Topical preparation for skin

Abstract

To provide a topical preparation for skin, which does not emit a smell and undergo coloration even when being stored at a high temperature, has excellent storage stability, and does not cause sticky feeling during application and after application.SOLUTION: The present invention relates to a topical preparation for skin, which contains the following components (A), (B), and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more components selected from osmolytes, and (C) water.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an external preparation for skin.

Background Art

[0002] γ-Aminobutyric acid is used by being formulated in cosmetics and the like. For example, Patent Document 1 describes that a skin cosmetic containing γ-aminobutyric acid is excellent in the effect of preventing skin aging. Patent Document 2 describes that a skin cosmetic containing γ-aminobutyric acid and vitamin B6 is excellent in the effect of preventing skin unevenness and the persistence of the effect. Patent Document 3 describes that a whitening cosmetic containing an extract obtained from Dioscorea composita and a medicinal ingredient such as γ-aminobutyric acid prevents inflammation caused by ultraviolet rays, suppresses melanin production due to ultraviolet damage, promotes the excretion of melanin pigments, and exhibits an excellent whitening effect in a short period of time.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, γ-aminobutyric acid has problems that coloring and odor occur over time during high-temperature storage, especially when water is present. Also, there is a problem of feeling sticky during and after application.

Means for Solving the Problems

[0005] The inventor of the present invention has found that by using an osmolyte in combination with γ-amino-β-hydroxybutyric acid, a skin external preparation can be obtained which has no odor or coloring even when stored at a high temperature, has excellent storage stability, and does not feel sticky during and after application, and has thus completed the present invention.

[0006] The present invention relates to a skin external preparation containing the following components (A), (B) and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more selected from osmolytes, (C) water and relates to a skin external preparation containing the same.

Effects of the Invention

[0007] The skin external preparation of the present invention has no change in odor or appearance even when stored at a high temperature, has excellent storage stability, and has no stickiness during and after application. Further, there is no numbness.

Modes for Carrying Out the Invention

[0008] γ-Amino-β-hydroxybutyric acid as component (A) is a known substance and has the following chemical properties.

[0009] [Chemical Formula 1] · Chemical name: γ-amino-β-hydroxybutyric acid (γ-amino-β-hydroxy butyric acid) · Molecular formula: C4H9NO3 · Molecular weight: 119.12 · Melting point: 205 to 210 °C · Structural formula: H2N-CH2-CH-CH2COOH | OH

[0010] The content of component (A) is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, particularly preferably 0.3% by mass or more, preferably 3.5% by mass or less, more preferably 2% by mass or less, still more preferably 1.5% by mass or less, even more preferably 1.2% by mass or less, and particularly preferably 1% by mass or less in the total composition, from the viewpoints of improving the anti-skin aging effect and reducing stickiness during and after application. Further, the content of component (A) is preferably 0.001% by mass or more and 3.5% by mass or less, more preferably 0.005% by mass or more and 2% by mass or less, still more preferably 0.05% by mass or more and 1.5% by mass or less, even more preferably 0.1% by mass or more and 1.2% by mass or less, and particularly preferably 0.3% by mass or more and 1% by mass or less in the total composition.

[0011] The osmolyte of component (B) is a chemical substance that mainly regulates osmotic pressure in organisms. In cells, while it has a function of maintaining cell volume against the inflow or outflow of water due to external osmotic stress (osmotic pressure gradient), it also functions to stabilize the structure and function of proteins such as enzymes over a wide concentration range and protect proteins from denaturation. Note that component (D) pH adjuster described later is not included in component (B). Examples of the osmolyte of component (B) include ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, arginine hydrochloride, carnitine chloride, taurine, glutamic acid, glutamate, serine, N-methyl-L-serine, trimethylglycine, alanine, N-amidinol-L-proline, and the like. As osmolytes, from the viewpoint of improving stability during high-temperature storage and reducing stickiness during and after coating, it is preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidinol-L-proline, more preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, and N-amidinol-L-proline, still more preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), arginine, trimethylglycine, and N-amidinol-L-proline, even more preferably contains one or more selected from ectoine, sodium pyrrolidone carboxylate (PCA-Na), trimethylglycine, and N-amidinol-L-proline, and most preferably contains ectoine.

[0012] Component (B) can be used in combination of one or more, and the content is preferably 0.015% by mass or more, more preferably 0.02% by mass or more, still more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, most preferably 0.8% by mass or more, most preferably 0.9% by mass or more, preferably 3.5% by mass or less, more preferably 3% by mass or less, still more preferably 2.5% by mass or less, even more preferably 2% by mass or less, most preferably 1.5% by mass or less, most preferably 1% by mass or less in the total composition from the viewpoints of improving stability during high-temperature storage and reducing stickiness during and after coating. Further, the content of component (B) is preferably 0.015% by mass or more and 3.5% by mass or less, more preferably 0.02% by mass or more and 3% by mass or less, still more preferably 0.3% by mass or more and 2.5% by mass or less, even more preferably 0.5% by mass or more and 2% by mass or less, most preferably 0.8% by mass or more and 1.5% by mass or less, most preferably 0.9% by mass or more and 1% by mass or less in the total composition.

[0013] In the present invention, the molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 or more, more preferably 0.01 or more, still more preferably 0.1 or more, even more preferably 0.5 or more, particularly preferably 0.75 or more, preferably 5 or less, more preferably 3 or less, still more preferably 2.5 or less, even more preferably 2 or less, and particularly preferably 0.85 or less, from the viewpoints of improving the stability during high-temperature storage and reducing stickiness during and after application. Further, the molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 or more and 5 or less, more preferably 0.01 or more and 3 or less, still more preferably 0.1 or more and 2.5 or less, even more preferably 0.5 or more and 2 or less, and particularly preferably 0.75 or more and 0.85 or less.

[0014] The water content of component (C) is preferably 20% by mass or more, more preferably 40% by mass or more, still more preferably 60% by mass or more, preferably 99.98% by mass or less, more preferably 90% by mass or less, and still more preferably 85% by mass or less in the total composition, from the viewpoints of uniformly dissolving component (B) and reducing stickiness during and after application. Further, the water content of component (C) is preferably 20% by mass or more and 99.98% by mass or less, more preferably 40% by mass or more and 90% by mass or less, and still more preferably 60% by mass or more and 85% by mass or less in the total composition.

[0015] The external preparation for skin of the present invention can further contain (D) a pH adjuster, and can improve the stability during high-temperature storage. Note that the osmolyte of component (B) is not included in component (D). Any pH adjuster can be used as long as it is usually used in cosmetics, and inorganic acids and their salts, organic acids having 6 or less carbon atoms and their salts are preferable, and organic acids having 6 or less carbon atoms and their salts are more preferable. As the inorganic acid, for example, it preferably contains one or more selected from hydrochloric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, phosphoric acid, phosphonic acid, phosphinic acid and their salts, and more preferably contains one or more selected from phosphoric acid and their salts. In addition, as the organic acids having 6 or less carbon atoms and their salts, water-soluble organic acids and their salts are preferable. For example, fatty acids having 1 to 6 carbon atoms, hydroxy acids, dicarboxylic acids, and their salts can be mentioned. Among these, it is preferable to contain one or more selected from malic acid, lactic acid, citric acid, succinic acid, acetic acid, tartaric acid, aspartic acid, adipic acid, and their salts. It is more preferable to contain one or more selected from malic acid, lactic acid, citric acid, succinic acid, and their salts. It is even more preferable to contain one or more selected from succinic acid, citric acid, and their salts. As the pH adjuster, it is preferable to contain one or more selected from organic acids having 6 or less carbon atoms and their salts, and it is more preferable to contain one or more selected from succinic acid, citric acid, and their salts.

[0016] Component (D) can be used in combination of one or more kinds. From the viewpoint of improving the stability during high-temperature storage, the content is preferably 0.01% by mass or more in the total composition, more preferably 0.03% by mass or more, even more preferably 0.05% by mass or more, still more preferably 0.08% by mass or more, preferably 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and still more preferably 0.1% by mass or less. Further, the content of component (D) is preferably 0.01% by mass or more and 1% by mass or less in the total composition, more preferably 0.03% by mass or more and 0.5% by mass or less, even more preferably 0.05% by mass or more and 0.3% by mass or less, and still more preferably 0.08% by mass or more and 0.1% by mass or less.

[0017] The external preparation for skin of the present invention can further contain water-soluble polysaccharides. The water-soluble polysaccharides are not limited as long as they are those used in ordinary cosmetics, and they may be derived from natural products or obtained by chemical synthesis.

[0018] In addition, derivatives of polysaccharides obtained by bonding an alkyl group, a hydroxyalkyl group, a polyalkylene oxide group such as a polyethylene oxide group or a polypropylene oxide group, a saccharide such as glucose, lactose, or sucrose, or a polymer having these saccharides as constituent units to a part of the sugar of the polysaccharide are also included as being analogous to polysaccharides.

[0019] Specific examples include, for example, locust bean gum, guar gum, tamarind gum, quince seed-derived gum, gum arabic, tragacanth gum, karaya gum, carrageenan, alginic acid, pectin, hydroxypropyl guar gum, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, tuberose polysaccharide, xanthan gum, polysaccharide produced by Alcaligenes latus, gellan gum, dextran, pullulan, hyaluronic acid or its salt, chondroitin sulfate, dermatan sulfate, mucopolysaccharides such as chitin and chitosan. Among these, from the viewpoint of improving the moisturizing feeling, it is preferable to contain one or more selected from carrageenan, hydroxypropylmethylcellulose, hyaluronic acid or its salt, and more preferably to contain at least hyaluronic acid or its salt.

[0020] Water-soluble polysaccharides can be used in combination of one or more kinds, and the content is preferably 0.01% by mass or more in the total composition, more preferably 0.02% by mass or more, further preferably 0.03% by mass or more, preferably 1% by mass or less, more preferably 0.5% by mass or less, and further preferably 0.1% by mass or less from the viewpoint of improving the feel when the external preparation is applied. Also, the content of the water-soluble polysaccharide is preferably 0.01% by mass or more and 1% by mass or less in the total composition, more preferably 0.02% by mass or more and 0.5% by mass or less, and further preferably 0.03% by mass or more and 0.1% by mass or less.

[0021] The external preparation for skin of the present invention can further contain a polyhydric alcohol. Note that the polyhydric alcohol does not include the osmolyte of component (B). The polyhydric alcohol is a compound having two or more hydroxyl groups in the molecule, and any one can be used as long as it is used in a normal topical skin preparation. Examples of the dihydric alcohol include polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, propanediol and the like. Examples of the trihydric alcohol include glycerin, trimethylolpropane and the like. Examples of the tetrahydric alcohol include diglycerin, erythritol and the like. Examples of the polyhydric alcohol having a valency of 5 or more include polyglycerins such as triglycerin; saccharides and sugar alcohols such as glucose, maltose, maltitol, sucrose, xylitol, sorbitol, maltvitol, polyoxyethylene methyl glucoside, polyoxyethylene ethyl glucoside, and polyoxyethylene propylene glucoside.

[0022] From the viewpoint of improving the moisturizing feeling, the polyhydric alcohol preferably contains one or more selected from dihydric alcohols, trihydric alcohols, tetrahydric alcohols, saccharides and sugar alcohols, more preferably contains one or more selected from trihydric alcohols, tetrahydric alcohols, saccharides and sugar alcohols, and even more preferably contains one or more selected from glycerin, diglycerin, sorbitol and glucose.

[0023] The polyhydric alcohol can be used in combination of one or more kinds. From the viewpoint of improving the touch when the topical preparation is applied, the content is preferably 1% by mass or more in the total composition, more preferably 3% by mass or more, even more preferably 5% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 12% by mass or less. Further, the content of the water-soluble polysaccharide is preferably 1% by mass or more and 20% by mass or less in the total composition, more preferably 3% by mass or more and 15% by mass or less, and even more preferably 5% by mass or more and 12% by mass or less.

[0024] In addition to the above components, the topical skin preparation of the present invention may contain components commonly used in topical skin preparations, such as oily components, surfactants, preservatives, antioxidants, pigments, fragrances, plant extracts, colorants, powders, ultraviolet absorbers, humectants excluding polyhydric alcohols, blood circulation promoters, cooling agents, antiperspirants, bactericides, skin activators, and the like. When containing diisopropylamidinocloroacetic acid, the content is preferably 0.1% by mass or less, more preferably 0.05% by mass or less, still more preferably 0.01% by mass or less, and even more preferably substantially not contained, from the viewpoints of improving the stability during high-temperature storage and reducing stickiness during and after application. Further, the topical skin preparation of the present invention can be used as a hypersensitivity reducing agent.

[0025] The topical skin preparation of the present invention can be produced according to a conventional method. For example, it can be produced by adding components (A), (B) and other components while stirring water and then stirring.

[0026] From the viewpoint of enhancing percutaneous absorbability, the topical skin preparation of the present invention preferably has a pH of 4 to 7, more preferably 4.5 to 6.5, and still more preferably 5 to 6. In the present invention, the pH is measured at 25°C using a desktop pH meter F-72 manufactured by HORIBA.

[0027] The topical skin preparation of the present invention can be applied to cosmetics, quasi-drugs which are quasi-pharmaceutical external preparations, pharmaceuticals, and the like. It is suitable as a cosmetic, more preferably as a skin care cosmetic such as skin care lotion, skin care emulsion, skin care cream, BB cream, beauty liquid, etc., and still more preferably as a skin care lotion.

[0028] Regarding the above-described embodiments, the present invention further discloses the following compositions. <1> The following components (A), (B) and (C): (A) γ-Amino-β-hydroxybutyric acid, (B) One or more selected from osmolytes, (C) Water A topical skin preparation containing the same. <2> It is preferable that the content of component (A) is 0.001% by mass or more and 3.5% by mass or less in the total composition, more preferably 0.005% by mass or more and 2% by mass or less, still more preferably 0.05% by mass or more and 1.5% by mass or less, even more preferably 0.1% by mass or more and 1.2% by mass or less, and most preferably 0.3% by mass or more and 1% by mass or less. The topical skin preparation according to <1>. <3> It is preferable that component (B) contains one or more selected from ectoin, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, alanine, and N-amidinol-L-proline. More preferably, it contains one or more selected from ectoin, sodium pyrrolidone carboxylate (PCA-Na), arginine, N-methyl-L-serine, trimethylglycine, and N-amidinol-L-proline. Still more preferably, it contains one or more selected from ectoin, sodium pyrrolidone carboxylate (PCA-Na), arginine, trimethylglycine, and N-amidinol-L-proline. Even more preferably, it contains one or more selected from ectoin, sodium pyrrolidone carboxylate (PCA-Na), trimethylglycine, and N-amidinol-L-proline. Most preferably, it contains ectoin. The topical skin preparation according to <1> or <2>. <4> It is preferable that the content of component (B) is 0.015% by mass or more and 3.5% by mass or less in the total composition, more preferably 0.02% by mass or more and 3% by mass or less, still more preferably 0.3% by mass or more and 2.5% by mass or less, even more preferably 0.5% by mass or more and 2% by mass or less, most preferably 0.8% by mass or more and 1.5% by mass or less, and most preferably 0.9% by mass or more and 1% by mass or less. The topical skin preparation according to any one of <1> to <3>. The molar ratio (B) / (A) of component (B) to component (A) is preferably 0.005 or more and 5 or less, more preferably 0.01 or more and 3 or less, even more preferably 0.1 or more and 2.5 or less, still more preferably 0.5 or more and 2 or less, and most preferably 0.75 or more and 0.85 or less, and is a topical skin preparation according to any one of <1> to <4>. <6>The content of component (C) is preferably 20% by mass or more and 99.98% by mass or less in the whole composition, more preferably 40% by mass or more and 90% by mass or less, and even more preferably 60% by mass or more and 85% by mass or less, and is a topical skin preparation according to any one of <1> to <5>. <7>The following components (A), (B) and (C): (A) γ-Amino-β-hydroxybutyric acid 0.3% by mass or more and 3.5% by mass or less, (B) One or more selected from osmolytes, (C) Water A topical skin preparation containing the same. <8>The following components (A), (B) and (C): (A) γ-Amino-β-hydroxybutyric acid 0.3% by mass or more and 3.5% by mass or less, (B) One or more selected from ectoine, sodium pyrrolidone carboxylate, arginine, trimethylglycine, N-methyl-L-serine, N-amidinol-L-proline, (C) Water A topical skin preparation containing the same. <9>The content of component (B) is 0.015% by mass or more and 3.5% by mass or less in the whole composition, and is a topical skin preparation according to <7> or <8>. <10>The following components (A), (B) and (C): (A) γ-Amino-β-hydroxybutyric acid, (B) One or more selected from ectoine, sodium pyrrolidone carboxylate, arginine, trimethylglycine, N-amidinol-L-proline, (C) Water A topical skin preparation containing the same. <11>The following components (A), (B) and (C): (A) γ-Amino-β-hydroxybutyric acid, (B) Ectoine, (C) Water A topical skin preparation containing the same. <12>The topical skin preparation according to <10> or <11>, wherein the content of component (A) is 0.001% by mass or more and 3.5% by mass or less in the total composition, and the content of component (B) is 0.015% by mass or more and 3.5% by mass or less in the total composition. <13>The topical skin preparation according to any one of <1> to <10>, further comprising at least one selected from (D) a pH adjuster, a water-soluble polysaccharide, and a polyhydric alcohol.

Examples

[0029] Examples 1 to 20, Comparative Example 1 Topical skin preparations (lotion) having the compositions shown in Tables 1 and 2 were manufactured, the pH was measured, and the odor after storage at 50°C for 1 month, the appearance after storage at 50°C for 1 month, and the stickiness during and after application were evaluated. The results are shown together with Table 1. Note that PCA-Na in Table 1 indicates sodium pyrrolidonecarboxylate.

[0030] (Manufacturing method) At 25°C, while stirring water, component (A), (B), and other components were added and stirred to manufacture a topical skin preparation (lotion).

[0031] (Evaluation method) (1) pH: For each topical skin preparation immediately after manufacture, the pH was measured at 25°C using a desktop pH meter F-72 manufactured by HORIBA.

[0032] (2) Odor after storage at 50°C for 1 month: Each topical skin preparation was filled with 40 g in a 50 mL glass bottle and stored in a thermostat at 50°C for 1 month. After storage, the glass bottle containing the topical skin preparation was taken out from the thermostat at 50°C and left standing at 25°C for 6 hours. Then, the lid of the glass bottle was opened, and the odor of the topical skin preparation was sensory-evaluated according to the following criteria. A: Only the odor of the original base material is felt. B: A weak off-odor is felt. C: An obvious off-odor is felt.

[0033] (3)Appearance after storage at 50°C for 1 month: Each topical skin preparation was filled with 40 g into a 50 mL glass bottle and stored in a thermostat at 50°C for 1 month. After storage, the glass bottle containing the topical skin preparation was taken out of the thermostat at 50°C and allowed to stand at 25°C for 6 hours. Then, the appearance of the cosmetic was observed with the naked eye and evaluated according to the following criteria. A: Colorless and transparent. B: Slight coloring can be confirmed. C: Obvious coloring can be confirmed.

[0034] (4)Degree of stickiness during and after application: About 0.2 g of each skin cosmetic was taken on the back of the hand by 10 professional panelists and applied with a finger, and the degree of stickiness during and after application was evaluated according to the following criteria. The results were shown as the total score of 10 people. 3 points: No stickiness is felt. 2 points: Slight stickiness is felt. 1 point: Strong stickiness is felt.

[0035] [Table 1]

[0036] [Table 2]

[0037] Formulation Example 1 (Lotion) (Components) 1. γ-Amino-β-hydroxybutyric acid 0.3 (mass%) 2. Allantoin 0.5 3. Citric acid appropriate amount (0.01 - 0.2) 4. Succinic acid appropriate amount (0.01 - 0.2) 5. Trisodium citrate appropriate amount (0.01 - 0.2) 6. Glycerin 5.0 7. Diglycerin 2.0 8. Sodium hyaluronate 0.1 9. Carrageenan 0.15 10. Ectoin 0.7 11. N-Methyl-L-serine 0.1 12. Sodium benzoate 0.2 13. Water residue Total 100

[0038] (Manufacturing method) While stirring water, sequentially add components 1 to 12, dissolve them, and filter to produce a lotion. (pH 4 - 7)

[0039] Formulation Example 2 (Beauty liquid) (Components) 1. Ascorbic acid 2-glucoside 3.0 (mass%) 2. γ-Amino-β-hydroxybutyric acid 1.5 3. Citric acid appropriate amount (0.01 - 0.2) 4. Trisodium citrate appropriate amount (0.01 - 0.2) 5. Potassium hydroxide appropriate amount (0.1 - 1.0) 6. Glycerin 3.0 7. Diglycerin 1.0 8. 1,3-Butylene glycol 5.0 9. Carboxyvinyl polymer appropriate amount (0.1 - 1.0) 10. Sodium hyaluronate 0.05 11. Alanine 0.5 12. Ectoin 0.05 13. Arginine appropriate amount (0.1 - 1.0) 14. Phenoxyethanol 0.3 15. Polyoxyethylene hydrogenated castor oil (60 E.O.) 0.2 16. Fragrance appropriate amount 17. Water residue Total 100

[0040] (Manufacturing method) While stirring water, components 1 to 13 are sequentially added and dissolved. Separately, 15 and 16 are mixed and then added to the previously heated aqueous phase to produce a beauty liquid. (pH 6 - 7) The blending amount of component 9 is adjusted so that the final viscosity of the beauty liquid measured with a B-type viscometer at 30°C is 1,000 - 20,000 mPa·s.

[0041] Formulation Example 3 (Emulsion) (Components) 1. γ-Amino-β-hydroxybutyric acid 0.2 (mass%) 2. Nicotinamide 1.0 3. Citric acid appropriate amount (0.01 - 0.2) 4. Trisodium citrate appropriate amount (0.01 - 0.2) 5. Glycerin 5.0 6. Carrageenan 0.2 7. N-Methyl-L-serine 0.2 8. Trimethylglycine 0.3 9. Water the balance 10. Hydrogenated soybean phospholipid (PC content 50 - 95%) 0.5 11. Cholesterol (phytosterol) 0.5 12. Sugar squalane 8.0 13. Polyglyceryl-10 diisostearate 1.0 14. Octyldodecyl myristate 3.0 15. Isostearic acid 0.5 16. Palmitic acid 0.1 17. Dipropylene glycol 5.0 18. 1,3-Butylene glycol 3.0 19. Perfume appropriate amount (0 - 0.5) 20. Phenoxyethanol 0.5 21. Carboxyvinyl polymer appropriate amount (0.1 - 1.0) 22. Appropriate amount of potassium hydroxide Total 100

[0042] (Manufacturing method) Dissolve Components 1 to 9 by stirring at 80°C, gradually add them to Components 10 to 19 that have been pre-dissolved at 80°C, disperse and emulsify with a homomixer (HM), and then cool. Sequentially add Components 20 to 22 near 50°C, disperse again with HM, and cool to 30°C to produce an emulsion. (pH 5 - 7) Adjust the blending amount of Component 21 so that the final viscosity of the emulsion measured with a B-type viscometer at 30°C is 1,500 - 20,000 mPa·s.

[0043] Formulation Example 4 (Cream) (Components) 1. γ-Amino-β-hydroxybutyric acid 2.0 (mass%) 2. Citric acid appropriate amount (0.01 - 0.2) 3. Trisodium citrate appropriate amount (0.01 - 0.2) 4. Phytic acid 0.1 5. Sodium benzoate 0.2 6. Dipotassium glycyrrhizinate 0.1 7. Glycerin 5.0 8. Maltitol 8.0 9. Sodium hyaluronate 0.1 10. PCA-Na 1.0 11. Ectoin 0.5 12. Water balance 13. Hydrogenated soy phosphatidylcholine 1.0 14. Cholesterol (phytosterol) 0.5 15. Palmitic acid 0.2 16. Behenyl alcohol 1.0 17. Vegetable squalane 10.0 18. Isostearic acid 0.5 19. Cetyl alcohol 0.5 20. Macadamia nut oil 3.0 21. Jojoba oil 3.0 22. Dipropylene glycol 5.0 23. 1,3-Butylene glycol 3.0 24. Fragrance appropriate amount (0 - 0.5) 25. Carbomer appropriate amount (0.1 - 1.0) 26. Appropriate amount of potassium hydroxide Total 100

[0044] (Manufacturing method) Ingredients 1 to 12 are stirred and dissolved at 80°C, gradually added to Ingredients 13 to 24 previously dissolved at 80°C, dispersed and emulsified with a homomixer (HM), and then cooled. Ingredients 25 and 26 are sequentially added near 50°C, dispersed again with HM, cooled to 30°C, and a cream is produced. (pH 5 to 7) The blending amount of Ingredient 25 is adjusted so that the final viscosity of the cream measured with a B-type viscometer at 30°C is 10,000 to 300,000 mPa·s.

[0045] All of the topical skin preparations of Formulation Examples 1 to 4 do not produce odor or coloring even when stored at high temperatures, have excellent storage stability, and do not feel sticky during and after application.

Claims

1. The following components (A), (B) and (C): (A) γ-amino-β-hydroxybutyric acid, (B) one or more selected from osmolytes, (C) water A topical skin preparation containing the same.

2. The topical skin preparation according to Claim 1, wherein the component (B) is one or more selected from ectoine, sodium pyrrolidone carboxylate, arginine, arginine hydrochloride, carnitine chloride, taurine, glutamic acid, glutamate, serine, N-methyl-L-serine, trimethylglycine, alanine.

3. The topical skin preparation according to Claim 1 or 2, wherein the molar ratio (B) / (A) of the component (B) to the component (A) is 0.005 to 5.

4. The topical skin preparation according to Claim 1 or 2, wherein the content of the component (A) is 0.001 to 3.5% by mass.

5. The topical skin preparation according to Claim 1 or 2, wherein the content of the component (B) is 0.015 to 3.5% by mass.

6. The topical skin preparation according to Claim 1 or 2, further containing (D) a pH adjuster.

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