Parts with needle-like projection

Abstract

To keep liquid composition / liquid cosmetic which do not limit active ingredients on the surface and inside of an object so that they do not leak from a gap in a part with needle-like projection.SOLUTION: A part (5) with a needle-like projection is for pouring liquid in an object and has: a plate body (511); one or more pedestal parts (512) projecting from one surface of the plate body (511); and one or more needle-like projections (513) projecting from respective end surfaces (CF2) of the pedestal parts (512). On the plate body (511) and the pedestal part (512), pour-out holes (515) which go through from the other surface of the plate body (511) to the end surfaces (CF2) of the pedestal parts (512) are formed.SELECTED DRAWING: Figure 12

Description

[Technical Field]

[0001] The present invention relates to a part with a needle-like protrusion, and more particularly to a part with a needle-like protrusion that is attached to the tip of a syringe barrel or mounted on a fixed-needle injection device. [Background technology]

[0002] BACKGROUND ART Conventionally, a multi-needle plate (multi-needle injection needle mechanism) for a syringe having a plurality of needles has been known.

[0003] Furthermore, in recent years, microneedle masks have become known in which dissolving microneedles are attached to the skin and left there to allow beauty ingredients to penetrate into the skin (see, for example, Patent Document 1).

[0004] On the other hand, Patent Document 2 proposes an injection device that is provided with a shield that expands like a trumpet on the outside of the needle in order to stretch the skin for puncturing. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 2017-051354 [Patent Document 2] Japanese Patent No. 4746818 Summary of the Invention [Problem to be solved by the invention]

[0006] However, in mask-type microneedles such as those described in Patent Document 1, the microneedles and cosmetic ingredients are integrally formed, so they need to be left for a long time to inject the cosmetic ingredients dissolved in the microneedles into the skin. Also, the cosmetic ingredients that can be integrated with the microneedles are limited.

[0007] Furthermore, if a separate shield is provided, as in Patent Document 2, there is a risk that the medicinal solution may overflow from the skin pores and enter the gap between the shield and the main device, which could reduce the amount of medicinal solution administered.

[0008] In view of the above circumstances, the present invention aims to provide a part with needle-like protrusions that can retain a liquid composition / liquid cosmetic, with any active ingredient, on the surface and inside of an object without leaking through gaps. [Means for solving the problem]

[0009] In order to solve the above problem, in one aspect of the present invention, A part with needle-like protrusions for injecting a liquid into a target, Plate and one or more pedestals protruding from one surface of the plate; one or more needle-like protrusions protruding from the tip end surface of each of the one or more pedestals, The plate and the one or more base portions have an injection hole formed therein, the injection hole penetrating from the other surface of the plate to the tip surface of the base portion. To provide a part with needle-like protrusions. [Effects of the Invention]

[0010] According to one embodiment, the part with needle-like projections can retain a liquid composition / liquid cosmetic, which does not limit the active ingredient, on the surface and inside of an object so as not to leak through gaps. [Brief explanation of the drawings]

[0011] [Figure 1] 1 is an overall view of a syringe set in which a part with a needle-shaped projection according to a first embodiment of the present invention is attached to a syringe barrel. [Figure 2] FIG. 2 is a cross-sectional view of the syringe set of FIG. 1. [Figure 3] FIG. 2 is an exploded view of the syringe set of FIG. 1, showing the syringe barrel, the plate portion of the part with a needle-like protrusion, and the mounting frame. [Figure 4] FIG. 2 is a cross-sectional perspective view of the part with needle-like projections according to the first embodiment. [Figure 5A] FIG. 2 is a diagram showing a state in which the part with needle-like projections according to the first embodiment has been punctured into a target object. [Figure 5B] FIG. 10 is a diagram showing a state in which a liquid is being injected into a target object from a part with needle-like projections according to the first embodiment. [Figure 6] FIG. 10 is a cross-sectional view showing a part with needle-like projections according to a second embodiment of the present invention. [Figure 7A] FIG. 7 is a bottom perspective view of the part with acicular projections of FIG. 6; [Figure 7B] FIG. 7 is a top perspective view of the part with spicules of FIG. 6; [Figure 8A] FIG. 10 is a bottom perspective view showing a modified example of the needle plate of the part with needle-like projections according to the second embodiment. [Figure 8B] FIG. 8B is a top perspective view of the spiculed part of FIG. 8A. [Figure 9] 10A and 10B are diagrams showing modified central holes in the part with pin-shaped projections of the present invention; [Figure 10] FIG. 10 is a cross-sectional perspective view of a part with needle-like projections according to a third embodiment of the present invention. [Figure 11A] FIG. 10 is a diagram showing a modified example of the needle-like projections of the part with needle-like projections of the present invention, the needle-like projections having a polygonal pyramid shape. [Figure 11B] FIG. 10 is a diagram showing a modified example of the needle-like protrusions of the part with needle-like protrusions of the present invention, the needle-like protrusions being in the shape of a five-pointed star cone. [Figure 11C] FIG. 10 is a diagram showing a modified example of the needle-like protrusion of the part with needle-like protrusions of the present invention, which has a two-stage shape consisting of a base and a tip needle. [Figure 12] FIG. 10 is a cross-sectional perspective view of a part with pin-shaped projections according to a fourth embodiment of the present invention. [Figure 13] FIG. 10 is a diagram showing a state in which a liquid is being injected into a target object from the needle plate of the part with needle-like projections according to the fourth embodiment. [Figure 14] FIG. 10 is an overall cross-sectional view of a part with a needle-like projection according to a fifth embodiment of the present invention mounted on a fixed-needle injection device. [Figure 15] FIG. 15 is an exploded perspective view of the fixed-needle injection device of FIG. 14. [Figure 16]FIG. 10 is a diagram showing a fixed-needle injection device in which the head portion of the outer cylinder and the needle plate are integrally formed. DETAILED DESCRIPTION OF THE INVENTION

[0012] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following describes embodiments of the present invention with reference to the accompanying drawings. In the following drawings, the same components are designated by the same reference numerals, and redundant explanations may be omitted.

[0013] The present invention relates to parts with needle-like protrusions, in particular parts with one or more tiny needle-like protrusions formed thereon, which can be attached to the tip of a syringe, mounted on a fixed-needle injection device, attached to a dial pen, knock pen, tube, pouch or other cosmetic container, or mounted on a protruding-needle injection device.

[0014] The part with needle-like projections of the present invention applies a liquid, such as a cosmetic ingredient, to the skin, which is the target object. The part with needle-like projections is mainly used for cosmetic or therapeutic purposes, and is used by puncturing the skin.

[0015] Syringe with needle-shaped projection plate attached A syringe set in which a part with a needle-like projection and a syringe barrel are connected according to a first embodiment of the present invention will be described with reference to Figures 1 to 5B. First, the overall configuration of the syringe set according to the first embodiment will be described with reference to Figures 1 to 3.

[0016] Fig. 1 is an overall view of a syringe set 100 in which a part with a needle-like protrusion according to a first embodiment of the present invention is attached to a syringe barrel. Fig. 2 is a cross-sectional view of the syringe set 100 of Fig. 1. Fig. 3 is an exploded view of the syringe 80, and the needle plate 11 and mounting frame 12 of the part with a needle-like protrusion 1 in the syringe set 100 of Fig. 1.

[0017] 2, syringe 80 includes a syringe barrel (syringe body, cylinder) 81 and a pusher (plunger) 85. Syringe barrel 81 contains liquid content L, and plunger 85 is inserted into syringe barrel 81. More specifically, syringe barrel 81 includes an outer cylindrical portion 82 that contains content L, a flange 83 provided at the rear end of outer cylindrical portion 82, and a cylindrical tip 84 that is the tip end.

[0018] The syringe 80 to which the needle-like protruding part 1 of the present invention is attached may have a volume of, for example, 1 mL, 2.5 mL, 5 mL, or 10 mL. Depending on the specific use of the needle-like protruding part 1, the syringe may have a larger or smaller volume.

[0019] In this embodiment, a part with a needle-like protrusion (needle assembly, component with a needle-like protrusion) 1 used in place of a general syringe needle having a single hollow needle is connected to a barrel tip 84 of a syringe barrel 81.

[0020] More specifically, the needle-like protrusion part 1 has a cylindrical mounting tube 126 that fits onto the barrel tip 84 of the syringe barrel 81. When the needle-like protrusion part 1 is attached to the syringe 80, the barrel tip 84 of the syringe barrel 81 is inserted into and engaged with the fitting hole 127 of the mounting tube 126 of the needle-like protrusion part. A syringe having a locking structure to prevent the mounting tube 126 of the needle-like protrusion part 1 and the barrel tip 84 of the syringe barrel 81 from easily coming off may be used. Alternatively, the shape may conform to standards such as ISO (International Organization for Standardization) or JIS (Japanese Industrial Standards).

[0021] Here, the acicular protrusions, which are solid needles that make up the acicular micro-protrusions applied to the part with acicular protrusions 1 of the present invention, preferably have a diameter at the thickest part of the needle in the range of 2 μm to 5000 μm, more preferably in the range of 5 μm to 3000 μm.

[0022] As shown in Figure 2, in syringe 80, when the pushing piece 86 at the rear end is pressed, the plunger 85 moves inside the outer tube portion 82 of the syringe barrel 81, and the contents L are released from the syringe barrel 81 into the part 1 with a needle-shaped protrusion.

[0023] When the contents L reach the inside of the part 1 with needle-like projections, the contents are sent to a target object such as the skin via the flow path 125 and the outlet hole 114.

[0024] 2, a gasket 87, which is a thin rubber or elastomer packing (sealing element) for preventing liquid leakage and foreign matter from entering, may be adhered to the tip of plunger 85. Note that the packing does not necessarily have to be provided.

[0025] Furthermore, in order to protect the multiple pin-like projections 112 of the pin-like projection part 1 of the present invention, a cap that covers the pin-like projection part 1 may be attached.

[0026] <First embodiment of part with needle-like projections> FIG. 4 is an enlarged perspective cross-sectional view of the part 1 with needle-like projections according to the first embodiment.

[0027] In this embodiment, the part 1 with pin-like projections is configured as an assembly of two members: a pin plate 11 and an attachment frame 12.

[0028] In the needle plate 11, a plurality of needle-like projections 112 and a lip portion 113 are provided on a circular, flat plate-shaped plate body 111. A pouring hole 114 is formed in the center of the plate body 111. The plate body 111 functions as a plate.

[0029] In the needle plate 11, a plurality of acicular projections 112 protrude from the tip surface CF of the plate body 111. The plurality of acicular projections 112 are so-called minute microneedles, and the length of each acicular projection 112 is approximately 1 μm to 5000 μm, more preferably approximately 5 μm to 3000 μm, and the diameter around the base of the acicular projection 112 is in the range of 2 μm to 5000 μm, more preferably approximately 5 μm to 3000 μm. It is also preferable that the plurality of acicular projections 112 are spaced apart from each other by approximately 0.1 mm to 10 mm. While FIG. 4 shows an example in which the acicular projections 112 have a conical outer shape, they may also have a polygonal pyramid shape or a cross shape, as shown in FIG. 11A. Furthermore, they may also have an asymmetric shape from the tip.

[0030] The number of needle-like projections 112 may be any number, ranging from one to several hundred, and more preferably from several to about 100. The multiple needle-like projections 112 may be arranged regularly or may be provided in random positions. The multiple needle-like projections 112 on the lower surface may be formed all at once from a single sheet (like a pinholder), or may be an assembly of one or more needle-like projection units in which multiple needle-like projections are formed in a row.

[0031] Alternatively, pyramidal needle-like projections 22A (see FIG. 11A) or star-shaped polygonal cone-shaped projections (see FIG. 11B), which will be described later, may be combined with conical needle-like projections 22. Furthermore, the needle-like projections may have a two-stage shape with a base provided below the conical tip (see FIG. 11C). Also, needle-like projections of a plurality of shapes may be mixed within the plate 31.

[0032] The lip portion 113 is formed on the outer edge of the tip surface (contact surface) CF of the plate body 111. In this embodiment, the lip portion 113 functions as a liquid stopper. The height of the lip portion 113 from the tip surface CF is the same as or shorter (lower) than the length of the needle-like projections 112. For example, the height of the lip portion 113 is a height that allows the liquid to spread over the object, and is about 10 to 2000 μm.

[0033] In this embodiment, the needle plate 11 including the needle-shaped protrusions 112 is preferably made of a biocompatible material, such as a biodegradable resin such as polyglycolic acid, polylactic acid, or polyglycolic acid-polylactic acid copolymer, but may also be made of a thermoplastic resin such as polypropylene (PP), polyethylene (PE), acrylonitrile butadiene styrene (ABS), polybutylene terephthalate (PBS), polyacetal (POM), polyethylene terephthalate (PET), polycarbonate (PC), or polyether ether ketone (PEEC).

[0034] On the other hand, the mounting frame 12 has a plate support portion 121 and a mounting cylinder 126 .

[0035] Specifically, the plate support part 121 is cylindrical with a top, and includes a round plate 122 that serves as the storage top surface and an outer cylinder 123 that serves as the storage side wall, with the bottom surface forming a recessed storage space. The bottom surface of the round plate 122 that serves as the storage top surface has an annular groove 124 at its outer edge, which forms the boundary with the outer cylinder 123.

[0036] When assembling the part with needle-like projections 1, the outer periphery of the needle plate 11 is fitted inside the outer tube 123 of the mounting frame 12. In this embodiment, this fitting brings the other surface of the plate body 111 of the needle plate 11 into close contact with one surface of the round plate 122 of the mounting frame 12. Then, in this embodiment, as shown in Fig. 5A, when the needle plate 11 is attached to the mounting frame 12, the tip surface LT of the lip portion 113 of the part with needle-like projections 1 protrudes outward (downward) from the lower end ST of the outer tube 123.

[0037] Furthermore, a hole is formed in the center of the plate support part 121, and this hole becomes a flow path 125 through which the contents pass in the part 1 with needle-like projections.

[0038] On the other hand, the mounting tube 126 has a cylindrical shape with one end open and the other end connected to the back surface of the plate support part 121, and the inside of the tube is a fitting hole 127. The other end of the mounting tube 126 has a cylindrical perforated bottom surface 128 formed therein.

[0039] 4 shows an example in which the diameters of the flow paths (holes) are in descending order of fitting hole 127 > flow path 125 > discharge hole 114, but the size of the holes is not important. With this configuration, when attaching the part 1 with a needle-like projection to the syringe 80, as the cylindrical tip 84 of the syringe 80 is fitted into the mounting tube 126, the tapered shape of the cylindrical tip 84 gradually narrows at the front relative to the mounting tube 126, ensuring a seal by the fitting of the tapered sides. Note that when the pushing stops due to this narrowing of the taper, the tip 84T of the cylindrical tip 84 may come into contact with the perforated bottom surface 128 between the fitting hole 127 and the flow path 125, as shown in FIG. 2.

[0040] 5A and 5B are diagrams illustrating the operation of the part 1 with needle-like projections relative to the object O according to the first embodiment.

[0041] By pressing the syringe barrel 81 of the syringe 80 into the object O, such as the skin, the object O is punctured by the multiple needle-like protrusions 112 (see FIG. 5A). At this time, the lip portion 113 on the outer edge of the contact surface CF of the part 1 with needle-like protrusions comes into contact with the object O.

[0042] Then, when the plunger 85 of the syringe 80 is pressed, the liquid L stored in the syringe 80 flows into the part 1 with needle-like protrusions, and the liquid spreads into the space formed between the object O, the lip portion 113, and the tip surface CF of the plate body 111, and enters the skin through the holes opened by the multiple needle-like protrusions 112, i.e., it penetrates through the gaps between the surface of the needle-like protrusions 112 and the skin (see Figure 5B).

[0043] After the injection, the part 1 with the needle-like projections is kept pressed against the object O via the syringe 80 for a predetermined time (less than 1 second to about 30 minutes, preferably about several seconds to several minutes).

[0044] After a predetermined time has elapsed, the syringe 80 is removed from the object O, thereby pulling out the needle-like projection 112 from the object O.

[0045] As described above, in the present invention, the liquid having a cosmetic effect on the skin, which is the object O, is spread on the inside of the lip portion 113 and also penetrates into the inside of the object O through the holes made by the needle-like projections 112. Therefore, the active ingredients contained in the liquid can penetrate from both the outside and the inside of the object O. For example, if the object O is skin, the cosmetic ingredients contained in the liquid can penetrate from both the outside and the inside of the skin.

[0046] <Second embodiment of part with needle-like projections> Next, a part with needle-like projections according to a second embodiment will be described with reference to FIGS. 6 to 7B.

[0047] Fig. 6 is a diagram showing a pin-shaped part 2 according to a second embodiment of the present invention. Fig. 7A is a bottom perspective view of the pin-shaped part 2 of Fig. 6, and Fig. 7B is a top perspective view of the pin-shaped part 2 of Fig. 6.

[0048] The above-mentioned part 1 with needle-like protrusions has an assembly structure (assembly structure) consisting of two components, the mounting frame 12 and the needle plate 11, but the part with needle-like protrusions may have an attachment function to the nozzle of the syringe and a puncture function integrated together.

[0049] In this embodiment, the part 2 with needle-like projections integrally includes a needle plate 21 and an attachment tube 26.

[0050] The integral part 2 with needle-like projections according to this embodiment is preferably made of a biocompatible material, such as a biodegradable resin, such as polyglycolic acid, polylactic acid, or polyglycolic acid-polylactic acid copolymer, but may also be made of a thermoplastic resin, such as polypropylene (PP), polyethylene (PE), acrylonitrile butadiene styrene (ABS), polybutylene terephthalate (PBS), polyacetal (POM), polyethylene terephthalate (PET), polycarbonate (PC), or polyether ether ketone (PEEC).

[0051] A circular, flat needle plate 21 is provided with a plurality of needle-like projections 22 and a lip portion 23. A pouring hole 24 is formed in the center of the needle plate 21.

[0052] The height of the lip portion 23 from the tip surface CF is configured to be lower (shorter) than the height of the needle-like projections 22.

[0053] The mounting cylinder 26 is formed with a fitting hole 27. In this configuration, the portion sandwiched between the inside of the inner circumferential surface of the fitting hole 27 and the outside of the pouring hole 24 forms a cylindrical perforated bottom surface 28, against which the contents L coming out of the flow path of the cylindrical tip 84 hits and passes when the mounting cylinder 26 engages with the cylindrical tip 84 of the syringe 80. The perforated bottom surface 28 may be tapered or curved toward the pouring hole 24, which is a through-hole, to allow the liquid to move smoothly.

[0054] Furthermore, in this embodiment, puncturing amount adjustment ribs 25 are provided to regulate the depth of penetration of needle-like protrusions 22 into the target object. The height of puncturing amount adjustment ribs 25 is configured to be lower than needle-like protrusions 22 and lower than or approximately equal to the height of lip portion 23.

[0055] In this embodiment, too, by providing the lip portion 23 integrally with the underside of the needle plate 21, the liquid effective for the target object is spread over the skin inside the lip portion 23 and also penetrates into the target object through the holes made by the needle-like protrusions 22. This allows the active ingredients contained in the liquid to penetrate into the target object from both the outside and the inside. For example, if the target object is skin, the cosmetic ingredients contained in the liquid can penetrate into the skin from both the outside and the inside.

[0056] <Modification of plate shape of part with needle-like protrusions> 8A and 8B are diagrams showing a part with needle-like projections according to a modified example of the second embodiment, where FIG. 8A is a bottom perspective view and FIG. 8B is a top perspective view.

[0057] In this modification, needle plate 21A that comes into contact with the target object is triangular in shape with rounded corners. Although an example in which needle plate 21A has a triangular outer shape is shown in Figures 8A and 8B, needle plate 21A may have another polygonal outer shape such as a square or a pentagon.

[0058] The needle plate 21A of the needle-shaped protrusion part of this modified example has a polygonal shape, so when you want to apply liquid to a straight, angular or curved part, such as near a person's nose or along the face line, using the needle-shaped protrusion part of the present invention, it is easier to press it against the object.

[0059] Although examples have been described in which the needle plate 21 (21A) is circular and triangular with rounded corners, it may be any shape, such as an ellipse, an oval, a polygon such as a square, a square with rounded corners, or a comma-shaped bead.

[0060] In addition, since the circular needle plate 21 in the above-mentioned part 2 with needle-like protrusions is suitable for application to large areas of the object or areas with few irregularities, it is preferable to select the shape of the plate appropriately depending on the application and size.

[0061] <Modification of the central hole> Although the example in which there is one central hole serving as the pouring hole has been described above, the number of holes does not have to be one.

[0062] 9 is a diagram showing a modified example of the pouring hole of the part with needle-like projections of the present invention. In this modified example, a reinforcing plate is provided to divide the pouring hole, resulting in four pouring holes 24A. By providing the reinforcing plate 241, strength can be ensured even if the diameter of the pouring hole 24A is increased.

[0063] 9 has the same diameter as that of the pouring hole 24 in FIG. 7A, the amount of inflow into the target can be reduced by providing a reinforcing plate 241. The optimum amount of inflow into the target per unit time varies depending on the properties of the liquid contained, so the presence or absence of a reinforcing plate 241 and the number of divisions of the hole can be selected according to the specifications as appropriate.

[0064] 8A to 9 show examples of modified embodiments of the second embodiment that are integrally formed with the mounting tube, such as an example in which the needle plate 21 is polygonal in shape and an example in which the shape of the central hole is modified. However, these modified embodiments may be applied to the two-piece needle-like protrusion parts 1 and 1A of the first and third embodiments, or to the needle-like protrusion part 3 described below, which is attached to an injection device and consists only of a plate without an attachment tube.

[0065] <Third embodiment of part with needle-like protrusions> Although the above description is given of an example in which the needle plate has one injection hole in the center, the injection hole does not have to be one, and does not have to be located in the center.

[0066] 10 is a cross-sectional perspective view of a part 1A with needle-like projections according to a third embodiment. In this embodiment, the needle plate 11A has multiple outlet holes 114a and 114b that penetrate vertically, rather than being located in the center. Therefore, liquid flowing in from the flow path 125 of the mounting cylinder 126 needs to be transferred to the outlet holes 114a and 114b that are located away from the center. Therefore, a gap is provided between the hole mounting frame 12A and the plate body 111A of the needle plate 11A to allow the liquid to pass through.

[0067] To achieve this gap, in this embodiment, an annular protrusion 129 is provided at a certain distance from the center on the tip surface of the round plate 122A of the plate support portion 121A of the mounting frame 12A. When the needle plate 11A is attached to the mounting frame 12A, the tip of the annular protrusion 129 abuts against the rear end side surface (back surface) BF of the plate main body 111A, thereby forming a partitioned gap space between the annular protrusion 129 and the rear end side surface BF of the plate main body 111A. When liquid enters this gap space from the flow path 125 of the mounting frame 12A, it forms a pool, from which the liquid can flow to the discharge holes 114a and 114b.

[0068] Therefore, in this embodiment, the positions of the pouring holes 114a, 114b provided in the plate main body 111A that functions as a plate are set so that the distance from the center is closer to the center than the position of the annular protrusion 129 of the mounting frame 12A.

[0069] In the part 1A with needle-like protrusions in this embodiment, the liquid flowing from the mounting tube 126 passes through the flow path 125 in the center of the perforated bottom surface 128, spreads as a puddle in the gap space on the upper surface of the plate main body 111A, and then enters the multiple discharge holes 114a, 114b.

[0070] When the liquid that has entered the multiple discharge holes 114a, 114b is pushed out of the tip surface CF of the plate body 111A, the liquid spreads over the object along the inner circumferential side of the lip portion 113, as described above, and also permeates into the object through the holes made by the needle-like projections 112. Therefore, the active ingredients contained in the liquid can permeate the object from both the outside and the inside.

[0071] In this embodiment, the plurality of outlet holes 114a, 114b away from the center and the gap spaces form two-stage liquid pools on the back surface and the front end surface of plate body 111A, which makes it easy for the liquid to spread outward. Therefore, even when the object has an uneven surface or protrusions on the surface that make it difficult for the liquid to spread from the center to lip portion 113 on the outer periphery, the presence of outlet holes 114a, 114b at positions halfway between the center and lip portion 113 makes it possible to more fully spread the liquid from the center outward.

[0072] The number of ejection holes 114a, 114b is a plural number equal to or greater than 2. In this configuration, the greater the number of ejection holes, the greater the effect of spreading from the center to the outside.

[0073] Furthermore, in this configuration example, in order to more efficiently move liquid from the center to the outside in the gap space between the plate body 111A and the round plate 122A, a band-shaped recess may be formed on the rear end side surface BF of the plate body 111A, with the shortest path for liquid to flow from the center to the injection holes 114a, 114b as a flow path.

[0074] <Modified needle-like protrusions> In the above-described first to third embodiments, examples have been shown in which the needle-like projections 22 (112) have a conical outer shape, but the needle-like projections may be polygonal pyramid-shaped or other needle-like shapes (star-shaped, cross-shaped, etc.). Furthermore, needle-like projections that are solid needles may also be hollow needles.

[0075] 11A to 11C are diagrams showing modified examples of the needle-like protrusions of the needle-like protrusion part of the present invention. In detail, Fig. 11A shows a polygonal pyramidal needle-like protrusion 22A, Fig. 11B shows a pentagram-shaped cone-shaped needle-like protrusion 22B, and Fig. 11C shows a two-tiered needle-like protrusion 22C with a base and a tip.

[0076] The polygonal pyramidal shaped needle-like protrusions 22A shown in Fig. 11A and the pentagram (five-pointed star) conical shaped needle-like protrusions 22B shown in Fig. 11B have sharp corners on the sides, making them easier to puncture an object, and are advantageous for puncturing thickened skin, for example. Note that Fig. 11A shows a triangular pyramid as an example of a polygonal pyramid, but other shapes such as a square pyramid or a pentagonal pyramid may also be used. Similarly, Fig. 11B shows an example of a five-pointed star conical shape as an example of a star-shaped polygonal pyramid, but other shapes such as a six-pointed star or a seven-pointed star may also be used.

[0077] As shown in Fig. 11C, in a two-stage needle-like projection 22C in which a base portion (base) 222 is provided below a conical tip needle 221, the provision of base portion 222 can eliminate the difficulty of puncturing due to deformation of the skin. Note that the shapes of tip needle 221 and base portion 222 in two-stage needle-like projection 22C shown in Fig. 11C are merely examples, and other shapes may be used. Note that base portion 222 does not puncture the target object, but stretches so as to expand the periphery of tip needle 221, and therefore the provision of base portion 222 can eliminate the difficulty of puncturing due to deformation of the skin.

[0078] 11A, conical acicular protrusions 22 and polygonal pyramidal acicular protrusions 22A may be mixed in one needle plate 21. Furthermore, acicular protrusions 22B and 22C as shown in FIGS. 11B and 11C may be mixed with acicular protrusions 22, 22A, 22B, and 22C of other shapes.

[0079] The height of the needle-like projections 22 may also be non-uniform. Furthermore, slits, minute grooves, or irregularities may be provided on the surface of the needle-like projections 22. In this case, the amount of liquid used can be reduced or the amount used can be increased in certain areas, and the penetration of the liquid through the holes in the skin created by puncturing can be promoted.

[0080] 11A to 11C may be applied to the two-piece needle-like projection part 1 of the first to third embodiments, or to the needle-like projection part 3, which is attached to an injection device and consists only of a plate without an attachment tube, as described below. Furthermore, needle-like projections 22A and 22B having the shapes shown in Fig. 11A and 11B may be applied to the fourth embodiment, as described below.

[0081] <Fourth embodiment of part with needle-like protrusions> In the above, an example was described in which the lip portion of the needle plate is provided on the outer peripheral edge of the plate body, but the lip portion that functions as a liquid stopper may also be provided on the outer peripheral edge of the tip surface of the base portion.

[0082] Therefore, a fourth embodiment in which a lip portion is provided on a base portion will be described with reference to Figures 12 and 13. Figure 12 is a cross-sectional perspective view of a part 5 with pin-like projections according to the fourth embodiment of the present invention. Figure 13 is a diagram showing a state in which liquid is being injected into a target object from the needle plate 51 of the part 5 with pin-like projections according to the fourth embodiment.

[0083] In this embodiment, the shape of the attachment frame 12B of the part 5 with needle-like projections is substantially the same as the attachment frame 12A of the third embodiment. However, the shape of the needle plate 51 is different from any of the first to third configurations.

[0084] The needle plate 51 of this embodiment is provided with one or more pedestal portions 512 protruding from one surface F1 of the plate body 511. The tip diameter (d), which is the diameter of the tip surface CF2 that forms the upper base surface of the truncated cone shape of the pedestal portion 512, is, for example, 100 μm to 1500 μm, and particularly preferably 300 μm to 600 μm.

[0085] Each of the multiple base portions 512 is provided with one or more minute needle-like protrusions 513 protruding from the tip surface CF2 of the base portion 512, and a lip portion 514 formed on the outer edge of the tip surface CF2 of the base portion 512.

[0086] The needle-like projections 513 of this embodiment are so-called minute microneedles, and the length (b) of each needle-like projection 513 is about 1 μm to 5000 μm, more preferably about 5 μm to 3000 μm, and the diameter around the base of the needle-like projection 513 is in the range of 2 μm to 5000 μm, more preferably 5 μm to 3000 μm. The pitch (c) between the apexes of the multiple needle-like projections 513 is, for example, 1 mm to 10 mm, more preferably about 2 mm to 5 mm, and is preferably spaced apart.

[0087] The height of lip portion 514 is shorter than or equal to the length (b) of needle-like projection 513, and is, for example, about 1 μm to 5000 μm, more preferably about 5 μm to 3000 μm. The thickness of lip portion 514 is about 0.05 mm to 5 mm.

[0088] The total height (a+b) of the height (a) of base portion 512 and the height (b) of needle-like projections 513 is approximately 600 μm to 5000 μm. It is also preferable that the ratio ((a+b) / c) of the total height (a) of base portion 512 and the height (b) of needle-like projections 513 to the pitch (c) of the needle-like projections is 0.1 or more and 2.8 or less.

[0089] In the needle plate 51, the plate body 511 and the multiple base portions 512 are formed with an injection hole 515 that penetrates vertically from the other surface F2 of the plate body 511 to the abutment surface CF2, which is the tip surface of the base portion 512.

[0090] In this embodiment, multiple discharge holes 515 penetrating vertically through needle plate 51 are provided at positions other than the center. Therefore, it is necessary to move the liquid flowing in from flow path 125 of mounting cylinder 126 to the multiple discharge holes 515 away from the center, so a gap is provided between mounting frame 12B and the other surface F2 of plate body 511 of needle plate 51 to allow the liquid to pass through.

[0091] To achieve this gap, in this embodiment, an annular protrusion 129 is provided on the tip surface of the round plate 122B of the plate support portion 121B of the mounting frame 12B, a certain distance from the center and further outward than the outermost discharge holes 515. When the needle plate 51 is attached to the mounting frame 12B, the tip of the annular protrusion 129 abuts against the other surface F2, which is the back surface of the plate main body 511, and the area surrounded by the annular protrusion 129 and the other surface F2 of the plate main body 511 becomes a partitioned gap space. When liquid enters this gap space from the flow path 125 of the mounting frame 12B, a liquid pool is formed, and the liquid can flow from the liquid pool to the multiple discharge holes 515.

[0092] In this embodiment, the position of the pouring hole 515 is set so as to penetrate the base portion 512, and therefore the position of the outermost base portion 512 on the plate body 511 is set to be closer to the center than the position of the annular protrusion 129 of the mounting frame 12B.

[0093] In the part 5 with needle-like protrusions in this embodiment, the liquid flowing from the mounting tube 126 passes through the flow path 125 in the center of the perforated bottom surface 128, and as shown in Figure 13, spreads as a puddle in the gap space on the upper surface of the plate body 511, and then flows into the multiple outlet holes 515.

[0094] Then, when the liquid that has passed through the outlet hole 515 that penetrates the plate body 511 and the base portion 512 reaches the abutment surface CF2 of the base portion 512 and is pushed out, as shown in Figure 13, the liquid spreads in the space formed between the object O, the lip portion 514, and the abutment surface CF2 at the tip of the base portion 512, and enters the inside of the object O through the hole opened by the needle-like protrusion 513.

[0095] In this embodiment, the liquid spreads over the object O on the contact surface CF2 of the base portion 512 toward the inner circumferential side of the lip portion 514, and also permeates into the object O through the holes formed by the needle-like protrusions 513. Therefore, the active ingredients contained in the liquid can permeate the object O from both the outside and the inside.

[0096] In this embodiment, a liquid pool is formed on the tip side of the pedestal portion 512, so the liquid spreads in the area inside the lip portion 514 of each pedestal portion 512. Therefore, for example, when the part 5 with needle-like protrusions is large and the area of ​​the plate body 511 is wide, it is possible to apply the liquid when it is desired to apply an active ingredient in a pinpoint manner.

[0097] Furthermore, in this embodiment, as shown in FIG. 13, due to the step between the base portion 512 and one surface F1 of the plate main body 511, the lip portion 514 connected to the base portion 512 spreads the target object, such as skin, over a narrow range, allowing the needle-like protrusions 513 to puncture it. Therefore, if the surface of the target object is uneven or soft, the needle-like protrusions 513 can easily pierce the target object O, making it possible to more reliably apply liquid from the outside and inside.

[0098] Furthermore, hollow needles have the disadvantage that if not all of the needle is pierced into the object, the difference in injection resistance causes liquid to be discharged from the needles that are not pierced, but in this embodiment, regardless of whether the needle-like projections 513 are pierced into the object, the lip portion 514 comes into contact with the object, and therefore the injection pressure (resistance) is applied uniformly to the area on the inner periphery of the lip portion 514, which is the entire tip portion. This has the advantage of reliably improving the injection performance.

[0099] Furthermore, in this configuration, in order to more efficiently move liquid from the center to the outside in the gap space between the plate body 511 and the round plate 122B, a band-shaped recess may be formed on the other surface F2 of the plate body 511, with the shortest path for liquid to flow from the center to the multiple injection holes 515 as a flow path.

[0100] Furthermore, a plurality of needle-like protrusions or a plurality of ejection holes may be provided in one pedestal 512. In that case, in each pedestal 512, the liquid pushed out from the plurality of ejection holes spreads over the object O on the inner circumferential side of the lip portion 514 on the contact surface CF2 of the pedestal 512, and can also permeate into the inside of the object O through holes made by the plurality of needle-like protrusions 513.

[0101] ≪Fixed needle injection device≫ Next, a fixed-needle injection device equipped with a part with a needle-like protrusion of the present invention will be described with reference to Figures 14 and 15. The part with a needle-like protrusion of the present invention can be used by being attached inside the fixed-needle injection device.

[0102] Fig. 14 is an overall cross-sectional view of an injection device 200 in which a part 3 with a needle-like projection according to a fifth embodiment of the present invention is attached to a fixed-needle injection device 90. Fig. 15 is an exploded perspective view of the injection device 200 of Fig. 14.

[0103] In the fifth embodiment, a fixed-needle injection device 90 to which a part with a needle-like protrusion 3 is attached comprises an injection device main body 91 and a plunger 95. The injection device main body (injection guide body) 91 of this embodiment contains liquid contents L, and the plunger 95 is inserted into it. In more detail, the injection device main body 91 comprises a cylindrical outer tube portion 92 that contains the contents L, and a head (holding portion, support portion) 93 that widens outward in a flange-like shape at the tip end.

[0104] 14 and 15, the tip surface of the head 93 has a thin plate portion 931 that serves as the storage top surface and a thick outer edge portion 932 that serves as the storage side wall, thereby forming a recess toward the tip side, and the inner surface of the thick outer edge portion 932 that forms a step between the thin plate portion 931 and the thick outer edge portion 932 forms a recess side surface 933. A communication hole 934 is formed in the center of the thin plate portion 931 of the head 93.

[0105] In this embodiment, the needle plate 11 is used as the part 3 with needle-like projections.

[0106] In this configuration, when assembling the fixed-needle injection device 90, the outer periphery of the needle plate 11 is fitted inside the recessed side surface 933 on the underside of the head 93. Then, as shown in Figure 14, when the needle plate 11 is attached to the injection device body 91, the tip surface LT of the lip portion 113 of the needle plate 11 protrudes outward (below) from the lower end ST of the thick-walled outer edge portion 932 of the head 93.

[0107] 14, a side hole 921 may be formed on the outer peripheral surface of outer cylinder 92. For example, when the same person wants to increase the amount of contents to be applied to the target at one time, the contents are injected into outer cylinder 92 through side hole 921 using a dropper or the like. At this time, the amount of contents is set so that it is below side hole 921.

[0108] The rear end of the plunger 95 (plunger) is provided with a widened flange-shaped or wing-shaped pressing piece 96 extending in two directions. A gasket 97, which is a thin rubber or elastomer packing to prevent liquid leakage and foreign matter from entering, is adhered to the tip of the plunger 95. In this configuration, the plunger 95, pressing piece 96, and gasket 97 form a pressing part. Note that the gasket 97 does not necessarily have to be provided.

[0109] Furthermore, in this embodiment, the inner periphery of the outer tubular portion 92 is formed as a hollow portion 94. Note that, in this embodiment, Figures 14 and 15 show a state in which an absorbent body 98 such as a sponge is set inside the hollow portion 94 of the outer tubular portion 92, but the absorbent body 98 does not necessarily have to be provided.

[0110] In this embodiment, by pressing the pressing piece 96 of the plunger 95 while the needle plate 11 is pressed against the object, the plunger 95 descends inside the outer tube 92, and the liquid that has been previously injected into the hollow portion 94 through the side hole 921 passes through the absorber 98, and is then forced out through the circulation hole 934 and the discharge hole 114, and gradually applied to the object. Note that if the absorber 98 is not provided, the liquid that has been previously injected into the hollow portion 94 is immediately forced out through the circulation hole 934 and the discharge hole 114, and applied to the object.

[0111] In this embodiment, too, by providing the lip portion 113 integrally with the underside of the needle plate 11, the liquid effective for the target object is spread over the target object's skin inside the lip portion 113 without leaking into the device, and also penetrates into the target object through the holes made by the needle-like protrusions 112. Therefore, the active ingredients contained in the liquid can penetrate into the target object from both the outside and the inside. For example, if the target object is skin, the cosmetic ingredients contained in the liquid can penetrate into the skin from both the outside and the inside.

[0112] (Variation 1) In this embodiment, as modified examples of the needle plate 11, needle-shaped protrusions having a triangular tip surface shape as shown in Figures 8A and 8B, polygonal pyramidal shapes, two-stage shapes, and star-shaped polygonal pyramidal shapes as shown in Figures 11A to 11C, and a configuration of extraction holes with a lattice as shown in Figure 9 may be applied.

[0113] (Variation 2) Furthermore, in this embodiment, the needle plate attached to the fixed-needle injection device 90 may be a needle plate 11A having multiple discharge holes formed therein, as shown in FIG. 10 , and spaced apart from the thin plate portion 931 of the head 93. In this configuration, when the pressing portion is operated, liquid flowing from the communication hole 934 of the head 93 spreads as a puddle in the gap space on the rear end side surface BF of the plate body 111A of the needle plate 11A and then flows into the multiple discharge holes 114a and 114b. When the liquid passing through the discharge holes 114a and 114b is pushed out of the front end surface CF of the plate body 111A, the liquid spreads over the target on the inner periphery of the lip portion 113 and also penetrates into the target through the holes formed by the needle-like protrusions 112.

[0114] (Variation 3) 12 and 13 , which is provided with a gap from the thin plate portion 931 of the head 93, may be used as the needle plate attached to the fixed-needle injection device 90. This needle plate 51 has a plurality of base portions 512, each of which is provided with a minute needle-like protrusion 513 and a lip portion 514, and is formed with the same number of discharge holes 515 as the number of base portions 512 that penetrate the base portions 512 and the plate body 511. In this configuration, when the pressing portion is operated, liquid flowing from the communication holes 934 of the head 93 spreads as puddles in the gap space on the upper surface of the plate body 511 of the needle plate 51 and then flows into the plurality of discharge holes 515. Then, when the liquid that has passed through the dispensing hole 515 is pushed out of the tip surface CF2 of the base portion 512, which is outside the plate body 511, the liquid spreads over the object on the inner side of the lip portion 514 of the base portion 512, and also penetrates into the object through the holes made by the needle-like protrusions 513.

[0115] Sixth Embodiment As another embodiment of the part with a needle-like projection, in a part with a needle-like projection that is applied to a fixed-needle injection device, the injection device main body and the needle plate may be formed integrally.

[0116] 16 shows a sixth embodiment of a part 4 with needle-like protrusions, in which needle-like protrusions 42 are provided on a head portion 41 that is integrated with a tubular portion 46. In this embodiment, the head portion 41 is formed integrally with the needle plate 11 shown in the fifth embodiment and a head (holding portion, support portion) 93 that spreads outward like a brim on the tip end side.

[0117] A plurality of needle-like projections 42 and a lip portion 43 are provided on the circular flat tip side of the head portion 41. A pouring hole 44 is formed in the center of the tip surface CF of the head portion 41.

[0118] In this configuration as well, the height of the lip portion 43 from the plate tip surface CF of the head portion 41 is configured to be lower (shorter) than the height of the needle-like projections .

[0119] A hollow portion 47 is formed in the cylindrical portion 46. In this configuration, the portion sandwiched between the inside of the inner circumferential surface at the tip end of the hollow portion 47 and the outside of the pouring hole 44 forms a cylindrical perforated bottom surface 48, against which the extruded content L collides and passes. The perforated bottom surface 48 may be tapered or curved toward the pouring hole 44 so that the liquid can move smoothly.

[0120] Furthermore, in this embodiment as well, although not shown, a puncturing amount adjustment rib may be provided to regulate the depth of penetration into the target by the needle-like protrusions 42. The height of the puncturing amount adjustment rib is configured to be lower than the needle-like protrusions 42 and lower than or approximately equal to the height of the lip portion 43.

[0121] In this embodiment, the lip portion 43 is provided integrally with the tip surface (lower surface) of the head portion 41, so that the liquid effective on the target object is spread over the target object inside the lip portion 43 and also penetrates into the target object through the holes made by the needle-like projections 42. Therefore, the active ingredients contained in the liquid can penetrate into the target object from both the outside and the inside.

[0122] (Variation) As modified examples of the head portion 41 of the sixth embodiment, a plate shape with a triangular tip surface as shown in Figures 8A and 8B, a polygonal pyramidal shape, a two-step shape, or a star-shaped polygonal pyramidal shaped needle-like protrusion as shown in Figures 11A to 11C, or a configuration of an injection hole with a lattice as shown in Figure 9 may be applied.

[0123] In any of the configurations of the above-described embodiments and modified examples, the lip portion is formed integrally with the pressing surface, so that a liquid having some effective effect on the target object is spread over the target object along the inner periphery of the lip portion without leaking through gaps into the device, and is also allowed to penetrate into the target object through holes made by the needle-like protrusions. In other words, a device employing the part with needle-like protrusions of the present invention can retain a liquid composition / liquid cosmetic, with any active ingredient, on the surface and inside of the target object without leaking through gaps.

[0124] In the above-described embodiments of the present invention, the contents (liquid substances) used in the syringes and injection devices to which the needle-shaped protrusion parts are connected have been described as cosmetic substances, but the contents may also be selected from the group consisting of cell suspensions, gel-like materials, therapeutic substances, and diagnostic substances.

[0125] The cosmetic substances include common cosmetic substances that can be included in cosmetic compositions and cosmetic substances used in cosmetic medicine, such as ascorbic acid and its derivatives, tranexamic acid, arbutin, and 4-MSK (4-methoxysalicylic acid potassium salt) for whitening, and retinol, niacinamide, hyaluronic acid and its derivatives for anti-wrinkle, but are not limited to these.

[0126] In addition to common cosmetic substances that may be included in cosmetic compositions, the injected cosmetic substances may include, but are not limited to, fillers such as fat cells, hyaluronic acid, or botulinum toxin (Botox, Btx) in wrinkle treatment.

[0127] Therapeutic substances may include, but are not limited to, antibiotics, anesthetics, analgesics, vaccines, and antibodies.

[0128] Furthermore, the needled part of the present invention may be used to inject cells in suspension or in a liquid medium into a subject as the contents contained within the syringe.

[0129] Additionally, the contents contained within the syringe may include a cell suspension mixed with growth factors or a gel-like structure, preferably representing a mixture of extracellular matrix proteins that mimic the extracellular environment of distinct tissues, more preferably a gel-like structure such as hyaluronic acid.

[0130] Although human skin has been described above as an example of an object to which a liquid can be applied using a syringe or injection device equipped with the part with needle-like projections 1 of the present invention, the object can also be animal skin, the surface of plant stems, trunks, leaves, etc. Alternatively, the object may be tissue such as skin or organs removed from a human subject or test animal.

[0131] Although the preferred embodiments of the present invention have been described in detail above, the present invention is not limited to such specific embodiments, and various modifications and changes are possible within the scope of the gist of the embodiments of the present invention described in the claims.

[0132] This international application claims priority based on Japanese Patent Application No. 2020-166213 filed on September 30, 2020, the entire contents of which are incorporated herein by reference. [Explanation of symbols]

[0133] 1,2,3,4,5 Parts with needle-like protrusions 11 Needle plate 12 Mounting frame 22,42 Acicular process 23,43 Lip 24,44 Outlet hole 26 Mounting tube 41 Head 51 Needle plate 511 Plate body 512 Base 513 Acicular process 514 Lip 515 Outlet hole 61 Contact cylinder part 65 Elevator section 80 syringe 84 Tube tip 85 piston 86 Pressing piece (piston) 87 Gasket (piston) 90 fixed needle injection device 92 Outer cylinder (injection guide body) 93 Head (injection guide body) 95 Pusher (pressing part) 96 Pressing piece (pressing part) 97 Gasket (pressure part) 111,111A Plate body (plate) 112,112A Acicular process 113 Lip 114,114a,114b Outlet hole 121 Plate support 125 flow path 126 Mounting tube 200 Injection device L Contents (liquid)

Claims

1. A part with needle-like protrusions for injecting a liquid into a target, Plate and one or more pedestals protruding from one surface of the plate; one or more needle-like projections projecting from a tip end surface of each of the one or more pedestals, The plate and the one or more base portions have an outlet hole formed therein, the outlet hole passing through from the other surface of the plate to the tip surface of the base portion. Parts with needle-like protrusions.

2. The pinned part according to claim 1 , wherein the pinned protrusions are solid needles.

3. a lip portion formed on the outer edge of the tip surface of the base portion; The part with needle-like projections according to claim 1 or 2.

4. The part with a needle-like protrusion can be used by being attached to a syringe barrel, The part with needle-like protrusions is a mounting frame into which the plate is fitted and to which the tip of the syringe barrel is attached; When a piston fitted inside the syringe barrel is pressed, the liquid is sent out from the tip of the syringe barrel and pushed out through the ejection hole. The part with pin-like projections according to any one of claims 1 to 3.

5. The pouring hole is formed in a plurality of positions away from the center of the plate, the plate is fitted into the mounting frame so that the other surface of the plate and one surface of the mounting frame face each other with a predetermined gap therebetween; When the piston fitted inside the syringe barrel is pressed, the liquid is sent out from the tip of the syringe barrel to one side of the mounting frame, and after the liquid moves so as to spread between the other side of the plate and one side of the mounting frame, it is pushed outward through the ejection hole. The part with pin-like projections according to claim 4.

6. The part with a needle-like protrusion can be attached to a fixed-needle injection device and used; The fixed needle injection device comprises: an injection guide body having a cylindrical side wall with an injection hole formed therein and a head provided at the tip of the side wall with a flow hole formed therein; a pressing portion that is partially fitted inside the side wall of the injection guide body and is capable of moving up and down within the side wall, the plate of the part with needle-like projections is fitted and engaged with the tip of the head, After the liquid is injected into the injection guide body through the injection hole, the pressing portion is pushed down within the side wall, and the liquid is pushed outward through the circulation hole of the head and the injection hole of the plate. The part with pin-like projections according to any one of claims 1 to 5.

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