Dosing device

Abstract

To provide a dosing device in which an administered substance can be administered in a wide range from a discharge hole situated in a loop, by enlarging the loop that is protruding outside from a shaft.SOLUTION: A dosing device 10 for administering an administered substance to the surface of a biological organ, comprises: a shaft 20 that extends longitudinally between the tip end and the base end, and has at least one lumen opening at least at one opening part in the tip end; and a loop tube 30 that is a tube body extending between a first end part 31 and a second end part 32, protrudes from one of the opening parts to the outside of the shaft 20 toward the second end part 32 from the first end part 31, forms a loop 40 and is housed from one of the opening parts to the inside of the shaft 20, and is provided with a plurality of discharge holes 38 in a pipe wall 37 between the first end part 31 and the second end part 32, at least a part of the loop tube capable of sliding the lumen in the longitudinal direction.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a dispensing device. [Background technology]

[0002] In recent years, a procedure has been performed in which a long therapeutic device is delivered into the body to treat a lesion that has occurred in a biological organ (see, for example, Patent Document 1). The therapeutic device described in Patent Document 1 has a portion shaped in a substantially circular ring at its tip, and this portion is formed with a portion for ejecting a substance to be administered. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2014-14403 Summary of the Invention [Problem to be solved by the invention]

[0004] When a long device is inserted into a living body and used, it is difficult to administer the substance to a wide area within the living body.

[0005] The present invention has been made to solve the above-mentioned problems, and aims to provide an administration device that can expand a loop protruding outward from a shaft and administer the administered substance over a wide area through an emission hole located in the loop. [Means for solving the problem]

[0006] The above object can be achieved by the invention described in (1) below.

[0007] (1) The administration device of the present invention is an administration device for administering a substance to the surface of a biological organ, characterized in that it comprises: a shaft extending longitudinally between a tip and a base end and having at least one lumen opening at at least one opening at the tip; and a loop tube which is a tubular body extending between a first end and a second end, protruding from the shaft from one of the openings toward the second end from the first end, forming a loop and being accommodated inside the shaft from one of the openings, having a plurality of release holes in the tubular wall between the first end and the second end, and at least a portion of which is capable of sliding longitudinally along the lumen. [Effects of the Invention]

[0008] The administration device described in (1) above can expand the loop protruding from the shaft by sliding the loop tube longitudinally within the lumen of the shaft, thereby administering the substance to be administered over a wide area through the release hole located in the loop.

[0009] (2) In the administration device described in (1) above, the plurality of release holes may be arranged side by side along the longitudinal axis of the loop tube at positions inside the loop, thereby enabling the administration device to administer the substance to be administered with high precision from the release holes toward an area surrounded by the loop of the loop tube protruding outward from the shaft.

[0010] (3) In the administration device described in (1) or (2) above, the administration device may have at least two lumens, and the portion of the loop tube extending from the first end toward the distal end and the portion of the loop tube extending from the second end toward the distal end may be located in different lumens. This allows the portion of the loop tube extending from the first end toward the distal end and the portion of the loop tube extending from the second end toward the distal end to slide smoothly along the shaft without interfering with each other within the shaft.

[0011] (4) The administration device according to any one of (1) to (3) above may have a pusher that pushes the second end of the loop tube disposed in the lumen of the shaft toward the distal end. This allows the administration device to expand the loop on the distal side of the shaft by pushing the second end of the loop tube from the proximal end with the pusher.

[0012] (5) The administration device described in (4) above may have a stopper that restricts movement of the pusher inside the shaft. This prevents the second end of the loop tube from being unintentionally pushed out from the opening of the shaft due to pressure from the pusher, allowing the administration device to expand the loop to an appropriate size outside the shaft.

[0013] (6) In the administration device described in (5) above, the stopper may be removable from the pusher, whereby the administration device can push the second end of the loop tube outward from the opening of the shaft by pressing with the pusher after the stopper has been removed.

[0014] (7) In the administration device according to any one of (4) to (6), the pusher may have a visual marker on its outer surface to indicate its position in the longitudinal direction. This allows the administration device to indicate the length by which the second end of the loop tube is pushed out from the opening of the shaft by pressing with the pusher, based on the position of the visual marker relative to the shaft. This allows the surgeon to expand the loop to an appropriate size outside the shaft.

[0015] (8) In the administration device described in any one of (1) to (7) above, the portion of the loop tube extending distally from the first end and the portion extending distally from the second end may be housed in the common lumen, with their outer surfaces facing each other, and the release hole may be formed on the opposing surfaces of the outer surfaces. This allows the administration device to prevent leakage of the substance to be administered from the release hole of the loop tube arranged in the lumen of the shaft by contact or proximity between the opposing surfaces of the loop tube. Furthermore, because the portion of the loop tube extending distally from the first end and the portion extending distally from the second end are housed in the common lumen, the outer diameter of the shaft can be reduced, thereby reducing invasiveness.

[0016] (9) In the administration device according to any one of (1) to (8) above, the loop tube may have a reinforcing wire, which allows the shape of the loop formed by the loop tube to be appropriately maintained. [Brief explanation of the drawings]

[0017] [Figure 1] 1A and 1B are diagrams showing an administration device according to the present embodiment, in which (A) is a plan view and (B) is a cross-sectional view taken along line AA in FIG. 1A. [Figure 2] 1 is a plan view showing a state in which an administration substance is being supplied from a release hole of a loop tube by an administration device according to this embodiment. FIG. [Figure 3] 10 is a plan view showing a state in which the second end of the loop tube is pushed outward from the shaft. FIG. [Figure 4] FIG. 10 is a plan view showing a state in which the loop tube is being collected. [Figure 5] 1A and 1B are cross-sectional views of the shaft and loop tube of modified administration devices, where (A) shows a first modified example, (B) shows a second modified example, and (C) shows a third modified example. [Figure 6] A cross-sectional view showing the second end of the loop tube and the tip of the pusher in a fourth variant of the administration device. [Figure 7]FIG. 10 is a plan view showing the tip of a fifth variant of the administration device. [Figure 8] FIG. 10 is a plan view showing the tip of a sixth variant of the administration device. DETAILED DESCRIPTION OF THE INVENTION

[0018] Hereinafter, embodiments of the present invention will be described with reference to the drawings. For convenience of explanation, the dimensions of the drawings may be exaggerated and may differ from the actual dimensions. Furthermore, in this specification and the drawings, components having substantially the same functions are designated by the same reference numerals, and redundant explanations will be omitted. In this specification, the side of the device that is inserted into the living body will be referred to as the "distal side," and the side that is operated will be referred to as the "proximal side."

[0019] 1, the administration device 10 according to this embodiment is a device that is inserted into a living body via a cylindrical body such as a trocar that is percutaneously inserted into a body cavity such as the abdominal cavity or the thoracic cavity, an endoscope, a catheter, or the like, and supplies a fluid substance to the surface of a biological organ. The biological organ is not particularly limited, but examples of biological organs that can be reached from the abdominal cavity include the liver, pancreas, small intestine, large intestine, duodenum, and diaphragm (peritoneal cavity side). Examples of biological organs that can be reached from the thoracic cavity include the surfaces of blood vessels such as the heart, lungs, and aorta.

[0020] The administration device 10 has a long shaft 20 extending in the longitudinal direction X between the tip and base ends, a loop tube 30 that can be housed inside the shaft 20, a pusher 50 that can press the loop tube 30 inside the shaft 20, and a stopper 60 that restricts the movement of the pusher 50 inside the shaft 20.

[0021] The shaft 20 has a first lumen 21 and a second lumen 22 that penetrate in the longitudinal axis direction X, and the first lumen 21 and the second lumen 22 open at a first opening 23 and a second opening 24 at the tip of the shaft 20. The shaft 20 has a partition wall 25 between the first lumen 21 and the second lumen 22 that separates the first lumen 21 and the second lumen 22.

[0022] The loop tube 30 can be inserted into the first lumen 21 and / or the second lumen 22 of the shaft 20, and extends longitudinally between a first end 31 and a second end 32. The loop tube 30 has a tube body 33, which is a long tubular body, located on the second end 32 side, and a hub 34, which is located on the first end 31 side and fixed to the base end of the tube body 33.

[0023] Hub 34 has two ports 35 to which syringes 70, which are containers for supplying the substance to be administered, can be connected. The two ports 35 converge inside hub 34 and communicate with supply lumen 36 formed inside tube body 33.

[0024] The tube body 33 is a flexible tubular body and has a supply lumen 36 extending from the first end 31 side to the second end 32 side, and a plurality of discharge holes 38 formed in a tubular wall 37 that forms the tubular body of the tube body 33. The supply lumen 36 communicates with a port 35 of the hub 34 on the first end 31 side and is closed on the second end 32 side. The discharge holes 38 penetrate the tubular wall 37 from the inner circumferential surface to the outer circumferential surface, exposing the supply lumen 36 to the outside. The tube body 33 is preferably made of a resin material that has a certain degree of flexibility.

[0025] The tube body 33 extends distally from the first end 31 (hub 34) side, which is disposed closer to the base end than the shaft 20, and penetrates the first lumen 21 of the shaft 20 to protrude distally from the first opening 23. The tube body 33 is fixed to the first lumen 21. Alternatively, the tube body 33 may be slidable within the first lumen 21 without being fixed to the first lumen 21. The tube body 33 protruding distally from the shaft 20 bends at the folded portion 39, faces proximal, and is inserted into the second lumen 22 through the second opening 24. In the administration device 10 before use, the second end 32 is disposed inside the second lumen 22 of the shaft 20. In the administration device 10 before use, the distance from the tip of the shaft 20 to the folded portion 39 is preferably short so that the tube body 33 does not expand outside the distal end of the shaft 20.

[0026] The discharge holes 38 are arranged approximately evenly along the longitudinal axis of the tube wall 37, which faces the portion of the tube body 33 that protrudes outward distally of the shaft 20 and the portion housed in the second lumen 22 by being folded back by a folded portion 39. Before use, the tube body 33 does not have a discharge hole 38 at the position housed in the first lumen 21 in the administration device 10, but it may have one.

[0027] The pusher 50 is a long member that can be inserted into the second lumen 22 of the shaft 20. The pusher 50 can enter the second lumen 22 of the shaft 20 from the proximal end side and push out the loop tube 30 from the second opening 24. For this reason, the length of the pusher 50 in the longitudinal axis direction X is preferably longer than the length of the shaft 20 in the longitudinal axis direction X.

[0028] The shaft 20 may have a visual marker 51 such as a scale or symbol on its outer surface so that the surgeon can grasp the position in the longitudinal axis direction X of the tip of the pusher 50 in the second lumen 22 of the shaft 20. By checking the position of the visual marker 51 relative to the base end of the shaft 20, the surgeon can recognize the size of the loop 40 formed by the loop tube 30 that protrudes distally beyond the shaft 20.

[0029] The stopper 60 is a removable tubular body connected to a predetermined position on the outer circumferential surface of the shaft 20. The outer diameter of the stopper 60 is larger than the inner diameter of the second lumen 22 of the shaft 20, and the stopper 60 cannot be inserted into the second lumen 22. The stopper 60 prevents the pusher 50, which is inserted into the second lumen 22 to push out the loop tube 30 arranged in the second lumen 22, from being inserted into the second lumen 22 beyond a predetermined position.

[0030] The stopper 60 has a structure that allows it to be easily removed from the pusher 50. For example, the stopper 60 has a weak portion 61 that is partially weak and can be easily broken. The weak portion 61 is, for example, two notches or perforations formed on one end side of the stopper 60 in the longitudinal axis direction X. The surgeon can cut the weak portion 61 from one end side to the other end side in the longitudinal axis direction X by pinching and pulling between the two notches, and remove the stopper 60 from the pusher 50.

[0031] Two syringes 70 (containers) contain a substance that gels, thickens, or hardens upon mixing together with a therapeutic substance. In this embodiment, one syringe 70 contains a fibrinogen solution, and the other syringe 70 contains a thrombin solution. One or both syringes 70 contain cultured cells as a therapeutic substance. When the fibrinogen solution and the thrombin solution are mixed, the fibrinogen turns into fibrin through the action of thrombin, resulting in gelation. Note that gelation also refers to thickening or hardening, as it increases viscosity and hardness. Note that the substance that gels, thickens, or hardens upon mixing is not limited to fibrinogen solution and thrombin solution. For example, a first aqueous solution containing NHS-modified CM dextrin and trehalose hydrate and a second aqueous solution containing sodium carbonate and sodium bicarbonate may also be used. The first aqueous solution and the second aqueous solution gel when mixed.

[0032] Cultured cells that are therapeutic substances include, for example, differentiated cells derived from somatic stem cells, adult stem cells, mesenchymal stem cells, ES cells (embryonic stem cells), or iPS cells (induced pluripotent stem cells). Somatic stem cells include, for example, skeletal myoblasts (myoblast cells). Differentiated cells include, for example, cardiomyocytes and fibroblast cells.

[0033] The therapeutic substance does not have to be a cell, but may be, for example, a drug. Furthermore, the therapeutic substance to be administered may be a substance that gels, thickens, or hardens. If the act of covering a biological organ with a gelling, thickening, or hardening substance itself has a therapeutic effect, the substance that gels, thickens, or hardens may be the therapeutic substance.

[0034] Furthermore, when a substance that gels, thickens, or hardens without mixing (such as a substance used in medical adhesives) is used as the substance to be administered, there may be only one syringe 70. In this case, the hub 34 may have only one port 35.

[0035] Next, a method of using the administration device 10 according to this embodiment will be described.

[0036] First, as shown in Figure 1, the surgeon inserts the distal end of the administration device 10 into the living body while keeping the loop tube 30 protruding distally beyond the shaft 20 small, until it reaches the vicinity of the surface of the living organ. Next, the surgeon connects two syringes 70 to the ports 35 of the hub 34.

[0037] Next, as shown in Figure 2, the surgeon inserts the tip of the pusher 50 into the opening on the proximal end side of the second lumen 22 of the shaft 20, and presses the second end 32 of the loop tube 30 with the pusher 50. This causes the second end 32 side of the loop tube 30 to protrude from the second lumen 22 toward the distal end of the shaft 20. As a result, the loop tube 30 protruding distally beyond the shaft 20 forms a ring-shaped loop 40. The surgeon moves the pusher 50 toward the distal end relative to the shaft 20 until the stopper 60 comes into contact with the proximal end of the shaft 20 and the movement of the pusher 50 is restricted.

[0038] The surgeon stops pushing the pusher 50 when the stopper 60 contacts the base end of the shaft 20. This causes the loop 40 to expand to a predetermined size. Furthermore, the second end 32 of the loop tube 30 is maintained in the second lumen 22 without being unintentionally pushed out from the second opening 24, so the loop 40 can be maintained. The surgeon may expand the loop 40 to a desired size while checking the visual marker 51 that indicates the size of the loop 40.

[0039] The surgeon places the loop 40 of the administration device 10 so as to surround the surface of the biological organ to which the administration substance is to be administered. Next, the surgeon presses the plungers of the two syringes 70. This causes the substances supplied from the two syringes 70 to mix and gelatinize.

[0040] The mixed substance to be administered travels through the supply lumen 36 and reaches the loop 40 of the loop tube 30. At this time, the loop tube 30 disposed in the first lumen 21 does not have a release hole 38, allowing the substance to reach the loop 40 without leakage. The substance to be administered that reaches the loop 40 is supplied from the multiple release holes 38 to the surface of the biological organ within the area surrounded by the loop 40, spreading out in a planar form to cover the surface of the biological organ. Because the release holes 38 are formed on the surfaces of the loop tube 30 that face each other and form the loop 40, the substance to be administered supplied from the release holes 38 is effectively supplied to the surface of the biological organ within the area surrounded by the loop 40. The substance to be administered that is supplied to the surface of the biological organ within the area surrounded by the loop 40 adheres to the surface of the biological organ, spreads out in a planar form (sheet-like), gels, and maintains its shape as a sheet-like indwelling object 100. In other words, the administration device 10 can form the substance to be administered into a sheet-like form inside the living body, eliminating the need to transport a large sheet-like indwelling object into the living body beforehand, improving operability.

[0041] Next, as shown in FIG. 3, the surgeon breaks the fragile portion 61 and removes the stopper 60 from the pusher 50. Next, the surgeon moves the pusher 50 further toward the distal end relative to the shaft 20, pushing the second end 32 of the loop tube 30 out of the second opening 24. Next, the surgeon pulls out the administration device 10 from the living body, as shown in FIG. 4. At this time, the second end 32 of the loop tube 30 is positioned more distal than the shaft 20, and the ring-shaped loop 40 disappears. Therefore, the surgeon can pull out the administration device 10 while preventing the loop 40 from coming into contact with the indwelling object 100 supplied to the surface of the living organ.

[0042] As described above, the administration device 10 according to this embodiment is an administration device 10 for administering a substance to the surface of a biological organ, and includes: a shaft 20 extending in the longitudinal axis direction X between a distal end and a proximal end and having at least one lumen opening at at least one opening at the distal end; and a loop tube 30 which is a tubular body extending between a first end 31 and a second end 32, protruding from one of the openings to the outside of the shaft 20 from the first end 31 toward the second end 32, forming a loop 40 which is housed inside the shaft 20 through one of the openings, and which has a plurality of release holes 38 in a tubular wall 37 between the first end 31 and the second end 32, at least a portion of which is slidable along the lumen in the longitudinal axis direction X. In this way, the administration device 10 can expand the loop 40 protruding from the shaft 20 by sliding the loop tube 30 within the lumen of the shaft 20 in the longitudinal axis direction X, thereby allowing the substance to be administered over a wide area through the release holes 38 located in the loop 40.

[0043] The multiple release holes 38 are arranged side by side along the longitudinal axis of the loop tube 30 at positions inside the loop 40. This allows the administration device 10 to administer the substance to be administered with high precision from the release holes 38 toward the area surrounded by the loop 40 of the loop tube 30 protruding outward from the shaft 20.

[0044] There are at least two lumens, and the portion of the loop tube 30 extending distally from the first end 31 and the portion of the loop tube 30 extending distally from the second end 32 are arranged in different lumens. This prevents the portion of the loop tube 30 extending distally from the first end 31 and the portion of the loop tube 30 extending distally from the second end 32 from interfering with each other within the shaft 20, allowing the loop tube 30 to slide smoothly relative to the shaft 20.

[0045] The administration device 10 may have a pusher 50 that pushes the second end 32 of the loop tube 30 disposed in the lumen of the shaft 20 in a distal direction. This allows the administration device 10 to expand the loop 40 on the distal side of the shaft 20 by having the second end 32 of the loop tube 30 pushed from the proximal direction by the pusher 50.

[0046] The administration device 10 has a stopper 60 that restricts movement of the pusher 50 inside the shaft 20. As a result, the administration device 10 uses the stopper 60 to prevent the second end 32 of the loop tube 30 from being unintentionally pushed out from the opening of the shaft 20 due to pressure from the pusher 50, and can expand the loop 40 to an appropriate size outside the shaft 20.

[0047] The stopper 60 is removable from the pusher 50. This allows the administration device 10 to push the second end 32 of the loop tube 30 outward from the opening of the shaft 20 by pressing with the pusher 50 after the stopper 60 has been removed.

[0048] The pusher 50 has a visual marker 51 on its outer surface that indicates the position in the longitudinal axis direction X. This allows the administration device 10 to indicate the length by which the second end 32 of the loop tube 30 is pushed out from the opening of the shaft 20 when pressed by the pusher 50, based on the position of the visual marker 51 relative to the shaft 20. This allows the surgeon to expand the loop 40 to an appropriate size outside the shaft 20.

[0049] The present invention is not limited to the above-described embodiment, and various modifications may be made by those skilled in the art within the technical spirit of the present invention. For example, in the administration device 10, the loop 40 may be expanded by the movement of the loop tube 30 disposed in the first lumen 21 toward the distal end, rather than by the movement of the loop tube 30 disposed in the second lumen 22. In this case, the loop tube 30 may be immovably fixed to the second lumen 22. When the loop tube 30 is fixed to the second lumen 22, the administration device 10 may not include the pusher 50. The loop 40 that expands distally of the shaft 20 is formed by the loop tube 30 housed in the first lumen 21. For this reason, it is preferable that the loop tube 30 has a release hole 38 at the position where it is housed in the first lumen 21, but does not have a release hole 38 at the position where it is housed in the second lumen 22.

[0050] Alternatively, the administration device 10 may expand the loop 40 by moving both the loop tubes 30 arranged in the first lumen 21 and the second lumen 22 toward the distal end. In this case, the loop 40 expanded distally of the shaft 20 is formed by the loop tubes 30 housed in the first lumen 21 and the second lumen 22. For this reason, it is preferable that the loop tube 30 has a release hole 38 at both the position housed in the first lumen 21 and the position housed in the second lumen 22.

[0051] 5(A), the shaft 20 may have only one lumen 26 having a substantially elliptical or oval cross section. Alternatively, the shaft 20 may have only one lumen 26 except for a portion of the distal end, and a partition wall 25 may be formed in a portion of the distal end of the shaft 20 to form the first lumen 21 and the second lumen 22. Alternatively, the shaft 20 may have only one lumen 26 having two protrusions 27 on opposing inner wall surfaces between the regions where the two tubes are housed so that adjacent tubes do not interfere with each other.

[0052] 5(C), the lumen 26 of the shaft 20 in which the loop tube 30 is housed may have only one substantially circular cross section, and the loop tube 30 may have a semicircular cross section. As a result, the loop tube 30 that is folded back and placed in the lumen 26 forms a single substantially circular shape with two tubes overlapping each other and is housed in the lumen 26. This reduces the outer diameter of the shaft 20, thereby reducing the invasiveness of the procedure. The outer surface of the folded and overlapping loop tube 30 is formed flat. Preferably, the release hole 38 is formed on this flat outer surface.

[0053] As described above, in the third modified example, the portion of the loop tube 30 extending distally from the first end 31 and the portion extending distally from the second end 32 are housed in the common lumen 26, with their outer surfaces facing each other, and the release hole 38 is formed on the facing surface of the outer surface. The facing surfaces are in contact or close proximity to each other. This allows the administration device 10 to prevent leakage of the administered substance from the release hole 38 of the loop tube 30 disposed in the lumen 26 of the shaft 20 by the contact or close proximity of the facing surfaces of the loop tube 30. Furthermore, because the portion of the loop tube 30 extending distally from the first end 31 and the portion extending distally from the second end 32 are housed in the common lumen 26, the outer diameter of the shaft 20 can be reduced, thereby reducing invasiveness.

[0054] 6 , the second end 32 of the loop tube 30 and the tip of the pusher 50 may be detachably connected. As an example, the second end 32 of the loop tube 30 has a female thread 41, and the tip of the pusher 50 has a male thread 52 that can be threaded into the female thread 41. Alternatively, the arrangement of the male and female threads may be reversed. Alternatively, the second end 32 of the loop tube 30 and the tip of the pusher 50 may be connected by a member that can be burned off by heating, and a heating coil connected to a conductor extending from the first end 31 of the loop tube 30 or the proximal end of the pusher 50 may be disposed at this location. In this manner, the heating coil can be heated by passing an electric current through a conductor located outside the body, burning off the member between the second end 32 of the loop tube 30 and the tip of the pusher 50, allowing the tip of the pusher 50 to be removed from the second end 32 of the loop tube 30.

[0055] 7, the loop tube 30 may have a reinforcing wire 41. The reinforcing wire 41 is disposed, for example, over all or part of the loop 40 and embedded in the resin material forming the loop tube 30. This allows the shape of the loop 40 formed by the loop tube 30 to be properly maintained. Furthermore, when the second end 32 is extruded from the second opening 24, the reinforcing wire 41 can prevent the loop tube 30 from bending on the distal side of the shaft 20 as shown in FIG.

[0056] 8, the first lumen 21 and the second lumen 22 may be joined to form a single lumen at the distal end of the shaft 20. That is, the distal end 25A of the partition 25 is located closer to the proximal end than the distal end of the shaft 30. This allows a portion or all of the loop 40 to be contained within the shaft 30. This allows the outer diameter of the distal end of the administration device 10 to be reduced. The proximal end of the partition 25 may be located at the proximal end of the shaft 20 or closer to the distal end than the proximal end of the shaft 20.

[0057] Suitable materials for the reinforcing wire 41 include, for example, a shape memory alloy that can be given a shape memory effect or superelasticity by heat treatment, stainless steel, etc. Suitable shape memory alloys include Ni-Ti, Cu-Al-Ni, Cu-Zn-Al, and combinations thereof. The reinforcing wire 41 may be formed from a single wire rod or multiple wire rods. [Explanation of symbols]

[0058] 10. Administration Device 20 shaft 21 First Lumen (Lumen) 22 Second Lumen (Lumen) 23 First opening (opening) 24 Second opening (opening) 25 Bulkhead 30 Loop Tube 31 First end 32 Second end 36 supplied lumens 37 Pipe wall 38 Discharge hole 40 Loops 41 Reinforcing wire 50 Pusher 51 Visible Marker 60 Stopper X Long axis direction

Claims

1. 1. An administration device for administering a substance to a surface of a living organ, comprising: a shaft extending longitudinally between a distal end and a proximal end and having at least one lumen opening at the distal end; An administration device characterized by having a loop tube, which is a tubular body extending between a first end and a second end, protruding from the first end toward the second end through one of the openings to the outside of the shaft, forming a loop and being accommodated inside the shaft through one of the openings, having a plurality of release holes in the tubular wall between the first end and the second end, and at least a portion of which is slidable in the longitudinal direction of the lumen.

2. The administration device of claim 1 , wherein the plurality of release holes are arranged side by side along the longitudinal axis of the loop tube at positions inside the loop.

3. There are at least two lumens; An administration device as described in claim 1 or 2, characterized in that the portion of the loop tube extending distally from the first end and the portion extending distally from the second end are positioned in different lumens.

4. The administration device according to claim 1, further comprising a pusher for pushing the second end of the loop tube disposed in the lumen of the shaft in a distal direction.

5. The dispensing device according to claim 4, further comprising a stopper that restricts movement of the pusher within the shaft.

6. 6. The dispensing device of claim 5, wherein the stopper is removable from the pusher.

7. The administration device according to any one of claims 4 to 6, characterized in that the pusher has a visual marker on its outer surface indicating its position in the longitudinal direction.

8. The administration device described in claim 1 or 2, characterized in that the portion extending from the first end of the loop tube toward the tip and the portion extending from the second end toward the tip are contained in a common lumen, with their outer surfaces facing each other, and the release hole being formed on the opposing surfaces of the outer surfaces.

9. 3. The administration device according to claim 1, wherein the loop tube has a reinforcing wire.

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