrances, and further, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor and other compounded flavors, etc., known fragrance materials used in oral compositions can be used in combination. When formulating a fragrance, the amount is preferably 0.005 to 3% of the whole composition, and more preferably 0.1 to 1%. When the content of the fragrance is at least the above lower limit value, the aroma of the liquid oral composition is improved and the usability is further enhanced. When the content of the fragrance is at most the above upper limit value, the long-term stability of the appearance of the liquid oral composition is further enhanced.

[0040] Examples of the pH adjuster include organic acids such as citric acid and lactic acid and their salts, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium dihydrogen phosphate, and disodium hydrogen phosphate. When formulating a pH adjuster, its amount is appropriately adjusted according to the target pH, and 0.05 to 5% of the whole composition is preferable, and 0.1 to 3% is more preferable. When the content of the pH adjuster is within the above numerical range, the long-term stability of the appearance of the liquid oral composition can be further enhanced.

[0041] The pH of the liquid oral composition of the present invention at 25°C is preferably 4.5 to 9.4, and more preferably 5.0 to 8.5. When the pH is within the above numerical range, the long-term stability of the appearance can be maintained well. The pH is measured at 25°C for the measurement target using a pH meter (for example, "HM-30G" (product name) manufactured by Toa DKK Corporation).

[0042] Examples of the preservative include paraoxybenzoic acid esters and sodium benzoate. When formulating a preservative, its amount is preferably 0.05 to 0.6% of the whole composition, and more preferably 0.1 to 0.4%. When the content of the preservative is not less than the above lower limit value, the long-term stability of the appearance of the liquid oral composition can be further enhanced. When the content of the preservative is not more than the above upper limit value, the liquid oral composition is easier to hold in the mouth, and the usability is further enhanced.

[0043] Examples of the colorant include highly safe water-soluble dyes. Examples of the water-soluble dye include Food Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105. When formulating a colorant, its amount is preferably 0.001 to 0.05% of the whole composition, and more preferably 0.003 to 0.01%. When the content of the colorant is not less than the above lower limit value, the appearance of the liquid oral composition can be improved, and the usability is further enhanced. When the content of the colorant is not more than the above upper limit value, the liquid oral composition is easier to hold in the mouth, and the usability is further enhanced.

[0044] [Method for producing a liquid oral composition] The liquid oral composition of the present embodiment can be obtained by mixing a pre-prepared (B) emulsion with the (A) component and the (C) component, and a known method can be appropriately selected as the mixing method.

[0045] The liquid oral composition of the present invention can be filled in a known container, and the structure of the container is not limited either. It can also be filled in a refillable pouch container.

Examples

[0046] Hereinafter, examples and comparative examples will be shown to specifically explain the present invention, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[0047] [Preparation Example: Emulsion] <Method for Preparing Emulsion> An O / W type emulsion having the following composition was prepared by the following method. The stirring with a homomixer was carried out using a known high-pressure homogenizer (pressure conditions: 30 to 100 MPa), and the addition of the oil phase to the aqueous phase and the emulsification operation were carried out at 25 to 50°C. In addition, the average particle diameter of the emulsion particles was measured at 25°C by diluting the emulsion 1,000-fold with purified water, putting it in a cell, and using a dynamic light scattering photometer DLS-8000 manufactured by Otsuka Electronics Co., Ltd.

[0048] <Composition of Emulsion> [Composition of Emulsion 1 (average particle diameter 50 nm)] Polyoxyethylene (20) hydrogenated castor oil 20% Trioctyl / tripelarginate 20% Dipropylene glycol 10% Water 50% Total 100% After pre-stirring dipropylene glycol, half of the water, and polyoxyethylene (20) hydrogenated castor oil, trioctyl / tripelarginate was added, stirred with a homomixer, and finally the remaining water was added for preparation.

[0049] <Composition of Emulsion> [Composition of Emulsion 2 (Average Particle Size 100 nm)] Decaglyceryl Monomyristate 15% Glyceryl Tri(caprylyl / caprate) 40% Glycerin 10% Water 35% Total 100% After pre-stirring glycerin, half amount of water, and decaglyceryl monomyristate, glyceryl tri(caprylyl / caprate) was added, stirred with a homomixer, and finally the remaining water was added for preparation.

[0050] Examples are shown below, but the present invention is not limited to the following examples. [Example 1] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sucralose 0.004 Citric Acid 0.1 Sodium Citrate 0.3 Isopropylmethylphenol 0.05 Sodium Lauroyl Sarcosinate 0.1 Polyoxyethylene Hydrogenated Castor Oil 60 0.4 Propylene Glycol 4 Sorbitol Solution 3 Sodium Benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0051] [Example 2] Composition % (A) Glycerin 10 (B) Emulsion 2 0.5 (C) Sucralose 0.004 Citric Acid 0.1 Sodium Citrate 0.3 Isopropylmethylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.4 Propylene glycol 4 Sorbitol solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0052] [Example 3] Composition % (A) Glycerin 20 (B) Emulsion 1 1 (C) Sucralose 0.01 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.8 Propylene glycol 4 Sorbitol solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0053] [Example 4] Composition % (A) Glycerin 3 (B) Emulsion 1 0.3 (C) Sucralose 0.001 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.1 Propylene glycol 4 Sorbitol solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0054] [Example 5] Composition % (A) Glycerin 20 (B) Emulsion 2 1 (C) Sucralose 0.01 Citric acid 0.1 Sodium citrate 0.3 Isopropylmethylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.8 Propylene glycol 4 Sorbitol solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0055] [Example 6] Composition % (A) Glycerin 3 (B) Emulsion 2 0.3 (C) Sucralose 0.001 Citric acid 0.1 Sodium citrate 0.3 Isopropylmethylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.1 Propylene glycol 4 Sorbitol solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0056] [Example 7] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sucralose 0.004 Citric acid 0.1 Sodium citrate 0.3 Cetylpyridinium chloride 0.05 Polyoxyethylene hydrogenated castor oil 60 0.3 Ethanol 8 Sorbit solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0057] [Example 8] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sucralose 0.004 Citric acid 0.1 Sodium citrate 0.3 Cetylpyridinium chloride 0.05 Polyoxyethylene hydrogenated castor oil 60 0.3 Ethanol 8 Propylene glycol 4 Sorbit solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0058] [Example 9] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sucralose 0.004 Citric acid 0.1 Sodium citrate 0.3 Isopropylmethylphenol 0.05 Sodium lauroyl sarcosinate 0.1 β-Glycyrrhetinic acid 0.05 Polyoxyethylene hydrogenated castor oil 60 0.4 Propylene glycol 4 Sorbit solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0059] [Example 10] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sodium saccharin 0.004 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Sodium lauroyl sarcosinate 0.1 Polyoxyethylene hydrogenated castor oil 60 0.3 Propylene glycol 4 Sorbit solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0060] The following liquid oral composition (liquid dentifrice) was prepared by a conventional method. The same evaluation as above was carried out. All examples were judged to be able to achieve both a moist and mild feeling in use, and a good feeling of intraoral retention and aftertaste. [Example 11] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sodium saccharin 0.002 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Tranexamic acid 0.1 Polyoxyethylene hydrogenated castor oil 60 0.25 Sodium lauroyl methyl taurate 0.15 Polyethylene glycol 5 Propylene glycol 4 Sorbit solution 3 Sodium benzoate 0.3 Fragrance 0.3 Purified water the remainder Total 100.0

[0061] [Example 12] Composition % (A) Glycerin 3 (B) Emulsion 1 0.1 (C) Sodium saccharin 0.001 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Tranexamic acid 0.1 Polyoxyethylene hydrogenated castor oil 60 0.3 Sodium lauroyl methyl taurate 0.05 Polyethylene glycol 5 Propylene glycol 2 Sorbit solution 2 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0062] [Example 13] Composition % (A) Glycerin 10 (B) Emulsion 2 0.5 (C) Sodium saccharin 0.002 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Tranexamic acid 0.1 Polyoxyethylene hydrogenated castor oil 60 0.25 Sodium lauroyl methyl taurate 0.15 Polyethylene glycol 5 Propylene Glycol 4 Sorbitol Solution 3 Sodium Benzoate 0.3 Fragrance 0.3 Purified water the remainder Total 100.0

[0063] [Example 14] Composition % (A) Glycerin 3 (B) Emulsion 2 0.1 (C) Sodium Saccharin 0.001 Citric Acid 0.1 Sodium Citrate 0.3 Isopropyl Methylphenol 0.05 Tranexamic Acid 0.1 Polyoxyethylene Hydrogenated Castor Oil 60 0.3 Sodium Lauroyl Methyl Taurate 0.05 Polyethylene Glycol 5 Propylene Glycol 2 Sorbitol Solution 2 Sodium Benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0064] [Example 15] Composition % (A) Glycerin 10 (B) Emulsion 1 1 (C) Sodium Saccharin 0.01 Citric Acid 0.1 Sodium Citrate 0.3 Isopropyl Methylphenol 0.05 Tranexamic Acid 0.1 Polyoxyethylene Hydrogenated Castor Oil 60 1.0 Sodium Lauroyl Methyl Taurate 0.3 Polyethylene Glycol 5 Propylene Glycol 5 Sorbitol Solution 5 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0065] [Example 16] Composition % (A) Glycerin 10 (B) Emulsion 1 0.5 (C) Sodium saccharin 0.002 Citric acid 0.1 Sodium citrate 0.3 Isopropyl methylphenol 0.05 Tranexamic acid 0.1 β-Glycyrrhetinic acid 0.05 Polyoxyethylene hydrogenated castor oil 60 0.4 Sodium lauroyl methyl taurate 0.15 Polyethylene glycol 5 Propylene glycol 4 Sorbit solution 3 Sodium benzoate 0.2 Fragrance 0.3 Purified water the remainder Total 100.0

[0066] The following is the fragrance composition used in the above formulation example. The effects of the present invention could be obtained regardless of which of the following fragrance compositions was used.

[0067]

Table 1

[0068]

Table 2

[0069] The compositions of Flavors 1 to 8 and the solvent are as follows.

Table 3

[0070]

Table 4

[0071]

Table 5

[0072]

Table 6

[0073]

Table 7

[0074]

Table 8

[0075]

Table 9

[0076]

Table 10

[0077]

Table 11

Claims

1. (A)glycerol, (B)an O / W type emulsion in which a polyhydric alcohol and water are used as a dispersion medium, the dispersed substance is an oily component which is an oil and fat that is liquid at 25°C, and the emulsifier is a nonionic surfactant, and (C)a liquid oral composition containing at least one selected from saccharin, sodium saccharin and sucralose.

2. The liquid oral composition according to claim 1, wherein the amount of the oily component which is an oil and fat that is liquid at 25°C is 20 to 50% by mass of the whole of the emulsion (B), and the amount of the nonionic surfactant is 5 to 20% by mass of the whole of the emulsion (B).

3. The liquid oral composition according to claim 1 or 2, wherein the oily component is at least one selected from glyceryl tri-fatty acids in which the carbon chain number of the fatty acid is 6 to 12.

4. The liquid oral composition according to claim 1 or 2, wherein the average particle diameter of the particles of the emulsion is 30 to 300 nm.

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