Calibration curve generation system and control method of calibration curve generation system

Abstract

To provide a calibration curve generation system and a control method of a calibration curve generation system, capable of improving work efficiency in generating a calibration curve.SOLUTION: A calibration curve generation system includes: an inspection device 11 disposed in a clean room 6 and configured to inspect an article according to a spectroscopic spectrum of the article measured by a spectrophotometer 10; a calibration curve generation device 2 disposed outside the clean room 6 and configured to generate a calibration curve to be referred to by the inspection device; and a data storage unit 5 accessible by the inspection device 11 and the calibration curve generation device 2. The inspection device 11 causes the data storage unit 5 to store a plurality of absorption spectra respectively obtained by the spectrophotometer 10 for a plurality of articles whose true values are known, while associating with the true values. The calibration curve generation device 2 generates a calibration curve from respective true values of the plurality of articles stored in the data storage unit 5 and absorption spectra respectively associated with the true values and stored in the data storage unit 5.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a calibration curve generating system and a control method for the calibration curve generating system. [Background technology]

[0002] Patent Document 1 discloses a system that causes a learning device connected via a network to generate a learning model that the inspection device uses during inspection, in order to reduce the processing load on the CPU of the inspection device. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent Publication No. 2021-096148 Summary of the Invention [Problem to be solved by the invention]

[0004] However, the system described in Patent Document 1 has the problem that when generating a learning model (hereinafter referred to as a "calibration curve" because it corresponds to the calibration curve in the present invention), the inspection device and the learning device must be online to the network, which reduces work efficiency.

[0005] The present invention has been made in consideration of the above-mentioned circumstances, and aims to provide a calibration curve generating system and a control method for a calibration curve generating system that can improve work efficiency when generating a calibration curve. [Means for solving the problem]

[0006] The calibration curve generation system according to the present invention is a calibration curve generation system comprising: an inspection device (11) provided in a clean room (6) for inspecting an object based on the spectroscopic spectrum of the object measured by a spectroscopic measurement device (10); and a calibration curve generation device (2) provided outside the clean room for generating a calibration curve to be referenced by the inspection device, and further comprising a data storage device (5) accessible by the inspection device and the calibration curve generation device, wherein the inspection device stores in the data storage device a plurality of absorption spectra obtained by the spectroscopic measurement device for a plurality of objects whose true values ​​are known, in association with the true values, and the calibration curve generation device generates a calibration curve from the true values ​​of the plurality of objects stored in the data storage device and the absorption spectra stored in association with the true values.

[0007] With this configuration, the calibration curve generation system according to the present invention stores the absorption spectra of a plurality of articles in association with true values ​​in a data storage device, and generates a calibration curve from each true value of the plurality of articles stored in the data storage device and the absorption spectra stored in association with each true value in the data storage device. This allows the inspection device and the calibration curve generation device to operate independently when generating the calibration curve, thereby improving work efficiency when generating the calibration curve.

[0008] In the calibration curve generating system according to the present invention, the data storage device may be configured as a cloud.

[0009] With this configuration, the calibration curve generating system according to the present invention can improve scalability.

[0010] Furthermore, the calibration curve generating system according to the present invention may further include a calibration curve storage device (4) accessible to the inspection device and the calibration curve generating device, wherein the calibration curve generating device stores the generated calibration curve in the calibration curve storage device, and the inspection device inspects the item using the calibration curve stored in the calibration curve storage device.

[0011] With this configuration, the calibration curve generation system of the present invention stores the calibration curve in a calibration curve memory device and inspects an item using the calibration curve stored in the calibration curve memory device, thereby allowing the inspection device to operate independently when inspecting an item, thereby improving work efficiency when inspecting an item.

[0012] Furthermore, the calibration curve generating system according to the present invention may further comprise a high-definition measuring device (3) that is provided outside the clean room and that measures the true values ​​of the plurality of articles, the data storage device being accessible by the high-definition measuring device, and the high-definition measuring device storing the true values ​​of the plurality of articles in the data storage device.

[0013] With this configuration, the calibration curve generation system according to the present invention stores the true values ​​of a plurality of articles in a data storage device, and generates a calibration curve from each true value of the plurality of articles stored in the data storage device and the absorption spectrum stored in the data storage device in association with each true value. This allows the high-definition measuring device to operate independently of the inspection device and the calibration curve generation device when generating the calibration curve, thereby improving work efficiency when generating the calibration curve.

[0014] A control method for a calibration curve generation system according to the present invention is a control method for controlling a calibration curve generation system including: an inspection device (11) provided in a clean room (6) that inspects an article based on the spectroscopic spectrum of the article measured by a spectroscopic measurement device (10); and a calibration curve generation device (2) provided outside the clean room that generates a calibration curve to be referenced by the inspection device, wherein the calibration curve generation system further includes a data storage device (5) accessible by the inspection device and the calibration curve generation device, and includes the steps of causing the inspection device to execute a process of storing in the data storage device a plurality of absorption spectra obtained by the spectroscopic measurement device for a plurality of articles whose true values ​​are known, in association with the true values; and causing the calibration curve generation device to execute a process of generating a calibration curve from each true value of the plurality of articles stored in the data storage device and the absorption spectra stored in the data storage device in association with each true value.

[0015] In this way, the control method for a calibration curve generating device according to the present invention associates the absorption spectra of a plurality of articles with true values ​​and stores them in a data storage device, and generates a calibration curve from each true value of the plurality of articles stored in the data storage device and the absorption spectra associated with each true value and stored in the data storage device. This allows the inspection device and the calibration curve generating device to operate independently when generating the calibration curve, thereby improving work efficiency when generating the calibration curve. [Effects of the Invention]

[0016] According to the present invention, it is possible to provide a calibration curve generating system and a control method for the calibration curve generating system that can improve the work efficiency when generating a calibration curve. [Brief explanation of the drawings]

[0017] [Figure 1] FIG. 1 is a functional block diagram of an article inspection device equipped with a calibration curve generating device according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0018] Hereinafter, an article inspection system including a calibration curve generation system according to one embodiment of the present invention will be described with reference to the drawings. As shown in Fig. 1, an article inspection system 100 according to this embodiment includes an article inspection device 1, a calibration curve generation device 2, a high-definition measurement device 3, a calibration curve storage device 4, and a data storage device 5.

[0019] The article inspection device 1 is installed in a clean room 6. When an article to be inspected, which is conveyed individually along a conveying path by a conveying unit, reaches a predetermined inspection position, the article inspection device 1 irradiates light onto the article, which is in a fixed position at the predetermined inspection position, and inspects the quality of the article based on the spectral spectrum of the transmitted light that passes through the article upon irradiation with this light (also referred to as irradiated light).

[0020] The items to be inspected include unpackaged items with an outer diameter of several to several tens of mm that can be transported individually, bite-sized items, as well as items and molded products of a predetermined shape manufactured using existing manufacturing equipment or manufacturing equipment without inspection capabilities, and especially items that do not change shape during transportation.

[0021] Examples of such articles include pharmaceutical preparations such as tablets, capsules, lozenges, and drops, as well as candy and chocolate. The following description will be given taking as an example an article to be inspected a tablet W that is circular in plan view, has a height (thickness) smaller than its diameter, and is roughly cylindrical in side view. Note that the article to be inspected is not limited to a circular shape in plan view, and articles of various shapes such as an oval shape or a polygonal shape can also be used.

[0022] Examples of the conveying unit include a conveying belt, a conveying disk, a conveying chute, and the like, which are configured to align and convey articles individually.

[0023] The article inspection device 1 according to this embodiment includes a spectroscopic measurement device 10 and an inspection device 11.

[0024] The spectroscopic measurement device 10 includes a light source unit and a light detection unit. The spectroscopic measurement device 10 irradiates a tablet W to be measured with broadband light (visible light, near-infrared to terahertz light (terahertz waves)), and measures the spectrum of the light transmitted through the tablet W in response to the irradiation of this light.

[0025] In this embodiment, the inspection device 11 is composed of a computer unit equipped with a CPU (Central Processing Unit), RAM (Random Access Memory), ROM (Read Only Memory), a storage device such as a hard disk drive, and a communication port.

[0026] The ROM and storage device of this computer unit store a program for causing the computer device to function as the inspection device 11. That is, the CPU executes the program stored in the ROM and storage device using the RAM as a working area, causing the computer unit to function as the inspection device 11 in this embodiment.

[0027] The inspection device 11 calculates the absorbance A of the tablet W at each wavelength λ from the light intensity Ii at the wavelength λ of the reference spectrum stored in the storage device and the light intensity I at the wavelength λ of the spectrum of the tablet W measured by the spectrometer 10, as follows: A=-log 10 The absorption spectrum of the tablet W is calculated by performing calculation according to (I / Ii). In this embodiment, the spectrum measured by the spectroscopic measurement device 10 in the absence of a measurement object is used as the reference spectrum.

[0028] The inspection device 11 performs preprocessing for a predetermined wavelength range of the absorption spectrum of tablet W. The preprocessing performed by the inspection device 11 is the same as the preprocessing executed by the preprocessing unit 20 of the calibration curve generating device 2 described later, and therefore a description thereof will be omitted. When the preprocessing of the absorption spectrum of tablet W is completed, the inspection device 11 refers to the calibration curve stored in the calibration curve storage device 4 and calculates a measurement value corresponding to the absorption spectrum of tablet W.

[0029] In this embodiment, the measured value represents the content of the component to be inspected contained in the tablet W. The calibration curve is generated by the calibration curve generating device 2 and stored in the calibration curve storage device 4. The calibration curve storage device 4 is provided so as to be accessible to the inspection device 11 and the calibration curve generating device 2. In this embodiment, the calibration curve storage device 4 is configured by network storage.

[0030] The inspection device 11 judges whether the quality of the tablets W is good or bad based on the measured values. The inspection device 11 outputs a sorting signal based on the quality or bad result of the judgment to a sorting device (not shown) that sorts the tablets W into normal products and defective products. The sorting device sorts the tablets W into normal products and defective products based on the sorting signal.

[0031] The calibration curve generating device 2 is provided in the office area 7 outside the clean room 6. The calibration curve generating device 2 generates a calibration curve that is referenced by the inspection device 11 in order to inspect the tablets W measured by the spectroscopic measurement device 10. In this embodiment, the calibration curve generating device 2 is configured by a computer device including a CPU, RAM, ROM, a storage device such as a hard disk drive, a communication port, a display device, and an input device.

[0032] The ROM and storage device of this computer device store a program for causing the computer device to function as the calibration curve generating device 2. That is, the CPU executes the program stored in the ROM and storage device using the RAM as a working area, causing the computer device to function as the calibration curve generating device 2 in this embodiment.

[0033] The display device may be, for example, a liquid crystal display device. The input device may be, for example, a keyboard device or a pointing device. The input device may be, for example, a touch pad that is integrated with the display device.

[0034] The high-precision measuring device 3 is provided in the research area 8 outside the clean room 6. The high-precision measuring device 3 is composed of a high-performance liquid chromatography device. The high-precision measuring device 3 measures the true value of the tablet with high precision.

[0035] The data storage device 5 is provided so as to be accessible to the inspection device 11, the calibration curve generating device 2, and the high-definition measurement device 3. In this embodiment, the data storage device 5 is configured by network storage. The true values ​​measured by the high-definition measurement device 3 and the absorption spectra calculated by the inspection device 11 are stored in association with each other.

[0036] In this embodiment, the data storage device 5 stores the absorption spectra of a plurality of tablets grouped according to their true values. For example, the first group is assigned the absorption spectra of 80 tablets whose true values ​​are close to 2. The second group is assigned the absorption spectra of 80 tablets whose true values ​​are close to 4. The third group is assigned the absorption spectra of 80 tablets whose true values ​​are close to 8. The fourth group is assigned the absorption spectra of 80 tablets whose true values ​​are close to 12.

[0037] The calibration curve generating device 2 includes a preprocessing unit 20, a classification unit 21, a calibration curve calculation unit 22, and a calibration curve evaluation unit .

[0038] The preprocessing unit 20 performs predetermined preprocessing on the absorption spectra stored in the data storage device 5 to convert them into a data format suitable for multivariate analysis, which will be described later. The predetermined preprocessing includes at least one of the four arithmetic operations, differentiation, integration, and normalization.

[0039] The classification unit 21 classifies the preprocessed absorption spectra into teacher data Tr and test data Te. In this embodiment, the classification unit 21 classifies the preprocessed absorption spectra equally into teacher data Tr and test data Te.

[0040] The calibration curve calculation unit 22 performs multivariate analysis on the teacher data Tr and the true values ​​associated with the teacher data Tr to calculate a calibration curve that represents the correlation between the teacher data Tr and the true values.

[0041] The calibration curve calculation unit 22 performs multivariate analysis using, for example, simple regression analysis, multiple regression analysis, quantification type 1, quantification type 2, quantification type 3, discriminant analysis, logistic regression analysis, principal component analysis, partial least squares regression (PLS regression), factor analysis, cluster analysis, correspondence analysis, multidimensional scaling, conjoint analysis, support vector machine, decision tree, random forest, naive Bayes, neural network, and deep learning.

[0042] In this embodiment, the calibration curve calculation unit 22 performs multivariate analysis by PLS regression. The calibration curve calculated by the calibration curve calculation unit 22 is stored in the calibration curve storage device 4 in response to, for example, an operation of the input device.

[0043] The calibration curve evaluation unit 23 calculates an evaluation value of the calibration curve calculated by the calibration curve calculation unit 22 using the test data Te and the true value associated with the test data Te, and evaluates the accuracy of the calibration curve based on the evaluation value.

[0044] In this embodiment, the calibration curve evaluation unit 23 calculates an evaluation value of the calibration curve based on at least one index such as the mean square error, the root mean square error, the mean absolute error, the mean error, the prediction standard error, the coefficient of determination, and the coefficient of determination adjusted for the degrees of freedom.

[0045] As described above, the product inspection system according to this embodiment stores the absorption spectra of multiple products in the data storage device 5 in association with true values, and generates a calibration curve from each true value of the multiple products stored in the data storage device 5 and the absorption spectra stored in the data storage device 5 in association with each true value. This allows the inspection device 11 and the calibration curve generating device 2 to operate independently when generating the calibration curve, thereby improving work efficiency when generating the calibration curve.

[0046] Furthermore, the item inspection system of this embodiment stores the calibration curve in the calibration curve memory device 4 and inspects the item using the calibration curve stored in the calibration curve memory device 4, thereby allowing the inspection device 11 to operate independently when inspecting the item, thereby improving work efficiency when inspecting the item.

[0047] Furthermore, the product inspection system according to this embodiment stores the true values ​​of a plurality of products in the data storage device 5, and generates a calibration curve from each true value of the plurality of products stored in the data storage device 5 and the absorption spectrum associated with each true value and stored in the data storage device 5. This allows the high-definition measuring device 3 to operate independently of the inspection device 11 and the calibration curve generating device 2 when generating the calibration curve, thereby improving work efficiency when generating the calibration curve.

[0048] In the present embodiment, an example has been described in which the calibration curve storage device 4 is configured by network storage. However, the calibration curve storage device 4 may be configured by the cloud. By configuring the calibration curve storage device 4 by the cloud, the product inspection system according to this embodiment can improve its scalability. Furthermore, the calibration curve storage device 4 may be configured by a highly portable storage medium such as a USB (Universal Serial Bus) memory.

[0049] In addition, in the present embodiment, an example has been described in which the data storage device 5 is configured as a network storage. However, the data storage device 5 may be configured as a cloud. By configuring the data storage device 5 as a cloud, the scalability of the article inspection system according to this embodiment can be improved. Furthermore, the data storage device 5 may be configured as a highly portable storage medium such as a USB memory.

[0050] In the present embodiment, an example has been described in which the calibration curve storage device 4 and the data storage device 5 are configured separately. However, the calibration curve storage device 4 and the data storage device 5 may be configured as an integrated device. For example, the calibration curve storage device 4 and the data storage device 5 may be configured as a single network storage.

[0051] While embodiments of the present invention have been disclosed above, it will be apparent to those skilled in the art that modifications may be made without departing from the scope of the present invention. All such modifications and equivalents are intended to be encompassed by the following claims. [Explanation of symbols]

[0052] 2. Calibration curve generator 3 High-precision measuring device 4 Calibration curve storage device 5 Data storage devices 6. Clean Room 10 Spectrometer 11 Inspection equipment

Claims

1. an inspection device (11) provided in the clean room (6) for inspecting an item based on the spectroscopic spectrum of the item measured by the spectroscopic measurement device (10); a calibration curve generating device (2) that is provided outside the clean room and generates a calibration curve to be referenced by the inspection device, Further comprising a data storage device (5) accessible by the inspection device and the calibration curve generating device, the inspection device stores in the data storage device a plurality of absorption spectra obtained by the spectrometer for a plurality of articles whose true values ​​are known, in association with the true values; The calibration curve generating device is a calibration curve generating system that generates a calibration curve from the true values ​​of the plurality of articles stored in the data storage device and the absorption spectra stored in the data storage device in association with each true value.

2. The calibration curve generating system according to claim 1 , wherein the data storage device is configured as a cloud.

3. The apparatus further includes a calibration curve storage device (4) accessible by the inspection device and the calibration curve generating device, the calibration curve generating device stores the generated calibration curve in the calibration curve storage device; 2. The calibration curve generating system according to claim 1, wherein the inspection device inspects the article using the calibration curve stored in the calibration curve storage device.

4. Further, a high-precision measuring device (3) is provided outside the clean room and measures the true values ​​of the plurality of articles, the data storage device is accessible by the high definition measurement device; 2. The calibration curve generating system according to claim 1, wherein the high-precision measuring device stores true values ​​of the plurality of articles in the data storage device.

5. an inspection device (11) provided in the clean room (6) for inspecting an item based on the spectroscopic spectrum of the item measured by the spectroscopic measurement device (10); a calibration curve generating device (2) that is provided outside the clean room and generates a calibration curve to be referenced by the inspection device, The calibration curve generation system further comprises a data storage device (5) accessible by the inspection device and the calibration curve generation device, a step of causing the inspection device to execute a process of correlating a plurality of absorption spectra obtained by the spectroscopic measurement device with respect to a plurality of articles whose true values ​​are known with the true values ​​and storing the same in the data storage device; and causing the calibration curve generating device to execute a process of generating a calibration curve from each true value of the plurality of articles stored in the data storage device and from absorption spectra stored in the data storage device in association with each true value.

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