Skin care serum containing sodium hyaluronate and polyacrylamide polymer

Abstract

A physically stable skin care serum emulsion composition having a continuous phase and a dispersed phase. The continuous phase can include about 0.5% to about 1.5% sodium hyaluronate having a weight average molecular weight of about 500,000 to about 1,000,000 Da according to the European Pharmacopoeia. The continuous phase can also include a thickening agent, including polyacrylamide polymers and copolymers. The dispersed phase can include a silicone. The composition can have an average viscosity of about 4,000 cP to about 25,000 cP and can be stored and dispensed via a dropper package.

Description

[Technical field]

[0001] The present invention generally relates to a skin care composition containing hyaluronic acid and a thickening agent, and in particular to a skin care composition having a weight average molecular weight of about 200,000 Da to about 1.5 million Da, 0.5% or more of a thickening agent, and a viscosity of about 3000 cP (2 Pa * s)~Approx. 25,000cP(25Pa * The present invention relates to a physically stable skin care emulsion composition containing greater than 0.5% hyaluronic acid having an average viscosity of [Background technology]

[0002] Many consumers desire skin care products that contain sodium hyaluronate, especially relatively high levels of sodium hyaluronate (e.g., ≧0.5%, ≧0.7%, ≧0.9%, or ≧1%), which can increase skin hydration and reduce the appearance of fine lines and wrinkles.

[0003] Some consumers desire sodium hyaluronate in serums, which are low viscosity topical products, because they believe this product form can be particularly effective in delivering results quickly on the skin.Furthermore, serums are generally light enough in texture to be used under facial moisturizers, other facial treatments, or cosmetics.

[0004] Serums can have high concentrations of active ingredients, so generally only a few drops are needed to deliver results to the entire face and / or neck, and therefore many serums are dispensed from dropper packaging.This packaging also allows consumers to customize their skin care regimen by adding drops to other products.Furthermore, attractive dropper packaging can present efficacy, as droppers have traditionally been used in the pharmaceutical industry, while also embodying luxury and fashion.

[0005] However, it has been found that when a relatively high level of sodium hyaluronate is added to a traditional serum package, it unexpectedly builds up viscosity, which, when combined with one or more traditional polymer thickeners, makes the formulation too viscous to dispense with a dropper and / or spread easily across the face of the user.One way to reduce viscosity is to eliminate ingredients (e.g., thickeners) that are known to build up viscosity.However, serum needs sufficient viscosity for physical stability (i.e., no phase separation) throughout the entire shelf life of the product. Summary of the Invention [Problem to be solved by the invention]

[0006] Therefore, there is a need for a physically stable serum containing relatively high levels of sodium hyaluronate that is compatible with a dropper dispenser. [Means for solving the problem]

[0007] 1. A physically stable skin care serum composition comprising: (a) a continuous phase comprising: (i) about 0.5% to about 1.5% sodium hyaluronate having a weight average molecular weight of about 500,000 to about 1,000,000 Da; (ii) greater than 0.7% thickener, the thickener being a polyacrylamide polymer or copolymer; and (iii) water; and (b) a dispersed phase comprising a silicone, wherein the composition comprises a viscosity of about 4,000 cP to 25,000 cP.

[0008] 1. A physically stable skin care serum composition comprising: (a) about 0.5% to about 1.5% sodium hyaluronate having a weight average molecular weight of about 700,000 to about 1,000,000 Da; (b) greater than 1% of a thickening agent, the thickening agent being a polyacrylamide polymer or copolymer; and (c) water, wherein the composition comprises a viscosity of about 4,000 cP to 25,000 cP. [Brief description of the drawings]

[0009] While the specification concludes with claims particularly pointing out and distinctly claiming the subject matter of the invention, it is believed the present invention can be more readily understood from the following description taken in conjunction with the accompanying drawings. [Figure 1] FIG. 1 shows the effect of adjusting the weight average molecular weight of 1% sodium hyaluronate on the viscosity of a simple system. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] Hyaluronic acid is a naturally occurring biopolymer in the skin and is a natural mucopolysaccharide formed by combining N-acetyl-O-glucosamine with glucuronic acid. Sodium hyaluronate is the sodium salt of hyaluronic acid and can be used in skin care products.

[0011] Many consumers desire skin care compositions containing sodium hyaluronate because it can regulate the water within the surface cells of the skin, keeping the skin hydrated throughout the day. The mechanism by which hyaluronic acid and its salts hydrate the skin can also help reduce the appearance of fine lines and wrinkles.

[0012] Many currently commercially available skin care compositions contain relatively low levels of sodium hyaluronate. Some consumers may desire a skin care composition with a relatively high level of sodium hyaluronate (e.g., ≧0.5%, ≧0.7%, ≧0.9%, or ≧1%) to achieve more moisture and / or anti-aging benefits. Many consumers may desire to apply a skin care composition with sodium hyaluronate in a serum, which is a low-viscosity topical emulsion product that can be applied by a dropper.

[0013] However, it can be difficult to formulate a serum that has (1) a low enough viscosity so that it can be easily dispensed with a dropper and spread across the user's face and / or neck, (2) hydrophobic emollients such as silicones that increase consumer satisfaction during use, and (3) physical stability.

[0014] It was discovered that about 1% sodium hyaluronate unexpectedly built viscosity in the composition, and surprisingly, the amount of viscosity built was found to correlate with the molecular weight (Mw) of the sodium hyaluronate.

[0015] The figure shows the effect of weight average molecular weight of about 1% sodium hyaluronate in a simple system (containing 7% glycerin, 1% sodium hyaluronate, and the balance water) on the average viscosity. The figure shows that as the Mw of sodium hyaluronate increases, the viscosity increases.

[0016] The weight average molecular weight was provided in the Certificate of Analysis by the supplier. The average viscosity was determined according to the following method: The viscosity was measured for a simple system after the sample was held at about 25° C. for at least 24 hours. The viscosity of the examples is measured at 25° C. by a DV2T™-RV Viscometer (available from Brookfield Engineering Laboratories, Middleboro, Massachusetts) with an RV3 spindle rotating at 5 rpm. The spindle is fully submerged 2.5-3.0 cm below the surface of the composition. The spindle is rotated for 30 seconds before data collection begins, and then one data point is collected every 10 seconds for five readings, and the readings are averaged (mean) to determine the average viscosity.

[0017] Therefore, simply adding a relatively high level of sodium hyaluronate to a serum formulation, especially one that contains one or more thickeners, can result in a product with unexpectedly high viscosity.Traditionally, product viscosity can be reduced by removing thickeners in the formulation.However, when thickeners are removed from serum, they can become physically unstable, which can cause sodium hyaluronate, emollients, and other skin care actives to escape from serum emulsion, which can appear as different layers in serum products.

[0018] The formulations set forth in Table 1 below were then made to evaluate product stability and viscosity at different levels of thickener (Polyacrylamide & C13-14 Isoparaffin & Laureth-7, commercially available as Sepigel™ 305 from Seppic® Corporation) in combination with 1% sodium hyaluronate having different weight average molecular weights. The results are summarized in Table 2 below. Both the average viscosity and stability were determined after the compositions were stored at 60° C. for two weeks.

[0019] [Table 1] 1. The weight average molecular weight was 511,000 Da, 615,000 Da, 855,000 Da, or 920,000 Da, as shown in Table 2 below. 2. Sepigel™ 305 from Seppic® Corporation 3. DC1503 from Dow Corning®

[0020] The average viscosity was determined by the Viscosity Test Method described herein.

[0021] The weight average molecular weight of sodium hyaluronate was provided in the certificate of analysis by the supplier.

[0022] If there was no phase separation by visual detection, the example was physically stable. As used herein, "visual detection" means that a human observer can visually identify, with the naked eye (with the exception of standard corrective lenses adapted to correct myopia, hyperopia, or astigmatism, or other corrective vision) from 30 cm under illumination at least equivalent to the illuminance of a standard 100 watt incandescent light bulb, whether the product has separated into two distinct layers in a 2 ounce clear glass bottle.

[0023] [Table 2]

[0024] Table 2 shows that the average product viscosity increases as the concentration of Sepigel 305 increases and when the Mw of sodium hyaluronate increases. Also, when higher Mw sodium hyaluronate is used, the composition can have less thickener. For example, in compositions with sodium hyaluronate having average Mw of 855,000 Da and 920,000 Da, the compositions were stable at 0.9% and 1.2% Sepigel 305 thickener. However, in compositions with sodium hyaluronate having average Mw of 511,000 Da and 615,000 Da, they were both unstable at 0.9% and 1.2% Sepigel 305 thickener. These compositions were stable when 1.8% thickener was added.

[0025] Next, a formulation was made to test the functionality of the dropper package. To be functional, the dropper package needs to dispense sufficient product without undue effort. A formulation was tested according to the formula in Table 1 with 1.8% thickener (Polyacrylamide & C13-14 Isoparaffin & Laureth-7 commercially available as Sepigel™ 305 from Seppic® Corporation) and 1% Sodium Hyaluronate with Mw of 920,000 Da (hereinafter "High Viscosity Example"). The formulation was placed in the same dropper package as Olay® Regenerist® Retinol24® Night Facial Serum ("Retinol24®"). The weight of each dose from the dropper was compared to the weight of the dose from the dropper from Retinol24®, showing that Retinol24® is a successful commercial serum product with ease of operation and doses that are acceptable to consumers. The dose was taken by compressing the flexible top on the dropper to squeeze out the air and place the tip into the serum, then stopping compression on the top and allowing the low pressure inside the dropper to draw up the liquid. The dose was then weighed. The results are summarized in Table 3 below.

[0026] [Table 3]

[0027] Products were deemed acceptable to consumers if the dose volume from the dropper was within ±15% of the droplet size of the Retinol 24® Serum. The dose from the high viscosity example was within ±15% of the dose of the Retinol 24® Serum and was easy to dispense. Thus, the high viscosity example was acceptable to consumers, and the other physically stable examples in Table 2 are expected to be acceptable to consumers as well, as they have lower viscosities than the high viscosity example.

[0028] All percentages are by weight of the cosmetic composition unless specifically stated otherwise. All ratios are by weight unless specifically stated otherwise. All ranges are inclusive and combinable. The number of significant digits does not represent a limitation on the amounts stated, nor does it represent a limitation on the precision of the measurements. All quantities are understood to be modified by the word "about" unless specifically stated otherwise. All measurements are understood to be made at ambient conditions of approximately 25°C, unless otherwise stated, where "ambient conditions" means conditions of about 1 atmosphere and about 50% relative humidity. All numerical ranges are inclusive of narrower ranges. The upper and lower range limits delimited are interchangeable to create further ranges not expressly delimited.

[0029] definition "Effective amount" refers to the amount of the compound or composition that is sufficient to induce a significant positive effect on keratinous tissue over the course of the treatment period. The positive effect can be a health, appearance, and / or feel effect, including the effects disclosed herein, either individually or in combination. In a specific example, the effective amount of vitamin B3 compound is an amount that is sufficient to improve the health and / or appearance of psoriatic skin during the treatment period. In some cases, the effective amount can be demonstrated using ex vivo and / or in vitro methods.

[0030] "Improving the appearance of" means providing a measurable desired change or effect in the appearance of skin, which can be quantified, for example, by a reduction in redness, inflammation, and / or scaling of spots.

[0031] By "safe and effective amount" is meant an effective amount of an ingredient that is low enough to avoid serious side effects (within the scope of sound medical judgment).

[0032] "Skin care" refers to the control and / or improvement of skin condition. Some non-limiting examples include improving the appearance and / or feel of skin by providing a smoother, more uniform appearance and / or feel, increasing the thickness of one or more layers of skin, improving the elasticity or resilience of skin, improving firmness of skin, reducing the oily, shiny, and / or dull appearance of skin, improving skin hydration or moisturization, improving the appearance of fine lines and / or wrinkles, improving skin exfoliation or scaling, plumping skin, improving skin barrier properties, improving skin tone, reducing the appearance of redness or skin blemishes, and / or improving skin brightness, luster, or clarity.

[0033] "Skin care active" means a compound or combination of compounds that, when applied to the skin, produces an acute and / or chronic effect on the skin or a type of cell normally found in the skin. Skin care actives can regulate and / or improve the skin or cells associated therewith (e.g., improve skin elasticity, skin hydration, skin barrier function, and / or cell metabolism).

[0034] "Skin care composition" means a composition that contains skin care actives and that regulates and / or improves the condition of the skin.

[0035] As used herein, "treatment period" refers to the length of time and / or frequency that a material or composition is applied to a targeted skin surface.

[0036] composition The skin care composition may be a serum having a viscosity sufficient for physical stability and thin enough to be dispensed by a dropper and easily spread across the face and / or neck of the user. The average viscosity is 3000 cP (3 Pa * s), alternatively 4000cP (4Pa * s), alternatively 4500cP (4.5Pa * s), alternatively 5000cP (5Pa *The average viscosity may be greater than 25,000 cP (25 Pa * s), alternatively 20,000cP (20Pa * s), alternatively 18,000cP (1.8Pa * s), alternatively 15,000 (15Pa * s), alternatively 13,000 (13Pa * s), or alternatively 10,000 (10 Pa * The average viscosity may be less than about 3000 cP (3 Pa s). * s)~Approx. 25,000cP(25Pa * s), alternatively about 3500cP (3.5Pa * s)~Approx. 20,000cP(20Pa * s), alternatively about 4000cP (4Pa * s)~Approx. 15,000cP(15Pa * s), alternatively about 5000cP (5Pa * s)~Approx. 10,000cP(10Pa * s) The average viscosity can be determined by the Viscosity Test Method described hereinafter.

[0037] The composition may contain 0.5% or more, alternatively 0.6% or more, alternatively 0.7% or more, alternatively 0.8% or more, alternatively 0.9% or more, alternatively 1.0% or more sodium hyaluronate. The composition may contain about 0.5% to about 5%, alternatively about 0.6% to about 4%, alternatively about 0.75% to about 3%, alternatively about 0.9% to about 2%, alternatively about 1% to about 1.5% sodium hyaluronate.

[0038] Sodium hyaluronate may have a Mw of about 200,000 Da to about 1.5 million Da, alternatively about 300,000 Da to about 1.25 million Da, alternatively about 400,000 Da to about 1 million Da, alternatively about 500,000 Da to about 950,000 Da. Sodium hyaluronate may have a Mw of less than 3 million Da, alternatively less than 2 million Da, alternatively less than 1 million Da. Sodium hyaluronate may have a Mw of greater than 100,000 Da, alternatively greater than 200,000 Da, alternatively greater than 300,000 Da, alternatively greater than 400,000 Da, alternatively greater than about 500,000 Da. The Mw of sodium hyaluronate can be determined according to the method set forth in the European Pharmacopoeia (European Pharmacopoeia 9.0.Sodium Hyaluronate.01 / 2017) (hereinafter, the "European Pharmacopoeia").

[0039] The skin care composition may contain about 1% sodium hyaluronate having a Mw of about 300,000 Da to about 1 million Da, alternatively about 400,000 Da to about 950,000 Da, alternatively about 500,000 Da to about 920,000 Da, alternatively about 505,000 Da to about 855,000 Da, alternatively about 510,000 Da to about 620,000 Da, and greater than 1.6% thickening agent, alternatively greater than 1.7% thickening agent, alternatively greater than 1.75% thickening agent, alternatively about 1.8% or more thickening agent.

[0040] The skin care composition may contain about 1% sodium hyaluronate having a Mw of about 500,000 Da to about 1 million Da, alternatively about 550,000 Da to about 950,000 Da, alternatively about 575,000 Da to about 920,000 Da, alternatively about 600,000 Da to about 855,000 Da, alternatively about 610,000 Da to about 800,000, alternatively about 615,000 Da to about 750,000 Da, alternatively about 615,000 Da to about 700,000 Da, and greater than 1.5% thickening agent, alternatively greater than 1.55% thickening agent, alternatively 1.6% or more thickening agent.

[0041] The skin care composition may contain about 1% sodium hyaluronate having a Mw of about 700,000 Da to about 2 million Da, alternatively about 750,000 Da to about 1.5 million Da, alternatively about 800,000 Da to about 1.25 million Da, alternatively about 825,000 Da to about 1 million Da, alternatively about 850,000 Da to about 950,000 Da, alternatively about 855,000 Da to about 920,000 Da, and greater than 0.5% thickening agent, alternatively greater than 0.75% thickening agent, greater than 0.8% thickening agent, greater than 0.85% thickening agent, alternatively 0.9% or more thickening agent.

[0042] The skin care compositions may be phthalate-free, paraben-free, dye-free, synthetic fragrance-free, and / or fragrance-free.

[0043] Thickener Any or a combination of the three compositions may include one or more thickening agents. The compositions may include more than 0.5%, alternatively more than 0.7%, alternatively more than 0.9%, alternatively more than 1.0%, alternatively more than 1.1%, alternatively more than 1.2% thickening agent. The compositions may include 2% or less thickening agent, alternatively less than 1.9%, alternatively less than 1.8% thickening agent. The compositions may include about 1% to about 2%, alternatively about 1.2% to about 2.5%, alternatively about 1.3% to about 2.2%, alternatively about 1.4% to about 2.0%, alternatively about 1.5% to about 1.8% thickening agent. Suitable classes of thickening agents include, but are not limited to, carboxylic acid polymers, polyacrylamide polymers, sulfonated polymers, copolymers thereof, hydrophobically modified derivatives thereof, and mixtures thereof. The thickening agents may be polyacrylamide polymers and copolymers.

[0044] Suitable thickening agents include carbomers (e.g., CARBOPOL® 900 series, such as CARBOPOL® 954), and carboxylic acid polymers, such as Ultrez 10 and Ultrez 30. Other suitable carboxylic acid polymeric agents include C 10~30 Alkyl acrylates, acrylic acid, methacrylic acid, or short chains thereof (i.e., C 1~4Examples of copolymers include copolymers of one or more monomers of one of the acrylate / C esters, and the crosslinker is an allyl ether of sucrose or pentaerythritol. These copolymers include copolymers of one or more monomers of one of the acrylate / C esters, and the crosslinker is an allyl ether of sucrose or pentaerythritol. 10~30 They are known as alkyl acrylate crosspolymers and are commercially available from Noveon, Inc. as CARBOPOL® 1342, CARBOPOL® 1382, Ultrez 20, Ultrez 21, PEMULEN TR-1, and PEMULEN TR-2.

[0045] Other suitable thickeners include polyacrylamide polymers and copolymers. An exemplary polyacrylamide polymer has the CTFA designation "polyacrylamide and isoparaffin and laureth-7" and is available under the trade name SEPIGEL 305 from Seppic Corporation (Fairfield, NJ). Other polyacrylamide polymers useful herein include multi-block copolymers of acrylamide and substituted acrylamide with acrylic acid and substituted acrylic acid. Commercially available examples of these multi-block copolymers include HYPAN SR150H, SS500V, SS500W, SSSA100H from Lipo Chemicals, Inc. (Patterson, NJ).

[0046] Other suitable thickening agents useful herein are sulfonated polymers such as sodium polyacryloyldimethyltaurate with the CTFA designation available under the trade name Simulgel 800 from Seppic Corp. and Viscolam at 100 P available from Lamberti SpA, Gallarate, Italy. Another commercially available material comprising a sulfonated polymer is Sepiplus™ 400 available from Seppic Corp.

[0047] Additionally, suitable thickening agents may include superabsorbent polymers. These superabsorbent polymers are crosslinked sodium polyacrylates, such as those sold under the names Octacare X100, X110 and RM100 by Avecia®, those sold under the names Flocare GB300 and Flosorb 500 by SNF®, those sold under the names Luquasorb 1003, Luquasorb 1010, Luquasorb 1280 and Luquasorb 1100 by BASF®, those sold under the names Water Lock G400 and G430 (INCI name: acrylamide / sodium acrylate copolymer) by Grain Processing®, or sodium acrylate crosspolymer-2, such as Aqua Keep® 10 SH NF, Aqua Keep® 10 SH NFC offered by Sumitomo Seika, starch grafted with acrylic acid polymers (homopolymers or copolymers), in particular with sodium polyacrylate, such as those sold under the name Sanfresh®. They may be selected from those sold by Sanyo Chemical Industries® under the names ST-100C, ST100MC, and IM-300MC, Makimousse 12 and Makimousse 25 (INCI name: sodium polyacrylate starch) supplied by Kobo Products Inc, acrylic acid polymers (homopolymers or copolymers), in particular hydrolyzed starches grafted with acryloacrylamide / sodium acrylate copolymers, such as those sold by Grain Processing® under the names Water Lock A-240, A-180, B-204, D-223, A-100, C-200, and D-223 (INCI name: starch / acrylamide / sodium acrylate copolymer). Preferred superabsorbent polymers may include Makimousse 12 and Makimousse 25.

[0048] Suitable thickening agents for use herein include gums. "Gum" is a term that is broadly defined in the art. Gums include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, derivatives thereof, and mixtures thereof.

[0049] Natural gums are polysaccharides of natural origin that can greatly increase the viscosity in solutions, even at low concentrations. They can be used as thickeners, gelling agents, emulsifiers, and stabilizers. Most often, these gums are found in woody elements of plants or in the skins of seeds. Natural gums can be classified according to their origin. They can also be classified as uncharged or ionic polymers (polyelectrolytes), examples of which include: natural gums obtained from seaweed, such as: agar, alginic acid; sodium alginate, and carrageenan. Natural gums obtained from non-marine plant sources include gum arabic from the sap of the Acacia tree, gum ghatti from the sap of the Anogeissus tree, gum tragacanth from the sap of the Astragalus shrub, and gum karaya from the sap of the Sterculia tree. Examples of uncharged gums include guar gum from guar beans, locust bean gum from the seeds of the carob tree; beta-glucan from oats or wheat bran; chicle gum, an older base for chewing gum obtained from the chicle tree; dammar gum from the sap of the dipterocarp tree; glucomannan from the konjac plant; mastic gum, a chewing gum from ancient Greece obtained from the mastic tree; psyllium seed husks from the Plantago plant; spruce gum, an American Indian chewing gum obtained from the spruce tree; tara gum from the seeds of the tara tree. Natural gums produced by bacterial fermentation include gellan gum and xanthan gum.

[0050] Vitamin B3 Compounds The compositions herein may contain a safe and effective amount of a vitamin B3 compound. In some cases, the compositions of the present invention may contain 0.01% to 10% by weight (e.g., 0.1% to 10%, 0.5% to 5%, or even 1% to 3%) of a vitamin B3 compound based on the weight or volume of the composition.

[0051] As used herein, a "vitamin B3 compound" is a compound having the formula:

[0052] [ka] wherein R is CONH2 (i.e., niacinamide), COOH (i.e., nicotinic acid), or CH2OH (i.e., nicotinyl alcohol), their derivatives, and salts of any of the foregoing.

[0053] Exemplary derivatives of vitamin B3 compounds include nicotinic acid esters, including non-vasodilatory esters of nicotinic acid (e.g., tocopheryl nicotinate, myristyl nicotinate), nicotinamide riboside, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, and niacinamide N-oxide.

[0054] Dermatologically acceptable carrier The compositions herein include a dermatologically acceptable carrier (which may be referred to as a "carrier"). The phrase "dermatologically acceptable carrier" means that the carrier is suitable for topical application to keratinous tissue, has good aesthetic properties, is compatible with the actives in the composition, and does not raise any undue safety or toxicity concerns. In one embodiment, the carrier is present in a concentration of about 50% to about 99%, about 60% to about 98%, about 70% to about 98%, or alternatively about 80% to about 95% by weight of the composition.

[0055] The carrier may be in a wide variety of forms. In some cases, the solubility or dispersibility of the components (e.g., extracts, sunscreen actives, additional ingredients) may determine the form and characteristics of the carrier. Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, sticks, flowable solids, or amorphous materials). In some cases, the dermatologically acceptable carrier is in the form of an emulsion with a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water emulsions) or a continuous oily phase (e.g., water-in-oil or oil-in-water-in-oil emulsions). The oil phase of the emulsion may include silicone oils, non-silicone oils (hydrocarbon oils, esters, ethers, etc.), and mixtures thereof. The aqueous phase may include water and water-soluble components (e.g., water-soluble moisturizers, conditioning agents, antibacterial agents, humectants, and / or other skin care actives). In some cases, the aqueous phase may contain components other than water, including, but not limited to, water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other water-soluble skin care actives. In some cases, the non-water components of the composition include humectants, such as glycerin and / or other polyols. The composition may contain from about 1% to about 15%, alternatively from about 3% to about 10%, alternatively from about 4% to about 9%, alternatively from about 5% to about 8% of a humectant.

[0056] In some cases, the compositions herein are in the form of oil-in-water ("O / W") emulsions that provide a light, non-greasy sensory feel. Suitable O / W emulsions herein may comprise more than 50% by weight of the composition of a continuous water phase, with the remainder being a dispersed oil phase. The water phase may comprise 1% to 99% water, based on the weight of the water phase, along with any water-soluble and / or water-miscible ingredients. In these cases, the dispersed oil phase is typically present at less than 30% by weight of the composition (e.g., 1% to 20%, 2% to 15%, 3% to 12%, 4% to 10%, or even 5% to 8%) to help avoid some of the undesirable sensory effects of oil-based compositions. The oil phase may comprise one or more volatile and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils). Some non-limiting examples of oils that may be suitable for use in the present compositions are disclosed in U.S. Pat. No. 9,446,265 and U.S. Patent Application Publication No. 2015 / 0196464.

[0057] The carrier may include one or more dermatologically acceptable diluents. As used herein, "diluent" refers to a material in which the skin care active herein can be dispersed, dissolved, or otherwise incorporated. Some non-limiting examples of hydrophilic diluents include organic hydrophilic diluents such as water, lower monohydric alcohols (e.g., C1-C4), and low molecular weight glycols and polyols, including propylene glycol, polyethylene glycol (e.g., molecular weight 200-600 g / mol), polypropylene glycol (e.g., molecular weight 425-2025 g / mol), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol esters, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol esters, butanediol, ether propanol, ethoxylated ethers, propoxylated ethers, and combinations thereof.

[0058] Silicone oil The composition may include a silicone oil selected from volatile silicone oils, non-volatile silicone oils, and combinations thereof. The silicone oil may be in a dispersed phase. The composition may include about 1% to about 10% silicone oil, alternatively about 3% to about 8% silicone oil, alternatively about 4% to about 7% silicone oil.

[0059] Volatile Silicone Oil Suitable volatile silicones include cyclic and linear volatile silicones. A description of various volatile silicones can be found in Todd, et al. "Volatile Silicone Fluids for Cosmetics", 91 Cosmetics and Toiletries 27-32 (1976). Suitable cyclic volatile silicones include cyclic dimethylsiloxane chains containing an average of about 3 to about 5 silicon atoms, preferably about 4 to about 5 silicon atoms. Exemplary cyclic volatile silicones of various viscosities include Dow Corning DC244, DC245, DC344, and DC345; GE Silicones-OSi Specialties Volatile Silicone 7207 and Volatile Silicone 7158; and GE Silicones SF1202. Suitable volatile linear silicones include polydimethylsiloxanes containing an average of about 2 to about 8 silicon atoms. Exemplary linear volatile silicones include the Dow Corning DC200 series, which have viscosities of 0.65 cst, 1.0 cst, and 2.0 cst. In certain embodiments, linear volatile silicones generally have a viscosity of about 4 centistokes or less at 25° C., and cyclic materials generally have a viscosity of less than about 6 centistokes at 25° C.

[0060] Non-volatile silicone oil Suitable non-volatile silicone oils include polysiloxanes. Non-volatile polysiloxanes may have a viscosity of from about 10 to about 1,000,000 centistokes at 25° C. Such polysiloxanes may be represented by the general chemical formula: R3SiO[R2SiO]xSiR3 wherein each R is independently selected from hydrogen or C1-30 linear or branched, saturated or unsaturated alkyl, phenyl or aryl, trialkylsiloxy, and x is an integer from 0 to about 10,000. In certain embodiments, R is methyl or ethyl. Commercially available polysiloxanes include polydimethylsiloxanes, also known as dimethicones, examples of which include the DM-Fluid series from Shin-Etsu, the Vicasil series sold by Momentive Performance Materials Inc., and the Dow Corning 200 series sold by Dow Corning Corporation. Specific examples of suitable polydimethylsiloxanes include Dow Corning 200 fluids (also sold as Xiameter PMX-200 Silicone Fluids). Suitable dimethicones include those represented by the following chemical formula: R3SiO[R2SiO]x[RR'SiO]ySiR3 where R and R' are each independently hydrogen or C1-30 linear or branched, saturated or unsaturated alkyl, aryl, or trialkylsiloxy, and x and y are each integers from 1 to 1,000,000. Examples include alkyl dimethicones, where at least R' is a fatty alkyl (e.g., C12-22). A suitable alkyl dimethicone is cetyl dimethicone, where R' is a C16 linear and R is methyl, available from Dow Corning as 2502 Cosmetic Fluid.

[0061] Preferred non-volatile oils include dimethicones (polydimethylsiloxanes), preferably having a viscosity of 10 cst to 1000 cst, more preferably 15 cst to 400 cst, and most preferably 20 cst to 200 cst. These preferred dimethicone materials have an average chain length of about 12 to about 375 dimethylsiloxane units, more preferably about 20 to about 200 dimethylsiloxane units, and most preferably about 27 to about 125 dimethylsiloxane units. In one embodiment, the second composition will include at least one non-volatile silicone oil. In one such embodiment, at least about 70% by weight of the non-volatile oil is a non-volatile silicone oil. In another embodiment, at least about 80% by weight of the non-volatile oil is a non-volatile silicone oil. In yet another embodiment, at least about 90% by weight of the non-volatile oil is a non-volatile silicone oil.

[0062] Other optional ingredients The present composition may optionally contain one or more additional ingredients commonly used in cosmetic compositions (e.g., colorants, skin care actives, anti-inflammatory agents, sunscreens, emulsifiers, buffers, rheology modifiers, combinations thereof, etc.), provided that the additional ingredients do not undesirably alter the skin health or appearance benefits provided by the present composition. If incorporated into the composition, the additional ingredients should be suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, etc. Some non-limiting examples of additional actives include vitamins, minerals, peptides and peptide derivatives, sugar amines, sunscreens, oil control agents, microparticles, flavonoid compounds, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliants, skin lightening agents, sunless tanning agents, lubricants, anti-acne actives, anti-cellulite actives, chelating agents, anti-wrinkle actives, anti-atrophy actives, phytosterols and / or plant hormones, N-acyl amino acid compounds, antibacterial agents, and antifungal agents. In some examples, the composition may include a fragrance, particularly a natural fragrance, or a colorant, particularly a natural colorant.Other non-limiting examples of additional ingredients and / or skin care actives that may be suitable for use herein are described in U.S. Patent Application Publication Nos. 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 00092408, 2008 / 0206373, 2010 / 0239510, 2010 / 0189669, 2010 / 0189702, 2010 / 0189704, 2010 / 0189706, 2010 / 0189708, 2010 / 0189709 ... Nos. 2010 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146, and 2013 / 0022557, as well as U.S. Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359, and 6,174,533.

[0063] When including optional ingredients in the compositions herein, it may be desirable to select ingredients that do not complex or otherwise interact undesirably with other ingredients in the composition, particularly pH-sensitive ingredients such as niacinamide, salicylates, and peptides. When present, optional ingredients may be included in an amount of 0.0001% to 50%, 0.001% to 20%, or even 0.01% to 10% (e.g., 50%, 40%, 30%, 20%, 10%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.1%) by weight of the composition.

[0064] How to use The skin care serum composition may be applied to the face, neck, and / or portions, or combinations thereof, at least once a day, twice a day, or more frequently per day during the treatment period. When applied twice a day, the first and second applications are separated by at least 1-12 hours. The composition is typically applied in the morning and / or at night before going to bed. The treatment period herein is ideally long enough for the sodium hyaluronate and / or other skin care actives to improve the appearance of the skin. The treatment period may last for at least one week (e.g., about 2 weeks, 4 weeks, 8 weeks, or even 12 weeks). In some cases, the treatment period will extend for several months (i.e., 3-12 months). In some cases, the composition may be applied at least once a day, or even twice a day, for the majority of days of the week (e.g., at least 4, 5, or 6 days per week) during a treatment period of at least 2 weeks, 4 weeks, 8 weeks, or 12 weeks.

[0065] The serum composition can be applied to a dry face after cleansing. The serum composition can be applied before or after other skin care compositions, including, but not limited to, moisturizers and / or sunscreens.

[0066] The serum composition may be intended to help improve the appearance of fine lines and wrinkles. The serum composition may be stronger, longer and last up to two times longer than other commercially available products. The serum composition may leave the skin feeling moisturized and fresh. EXAMPLES

[0067] The examples in Table 4 below could be prepared by conventional methods of making topical skin care emulsions. The following examples could be made by combining the water phase ingredients (e.g., sodium hyaluronate, glycerin, skin care actives, chelating agents, actioxidants, preservatives, and emulsifiers) in a container and mixing until uniform. The oil phase ingredients (e.g., oils with silicone oils and emulsifiers) could be combined in a separate container and mixed until uniform. The oil phase could then be added to the water phase and the resulting emulsion subjected to high shear mixing (e.g., Flacktek Speedmixer®, or rotor-stator mill). Finally, the remaining thickeners could be added to the emulsion and mixed until uniform, then the pH adjuster, if present, is added and the product subjected to high shear mixing until uniform.

[0068] [Table 4] 1 1,2-Hexanediol and Caprylyl Glycol from Symrise® 2 Iodopropynyl butylcarbamate, PEG-4 laurate, PEG-4 dilaurate, and polyethylene glycol from Lonza® 3 DMDM hydantoin, butane-1,3-diol, iodopropynyl butylcarbamate, water from Lonza® 4 Undecylenoyl Phenylalanine from Seppic® Corporation 5 Water and Hydrolyzed Serotonia Silica Seed Extract from Silab® 6 Water, glycerin, decyl glucoside, lactic acid, benzyl alcohol, and palmitoyl dipeptide-7 from Sederma® 7Sodium PEG-7 olive oil carboxylate from B&T Srl 8 Water, glycerin, PEG-100 stearate, benzyl alcohol, and palmitoyl pentapeptide-4 from Sederma® 9 Polyacrylamide, C13-14 Isoparaffin, and Laureth-7 from Seppic® Corporation 10 Sodium starch polyacrylate from Kobo® Products Inc. 12 Carbomer from Lubrizol® 13 Acrylates C10-30 Alkyl Acrylate Crosspolymer from Lubrizol® 14 Dimethicone (and) Dimethicone Crosspolymer from Dow Corning® 15 Dimethicone (and) Dimethiconol from Dow Corning®

[0069] Test Method Viscosity Test Method After storage at 25° C. for at least 24 hours, product viscosity is measured with a DV2T-RV viscometer (available from Brookfield Engineering Laboratories, Middleboro, Massachusetts) equipped with a TC spindle rotating at 5 rpm at 25° C. The spindle starts 2.5-3.0 cm below the product surface and progresses down the helipath, collecting one reading every 9 seconds for five readings. The average (mean) of the readings is calculated to determine the average viscosity.

[0070] combination A. A physically stable skin care serum composition comprising: a. A continuous phase, i. Sodium hyaluronate in an amount of about 0.5% to about 3%, having a weight average molecular weight of about 500,000 to about 1,000,000 Da, preferably about 500,000 Da to about 920,000 Da, more preferably about 505,000 Da to about 855,000 Da, and even more preferably about 510,000 Da to about 620,000 Da according to the European Pharmacopoeia method, and ii. A thickening agent in an amount greater than 0.7%, preferably greater than 1.0%, more preferably greater than 1.1%, and even more preferably 1.2% or more, which is a polyacrylamide polymer and copolymer, and iii. Water, and a continuous phase containing the same, and b. A dispersed phase containing silicone, and A composition having a viscosity of about 3,000 cP to 25,000 cP. B. A physically stable skin care cosmetic composition, and a. Sodium hyaluronate in an amount of about 0.5% to about 3%, having a weight average molecular weight of about 700,000 Da to about 2 million Da, preferably about 750,000 Da to about 1.5 million Da, more preferably about 800,000 Da to about 1.25 million Da, and even more preferably about 855,000 Da to about 920,000 Da according to the European Pharmacopoeia method, and b. A thickening agent in an amount greater than 1%, more preferably greater than 1.1%, and even more preferably 1.2% or more, which is a polyacrylamide polymer and copolymer, and c. Water, and wherein the composition has an average viscosity of about 3,000 cP (3 Pa * s) to 25,000 cP (25 Pa * s). C. The skin care composition is an emulsion containing a continuous phase and a dispersed phase, wherein the continuous phase contains sodium hyaluronate, a thickening agent, and water, and the dispersed phase contains silicone, the composition according to paragraph B. D. The average viscosity is about 3000 cP (3 Pa * s) to about 25,000 cP (25 Pa *s), preferably about 3500 cP (3.5 Pa * s)~Approx. 20,000cP(20Pa * s), more preferably about 4000 cP (4 Pa * s)~Approx. 15,000cP(15Pa * s), and even more preferably alternatively about 5000 cP (5 Pa * s)~Approx. 10,000cP(10Pa * The composition of any one of paragraphs A-C, wherein E. The composition described in any one of paragraphs A-D, wherein the composition comprises from about 0.6% to about 2% sodium hyaluronate, preferably from about 0.7% to about 1.5%, and more preferably from about 0.75% to about 1.25% sodium hyaluronate. F. The composition of any one of paragraphs A-E, wherein the composition contains 2% or less of a thickening agent, preferably 1.9% or less of a thickening agent, preferably 1.8% or less of a thickening agent. G. The composition of any one of paragraphs A-F, wherein the thickening agent comprises polyacrylamide and isoparaffin and laureth-7. H. The composition of any one of paragraphs A-G, wherein the composition is free of phthalates, parabens, dyes, synthetic fragrances, and / or fragrances. I. The composition of any one of paragraphs A-H, wherein the continuous phase further comprises from about 3% to about 10% glycerin, preferably from about 4% to about 9% glycerin, and more preferably from about 5% to about 8% glycerin. J. The composition of any one of paragraphs AI, wherein the continuous phase further comprises a vitamin B3 compound selected from niacinamide, nicotinic acid, nicotinyl alcohol, and combinations thereof. K. A skin care product comprising a dropper package adapted for storing and dispensing the skin care serum composition of any one of paragraphs A-J. L. Use of a skin care serum composition described in any one of paragraphs A-K to increase skin hydration and / or reduce the appearance of fine lines or wrinkles. Dimensions and values ​​disclosed herein should not be understood as being strictly limited to the exact numerical values ​​recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm."

[0071] All documents cited herein, including any cross-referenced or related patents or patent applications, and any patent applications or patents to which this application claims priority or benefit, are incorporated herein by reference in their entirety, unless expressly stated to the contrary, to the exclusion or otherwise limiting. The citation of any document shall not be deemed to be prior art to any invention disclosed or claimed herein, or to teach, suggest, or disclose any such invention, either alone or in combination with any other reference or references. Furthermore, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition given to that term in this document shall govern.

[0072] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims

1. 1. A physically stable skin care serum composition comprising: a. a continuous phase, i. 0.5% to 1.5% sodium hyaluronate, preferably 0.75% to 1.25% sodium hyaluronate, comprising a weight average molecular weight according to the European Pharmacopoeia of 500,000 to 1,000,000 Da, preferably 700,000 to 1,000,000 Da, more preferably 850,000 Da to 950,000 Da; ii. more than 0.7% thickener, preferably more than 1% thickener, more preferably more than 1.2% thickener, which are polyacrylamide polymers and copolymers; iii. A continuous phase comprising water; b. a dispersed phase comprising a silicone; The composition has an average viscosity of 4,000 cP (4 Pa ＊ s) to 25,000 cP (25 Pa ＊ s), preferably 4,000 cP (4 Pa ＊ s) to 15,000 cP (15 Pa ＊ s), more preferably 5,000 cP (5,000 Pa ＊ s) to 10,000 cP (10 Pa ＊ s), according to the viscosity test method described herein.

2. The composition of claim 1, wherein the thickening agent comprises polyacrylamide and isoparaffin and laureth-7.

3. 3. The composition of claim 1 or 2, wherein the composition is free of phthalates, parabens, dyes, synthetic fragrances, and / or perfumes.

4. 4. The composition according to any one of claims 1 to 3, wherein the continuous phase further comprises from 3% to 10% glycerin, preferably from 4% to 9% glycerin, more preferably from 5% to 8% glycerin.

5. The continuous phase comprises a B vitamin selected from niacinamide, nicotinic acid, nicotinyl alcohol, and combinations thereof. ３ The composition of any one of claims 1 to 4, further comprising a compound.

6. The continuous phase comprises a B vitamin selected from niacinamide, nicotinic acid, nicotinyl alcohol, and combinations thereof. ３ The composition of any one of claims 1 to 5, further comprising a compound.

7. The composition of any one of claims 1 to 6, wherein the composition is free of phthalates, parabens, dyes, synthetic fragrances, and / or perfumes.

8. A skin care product comprising a dropper package adapted for storing and dispensing the skin care serum composition of any one of claims 1 to 7.

9. Use of the skin care serum composition of any one of claims 1 to 8 to increase skin hydration and / or reduce the appearance of fine lines or wrinkles.

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