Liquid storage container, liquid-contained container, manufacturing method of liquid-contained container, and manufacturing method of liquid

Abstract

To provide a liquid storage container from which a liquid can be taken out safely.SOLUTION: A liquid storage container 10 includes: a storage part 20; a seal part 30 positioned in the circumference of the storage part 20; and at least three ports 40, 50, 60 respectively connected to the seal part 30. The at least three ports 40, 50, 60 are arranged side by side along the seal part 30. The at least three ports include the first port 40, the second port 50, and the third port 60. The second port 50 is a non-communication port having a partition wall 54 for dividing an inner side and an outer side of the storage part 20. A boundary E2 between the second port 50 and the storage part 20 is positioned on an outer side from the storage part 20 in an axial direction of the second port 50 compared with boundaries between the other ports 40, 60 and the storage part 20.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present disclosure relates to a liquid storage container, a container filled with liquid, a method for manufacturing a container filled with liquid, and a method for manufacturing a liquid. [Background technology]

[0002] Resin bags are sometimes used to store liquids such as blood or medicinal liquids (see, for example, Patent Document 1). Resin bags are usually provided with one or more ports. Liquids such as blood or medicinal liquids are introduced into the bag or removed from the bag via the ports provided in the bag. When removing liquid from the bag, a puncturing device such as a bottle needle or an infusion set may be inserted into the septum of the port to break the septum. In such a case, if the pressure inside the bag is higher than the pressure outside the bag, the liquid may spill out of the bag. In this case, the liquid inside the bag may be exposed to the surroundings or the amount of liquid may decrease. Furthermore, some liquid may remain in the bag and not be removed. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2006-142059 Summary of the Invention [Problem to be solved by the invention]

[0004] The present disclosure provides a liquid storage container that makes it easy to safely dispense liquid. [Means for solving the problem]

[0005] The embodiments of the present disclosure relate to the following [1] to

[11] .

[0006] [1] A liquid storage container comprising: a storage section; a sealing section located around the storage section; and at least three ports each connected to the sealing section, wherein the at least three ports are arranged in a line along the sealing section, and the at least three ports include a first port, a second port, and a third port, wherein the second port is a non-communicating port having a partition wall separating the inside and outside of the storage section, and the boundary between the second port and the storage section is located further outward from the storage section in the axial direction of the second port than the boundaries between the other ports and the storage section.

[0007] [2] The liquid storage container according to [1], wherein the first port is a communication port that connects the inside and outside of the storage section.

[0008] [3] A liquid storage container according to [1] or [2], wherein the second port is covered by a lid portion that is breathable and has bacterial barrier properties.

[0009] [4] A liquid storage container described in any one of [1] to [3], wherein the first port has a thick-walled portion located outside the sealing portion and a thin-walled portion located farther from the sealing portion than the thick-walled portion, and the thickness of the thin-walled portion is thinner than the thickness of the thick-walled portion.

[0010] [5] A liquid storage container as described in [4], in which a variable thickness portion having a variable thickness is located between the thin portion and the thick portion.

[0011] [6] A liquid storage container as described in [4] or [5], wherein the first port is covered with a cap, and the cap contacts the outer surface of the first port at a position closer to the sealing portion than the thin-walled portion.

[0012] [7] A liquid storage container according to [6], wherein the inner surface of the cap has a protrusion that contacts the outer surface of the first port.

[0013] [8] A liquid storage container according to any one of [1] to [7], which is a container for cryopreservation.

[0014] [9] A liquid-containing container comprising the liquid storage container described in any one of [1] to [8] and liquid contained in the storage section of the liquid storage container.

[0015]

[10] A method for manufacturing a liquid-filled container, comprising the steps of preparing a liquid storage container described in any one of [1] to [8], and storing liquid in the storage section of the liquid storage container.

[0016]

[11] A method for producing a liquid, comprising the steps of preparing a container containing the liquid described in [9], and obtaining the liquid by inserting a puncture member into the non-communicating port of the container containing the liquid. [Effects of the Invention]

[0017] According to the present disclosure, liquid can be safely removed from a liquid-containing container. [Brief explanation of the drawings]

[0018] [Figure 1] FIG. 1 is a front view showing a liquid storage container according to one embodiment. [Figure 2] FIG. 2 is a partially enlarged front view showing a liquid storage container according to one embodiment. [Figure 3] FIG. 3 is a longitudinal cross-sectional view showing the first port before sealing. [Figure 4] 4(A) and 4(B) are longitudinal cross-sectional views showing the first port after sealing. [Figure 5] FIG. 5 is a longitudinal cross-sectional view showing the first port covered with a cap. [Figure 6] FIG. 6 is a longitudinal cross-sectional view showing a modified example of the first port covered with a cap. [Figure 7] FIG. 7 is a perspective view showing a state in which the first port covered with the cap is attached to the seal portion. [Figure 8] FIG. 8 is a longitudinal cross-sectional view showing the second port. [Figure 9]9(A) and 9(B) are diagrams showing the second port covered with a lid portion. [Figure 10] 10(A)-(D) are diagrams showing a method for manufacturing a liquid-filled container according to one embodiment. [Figure 11] 11(A) to 11(C) are front views showing a liquid-filled container according to one embodiment. [Figure 12] FIG. 12 is a front view showing a liquid storage container according to a first modified example. [Figure 13] FIG. 13 is a front view showing a liquid storage container according to a second modified example. [Figure 14] FIG. 14 is a front view showing a liquid storage container according to a third modified example. [Figure 15] FIG. 15 is a front view showing a liquid storage container according to a fourth modified example. [Figure 16] FIG. 16 is a front view showing a liquid container according to a fifth modified example. [Figure 17] FIG. 17 is a front view showing another example of a liquid container according to the fifth modified example. [Figure 18] FIG. 18 is a front view showing another example of a liquid container according to the fifth modified example. [Figure 19] 19(A) to 19(E) are cross-sectional views showing the relationship between the attachment positions of the label and the seal portion in the fifth modified example. [Figure 20] FIG. 20 is a front view showing another example of a liquid storage container according to the fifth modified example. [Figure 21] FIG. 21 is a front view showing another example of a liquid storage container according to the fifth modified example. DETAILED DESCRIPTION OF THE INVENTION

[0019] An embodiment will be described in detail below with reference to the drawings. The figures shown below are schematic illustrations. Therefore, the size and shape of each part are appropriately exaggerated for ease of understanding. Furthermore, appropriate modifications can be made within the scope of the technical concept. In the figures shown below, identical parts are designated by the same reference numerals, and some detailed descriptions may be omitted. Furthermore, the numerical values, such as dimensions, and material names of each component described in this specification are examples of an embodiment. The numerical values, such as dimensions, and material names of each component are not limited to these and can be selected and used as appropriate. In this specification, terms specifying shapes or geometric conditions, such as parallel, orthogonal, and perpendicular, not only have their strict meanings but also include substantially the same state.

[0020] In this specification, the terms "top" and "top portion" refer to the direction in which liquid is extracted using the second port 50 as viewed from the storage portion 20. The terms "bottom" and "bottom portion" refer to the opposite direction to the direction in which liquid is extracted using the second port 50 as viewed from the storage portion 20. Typically, when breaking the partition 54 of the second port 50 with a syringe needle or a bottle needle, the top portion of the liquid storage container 10 faces vertically upward, and the bottom portion of the liquid storage container 10 faces vertically downward.

[0021] The liquid storage container according to this embodiment will be described in detail below, but the embodiment is not limited to the following description.

[0022] The configuration of a liquid storage container according to this embodiment will be described with reference to Fig. 1. Fig. 1 is a front view showing a liquid storage container 10 according to this embodiment.

[0023] [Liquid storage container] As shown in FIG. 1 , the liquid storage container 10 includes a storage section 20, a sealing section 30, and at least three ports 40, 50, and 60. The sealing section 30 is located around the periphery of the storage section 20. The at least three ports 40, 50, and 60 are each connected to the sealing section 30. The at least three ports are arranged in a row along the sealing section 30. The at least three ports include a first port 40, a second port 50, and a third port 60. The second port 50 is a non-communicating port having a partition wall 54 that separates the inside and outside of the storage section 20. A boundary E2 between the second port 50 and the storage section 20 is located further outward from the storage section 20 in the axial direction of the second port 50 than boundaries E1 and E3 between the other ports 40 and 60 and the storage section 20.

[0024] The liquid storage container 10 may also be called a bag. When the liquid storage container 10 is used for cryopreservation, it may also be called a cryopreservation container.

[0025] [Containment section] The storage section 20 is a space capable of storing a liquid such as a cell or a biological sample. The outer edge of the storage section 20 has multiple (four) sides 21 to 24. Specifically, the storage section 20 is surrounded by a storage section top side 21, a storage section first side 22, a storage section second side 23, and a storage section bottom side 24.

[0026] The storage unit top 21 forms the top of the storage unit 20. The storage unit top 21 has a top convex portion 25 and two top side portions 26a, 26b. The top convex portion 25 protrudes outward (in the direction of liquid removal) when viewed from the storage unit 20. A second boundary E2, which is the boundary between the second port 50 and the storage unit 20, is located on the top convex portion 25. The two top side portions 26a, 26b are located on either side of the top convex portion 25. A first boundary E1, which is the boundary between the first port 40 and the storage unit 20, is located on one top side portion 26a. A third boundary E3, which is the boundary between the third port 60 and the storage unit 20, is located on the other top side portion 26b.

[0027] The storage section bottom edge 24 forms the bottom of the storage section 20. The storage section bottom edge 24 has a bottom convex edge 27 and two bottom side edges 28a, 28b. The bottom convex edge 27 protrudes inward (in the direction in which the liquid is removed) when viewed from the storage section 20. The two bottom side edges 28a, 28b are located on either side of the bottom convex edge 27.

[0028] The first storage side 22 extends along one side of the storage section 20 from the top side 21 to the bottom side 24. The second storage side 23 extends along the other side of the storage section 20 from the top side 21 to the bottom side 24.

[0029] Since liquid tends to accumulate at the corners of the container 20, it is preferable to round or bevel the corners, which allows the appropriate amount of liquid to be administered and prevents the valuable liquid from being wasted.

[0030] While the capacity of the storage section 20 is not particularly limited, the smaller the size of the liquid storage container 10 and the greater the amount of liquid stored, the more readily the effects of this embodiment can be achieved. For example, the internal dimensions of the storage section 20 are 50 mm to 150 mm, preferably 70 mm to 120 mm, and more preferably 90 mm to 100 mm. Here, the internal dimensions of the storage section 20 refer to the vertical distance L1 and horizontal distance L2 of the storage section 20. The vertical distance L1 of the storage section 20 refers to the shortest distance between the top side portions 26a, 26b and the bottom side portions 28a, 28b. The horizontal distance L2 of the storage section 20 refers to the shortest distance between the first storage section side edge 22 and the second storage section side edge 23. For example, the internal dimensions of the storage section 20 are a vertical distance L1 of 100 mm and a horizontal distance L2 of 85 mm.

[0031] The liquid contained in the container 20 may be a medicinal solution such as a pharmaceutical product. Specific examples of such medicinal solutions include antirheumatic drugs, insulin preparations, sugar solutions such as glucose, electrolyte correction solutions such as sodium chloride and potassium lactate, protein preparations, antibody drugs, contrast agents, protease inhibitors, fat emulsions, antibiotics, anticancer drugs, anticoagulants, anesthetics, heparin calcium anticoagulants, and peritoneal dialysis solutions. Specific examples of medicinal solutions include so-called premixed preparations prepared by dissolving preparations such as analgesics, antipyretics, antiemetics, antitussives, antihistamines, antiallergic agents, bronchodilators, steroids, antiarrhythmic agents, and antiepileptic drugs in sterile water such as RO water or distilled water or physiological saline. Furthermore, the medicinal liquid may be a biological product such as a vaccine for influenza, tetanus, pneumococcus, polio, Japanese encephalitis, rubella, measles, yellow fever, Hib, hepatitis, chickenpox, rabies, rotavirus, mumps, cervical cancer, MR, DT, DPT, etc. Furthermore, the medicinal liquid may be a biological cell such as bone marrow or lymphocyte. The pharmaceutical solution may also be, for example, a cell preparation, specifically, hepatoma cells, hepatocytes (liver parenchymal cells), Kupffer cells, endothelial cells such as vascular endothelial cells and corneal endothelial cells, fibroblasts, osteoblasts, osteoclasts, periodontal ligament-derived cells, epidermal cells such as epidermal keratinocytes, epithelial cells such as tracheal epithelial cells, gastrointestinal epithelial cells, cervical epithelial cells, and corneal epithelial cells, mammary gland cells, pericytes, muscle cells such as smooth muscle cells and cardiac muscle cells, kidney cells, pancreatic islet cells of Langerhans, nerve cells such as peripheral nerve cells and optic nerve cells, chondrocytes, bone cells, or stem cells, embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells), etc. Examples of stem cells include mesenchymal stem cells, hematopoietic stem cells, vascular stem cells, neural stem cells, intestinal epithelial stem cells, adipose stem cells, skin stem cells, periodontal tissue stem cells, ciliary body stem cells, corneal limbal stem cells, and visceral stem cells.

[0032] The liquid contained in the container 20 may be a cell suspension. The cell suspension includes a cell preservation solution and cells. The cells may be, in particular, human mesenchymal stem cells (hMSCs). The cell preservation solution may include, for example, water, an electrolyte, and a cryoprotectant. The electrolyte may include, for example, Na ions, K ions, Ca ions, chloride ions, lactate ions, acetate ions, or bicarbonate ions. The cryoprotectant may include, for example, dimethyl sulfoxide or glycerol. When the electrolyte is dissolved in water, the pH of the liquid containing the electrolyte and water may be in the range of 6.5 to 7.5. The osmotic pressure ratio of the liquid containing the electrolyte and water to physiological saline may be 0.85 to 0.95, preferably 0.9.

[0033] The amount of liquid contained in the storage unit 20 may be 5 mL to 60 mL, preferably 10 mL to 40 mL, and more preferably 15 mL to 30 mL. As an example, the amount of liquid contained in the storage unit 20 is 16 mL or 25 mL.

[0034] The liquid storage container 10 is constructed, for example, by joining a first film 11 and a second film 12 together by heat welding or the like. The first film 11 is the film that constitutes the front surface of the liquid storage container 10 (the surface on the side shown in FIG. 1), and the second film 12 is the film that constitutes the back surface of the liquid storage container 10 (the surface behind the front surface).

[0035] [Sealing part] In FIG. 1, a sealed portion 30 is located around the periphery of the storage portion 20. The sealed portion 30 is a portion of the first film 11 and the second film 12 that is formed by heat welding. The storage portion 20 is surrounded by the sealed portion 30 over the entire periphery. In the manufacturing process of the liquid storage container 10, the first film 11 and the second film 12 may be prepared as separate films that are separated from each other, or may be prepared as a continuous film. There are no particular limitations on the type of liquid storage container 10 as long as it can properly store and seal the liquid. For example, the liquid storage container 10 may be configured as a three-sided sealed bag or a two-sided sealed bag.

[0036] As shown in FIG. 1 , the seal portion 30 formed by heat-sealing the films includes a top seal portion 31, a first side seal portion 32, a second side seal portion 33, and a bottom seal portion 34. The top seal portion 31 forms the top of the liquid storage container 10. Three ports 40, 50, and 60 are provided in the top seal portion 31. That is, the three ports 40, 50, and 60 are attached to the top seal portion 31 by heat-sealing the first film 11 and the second film 12 with the three ports 40, 50, and 60 sandwiched between them. The first side seal portion 32 extends from the top seal portion 31 to the bottom seal portion 34 along one side of the liquid storage container 10. The second side seal portion 33 extends from the top seal portion 31 to the bottom seal portion 34 along the other side of the liquid storage container 10. The bottom seal portion 34 forms the bottom of the liquid storage container 10. The top seal portion 31, the first side seal portion 32, the second side seal portion 33, and the bottom seal portion 34 are formed by heat welding the first film 11 and the second film 12 together.

[0037] A suspension hole 35 is located in the bottom seal portion 34. The suspension hole 35 penetrates the bottom seal portion 34 in the thickness direction. The suspension hole 35 is circular in a plan view, but may be polygonal, such as triangular or rectangular, or may be polygonal with rounded corners. The suspension hole 35 is located in the longitudinal center of the bottom seal portion 34, but is not limited to this, and may be offset from the longitudinal center of the bottom seal portion 34. By providing the suspension hole 35 in the liquid storage container 10, the liquid storage container 10 can be used by hanging it using the suspension hole 35 during intravenous drip.

[0038] The outer edge of the sealed portion 30 has multiple (four) sides 36a to 36d. Specifically, the sealed portion 30 includes a sealed portion top side 36a, a sealed portion first side side 36b, a sealed portion second side side 36c, and a sealed portion bottom side 36d. The sealed portion top side 36a constitutes the top side of the sealed portion 30. The sealed portion first side side 36b constitutes one side side of the sealed portion 30. The sealed portion second side side 36c constitutes the other side side of the sealed portion 30. The sealed portion bottom side 36d constitutes the bottom side of the sealed portion 30.

[0039] The size of the outer periphery of the sealed portion 30 is not particularly limited, but the vertical distance L3 and horizontal distance L4 of the outer periphery of the sealed portion 30 are 60 mm to 200 mm, preferably 80 mm to 150 mm, and more preferably 95 mm to 125 mm. The vertical distance L3 of the outer periphery of the sealed portion 30 refers to the shortest distance between the sealed portion top edge 36a and the sealed portion bottom edge 36d. The horizontal distance L4 of the sealed portion 30 refers to the shortest distance between the sealed portion first side edge 36b and the sealed portion second side edge 36c. As an example, the vertical distance L3 of the outer periphery of the sealed portion 30 is 125 mm, and the horizontal distance L4 is 95 mm.

[0040] The thickness of the sealing portion 30 is not particularly limited, but it is preferable to seal it to a thickness approximately equal to the combined thickness of the first film 11 and the second film 12 of the storage portion 20, as this improves the impact resistance when the liquid storage container 10 is frozen. For example, if polyethylene films with a thickness of 260 μm are used as the first film 11 and the second film 12, it is recommended to perform welding processing so that the thickness of the sealing portion 30 is 470 μm or more and 570 μm or less.

[0041] The material constituting the first film 11 and the second film 12 is a thermoplastic resin that can be thermally welded by heat sealing or the like. The first film 11 and the second film 12 are preferably capable of aseptically storing liquids such as cells and biological samples inside the storage section 20 using liquid nitrogen, a cryogenic freezer, or the like when forming the liquid storage container 10. The first film 11 and the second film 12 desirably have physical properties that allow them to withstand temperatures below 0°C, preferably below −80°C, more preferably below −150°C (the temperature in a cryogenic freezer or in the vapor phase of liquid nitrogen), and particularly preferably below −196°C (the temperature of liquid nitrogen). Suitable materials for such materials include thermoplastic resins, particularly polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), ethylene-vinyl acetate copolymer, and fluororesin. Among these, polyethylene is more preferred for its thermoplasticity, freeze resistance, and processability. The first film 11 and the second film 12 may be made of the same material as the other components attached to the first film 11 and the second film 12. Examples of other members that can be attached to the first film 11 and the second film 12 include ports 40, 50, 60 and labels 70 (described later). In this case, the adhesive strength between the first film 11 and the second film 12 and the other members is increased.

[0042] [port] Next, the three ports 40, 50, and 60 connected to the seal portion 30 will be described.

[0043] As described above, the three ports 40, 50, 60 are arranged side by side along the top seal portion 31 of the seal portion 30. The three ports 40, 50, 60 include a first port 40, a second port 50, and a third port 60. The first port 40, the second port 50, and the third port 60 are arranged side by side in this order from the first side seal portion 32 side toward the second side seal portion 33 side.

[0044] 2 is a partially enlarged view of the top seal portion 31 and its periphery in FIG. 1 . As shown in FIG. 2 , the second boundary E2, which is the boundary between the second port 50 and the accommodating portion 20, is located further outward in the axial direction of the second port 50 than the first boundary E1, which is the boundary between the first port 40 and the accommodating portion 20. Similarly, the second boundary E2, which is the boundary between the second port 50 and the accommodating portion 20, is located further outward in the axial direction of the second port 50 than the third boundary E3, which is the boundary between the third port 60 and the accommodating portion 20. Here, "outward in the axial direction of the second port 50" refers to the side farther from the bottom seal portion 34 in the direction of the central axis A2 of the second port 50. Note that the first boundary E1 and the third boundary E3 are located at the same position in the axial direction of the second port 50, but may be located at different positions.

[0045] In the axial direction of the second port 50, the distance D1 between the second boundary E2 and the first boundary E1 and the third boundary E3 may be, for example, 3 mm or more and 20 mm or less, preferably 4 mm or more and 15 mm or less, and more preferably 5 mm or more and 12 mm or less.

[0046] The angle C1 between the extension line of the top side portions 26a, 26b and the inclined side 25d of the top convex portion 25 may be, for example, 15 degrees or more and 65 degrees or less, preferably 20 degrees or more and 60 degrees or less, and more preferably 25 degrees or more and 50 degrees or less.

[0047] It is preferable that the inclined side 25d and each of the ports 40, 50, 60 are spaced apart from each other. A sealing margin S for each of the ports 40, 50, 60 exists between the inclined side 25d and each of the ports 40, 50, 60. In this case, operability is improved when welding each of the ports 40, 50, 60 to the top seal portion 31.

[0048] [Port 1] The first port 40 is located on one of the top side portions 26a of the top seal portion 31. A first boundary E1, which is a boundary between the first port 40 and the storage portion 20, exists on the one of the top side portions 26a. The first port 40 may be referred to as a filling port. The first port 40 may also be a communication port. A communication port is a port that does not have a partition wall inside and that communicates between the inside and outside of the storage portion 20, at least before being sealed. The first port 40 may also be a port used when filling the storage portion 20 with liquid. A filling nozzle 91 (see FIG. 10(A)) is passed through a first opening 45 of the first port 40 to fill the liquid. The first port 40 may then be physically or thermally sealed to hermetically seal the storage portion 20 and maintain the cleanliness of the interior.

[0049] 3 is a longitudinal cross-sectional view showing the first port 40, which is a communication port, and shows the first port 40 before sealing. As shown in FIG. 3, the first port 40 has a first connecting portion 41, a thick-walled portion 42, a thickness-varying portion 43, a thin-walled portion 44, and a first extending portion 46.

[0050] The first connecting portion 41 is connected to the top seal portion 31 by welding or the like. In this case, the first connecting portion 41 is connected to the first film 11 and the second film 12, respectively. The first connecting portion 41 may be boat-shaped when viewed from the central axis A1 of the first port 40. The first connecting portion 41 has a shape in which its thickness (distance in the thickness direction of the top seal portion 31) decreases with increasing distance from the central axis A1 of the first port 40. When viewed from the central axis A1, the portion of the first connecting portion 41 where the thickness decreases may be a straight line. When viewed from the central axis A1, the first connecting portion 41 may have a shape that is line-symmetrical with respect to a line that passes through the central axis A1 and extends in the thickness direction of the top seal portion 31. By forming the first connecting portion 41 in a boat shape, the adhesive strength between the first connecting portion 41 and the top seal portion 31 can be increased and stress at the adhesive interface can be reduced. The axial distance (vertical width) d2 of the first connecting portion 41 is not particularly limited. However, the longer the axial distance d2, the stronger the adhesive strength between the first connecting portion 41 and the top seal portion 31, improving impact resistance during freezing, etc. The axial distance d2 of the first connecting portion 41 is preferably, for example, 5 mm or more, and more preferably 8 mm or more.

[0051] The thick-walled portion 42 is located outward from the top seal portion 31. The thick-walled portion 42 is directly adjacent to the first connecting portion 41. The thick-walled portion 42 has a cylindrical shape. The thickness t1 of the thick-walled portion 42 is thicker than the thickness t2 of the thin-walled portion 44. The thick-walled portion 42 may be referred to as a second body portion. The thickness t1 of the thick-walled portion 42 may be 0.4 mm or more and 1.6 mm or less, and is preferably 0.6 mm or more and 1.4 mm or less.

[0052] The thickness-varying portion 43 is located between the thin portion 44 and the thick portion 42. The thickness-varying portion 43 is directly adjacent to the thick portion 42. The thickness-varying portion 43 is directly adjacent to the thin portion 44. The thickness-varying portion 43 is a portion where the thickness varies. The thickness of the thickness-varying portion 43 gradually decreases from the thick portion 42 side toward the thin portion 44 side. The length d3 of the thickness-varying portion 43 may be 2 mm or more and 15 mm or less, and preferably 5 mm or more and 10 mm or less. By setting the length d3 of the thickness-varying portion 43 to 15 mm or less, loss of contents can be reduced. By setting the length d3 of the thickness-varying portion 43 to 2 mm or more, deterioration of sealing performance and durability can be suppressed. By providing the thickness-varying portion 43 between the thin portion 44 and the thick portion 42, stress is dispersed when stress is applied to the boundary between the thin portion 44 and the thick portion 42, and deformation or breakage can be suppressed.

[0053] The thin-walled portion 44 is located farther from the seal portion 30 than the thick-walled portion 42 and the thickness-varying portion 43. The thin-walled portion 44 has a cylindrical shape before being sealed. The thin-walled portion 44 has a first opening 45. The thickness t2 of the thin-walled portion 44 is thinner than the thickness t1 of the thick-walled portion 42. The thin-walled portion 44 may be referred to as a first body portion. The thickness t2 of the thin-walled portion 44 may be 0.2 mm or more and 0.8 mm or less, and preferably 0.3 mm or more and 0.7 mm or less. By setting the thickness t2 of the thin-walled portion 44 to 0.8 mm or less, it is possible to prevent the thin-walled portion 44 from becoming difficult to heat seal. By setting the thickness t2 of the thin-walled portion 44 to 0.2 mm or more, it is possible to prevent a decrease in the durability of the thin-walled portion 44. The length d4 of the thin-walled portion 44 may be 2 mm or more and 20 mm or less, and preferably 5 mm or more and 10 mm or less. By setting the length d4 of the thin-walled portion 44 to 20 mm or less, loss of the liquid content can be reduced. By setting the length d4 of the thin-walled portion 44 to 2 mm or more, deterioration of the sealing ability and durability of the thin-walled portion 44 can be suppressed. When heat-sealing the thin-walled portion 44, the thin-walled portion 44 is crushed so that the opposing inner surfaces of the first opening 45 of the thin-walled portion 44 meet, thereby sealing (see Figures 4(A) and (B)). Therefore, by making the thin-walled portion 44 thin, the thin-walled portion 44 becomes easier to crush and heat-seal.

[0054] The first extension portion 46 is located inside the top seal portion 31. The first extension portion 46 is directly adjacent to the first connection portion 41. The first extension portion 46 has a generally cylindrical shape. The first extension portion 46 extends from the first connection portion 41 toward the inside of the storage portion 20. By providing the first extension portion 46, the first film 11 and the second film 12 are less likely to stick to each other around the first port 40, making it easier for the liquid in the storage portion 20 to flow. It is also preferable that a first slit 46a is provided in the first extension portion 46. In this case, the fluidity of the liquid is further improved around the first port 40. Furthermore, the improved fluidity makes it easier for the liquid to enter the storage portion 20 when filling it with liquid.

[0055] As shown in Fig. 5, the first port 40 may be covered by a cap 47. The cap 47 closes the first opening 45 before filling the liquid through the first port 40. The cap 47 covers at least the periphery of the thin-walled portion 44. The cap 47 prevents foreign matter from entering the storage portion 20 before filling the liquid through the first port 40. The cap 47 may also be called a protective cap.

[0056] The cap 47 contacts the outer surface of the first port 40 at a position closer to the first connecting portion 41 than the thin-walled portion 44. The cap 47 may contact the outer surface of the first port 40 at the thick-walled portion 42 (see FIG. 5). Alternatively, the cap 47 may contact the outer surface of the first port 40 at the variable-thickness portion 43 (see FIG. 6). It is preferable that the cap 47 does not contact the outer surface of the thin-walled portion 44. This prevents the relatively thin-walled thin-walled portion 44 from being deformed by the cap 47, thereby preventing deformation or damage to the thin-walled portion 44. As a result, it is possible to prevent the sealing performance of the thin-walled portion 44 from being impaired after the thin-walled portion 44 is heat-welded.

[0057] The cap 47 has a cap top portion 47a and a cap body portion 47b. The cap body portion 47b may be provided perpendicular to the cap top portion 47a or may be provided at an angle to the cap top portion 47a. The length of the cap body portion 47b may be long enough to cover the thin-walled portion 44 of the first port 40. The inner diameter of the portion of the cap body portion 47b that does not contact the first port 40 is desirably larger than the outer diameter of the thin-walled portion 44 of the first port 40 by 0.5 mm to 1.5 mm.

[0058] The cap 47 may have a protrusion 47c on the inner surface thereof that contacts the outer surface of the first port 40. The protrusion 47c is formed around the entire periphery of the inner surface of the cap 47. The contact between the protrusion 47c and the first port 40 ensures the cleanliness of the first port 40 and the interior of the storage section 20. The first port 40 may have a recess (not shown) that fits into the protrusion 47c. As shown in FIG. 5, by providing the protrusion 47c on the inner surface of the cap 47, a space SP is formed between the outer surface of the first port 40 and the cap 47. This means that the surface area of ​​the cap 47 is increased. This makes it easier for the cap 47 to absorb the radiation sterilization odor emanating from the side of the first port 40, reducing discomfort during use.

[0059] The material of the cap 47 is not particularly limited as long as it is a material that can protect the first port 40. For example, the material of the cap 47 can be an elastic material such as silicone or rubber. Among these, a silicone cap 47 is more preferable because it has excellent weather resistance and easily absorbs odors in the air. The thickness of the cap 47 is not particularly limited as long as it is a thickness that can protect the first port 40. The thickness of the cap 47 may be, for example, 2 mm or more and 15 mm or less.

[0060] 7, the cap 47 may have legs 48 to prevent it from rotating around its longitudinal central axis. Specifically, a plurality of legs 48 may be arranged at the end of the cap body 47b. The configuration and number of the legs 48 are not particularly limited as long as they are configured to sandwich the top seal portion 31.

[0061] [2nd port] As shown in FIG. 2 , the second port 50 is located in the top protrusion 25 of the top seal portion 31. The top protrusion 25 has a second boundary E2, which is the boundary between the second port 50 and the storage section 20. The second port 50 may be a non-communicating port. A non-communicating port has a partition 54 therein and does not communicate between the inside and outside of the storage section 20 before use. The second port 50 may be a port for extracting liquid contained in the storage section 20 and administering it to a patient, etc. The second port 50 may also be called an intravenous port. When in use, the partition 54 of the second port 50 is broken with a puncture member 94 such as a syringe needle or a bottle needle, and the liquid in the storage section 20 is extracted to the outside through the puncture member 94.

[0062] 8 is a longitudinal cross-sectional view showing the second port 50, which is a non-communicating port. As shown in FIG. 8, the second port 50 has a second connection portion 51, a body portion 52, a partition wall 54, and a second extension portion 56.

[0063] The second connection portion 51 is connected to the top seal portion 31 by welding or the like. The second connection portion 51 is connected to the first film 11 and the second film 12, respectively. The second connection portion 51 may be boat-shaped when viewed from the center axis A2 of the second port 50. The second connection portion 51 has a shape in which its thickness (distance in the thickness direction of the top seal portion 31) decreases with increasing distance from the center axis A2 of the second port 50. When viewed from the center axis A2, the portion of the second connection portion 51 where the thickness decreases may be a straight line. When viewed from the center axis A2, the second connection portion 51 may have a shape that is line-symmetrical with respect to a line that passes through the center axis A2 and extends in the thickness direction of the top seal portion 31. By making the second connection portion 51 boat-shaped, the adhesive strength between the second connection portion 51 and the top seal portion 31 can be increased. Furthermore, stress at the adhesive interface can be reduced. The axial distance (vertical width) d5 of the second connection portion 51 is not particularly limited. However, the longer the axial distance d5, the stronger the adhesive strength between the second connection part 51 and the top seal part 31, improving impact resistance during freezing, etc. The axial distance d5 of the second connection part 51 is preferably, for example, 5 mm or more, and more preferably 8 mm or more.

[0064] The body 52 is located outside the top seal portion 31. The body 52 is directly adjacent to the second connection portion 51. The body 52 has a cylindrical shape. The body 52 has a second opening 53. The wall thickness t4 of the body 52 may be 0.4 mm or more and 1.6 mm or less, and preferably 0.6 mm or more and 1.4 mm or less. The diameter of the body 52 is not particularly limited, but it is desirable that it has a diameter that allows connection of a commonly used bottle needle or a puncture member 94 (see FIG. 10(D)) such as an infusion set. For example, if the inner diameter d6 of the body 52 is 5.0 mm or more, a commonly used bottle needle can be connected. In addition, the portion of the body 52 that extends toward the second opening 53 beyond the partition 54 serves as a guide to ensure that the puncture member 94 is inserted in the correct direction. A side wall of the body 52 extends from the partition 54 toward the second opening 53. By inserting the puncturing member 94 along the side wall of the body 52, it is possible to prevent puncturing in the wrong direction. Furthermore, the portion of the body 52 that extends further toward the second opening 53 than the partition wall 54 prevents the puncturing member 94 from falling out after puncturing. Although the appropriate dimension may vary depending on the size of the puncturing member 94, the distance d7 from the partition wall 54 to the second opening 53 is preferably 5 mm or more and 20 mm or less, and more preferably 10 mm or more and 15 mm or less, so that the above function is easily achieved.

[0065] The partition 54 is located inside the body 52. ​​The partition 54 physically separates the portion of the body 52 on the second opening 53 side from the portion on the second connecting portion 51 side. As will be described later, the partition 54 is punctured by a puncturing member 94, such as a bottle needle or an infusion set, when withdrawing liquid from the storage portion 20 through the second port 50. This allows communication between the second opening 53 side and the second connecting portion 51 side of the second port 50. The thickness t5 of the partition 54 is not limited as long as it can be punctured by the puncturing member 94 and has appropriate strength. The thickness t5 of the partition 54 may be, for example, 0.2 mm or more and 0.8 mm or less, and preferably 0.3 mm or more and 0.6 mm or less.

[0066] The second extension portion 56 is located inward from the top seal portion 31. The second extension portion 56 is directly adjacent to the second connection portion 51. The second extension portion 56 has a generally cylindrical shape. The second extension portion 56 extends from the second connection portion 51 toward the inside of the storage portion 20. By providing the second extension portion 56, the first film 11 and the second film 12 are less likely to stick to each other around the second port 50, making it easier for the liquid to flow. It is also preferable that a second slit 56a is provided in the second extension portion 56. In this case, the fluidity of the liquid around the second port 50 is further improved. Furthermore, when the liquid is taken out of the storage portion 20, the amount of liquid remaining in the storage portion 20 can be reduced. In particular, when the liquid storage container 10 is turned upside down (i.e., the second port 50 is facing vertically downward) to take out the liquid, the fluidity of the liquid can be more effectively improved and the amount of liquid remaining in the storage portion 20 can be reduced. Furthermore, when liquid is stored in the storage portion 20, even if the tip of the second extension portion 56 is located in the liquid, the headspace HS (see FIG. 11) inside the storage portion 20 and the internal space of the second extension portion 56 can be directly connected. Therefore, when the puncture member 94 penetrates the partition wall of the second port 50 while the liquid inside the storage portion 20 is under positive pressure, air first flows into the second port 50. This makes it possible to prevent the liquid from leaking and being exposed to the outside.

[0067] As shown in FIGS. 9(A) and 9(B), the second port 50 may be covered by a lid portion 55. The lid portion 55 closes the second opening 53 until the partition 54 of the second port 50 is punctured by a puncture member 94, such as a syringe needle or a bottle needle. The lid portion 55 is spaced apart from the partition 54. The lid portion 55 is adhered to the periphery of the second opening 53 and covers the entire periphery of the second opening 53. The lid portion 55 prevents foreign matter from entering the second port 50 before the puncture member 94 punctures the partition 54 of the second port 50.

[0068] The lid 55 is breathable and has bacterial barrier properties. By providing the second port 50 with a bacterial barrier lid 55, the cleanliness of the partition 54 can be ensured until use. The lid 55 also preferably has easy-peel properties. In this case, the lid 55 can be easily removed when in use.

[0069] The lid portion 55 may have a flange 55a. The flange 55a is a portion of the lid portion 55 that is not in contact with the body portion 52 and is located outside the body portion 52. The flange 55a of the lid portion 55 makes it easier to remove the lid portion 55 during use. In FIGS. 9(A) and 9(B), the lid portion 55 has two flanges 55a, but the number of flanges 55a may be one, or three or more. Furthermore, the easy-peel property can be controlled by coating the lid portion 55 on the second port 50 side with a resin or the like.

[0070] The breathability of the lid portion 55 makes it less likely to deform due to pressure changes during freezing and thawing. This prevents leakage from the lid portion 55, which can prevent the partition wall 54 from losing its cleanliness. In contrast, if a film with low breathability were used for the lid portion 55, particularly if the lid portion 55 had easy-peel properties, a gap could form between the lid portion 55 and the second opening 53 when the lid portion 55 deforms. Furthermore, the breathability of the lid portion 55 allows air containing the radiation sterilization odor trapped in the space between the lid portion 55 and the partition wall 54 to easily escape to the outside. This reduces the discomfort caused by the radiation sterilization odor during use. In contrast, if a film with low breathability were used for the lid portion 55, air containing the radiation sterilization odor could accumulate in the space between the lid portion 55 and the partition wall 54, causing discomfort during use.

[0071] The material of the lid portion 55 is not particularly limited as long as it can be adhered to the second port 50. The material of the lid portion 55 is preferably a breathable material that inhibits the intrusion of bacteria and microorganisms. Specifically, the material of the lid portion 55 may be, for example, a high-density polyethylene fiber nonwoven fabric. Tyvek (registered trademark) may be used as the high-density polyethylene fiber nonwoven fabric. The high-density polyethylene fiber nonwoven fabric may be coated with a coating agent that enhances adhesion to the second opening 53. The air permeability of the lid portion 55 is preferably 150 sec / cc or less, and more preferably 100 sec / cc or less. The air permeability of the lid portion 55 is measured in accordance with JIS P 8117:2009.

[0072] The bacterial barrier LRV of the cover 55 may be 2 or more and 5 or less, or 3 or more and 4 or less. The bacterial barrier LRV of the cover 55 is measured in accordance with the ASTM F1608 method. The LRV (Log Reduction Value) is expressed as log 10 N0-Log 10 This can be calculated using the formula N1, where N0 is the number of colonies in the control and N1 is the number of colonies that penetrated the porous packaging material. ASTM F1608 is the standard test for microbial ranking of porous packaging materials (exposure method) and measures the ability of porous materials to prevent the penetration of bacterial spores. Compared to a completely impermeable control sample (zero microbial penetration), 10 per material 6 It indicates the permeability when exposed to (1 million) colony-forming units (cfu). For example, 10 6 If 10 spores per 100 pieces penetrate, the LRV is 5, and the bacterial barrier is 99.999%. If the LRV is 3, the bacterial barrier can be measured as 99.9%. The higher the LRV number, the better the bacterial barrier. As an example, the bacterial barrier of Tyvek 2FS (registered trademark) is LRV = 3.1.

[0073] [3rd Port] As shown in FIG. 2 , the third port 60 is located on the other top side 26b of the top seal portion 31. The top side 26b includes a third boundary E3 between the third port 60 and the storage unit 20. The third port 60 may be a non-communicating port. The third port 60 may also be a port for filling the storage unit 20 with diluent. The third port 60 may also be referred to as a dilution port. When filling the storage unit 20 with diluent, the partition 54 of the third port 60 is broken using an adapter 92 (described later) or a closed-system dilution set (a tube connected to a container containing the diluent and terminated in a bottle needle) to fill the storage unit 20 with diluent. The third port 60 is then sealed by physical or thermal sealing to maintain the cleanliness of the storage unit 20. The third port 60 may also be physically sealed by utilizing the closing function (e.g., a rubber membrane) of the bottle needle itself, which is fixed in place while connected to the third port 60. Alternatively, the third port 60 may be sealed by physically closing the needle-equipped thermoplastic tube used for dilution with a tube clamp. Alternatively, the third port 60 may be sealed by thermally closing the needle-equipped thermoplastic tube used for dilution (the needle may be a bottle needle) with a tube sealer. Note that the configuration of the third port 60, which is a non-communicating port, is substantially the same as the configuration of the second port 50, so a detailed description thereof will be omitted here.

[0074] In this embodiment, three ports 40, 50, and 60 are connected to the seal portion 30, but the present invention is not limited to this, and four or more ports may be connected to the seal portion 30.

[0075] [Operation of this embodiment] Next, the operation of this embodiment having such a configuration will be described with reference to FIGS. 10(A) to 10(D).

[0076] First, as shown in FIG. 10(A), an empty liquid storage container 10 is prepared, and a liquid such as cells or a biological sample is placed in the storage section 20 of the liquid storage container 10. In this case, the cap 47 is first removed from the first opening 45 of the first port 40. Next, the filling nozzle 91 is inserted into the first port 40, and the liquid such as cells or a biological sample is injected from the filling nozzle 91 into the storage section 20. At this time, the liquid level of the liquid such as cells or a biological sample does not have to reach the top seal section 31.

[0077] Next, as shown in Figure 10(B), the first opening 45 of the first port 40 is sealed. In this case, the thin-walled portion 44 of the first port 40 may be welded by heat sealing or the like. Next, the liquid storage container 10 may be frozen in the storage container, for example, with liquid nitrogen. The liquid storage container 10 is stored or transported in an environment of at least 0°C or below, preferably -80°C or below, more preferably -150°C or below (the temperature of an ultra-low temperature freezer or liquid nitrogen vapor), and particularly preferably -196°C (the temperature of liquid nitrogen).

[0078] In this way, a liquid-filled container 10A is obtained, comprising a liquid storage container 10 and a liquid stored in the storage section 20 of the liquid storage container 10. In this embodiment, such a liquid-filled container 10A is also provided. In addition, in this embodiment, a method for manufacturing the liquid-filled container 10A is also provided, which includes the steps of preparing the liquid storage container 10 and storing the liquid in the storage section 20 of the liquid storage container 10. Note that the steps shown in Figures 10(A) and (B) above may be carried out, for example, by a pharmaceutical company.

[0079] When using a biological sample such as cells, the liquid-containing container 10A is removed from the storage container and thawed. At this time, the liquid storage container 10 may be thawed by immersing it in a warm bath at 37°C to 40°C, for example.

[0080] Next, as shown in FIG. 10(C), a diluent is injected into the storage section 20 of the liquid-containing container 10A to dilute the liquid, such as cells or a biological sample, previously stored in the storage section 20. In this case, an adapter 92 is inserted into the third port 60, and the diluent is injected into the storage section 20 from a syringe 93 containing the diluent. The adapter 92 has a septum-piercing portion at one end and a rubber-like connector at the other end. The septum-piercing portion at one end of the adapter 92 is used to pierce the septum 54 of the third port 60. Then, the syringe 93 is connected to the rubber-like connector at the other end of the adapter 92, and the diluent from the syringe 93 is injected into the storage section 20. This dilutes the liquid, such as cells or a biological sample, in the storage section 20. Next, the syringe 93 is removed from the third port 60, thereby closing the third port 60. Note that the step shown in FIG. 10(C) does not necessarily have to be performed.

[0081] 11, the liquid level of the liquid contained in the container 20 reaches the space between the top convex portion 25 and the top side portions 26a, 26b. A headspace HS exists between the liquid level and the top seal portion 31. Note that the second extension portion 56 of the second port 50 has a second slit 56a (see FIG. 8), so that the headspace HS and the interior of the second port 50 directly communicate with each other.

[0082] Next, as shown in Figure 10(D), a puncture member 94, such as a bottle needle or an infusion set, is inserted into the second port 50. The puncture member 94 penetrates the partition wall of the second port 50, connecting the puncture member 94 to the storage section 20. Thereafter, the liquid inside the storage section 20 is extracted from the second port 50 via the puncture member 94. The steps shown in Figures 10(C) and (D) above may be performed in a medical institution such as a hospital.

[0083] In this embodiment, there is also provided a method for producing a liquid, which includes the steps of preparing a container 10A filled with liquid and obtaining the liquid by inserting a puncture member 94 into the second port 50 of the container 10A filled with liquid.

[0084] However, the internal pressure of the storage section 20 of the liquid storage container 10 does not necessarily coincide with atmospheric pressure. There are cases where the pressure in the storage section 20 becomes positive. In particular, after the step of injecting the diluent shown in FIG. 10(C), the internal pressure in the storage section 20 is likely to become positive. For this reason, when the puncture member 94 penetrates the partition wall 54 of the second port 50, the liquid in the storage section 20 may splash out due to the pressure difference between the inside and outside of the storage section 20. In this case, the liquid in the storage section 20 may leak out through the opening in the partition wall of the second port 50 or through the puncture member 94.

[0085] In contrast, according to the present embodiment, the boundary (second boundary E2) between the second port 50 and the accommodating portion 20 is located outward in the axial direction of the second port 50 than the boundaries (first boundary E1, third boundary E3) between the first port 40 and the third port 60 and the accommodating portion 20. In this way, since the second port 50 is located outward from the first port 40 and the third port 60, air in the accommodating portion 20 tends to collect near the second port 50. Therefore, when the puncture member 94 penetrates the partition wall 54 of the second port 50 while the liquid in the accommodating portion 20 is under positive pressure, air first flows into the second port 50. This makes it possible to prevent leakage and exposure of the liquid in the accommodating portion 20.

[0086] As a comparative example, if the first boundary E1, the second boundary E2, and the third boundary E3 were all located on the same straight line, it would be difficult for the air to gather in one place. In this case, it would be difficult for the air inside the accommodation section 20 to gather near the second port 50.

[0087] Alternatively, it is possible to increase the amount of air in the storage section 20 so that air can be more easily collected near the second port 50 when the puncture member 94 penetrates the partition wall 54 of the second port 50. However, if the amount of air in the storage section 20 is large, the following problems arise.

[0088] (1) The thickness of the liquid becomes uneven. This results in differences in the freezing and thawing times between thick and thin liquid areas. If the liquid contains a cellular preparation or biological sample, the state of the cells may change. (2) The liquid tends to foam. If the liquid contains a cellular preparation or biological sample, damage to the cells is likely to occur. (3) When the liquid-filled container 10A is removed from a frozen state, the air inside the storage section 20 expands, which may cause deformation or rupture of the liquid storage container 10.

[0089] To prevent the above problems, it is preferable to have a small amount of air inside the storage portion 20. According to the present embodiment, as described above, the air inside the storage portion 20 tends to gather near the second port 50. Therefore, even if the amount of air inside the storage portion 20 is small, leakage and exposure of the liquid inside the storage portion 20 can be prevented when the puncture member 94 penetrates the partition wall of the second port 50.

[0090] Furthermore, when liquid is taken out from the second port 50 by turning the liquid storage container 10 upside down (i.e., with the second port 50 facing vertically downward), the liquid in the storage section 20 can be more easily collected near the second port 50. This makes it possible to reduce loss of the liquid, particularly when the liquid in the storage section 20 is valuable.

[0091] [Variations] Next, various modifications of this embodiment will be described with reference to Figures 12 to 21. Figures 12 to 21 are diagrams showing modifications of this embodiment. In Figures 12 to 21, the same parts as those in the embodiment shown in Figures 1 to 12 are given the same reference numerals, and detailed descriptions thereof will be omitted.

[0092] (First Modification) Figure 12 shows a liquid storage container 10 according to a first modified example. In Figure 12, the second port 50 is located at the extreme end of the top seal portion 31. In Figure 12, the first port 40, the third port 60, and the second port 50 are arranged in this order from the first side seal portion 32 toward the second side seal portion 33. This is not a limitation, and the third port 60, the first port 40, and the second port 50 may also be arranged in this order from the first side seal portion 32 toward the second side seal portion 33. According to this modified example, the second port 50 is located at the extreme end of the liquid storage container 10, which makes it easier to remove liquid from the storage portion 20 and also reduces the amount of liquid remaining in the storage portion 20.

[0093] (Second Modification) FIG. 13 shows a liquid storage container 10 according to a second modified example. In FIG. 13, the first boundary E1 and the third boundary E3 are located at different positions in the axial direction of the second port 50. In FIG. 13, the second boundary E2 is located outward of the first boundary E1 and the third boundary E3 in the axial direction of the second port 50. Furthermore, the third boundary E3 is located outward of the first boundary E1 in the axial direction of the second port 50. This is not a limitation, and the first boundary E1 may be located outward of the third boundary E3 in the axial direction of the second port 50. According to this modified example, when injecting diluent with the third port 60 facing upward, the third boundary E3 is injected above the liquid level (E3 is not in contact with the liquid level), which reduces the likelihood of backflow of the liquid. As described above, it is preferable to have a small amount of air in the storage section 20. Therefore, when injecting diluent, the third boundary E3 can be placed above the liquid level under conditions where the amount of air in the storage section 20 is small.

[0094] (Third Modification) Figure 14 shows a liquid storage container 10 according to a third modified example. In Figure 14, the top convex portion 25 has a first convex portion side 25a, a second convex portion side 25b, and a third convex portion side 25c. The first convex portion side 25a is perpendicular to the top side portion 26a. The second convex portion side 25b is perpendicular to the first convex portion side 25a and the third convex portion side 25c. The third convex portion side 25c is perpendicular to the top side portion 26b.

[0095] (Fourth Modification) FIG. 15 shows a liquid storage container 10 according to a fourth modified example. In FIG. 15, the first port 40 does not have a first extension 46. The second port 50 does not have a second extension 56. Similarly, the third port 60 does not have an extension 56. According to this modified example, since the second port 50 does not have a second extension 56, even if the headspace HS (see FIG. 11) is small, it is easy to directly communicate the headspace HS with the interior of the second port 50. Therefore, when the puncture member 94 penetrates the partition wall 54 of the second port 50, it is possible to further prevent the liquid in the storage section 20 from splashing out.

[0096] (Fifth Modification) Figures 16 to 21 show a liquid container 10A according to a fifth modified example. In Figures 16 to 21, a label 70 is attached to the liquid storage container 10.

[0097] As shown in Figure 16, a label 70 may be attached to the liquid storage container 10 at an attachment portion 71. The label 70 may be plain (Figure 16), or may display information related to the liquid contents (Figure 17).

[0098] The label 70 may be attached to the container 20 or the seal 30. When the label 70 is attached to the seal 30, the label 70 may be attached to the bottom seal 34 (FIG. 16) or the first side seal 32 or the second side seal 33 (FIG. 18). The method for attaching the label 70 is not particularly limited as long as it is not easily separated. Examples of methods for attaching the label 70 include heat welding, adhesives, and pressure-sensitive adhesives. When heat welding is used, it is preferable that the container 20 and the attachment 71 are spaced apart to prevent the temperature of the liquid contents from rising. The distance p1 (FIG. 16) between the container 20 and the attachment 71 may be, for example, 5 mm or more, and more preferably 10 mm or more. This prevents heat applied to the attachment 71 during heat welding from being transmitted toward the container 20 from the seal 30 and affecting the liquid in the container 20.

[0099] When attaching label 70 to sealed portion 30, it is preferable that sealed portion 30 be wide. It is more preferable that the width of sealed portion 30 be equal to or greater than the width of attachment portion 71. For example, if the width of sealed portion 30 to which label 70 is not attached is 5 mm and the width of attachment portion 71 is 5 mm, it is preferable that the width of sealed portion 30 to which label 70 is attached is 10 mm or greater, and more preferably 15 mm or greater.

[0100] 19(A) to 19(E) are cross-sectional views showing the relationship between the attachment positions of the label 70 and the seal portion 30. FIG.

[0101] As shown in FIG. 19(A), the label 70 and the seal portion 30 may be attached so that the end 70a of the label 70 and the end 30a of the seal portion 30 overlap.

[0102] As shown in FIG. 19(B), the label 70 and the seal part 30 may be attached so that the end 70a of the label 70 is located inside (closer to the storage part 20) than the end 30a of the seal part 30.

[0103] As shown in FIG. 19(C), the label 70 and the seal part 30 may be attached so that the end 70a of the label 70 is located outside (on the side away from the storage part 20) than the end 30a of the seal part 30.

[0104] 19(D), the label 70 may be folded back and attached to the seal portion 30 so that the label 70 covers the end 30a of the seal portion 30. By folding back the label 70, the end 30a of the seal portion 30 covered by the label 70 can be physically protected.

[0105] 19(E), the label 70 may be folded back and attached to the sealed portion 30 so that the label 70 covers the end 30a of the sealed portion 30. In this case, parts of the label 70 may be adhered to each other. This allows the end 30a of the sealed portion 30 to be physically protected.

[0106] The label 70 may be attached to only a portion of the seal portion 30. In this case, it is easier to check the state of the liquid in the storage portion 20. Furthermore, compared to when the label 70 is attached to the storage portion 20, the label 70 is less likely to peel off if, for example, the liquid storage container 10 is bent, because it is less affected by the unevenness of the storage portion 20. Furthermore, when the label 70 is attached to the storage portion 20 via an adhesive, there is a risk that components derived from the adhesive will leach into the liquid content. For this reason, it is preferable to attach the label 70 to the seal portion 30.

[0107] The label 70 may have a non-attachment portion in addition to the attachment portion 71. In this case, the amount of information that can be displayed on the label 70 can be increased. Printing may be performed directly on the non-attachment portion of the label 70, or a separate display substrate may be adhered to the label 70. As shown in FIG. 17 , the label 70 may include a backing 72 and a display substrate 73. The backing 72 is adhered directly to the liquid storage container 10. The display substrate 73 is adhered to the backing 72. Furthermore, the printing or the display substrate 73 may be present on only one side of the label 70, or may be present on both sides of the label 70. When the printing or the display substrate is present on both sides of the label 70, information about the liquid can be confirmed even when the liquid storage container 10 is suspended using through holes 74 (see FIGS. 20 and 21 ) provided in the label 70 or the backing 72.

[0108] At least the portion of the label 70 that is directly attached to the liquid storage container 10 is made of a material that can adhere to the liquid storage container 10. Furthermore, it is desirable that the label 70 have physical properties that allow it to withstand temperatures of at least 0°C or below, preferably -80°C or below, and more preferably -150°C or below. This prevents the label 70 from deteriorating when the liquid-filled container 10A is frozen and stored using liquid nitrogen or a cryogenic freezer. Suitable materials for this purpose include thermoplastic resins, particularly polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), ethylene-vinyl acetate copolymer, and fluororesin. When the label 70 and the liquid storage container 10 are heat-sealed, the label 70 is preferably made of the same material as the liquid storage container 10. This enhances the adhesive strength between the label 70 and the liquid storage container 10. For example, if the liquid storage container 10 is made of polyethylene, it is preferable to select a polyethylene-based material for the label 70.

[0109] As shown in FIG. 17 , when a display substrate 73 is adhered to a mount 72, the display substrate 73 is made of a material that can adhere to the mount 72. Furthermore, it is desirable that the display substrate 73 and the mount 72 have physical properties that allow them to withstand temperatures of at least 0°C or below, preferably −80°C or below, and more preferably −150°C or below. This prevents deterioration of the display substrate 73 and the mount 72 when the liquid-filled container 10A is frozen and stored using liquid nitrogen, a cryogenic freezer, or the like. Such display substrates 73 generally contain adhesives, and these can also be used in the present embodiment. In this case, it is preferable to use a material with an uneven surface, such as a nonwoven fabric, as the material for the mount 72, as the adhesive penetrates into the fine irregularities in the surface, thereby improving adhesive strength.

[0110] Furthermore, when using a display substrate 73 containing an adhesive, using an adhesive with high stickiness allows the adhesive to penetrate into the minute irregularities on the surface of the mount 72, which tends to improve adhesive strength. Specifically, the characteristic value of the inclined ball tack test is preferably 11 or more, and more preferably 13 or more. The inclined ball tack test is measured in accordance with JIS Z0237:2009.

[0111] 20 and 21, the label 70 may have a through-hole 74. The through-hole 74 may be arranged so as to overlap the hanging hole 35 when the label 70 is moved toward the storage section 20 (FIG. 20), or may be arranged so as not to overlap the hanging hole 35 (FIG. 21).

[0112] 20, when the through-hole 74 is positioned so as to overlap the suspension hole 35, the liquid-filled container 10A can be stably suspended from the IV stand via the suspension hole 35 and the through-hole 74. When suspended in this manner, the label 70 or backing 72 is suspended overlapping the liquid-filled container 10A. This allows a more intuitive understanding of the type of medicinal liquid to be administered intravenously, and is also advantageous in terms of preventing mix-ups.

[0113] As shown in FIG. 20 , when through hole 74 is positioned so as to overlap suspension hole 35, the diameter of through hole 74 may be the same as or larger than the diameter of suspension hole 35. When the diameter of through hole 74 is the same as the diameter of suspension hole 35, a larger display space can be secured. This allows the characters on label 70 to be larger, making them easier to read, and makes it easier to increase the amount of display content. When the diameter of through hole 74 is larger than the diameter of suspension hole 35, it is possible to prevent the hook from damaging display base 73 due to an error when passing the hook through suspension hole 35 and through hole 74 on the IV stand.

[0114] As shown in Figure 21, when the through-hole 74 is positioned so as not to overlap the hanging hole 35, the liquid-filled container 10A can be indirectly hung from an IV stand by hanging the through-hole 74 from a hook on the IV stand. When hanging in this manner, the label 70 or backing 72 does not overlap with the suspended liquid-filled container 10A. This has the advantage of making it easy to visually check the remaining amount of medicinal liquid in the liquid-filled container 10A.

[0115] It is also possible to combine the multiple components disclosed in the above-described embodiments and modifications as needed, or to delete some of the components disclosed in the above-described embodiments and modifications. [Explanation of symbols]

[0116] 10 Liquid storage containers 10A Liquid container 20 Storage section 30 Seal part 31 Top seal part 32 First side seal 33 Second side seal 34 Bottom seal 40 Port 1 41 First connection part 42 Thick wall part 43 Thickness fluctuation part 44 Thin-walled section 45 First opening 46 1st extension part 47 Cap 48 Foot 50 Second Port 51 Second connection part 52 Torso 53 Second Opening 54 Bulkhead 55 Lid 56 Second extension part 60 Third Port 70 Labels

Claims

1. A liquid storage container, A storage section; a seal portion located around the periphery of the housing portion; at least three ports respectively connected to the sealing portion; the at least three ports are arranged side by side along the seal; the at least three ports include a first port, a second port, and a third port; the second port is a non-communicating port having a partition wall separating the inside and the outside of the accommodation portion, A liquid storage container, wherein the boundary between the second port and the storage portion is located further outward in the axial direction of the second port than the boundaries between the other ports and the storage portion.

2. The liquid storage container according to claim 1 , wherein the first port is a communication port that connects the inside and outside of the storage portion.

3. 2. The liquid storage container according to claim 1, wherein the second port is covered by a lid portion having breathable and bacterial barrier properties.

4. 2. The liquid storage container of claim 1, wherein the first port has a thick portion located outside the sealing portion and a thin portion located farther from the sealing portion than the thick portion, and the thickness of the thin portion is thinner than the thickness of the thick portion.

5. The liquid storage container according to claim 4 , wherein a variable thickness portion having a variable thickness is located between the thin portion and the thick portion.

6. The liquid storage container according to claim 4 , wherein the first port is covered with a cap, and the cap contacts the outer surface of the first port at a position closer to the sealing portion than the thin-walled portion.

7. The liquid storage container according to claim 6 , wherein the cap has an inner surface that is provided with a protrusion that contacts the outer surface of the first port.

8. The liquid storage container according to claim 1, which is a container for cryopreservation.

9. A liquid-containing container, The liquid storage container according to claim 1; A liquid-filled container comprising: a liquid contained in the container portion of the liquid storage container.

10. providing a liquid storage container according to claim 1; and storing liquid in the storage portion of the liquid storage container.

11. A step of preparing a liquid-filled container according to claim 9; and obtaining the liquid by inserting a puncture member into the non-communicating port of the liquid-containing container.

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