Cleanability evaluation method and cleanability evaluation device

Abstract

To provide a method for evaluating, accurately in a shorter time, a cleaning state of a container, an apparatus, or a facility used for manufacturing medicines.SOLUTION: A method for evaluating cleanability of a container, an apparatus, or a facility used for manufacturing medicines includes the steps of: attaching a powder composition for cleanability evaluation having fluorescent emission properties to the container, apparatus, or facility used for manufacturing medicines; cleaning the container, apparatus, or facility; while irradiating a surface on which the cleanability of the container, apparatus, or facility is to be evaluated with light at an excitation wavelength of the powder composition for cleanability evaluation, picking up an image of fluorescent light emitted by the powder composition for cleanability evaluation on the surface with a 360-degree camera; and evaluating the cleanability of the container, apparatus, or facility on the basis of the picked-up image obtained with the 360-degree camera.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a cleaning property evaluation method and a cleaning property evaluation device.

Background Art

[0002] In the production of pharmaceuticals, equipment is often shared. In such cases, cleaning operations of containers, equipment, and facilities are important to prevent cross - contamination and foreign matter from being mixed in. That is, it is necessary to verify the cleaning method so that the residual amounts of the pharmaceuticals, cleaning agents, etc. are always below the allowable limit values.

[0003] The objects of cleaning include active ingredients, decomposition products, additives, cleaning agents, or microorganisms, etc. Evaluation methods for cleaning effects include the swab ( wiping ) method, the final rinse method, and the visual inspection method, etc. There are also several ways of setting the residual allowable standard values, such as the 0.1% administration limit (0.1% standard), the 10 ppm limit (10 ppm standard), the visual standard (4 μg / cm 2 below), and the acceptable intake amount (NOEL, the maximum exposure amount where no NOEL effect is observed) standard, etc. Several ideas have been proposed (Non - Patent Document 1, Non - Patent Document 2), but currently each company sets them independently.

[0004] Patent Document 1 describes a tracer substance characterized by containing an excipient and a fluorescent substance.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Non - Patent Documents

[0006]

Non - Patent Document 1

Non-Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0007] Visual criteria are an effective way to provide the minimum level of cleaning. That is, the state of being visually clean is essential in all cases. However, visual judgment has a large individual difference, and there is also a possibility of difference in judgment depending on the surrounding light environment. In addition, since the human visual field is narrow, it is impossible to overlook the whole at once, and it is difficult to accurately evaluate the cleaning state in a short time.

[0008] The present invention has been made in view of the above circumstances, and an object thereof is to provide a method for more accurately evaluating the cleaning state of a container, device, or equipment used in the manufacture of pharmaceuticals in a shorter time.

Means for Solving the Problems

[0009] [1] A step of attaching a powder composition for cleaning evaluation having fluorescence emission properties to a container, device, or equipment used in the manufacture of pharmaceuticals, A step of cleaning the container, device, or equipment, A step of imaging the fluorescence emitted by the powder composition for cleaning evaluation on the surface to be evaluated for the cleaning property of the container, device, or equipment with a 360-degree camera while irradiating light having an excitation wavelength of the powder composition for cleaning evaluation on the surface, and A step of evaluating the cleaning property of the container, device, or equipment based on the image obtained by imaging with the 360-degree camera A method for evaluating the cleaning property of a container, device, or equipment used in the manufacture of pharmaceuticals, comprising: [2] The cleaning property evaluation method according to [1], wherein the powder composition for cleaning evaluation contains an excipient and a fluorescent substance. [3] The method for evaluating detergency according to [2], wherein the excipient is lactose and the fluorescent substance is riboflavin. [4] The method for evaluating detergency according to [2], wherein the excipient contains at least one selected from the group consisting of a disaccharide, a sugar having three or more saccharides, and polyoxyalkylene. [5] The method for evaluating detergency according to [2], wherein the excipient consists of a first particle containing a disaccharide and a second particle containing at least one selected from the group consisting of a sugar having three or more saccharides and polyoxyalkylene, and the fluorescent substance is contained in the fluorescent particles. [6] The method for evaluating detergency according to [5], wherein the fluorescent particles are attached to the surface of the first particle. [7] The method for evaluating detergency according to any one of [4] to [6], wherein the disaccharide is at least one selected from the group consisting of sucrose, lactulose, lactose, maltose, trehalose, cellobiose, kojibiose, nigerose, isomaltose, β,β-trehalose, α,β-trehalose, sophorose, laminaribiose, gentiobiose, turanose, maltulose, palatinose, gentiobiouronic acid, mannobiose, melibiose, melibiosuronic acid, neolactose, galactosucrose, syrabiose, neohesperidose, rutinose, rutinosuronic acid, bicinose, xylobiose, primeverose, trehalosamine, maltitol, cellobionic acid, lactosamine, lactosediamine, lactobionic acid, lactitol, hyalobiuronic acid, and sucralose. [8] The method for evaluating detergency according to any one of [4] to [7], wherein the sugar having three or more saccharides includes starch, glycogen, β-1,6-glucan, cellulose, curdlan, paramylon, β-1,2-glucan, chitin, dextran, α-1,3-glucan, α-1,2-glucan, nigeran, agarose, carrageenan, heparin, alginic acid, hyaluronic acid, pectic acid, xyloglucan, xylan, glucomannan, and levan, and the polyoxyalkylene includes polyoxyethylene and polyoxypropylene. [9] The cleaning property evaluation method according to any one of [4] to [8], wherein the fluorescent substance is at least one selected from the group consisting of merocyanine, perylene, acridine, luciferin, pyranine, stilbene, rhodamine, coumarin, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran, pyromethene, fluorescein, eosin Y, rhodamine B, rhodamine 6G, umbelliferone, naphthalene, anthracene, naphthacene, pentacene, hexacene, and riboflavin.

[10] A cleaning property evaluation device including an imaging unit composed of a 360-degree camera, a light source unit that irradiates excitation light, and a holding unit that holds the 360-degree camera. [Advantages of the Invention]

[0010] According to the present invention, it is possible to provide a method for more accurately evaluating the cleaning state of containers, devices, or facilities used in the production of pharmaceuticals in a shorter time. [Brief Description of the Drawings]

[0011]

Figure 1

Figure 2

Figure 3

[0012] Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described below, and various modifications are possible without departing from the gist of the present invention.

[0013] [Cleaning Property Evaluation Method] The cleaning property evaluation method of the present embodiment includes the following steps. (1) Step of attaching a powder composition for cleaning property evaluation having fluorescence to a container, device, or equipment used in the manufacture of pharmaceuticals (attachment step). (2) Step of cleaning the container, device, or equipment (cleaning step). (3) Step of imaging, with a 360-degree camera, the fluorescence emitted by the powder composition for cleaning property evaluation on the surface to be evaluated for the cleaning property of the container, device, or equipment, while irradiating the surface with light of the excitation wavelength of the powder composition for cleaning property evaluation (imaging step). (4) Step of evaluating the cleaning property of the container, device, or equipment based on the image obtained by imaging with the 360-degree camera (evaluation step).

[0014] <Attachment step> In the attachment step, as a substitute for pharmaceuticals, particles of a powder composition for cleaning property evaluation having fluorescence (hereinafter also referred to as "fluorescent simulation powder") are used, and the same treatment as in the manufacture of pharmaceuticals is performed to attach the fluorescent simulation powder to a container, device, or equipment (hereinafter also referred to as "pharmaceutical manufacturing container, etc.") used in the manufacture of pharmaceuticals.

[0015] <Cleaning step> In the cleaning step, the pharmaceutical manufacturing container, etc. is cleaned by a method considered as a cleaning method of the pharmaceutical manufacturing container, etc. during the actual manufacture of pharmaceuticals.

[0016] <Imaging step> In the imaging step, while irradiating the surface to be evaluated for the cleaning property of the pharmaceutical manufacturing container, etc. with light of the excitation wavelength of the fluorescent substance of the fluorescent simulation powder, the fluorescence emitted by the fluorescent simulation powder on the surface is imaged with a 360-degree camera.

[0017] Since fluorescence has high visibility, it is easier to determine the presence or absence of even a trace amount of residue than when viewed under normal light. Also, by keeping the observation conditions of fluorescence constant, variations due to individual differences and the surrounding environment can be reduced.

[0018] In the cleaning evaluation method of this embodiment, a 360-degree camera can be used to capture an image of the entire pharmaceutical manufacturing container, etc., so that the cleaning condition of the surface can be evaluated more accurately in a shorter period of time.

[0019] <Evaluation process> In the evaluation step, the cleanability of the container, device, or equipment is evaluated based on images captured by a 360-degree camera.

[0020] The adhesion of the fluorescent simulant powder to the surface may be evaluated by observing the image captured by a 360-degree camera with the naked eye of an observer, or it may be evaluated mechanically by inputting the image from the 360-degree camera into an information processing device.

[0021] <Explanation by example> A more specific explanation will be given with reference to the drawings. In the following example, a description will be given of a case where a stainless steel cylindrical container with a capacity of 80 L is used as a pharmaceutical manufacturing container, etc.

[0022] Figure 1 shows image data obtained by attaching fluorescent imitation powder to the inside of a container, photographing the inside of the container with a 360-degree camera, and processing the image data. The state of the rear surface 101 of the lid of the container 100 and the state of the inner surface 102 of the bottom can be observed simultaneously, and the entire inside of the container can be viewed in an instant. This allows the cleaning state to be grasped accurately in a short time.

[0023] FIG. 2 shows an example of a means for evenly irradiating the inner surface of the container with excitation light. (A) A 360-degree camera is fixed to the lid of a container via a rod-shaped member, and a sheet-shaped light source (light-emitting sheet) that emits excitation light is attached to the rod-shaped member. The rod-shaped member may be omitted by increasing the rigidity of the sheet-shaped light source. (B) A 360-degree camera is fixed to the lid of the container via a rod-shaped member, and a string-shaped light source (string-shaped light emitter) that emits excitation light is attached to the rod-shaped member. The rod-shaped member may be omitted by increasing the rigidity of the string-shaped light source. (C) An opening is provided in the lid installed on the upper part of the container, and a pen-shaped small light is inserted here to irradiate the inside. The wavelength of the excitation light varies depending on the target fluorescent substance. However, in the case of the fluorescent simulation powder described in Japanese Patent No. 6296288 where the fluorescent substance is riboflavin, a light source with a peak at 365 nm is suitable. This wavelength is not special, and the pen-shaped light used as the light source is generally inexpensive and commercially available.

[0024] Figure 3 shows an example of the combination of the insertion angles of the small lights installed on the lid. As shown in Figure 3, by changing the insertion angle little by little and simultaneously irradiating the inside using a plurality of light sources, the inside of the container can be made to emit light evenly. Also, by gradually rotating the upper lid, the fluorescence emission on the entire inner wall of the container can be observed, enabling an accurate evaluation of the detergency.

[0025] <Powder composition for detergency evaluation> As one aspect of the powder composition for detergency evaluation (fluorescent simulation powder), those described in Japanese Patent No. 6296288 can be mentioned.

[0026] This tendency simulation powder is powder particles from several microns to several tens of microns, in which ultrafine particles of riboflavin (vitamin B2), which is a fluorescent substance, are laminated on the surface of lactose particles. When visually observing using this fluorescent simulation powder, fluorescence can be observed up to a residual concentration of 0.25 μg / cm 2 and a trace amount of residue down to 1 / 10 or less can be evaluated compared to normal visual observation.

[0027] As another aspect of the powder composition for detergency evaluation, there is a powder composition for detergency evaluation containing at least one selected from the group consisting of a disaccharide, a sugar of trisaccharide or higher, and a polyoxyalkylene, and a fluorescent substance.

[0028] The disaccharide is not particularly limited as long as it is a sugar in which two molecules of monosaccharide are dehydrated and condensed to form a glycosidic bond to become one molecule. Examples of the monosaccharides include ketoses such as ribulose, xylulose, psicose, fructose, sorbose, and tagatose; aldoses such as ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, and talose; deoxysugars such as deoxyribose, fucose, fuculose, and rhamnose; sugar alcohols such as arabinitol, xylitol, ribitol (adonitol), iditol, galactitol (dulcitol), glucitol (sorbitol), and mannitol; and derivatives and enantiomers of these monosaccharides. Examples of the derivatives of the monosaccharides include those in which one or more of the hydroxy groups of the monosaccharides are substituted with chlorine molecules, amino acids (amino sugars) in which one or more of the hydroxy groups of the monosaccharides are substituted with amino groups, carboxylic acids (aldonic acids) in which the formyl group at the 1-position of the aldoses is converted to a carboxy group, carboxylic acids (uronic acids) in which the hydroxymethyl group at the end of the main chain of the aldoses is converted to a carboxy group, and dicarboxylic acids (aldaric acids) in which both the formyl group at the 1-position and the hydroxymethyl group at the end of the main chain of the aldoses are converted to carboxy groups. Specific examples of the amino sugars include fructosamine, galactosamine, glucosamine, and mannosamine. Specific examples of the aldonic acids include gluconic acid, lactonic acid, and mannonic acid. Specific examples of the uronic acids include arabinonic acid, fructuronic acid, tagaturonic acid, glucuronic acid, iduronic acid, galacturonic acid, mannuronic acid, and guluronic acid. Specific examples of the aldaric acids include glucaric acid, galactaric acid, and mannaric acid.

[0029] As the disaccharide, at least one selected from the group consisting of sucrose, lactulose, lactose, maltose, trehalose, cellobiose, kojibiose, nigerose, isomaltose, β,β - trehalose, α,β - trehalose, sophorose, laminaribiose, gentiobiose, turanose, maltulose, palatinose, gentiobiouronic acid, mannobios, melibiose, melibiouronic acid, neolactose, galactosucrose, syrabiose, neohesperidose, rutinose, rutinosulose, bicinose, xylobiose, primeverose, trehalosamine, maltitol, cellobionic acid, lactosamine, lactosediamine, lactobionic acid, lactitol, hyalobiuronic acid, and sucralose is preferable, at least one selected from the group consisting of sucrose, lactulose, lactose, maltose, trehalose, and cellobiose is more preferable, and lactose is even more preferable. The disaccharide may be used alone or in combination of two or more.

[0030] The content of the disaccharide in the fluorescent simulated powder of this embodiment is not particularly limited, but is preferably 67 to 97% by mass based on the total mass of the fluorescent simulated powder of this embodiment.

[0031] The trisaccharide or higher sugar is not particularly limited as long as it is a sugar in which three or more monosaccharides are linked by glycosidic bonds. Examples of the monosaccharide include the monosaccharides described above. Examples of the trisaccharide or higher sugars include starch, glycogen, β-1,6-glucan, cellulose (β-1,4-glucan), curdlan (β-1,3-glucan), paramylon (β-1,3-glucan), β-1,2-glucan, chitin, dextran (α-1,6-glucan), α-1,3-glucan, α-1,2-glucan, nigeran, agarose, carrageenan, heparin, alginic acid, hyaluronic acid, pectic acid, xyloglucan, xylan, glucomannan, and levan. At least one selected from the group consisting of polyoxyethylene and polyoxypropylene is preferable as the polyoxyalkylene, at least one selected from the group consisting of starch, glycogen, and cellulose is more preferable, and starch is even more preferable. As the starch, either amylose (α-1,4-glucan) or amylopectin can be used. Examples of the starch include corn starch, wheat flour starch, rice starch, mylo starch, potato starch, sweet potato starch, tapioca starch, sago starch, kudzu starch, bracken starch, lotus root starch, mung bean starch, etc. At least one selected from the group consisting of corn starch, wheat flour starch, and rice starch is preferable, and corn starch is more preferable. The mass average molecular weight of the starch is not particularly limited, but is preferably 10,000 to 1,000,000, and more preferably 10,000 to 100,000. The mass average molecular weight of the glycogen is not particularly limited, but is preferably 1,000,000 to 10,000,000. The mass average molecular weight of the cellulose is preferably 10,000 to 1,000,000, and more preferably 10,000 to 100,000. Examples of the cellulose include microcrystalline cellulose, powdered cellulose, etc.

[0032] The polyoxyalkylene is not particularly limited as long as it is a compound having a structure in which two or more alkylene glycols are dehydrated and condensed. As the polyoxyalkylene, at least one selected from the group consisting of polyoxyethylene and polyoxypropylene is preferable, and polyoxyethylene is more preferable. The number average molecular weight of the polyoxyalkylene is not particularly limited, but is preferably 5,000 to 50,000, and more preferably 5,000 to 20,000. As the polyoxyethylene, "Macrogol" in the Japanese Pharmacopoeia may be used. The terminal hydroxy group of the polyoxyalkylene may be modified.

[0033] The content of at least one selected from the group consisting of the sugar of trisaccharide or more and polyoxyalkylene in the fluorescent simulated powder of this embodiment is not particularly limited, but is preferably 30 to 60% by mass based on the total mass of the fluorescent simulated powder of this embodiment.

[0034] The fluorescent substance is not particularly limited, but is preferably at least one selected from the group consisting of merocyanine, perylene, acridine, luciferin, pyranine, stilbene, rhodamine, coumarin, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran, pyromethene, fluorescein, eosin Y, rhodamine B, rhodamine 6G, umbelliferone, naphthalene, anthracene, naphthacene, pentacene, hexacene, and riboflavin (vitamin B 2 ) and more preferably riboflavin.

[0035] The content of the fluorescent substance in the fluorescent simulated powder of this embodiment is not particularly limited, but is preferably 0.001 to 1% by mass, and more preferably 0.01 to 0.11% by mass based on the total mass of the fluorescent simulated powder of this embodiment.

[0036] The fluorescent simulated powder of this embodiment may contain particles containing the disaccharide, at least one selected from the group consisting of the sugar of trisaccharide or more and polyoxyalkylene, and the fluorescent substance. The particles may contain at least one selected from the group consisting of the disaccharide, the sugar of trisaccharide or higher, and polyoxyalkylene, and components other than the fluorescent substance. Such components are not particularly limited, but pharmaceutically acceptable excipients are preferred. Examples of the pharmaceutically acceptable excipients include lactose, starch, dextrin, sucrose, precipitated silica, and the like. The average particle size of the particles is not particularly limited, but is preferably 5 to 100 μm. The average particle size is the 50% particle size measured by the laser diffraction method.

[0037] Alternatively, it may include a first particle containing the disaccharide, a second particle containing at least one selected from the group consisting of the sugar of trisaccharide or higher and polyoxyalkylene, and a fluorescent particle containing the fluorescent substance. In this case, as shown in FIG. 1, the fluorescent simulated powder 1 of this embodiment may include a fluorescent composite particle 10 in which the fluorescent particle 11 is attached to the surface of the first particle 12, and the second particle 13.

[0038] The first particle may contain components other than the disaccharide. Such components are not particularly limited, but pharmaceutically acceptable excipients are preferred. The second particle may contain components other than at least one selected from the group consisting of the sugar of trisaccharide or higher and polyoxyalkylene. Such components are not particularly limited, but pharmaceutically acceptable excipients are preferred. The fluorescent particle may contain components other than the fluorescent substance. Such components are not particularly limited, but pharmaceutically acceptable excipients are preferred. Examples of the pharmaceutically acceptable excipients include lactose, starch, dextrin, sucrose, precipitated silica, and the like. However, the excipients exclude the disaccharide, the sugar of trisaccharide or higher, and polyoxyalkylene contained in the fluorescent simulated powder.

[0039] The average particle size of the first particle is not particularly limited, but is preferably 5 to 100 μm. The average particle diameter of the second particles is not particularly limited, but is preferably 1 to 200 μm. The average particle diameter of the fluorescent particles is not particularly limited, but is preferably 0.01 to 1 μm. The average particle diameter is the 50% particle diameter measured by the laser diffraction method.

[0040] The fluorescent simulated powder of this embodiment can be used as a simulated powder as it is, and can also be mixed with an oily base material such as petrolatum or a hydrophilic base material such as macrogol to be used as a simulated ointment or a simulated cream for the cleaning evaluation after the production of ointments and creams.

[0041] [Cleaning evaluation device] The cleaning evaluation device of this embodiment includes an imaging unit composed of a 360-degree camera, a light source unit that irradiates excitation light, and a holding unit that holds the 360-degree camera. For example, as shown in FIG. 2, a 360-degree camera (imaging unit) is fixed to a rod-shaped member (holding unit), and a sheet-shaped light source (emitting sheet) (light source unit) that emits excitation light is installed on the rod-shaped member (holding unit); a 360-degree camera (imaging unit) is fixed to a rod-shaped member (holding unit), and a string-shaped light source (string-shaped light emitter) (light source unit) that emits excitation light is installed on the rod-shaped member (holding unit), etc. can be mentioned.

[0042] [Function and effect] In the present invention, by using the same "powder" as the form used in actual production, the cleanability can be evaluated under conditions closer to actual pharmaceuticals. Furthermore, in the present invention, the fluorescence observation of the surface of a pharmaceutical production container or the like is performed using a 360-degree camera. Thereby, it is possible to overlook the entire surface in an instant, and the accurate cleaning state can be evaluated in a short time. [Industrial applicability]

[0043] It becomes possible to easily and highly sensitively visually observe and determine the cleanliness after the cleaning operation essential in the pharmaceutical production process on-site, which can contribute to maintaining the quality of pharmaceuticals and improving productivity. [Explanation of symbols]

[0044] 100 ··· Container 101 ··· The back surface of the lid part 102 ··· The inner surface of the bottom

Claims

1. A step of attaching a powder composition for cleaning evaluation having fluorescence to a container, device, or equipment used in the manufacture of pharmaceuticals, A step of cleaning the container, device, or equipment, A step of imaging, with a 360-degree camera, the fluorescence emitted by the powder composition for cleaning evaluation on the surface while irradiating the surface to be evaluated for the cleanability of the container, device, or equipment with light having an excitation wavelength of the powder composition for cleaning evaluation, and A step of evaluating the cleanability of the container, device, or equipment based on the image obtained by imaging with the 360-degree camera A method for evaluating the cleanability of a container, device, or equipment used in the manufacture of pharmaceuticals, comprising:

2. The method for evaluating cleanability according to claim 1, wherein the powder composition for cleaning evaluation contains an excipient and a fluorescent substance.

3. The method for evaluating cleanability according to claim 2, wherein the excipient is lactose and the fluorescent substance is riboflavin.

4. The method for evaluating cleanability according to claim 2, wherein the excipient contains at least one selected from the group consisting of a disaccharide and at least one selected from the group consisting of sugars of trisaccharide or higher and polyoxyalkylene.

5. The method for evaluating cleanability according to claim 2, wherein the excipient consists of a first particle containing a disaccharide and a second particle containing at least one selected from the group consisting of sugars of trisaccharide or higher and polyoxyalkylene, and the fluorescent substance is contained in fluorescent particles.

6. The method for evaluating cleanability according to claim 5, wherein the fluorescent particles are attached to the surface of the first particle.

7. The disaccharide is at least one selected from the group consisting of sucrose, lactulose, lactose, maltose, trehalose, cellobiose, kojibiose, nigerose, isomaltose, β,β-trehalose, α,β-trehalose, sophorose, laminaribiose, gentiobiose, turanose, maltulose, palatinose, gentiobiouronic acid, mannobiose, melibiose, melibiosuronic acid, neolactose, galactosucrose, syrabiose, neohesperidose, rutinose, rutinosuronic acid, bicinose, xylobiose, primeverose, trehalosamine, maltitol, cellobionic acid, lactosamine, lactosediamine, lactobionic acid, lactitol, hyalobiuronic acid, and sucralose. The method for evaluating cleanability according to any one of claims 4 to 6.

8. The cleaning property evaluation method according to any one of claims 4 to 6, wherein the sugar having three or more saccharides includes starch, glycogen, β-1,6-glucan, cellulose, curdlan, paramylon, β-1,2-glucan, chitin, dextran, α-1,3-glucan, α-1,2-glucan, nigeran, agarose, carrageenan, heparin, alginic acid, hyaluronic acid, pectic acid, xyloglucan, xylan, glucomannan, and levan, and the polyoxyalkylene includes polyoxyethylene and polyoxypropylene.

9. The cleaning property evaluation method according to any one of claims 4 to 6, wherein the fluorescent substance is at least one selected from the group consisting of merocyanine, perylene, acridine, luciferin, pyranine, stilbene, rhodamine, coumarin, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran, pyromethene, fluorescein, eosin Y, rhodamine B, rhodamine 6G, umbelliferone, naphthalene, anthracene, naphthacene, pentacene, hexacene, and riboflavin.

10. A cleaning property evaluation device comprising an imaging unit composed of a 360-degree camera, a light source unit that irradiates excitation light, and a holding unit that holds the 360-degree camera.

Images