Skin-external preparation and sunscreen cosmetic using the same

Abstract

To provide a skin-external preparation using a SPF booster agent that is derived from a naturally sourced component and is expected to exhibit SPF boosting effects for both ultraviolet absorbers and ultraviolet scatterers.SOLUTION: A skin-external preparation of the present invention includes an ultraviolet absorber, an ultraviolet scatterer, and a SPF booster agent. The SPF booster agent is a component derived from a fermentation liquid or a culture liquid utilizing microorganisms.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an external preparation for skin containing an SPF booster and a sunscreen cosmetic using the same.

Background Art

[0002] Conventionally, various sunscreen cosmetics have been developed to suppress damage to the skin caused by ultraviolet rays. Sunscreen cosmetics generally defend against ultraviolet rays in sunlight and protect the skin from the adverse effects of ultraviolet rays by blending ultraviolet absorbers, ultraviolet scatterers, and the like. However, some ultraviolet absorbers have adverse effects such as strong irritation to the skin when the blending amount increases. Therefore, similar to general cosmetics such as emulsions and lotions, components that protect the skin by enhancing the moisture retention of the skin may be added to sunscreen cosmetics.

[0003] In addition, for external preparations for skin that are directly used on the skin, it is desirable to use many substances derived from natural ingredients. Therefore, as a component for protecting the skin as described above, the use of a fermentation broth or a culture broth using bacteria has attracted attention. A fermentation broth or a culture broth using bacteria is a natural ingredient containing many components that activate skin cells such as minerals, amino acids, nucleic acids, and vitamins. For example, a culture broth in which yeast is grown is known to contribute to skin protection and moisturization, and skin cosmetics using the same have been manufactured. Furthermore, the development of a sunscreen cosmetic added with an ultraviolet absorber has been proposed (see, for example, Patent Document 1).

[0004] However, such a fermentation broth or culture broth is known as a component for protecting the skin, but is not considered to enhance the absorption effect of the ultraviolet absorber. That is, it compensates for the negative effect on the skin by the ultraviolet absorber with the positive effect of protecting the skin, but does not reduce the negative effect itself. On the other hand, by adding an SPF booster agent that enhances the absorption effect of the ultraviolet absorber, a sunscreen cosmetic with a reduced blending amount of the ultraviolet absorber is known (see, for example, Patent Document 2). In the cosmetic described in Patent Document 2, as the SPF booster agent, hollow silica sphere particles are used to refract and scatter the ultraviolet rays radiated in the composition, thereby enhancing the absorption effect of the ultraviolet absorber.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0006] However, the hollow silica sphere particles used as the SPF booster agent are artificial products and are not suitable for the current trend where the use of natural ingredients is desired. The present invention has been made to solve the above problems, and an object thereof is to provide a skin external preparation using an SPF booster agent derived from a natural ingredient and having an expected SPF boosting effect for enhancing the absorption effect of an ultraviolet absorber, and a sunscreen cosmetic using the same.

Means for Solving the Problems

[0007] To achieve the above object, the present invention contains an ultraviolet absorber, an ultraviolet scattering agent, and an SPF booster agent, and the SPF booster agent is a component derived from a fermentation broth or a culture broth using bacteria.

[0008] Also, in the above-mentioned external preparation for skin, it is preferable that the SPF booster agent is a component derived from a fermentation broth or a culture broth using Bacillus subtilis, lactic acid bacteria or Lactobacillus.

[0009] Also, in the above-mentioned external preparation for skin, it is preferable that the SPF booster agent is a component derived from a fermentation broth or a culture broth of yeast or Aspergillus.

[0010] Also, in the above-mentioned external preparation for skin, it is preferable that the SPF booster agent is a component derived from a Thermus thermophilus culture broth.

[0011] Also, in the above-mentioned external preparation for skin, it is preferable that the content of the SPF booster agent exceeds 0.1% by mass.

[0012] Also, in the above-mentioned external preparation for skin, it is preferable that the content of the ultraviolet absorber is 11% by mass or less.

[0013] Also, the above-mentioned external preparation for skin is preferably used as a sunscreen cosmetic.

Advantages of the Invention

[0014] According to the present invention, by using a fermentation broth or a culture broth using bacteria as an SPF booster agent derived from natural components, a high SPF boosting effect can be obtained with respect to the ultraviolet absorber.

Embodiments for Carrying Out the Invention

[0015] Hereinafter, an external preparation for skin according to an embodiment of the present invention and a sunscreen cosmetic using the same will be described. The external preparation for skin according to the embodiment of the present invention is Component (A) an ultraviolet absorber, Component (B) an ultraviolet scattering agent, Component (C) an SPF booster agent, and contains The SPF booster agent of the above component (C) is a component derived from a fermentation broth or a culture broth using bacteria. Note that SPF (Sun Protection Factor) means the ultraviolet protection effect, and generally indicates an index for preventing ultraviolet B waves (UVB (wavelength 280 - 320 nm)) which cause sunburn. However, the "SPF booster agent" in this embodiment also includes the role of a booster agent that increases the absorption effect not only of UVB but also of ultraviolet A waves (UVA (wavelength 320 - 400 nm)).

[0016] Examples of the ultraviolet absorber of component (A) in this embodiment include, for example, 2-ethylhexyl p-methoxycinnamate, 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)1,3,5-triazine, octocrylene, dimethicone diethylbenzalmalonate, polysilicone-15, t-butylmethoxydibenzoylmethane, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bisethylhexyloxyphenol methoxyphenyl triazine, oxybenzone-3, methylene bisbenzotriazolyl tetramethylbutylphenol, phenylbenzimidazole sulfonic acid, homosalate, ethylhexyl salicylate, ethylhexyl methoxycinnamate, ethylhexyl triazone, ferulic acid and other ultraviolet absorbers. Examples of commercially available products include Tinosorb (registered trademark) S, Tinosorb (registered trademark) M, Uvinul (registered trademark) A Plus Glanular, Uvinul (registered trademark) MC-80N, Uvinul (registered trademark) T-150 (above, BASF Japan Ltd.), Eusolex 9020 (Merck KGaA), Eusolex OCR (Merck KGaA), Parsol SLX (DSM Nutritional Products Japan Ltd.), etc. These ultraviolet absorbers can be used in combination of two or more. Also, commercially available ultraviolet absorbers include those to which an ultraviolet scattering agent and other components are added.

[0017] As the ultraviolet scattering agent of component (B) in the present embodiment, for example, a dispersion of metal oxide fine particles such as zinc oxide, titanium dioxide, zirconium oxide, and cerium oxide is used. Examples of commercially available products include MCP55XZ4J (KOBO Dispatech Co., Ltd.), IOPP50TIJ (KOBO Dispatech Co., Ltd.), IOPP50XZ4J (KOBO Dispatech Co., Ltd.), DIF-3ST2 (Sakai Chemical Industry Co., Ltd.), DIS-11A (Sakai Chemical Industry Co., Ltd.), and the like. Note that commercially available ultraviolet scattering agents include those to which an ultraviolet absorber or other components are added. For example, the above MCP55XZ4J is composed of ethylhexyl methoxycinnamate, polyhydroxystearic acid, and methicone components in addition to zinc oxide.

[0018] As the SPF booster agent of component (C) in the present embodiment, for example, components derived from a fermentation broth using Bacillus subtilis or lactic acid bacteria, components derived from a culture broth of yeast or Aspergillus, components derived from a Thermus thermophilus culture broth, and the like are used. These are not limited to the case of being used alone, and may be used in appropriate combinations. In addition, as the substrate for the above fermentation broth / culture broth, a carbon source such as glucose, sucrose, and other saccharides, and extracts of plant-derived raw materials such as grains, fruits, vegetables, beans, and seeds are used.

[0019] Examples of usable bacteria include, for example, Aureobasidium pullulans, Acantopanax koreanum, Aquifex pyrophilus, Asaccharomyces, Acidophilus, Acinetobacter, Aspergillus, Acetobacter, Arthrobacter, Alteromonas, Enterococcus faecium, Endomyces, Aurantiochytrium, Kazachstania, Grifola frondosa, Galactomyces, Candida glabrata, Xylinum, Kluyveromyces, Gluconobacter, Cryptococcus, Clostridium acetigene, Corynebacterium, Thermus thermophilus, Zymomonas, Saccharomycopsis, Saccharomyces, Lentinula edodes, Zygosaccharomyces, Zygosaccharomyces microellipsoides, Schizosaccharomyces, Sinomonas, Pseudalteromonas, Suillus granulatus, Staphylococcus epidermidis, Streptococcus thermophilus, Streptomyces pulveraceus, Sphingomonas, Sphingomonas, Scenedesmus desiccicola, Seriporia lacerata, Soilminerals, Taiwanofungus camphoratus, Deinococcus, Tenacibaculum discolor, Torulaspora delbrueckii, Pleurotus eryngii, Nocardioides, Paecilomyces japonica, Bacillus, Hericium coralloides, Pantoea, Pantoea agglomerans, Pantoea vagans, Pichia, Pichia caribbica, Vitreoscilla, Bifidobacterium, Bifidobacterium, Vibrio alginolyticus, Pleurotus eryngii var. tuoliensis, Phytosterols, Ferinus baumii, Filobasidiella, Pseudozyma antarctica, Pseudozyma aphidis, Pseudozyma tsukubaensis, Promicromonospora, Monascus purpureus, Pediococcus, Grifola frondosa var. chejuensis, Botrytis cinerea, Porphyridium cruentum, Ganoderma lucidum, Macrolepiota procera, Mesima, Rhodotorula, Rhodococcus, Rhizopus, Lipomyces, Leuconostoc, Rhodopseudomonas sphaeroides, etc.

[0020] The topical skin preparation of this embodiment can be used as a sunscreen cosmetic in various dosage forms such as emulsions, gels, creams, etc. Depending on the dosage form, additives such as thickeners, humectants, preservatives, emulsifiers, stabilizers, and oils are appropriately added. In the examples described later, various additives are added assuming an emulsion as the dosage form, and examples of additives that can be used are shown below. However, the components of the topical skin preparation of this embodiment are not limited to the materials shown below.

[0021] Examples of thickeners include xanthan gum, hydroxyethyl cellulose, carbomer, polyacrylamide, etc. Examples of commercially available products include HEC Daicel SE400 (Daicel Miraiz Co., Ltd.), Carbopol 910 (Lubrizol Advanced Materials), Sepigel 305 (SEPPIC), etc.

[0022] As the humectant, for example, polyhydric alcohols such as butylene glycol and propanediol are used. Examples of polyhydric alcohols include ethylene glycol, 1,2 - propanediol, 1,2 - butanediol, 1,3 - propanediol, 1,4 - butanediol, 1,2 - hexanediol, 1,2 - octanediol, 1,8 - octanediol, 1,2 - decanediol, 2 - ethyl - 1,3 - hexanediol, diethylene glycol, etc.

[0023] Examples of preservatives include phenoxyethanol, benzoic acid and its salts, salicylic acid and its salts, phenol, sorbic acid and its salts, dehydroacetic acid and its salts, paraoxybenzoic acid esters (such as methylparaben, ethylparaben, butylparaben, etc.), chlorocresol, hexachlorophene, resorcinol, isopropylmethylphenol, orthophenylphenol, benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, alkylisquinolinium bromide, trichlorocarbanilide, halocarban, photosensitizer No. 201, triclosan, methylchloroisothiazolinone / methylisothiazolinone solution, bisabolol, alkyldiaminoethylglycine hydrochloride, trichloro - salicylanilide (TCSA), tribromo - salicylanilide (TBS), etc.

[0024] Emulsifiers are used to stably disperse ultraviolet scattering agents and SPF booster agents in the liquid agent. For example, general - purpose non - ionic surfactants, glyceryl isostearate, sorbitan isostearate, hydrogenated castor oil, hydrogenated lecithin, etc. are used. As the above - mentioned hydrogenated lecithin, NIKKOL Resinol S - 10 (manufactured by Nikko Chemicals Co., Ltd.) can be mentioned.

[0025] Examples of oil agents include silicone oil, ester oil, hydrocarbon oil, etc., and it is preferable to contain silicone oil. Examples of silicone oil include linear or branched polysiloxanes such as dimethicone (dimethylpolysiloxane), methylphenylpolysiloxane, methylhydrogenpolysiloxane, diphenylsiloxyphenyltrimethicone, etc., cyclic polysiloxanes such as octamethylcyclotetrasiloxane, cyclopentasiloxane (decamethylcyclopentasiloxane), dodecamethylcyclohexasiloxane, and caprylyl methylcon. Examples of commercially available silicone oils include KF - 96A - 5cs (manufactured by Shin - Etsu Chemical Co., Ltd.), SH200 Fluid 1.5CS (manufactured by Toray Dow Corning Co., Ltd.), TSF4045 (manufactured by Momentive Performance Materials Inc.), etc.

[0026] In this embodiment, examples of the water added as a residue include tap water, ion-exchanged water, distilled water, purified water, or natural water, and preferably sterilized water.

[0027] The following tests were conducted to examine how the SPF values of the obtained topical skin preparations changed when using multiple types of SPF booster agents (component (C)). For the samples of each example and comparative example, the SPF value and UVAPF value were measured using an SPF analyzer (UV-2000S, manufactured by Labsphere). In addition, in all the tests shown below, the SPF value and UVAPF value were derived from the average value of 4 samples under the same conditions.

[0028] <Test 1> In Test 1, the following was examined: how the SPF value and UVAPF value of the obtained topical skin preparation changed by using four types of component (C) SPF booster agents in component (A) ultraviolet absorber (Tinosorb (registered trademark) S) and component (B) ultraviolet scattering agent (MCP55XZ4J), and the results are shown in Table 1 below. Note that 8% by mass of the 19% by mass of MCP55XZ4J contains components of an ultraviolet absorber. As the component (C) SPF booster agent, in Experiment 1A, Bacillus fermentate (NAKETO ULTRA, manufactured by Hangzhou Yumada Biotechnology Co., Ltd.) was used; in Experiment 1B, Saccharomyces / rice fermentation broth (rice fermentation broth PD, manufactured by Maruzen Pharmaceutical Co., Ltd.) was used; in Experiment 1C, Galactomyces culture solution (manufactured by RADIANT) was used; and in Experiment 1D, Thermus thermophilus culture solution / yeast extract (TIRACLE, manufactured by Guangdong Boxi Biotechnology) was used. In addition to the above components (A) to (C), an oil agent (KF-96A-5cs), an emulsifier (NIKKOL Resinol S-10), a thickener (SEPIGEL 305), a humectant (1,3-butylene glycol), and a preservative (phenoxyethanol) were added in the contents shown in Table 1, and water was added as a residue.

[0029]

Table 1

[0030] As shown in Table 1, in Examples 1A to 1D, the SPF value and UVAPF value both increased compared to Comparative Example 1E. That is, it was shown that the component (C) of this embodiment, the component derived from the fermentation broth or culture broth using bacteria, which is an SPF booster agent, has an SPF boosting effect on the ultraviolet absorber. The fermentation broth or culture broth using bacteria contains various minerals, amino acids, proteins, nucleic acids, vitamins, etc. Among these, it is considered that components having absorption wavelengths in the ranges of UVB (wavelength 280 to 320 nm) and UVA (wavelength 320 to 400 nm) are contained to a certain extent. However, the fermentation broth or culture broth using bacteria has low ultraviolet absorption performance by itself and is not generally recognized as an ultraviolet absorber. That is, the results of Examples 1A to 1D in which the SPF value and UVAPF value were clearly improved compared to Comparative Example 1E are presumed to be due to the fermentation broth or culture broth using bacteria functioning as an SPF booster agent that increases the absorption effect of the ultraviolet absorber.

[0031] <Test 2> In Test 2, the Bacillus fermented product (NAKETO ULTRA), which had the highest boosting effect in Test 1, was used as the component (C) SPF booster agent, and by changing its content (mass %) to be more than that in Test 1A, it was tested how the SPF value and UVAPF value of the obtained topical skin preparation would change, and the results are shown in Table 2 below. Other additives were the same as in Test 1.

[0032]

Table 2

[0033] As shown in Table 2, in Examples 2A to 2F, the SPF value and UVAPF value both increased compared to Comparative Example 2G, and it was shown that the increase rate was higher than that in Test 1A (= 2A). That is, it was shown that increasing the content of the Bacillus ferment (NAKETO ULTRA) used as the component (C) booster agent in this embodiment has a higher SPF boosting effect. However, from the results of Test 2E, it was shown that the SPF value and UVAPF value do not necessarily increase as the content of the Bacillus ferment (NAKETO ULTRA) increases.

[0034] <Test 3> In Test 3, similar to Test 2, the Bacillus ferment (NAKETO ULTRA) with the highest boosting effect was used as the component (C) SPF booster agent, and its content (% by mass) was changed to be less than that in Test 1A to test how the SPF value and UVAPF value of the obtained external preparation for skin change. The results are shown in Table 3 below. Other additives were the same as in Tests 1 and 2.

[0035]

Table 3

[0036] As shown in Table 3, in Examples 3A to 3F, the SPF value and UVAPF value both increased compared to Comparative Example 3G. That is, when the Bacillus ferment (NAKETO ULTRA) was used as the component (C) SPF booster agent in this embodiment, it was shown that there was an SPF boosting effect at a content of 0.1% by mass or more. In addition, Examples 3A to 3F obtained an even higher SPF boosting effect than Example 1A of Experiment 1. In particular, the SPF boosting effect in Examples 3A to 3C was high, and the content of the SPF booster agent preferably exceeded 0.1% by mass and was less than 5% by mass.

[0037] Fermentation broth or culture solution using bacteria contains various components such as minerals, amino acids, nucleic acids, vitamins, etc. It increases the absorption effect by ultraviolet absorbers, has an ultraviolet absorption effect by various solid components, and is considered to exhibit a high SPF boosting effect due to the synergistic effect with ultraviolet scattering agents. Also, there is a possibility that the metabolites of bacteria increase the ultraviolet absorption effect, and further study is required to elucidate the mechanism. Thus, in this embodiment, since a fermentation broth or culture solution using bacteria, which is a natural-derived component, is used as the SPF booster agent, an SPF boosting effect can be obtained for the ultraviolet absorber.

[0038] Adding a fermentation broth or culture solution using bacteria to cosmetics as a component for protecting the skin such as moisturizing is already known as prior art. However, the fact that the fermentation broth or culture solution using bacteria has a boosting effect of increasing the absorption effect by ultraviolet absorbers is a new finding clarified by the present invention. Also, according to the present invention, by adding a fermentation broth or culture solution using bacteria, the absorption effect by the ultraviolet absorber increases, so a reduction in the addition amount of the ultraviolet absorber can be expected. From the results of the above tests, the content of the component (A) ultraviolet absorber is desirably 11% by mass or less. Also, when the absorption effect by the ultraviolet absorber increases, the content of the ultraviolet scattering agent can be reduced. When the content of the ultraviolet scattering agent is high, the viscosity of the liquid agent may increase or it may give a rough feeling of use. On the other hand, as in the present invention, for example, in a lotion-type sunscreen cosmetic, by adding a fermentation broth or culture solution using bacteria, the content of the ultraviolet scattering agent can be reduced, and a liquid agent with a smooth and good sense of elongation can be realized.

[0039] The topical skin preparation of this embodiment can contain any optional components as appropriate, in addition to the above components, as long as the effects of the invention are not impaired. Examples of the optional components include crude drugs, pH adjusters, chelating agents, antioxidants, cooling agents, vitamins, proteins, polymers, fragrances, antibacterial agents, or pigments. Specifically, examples of the polymer include polyquaternium-10, and examples of the chelating agent include sodium EDTA-2.

Claims

1. A topical skin preparation comprising an ultraviolet absorber, an ultraviolet scattering agent, and an SPF booster, wherein the SPF booster is a component derived from a fermentation broth or a culture broth using bacteria.

2. The topical skin preparation according to Claim 1, wherein the SPF booster is a component derived from a fermentation broth or a culture broth using Bacillus subtilis, lactic acid bacteria or Lactobacillus.

3. The topical skin preparation according to Claim 1, wherein the SPF booster is a component derived from a fermentation broth or a culture broth of yeast or Aspergillus.

4. The topical skin preparation according to Claim 1, wherein the SPF booster is a component derived from a Thermus thermophilus culture broth.

5. The topical skin preparation according to Claim 1, wherein the content of the SPF booster exceeds 0.1% by mass.

6. The topical skin preparation according to Claim 1, wherein the content of the ultraviolet absorber is 11% by mass or less.

7. A sunscreen cosmetic using the topical skin preparation according to any one of Claims 1 to 6.

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