Cannula system

Abstract

A system and method are provided for a percutaneous ventricular assist device that includes a pump assembly and a cannula assembly. The pump assembly includes one or more connectors at or near its tip. The cannula assembly includes a cannula, an inflow cage, and a mating connector engageable with the connector of the pump assembly such that the first cannula assembly is attachable to the pump assembly. In various embodiments, the cannula assembly may be fixedly attached to the pump assembly or removably attached from the pump assembly.

Description

Technical Field

[0001] Cross - reference to Related Applications

[0001] This application claims priority to U.S. Provisional Patent Application No. 63 / 355,355, filed on June 24, 2022, which is incorporated herein by reference in its entirety.

[0002] Technical Field

[0002] The present disclosure relates to medical devices, and more particularly, to percutaneous ventricular assist devices having a cannula assembly for moving fluid into, out of, or through a body cavity such as a blood vessel or the heart.

Background Art

[0003] Background

[0003] For example, different types of blood pumps are known, such as axial blood pumps, centrifugal blood pumps, or hybrid - type blood pumps, and blood flow is caused by both axial and radial forces. One such example of a blood pump is the Impella® line of blood pumps from Abiomed of Danvers (e.g., Impella 2.5®, Impella CP®, Impella 5.5®, etc.). Intravascular blood pumps can be inserted into a patient's blood vessels via a catheter, for example, through the aorta.

Summary of the Invention

Means for Solving the Problems

[0004] Brief Summary

[0004] In some embodiments, a mechanical circulatory support device (MCS), such as a percutaneous ventricular assist device (PVAD), is provided. The PVAD, which can be, for example, a heart pump using a percutaneous catheter, can include a pump assembly and a first cannula assembly. The pump assembly can have one or more connectors at or near its tip. The first cannula assembly can include a first cannula and a first inflow cage, and a proximal end of the first cannula assembly can include one or more mating connectors engageable with one or more connectors of the pump assembly such that the first cannula assembly is attachable to the pump assembly.

[0005]

[0005] In some embodiments, the first cannula assembly can be configured to be attached to the pump assembly by a clinician prior to a medical procedure. In some embodiments, the first cannula assembly can be removably attachable to the pump assembly.

[0006]

[0006] In some embodiments, the PVAD can include a pigtail operably connected to a distal portion of the first cannula assembly. In some embodiments, the pigtail can be fixedly attached to the tip of the first cannula assembly such that the first cannula assembly and the pigtail are attachable to the pump assembly as a single, combined assembly. In some embodiments, the pigtail can be fixedly attached to the first inflow cage. In some embodiments, the pigtail can be removably attachable to the first inflow cage.

[0007]

[0007] In some embodiments, the PVAD may include a second cannula assembly that may include a second cannula and a second inflow cage. The second cannula assembly may be different from the first cannula assembly. The second cannula assembly may have a tip and a proximal end, and the proximal end of the second cannula assembly may include one or more mating connectors that can engage with a connector of the pump assembly such that the second cannula assembly can be attached to the pump assembly. In some embodiments, one of the first cannula assembly and the second cannula assembly may be configured to be attached to the pump assembly by a clinician prior to a medical procedure.

[0008]

[0008] In some embodiments, the pump assembly may include a motor operably connected to an impeller, and the impeller is configured to flow blood through the first inlet cage, the cannula assembly, or a combination thereof.

[0009]

[0009] In some embodiments, each mating connector may include a threaded portion. In some embodiments, each mating connector, each connector, or both may have a coating that includes an additive (e.g., silicone).

[0010]

[0010] In some embodiments, one mating connector may include a detent, and one connector may include at least one wall that defines an opening that at least partially extends through the wall, and the opening is configured to receive at least a portion of the detent. In some embodiments, each mating connector may include a detent, and each connector may include at least one wall that defines an opening that at least partially extends through the wall, and each opening is configured to receive at least a portion of one detent of the mating connector. In some embodiments, each mating connector further includes a silicone gasket, and the detent is positioned between the silicone gasket and the connector.

[0011]

[0011] In some embodiments, each mating connector, each connector, or both may include a magnetic element.

[0012]

[0012] In some embodiments, a system may be provided. The system may include the PVAD disclosed herein and a controller configured to control the PVAD.

[0013]

[0013] In some embodiments, a kit may be provided. The kit may include a pump assembly, a first cannula, and a second cannula different from the first cannula. The pump assembly may have one or more connectors at or near its distal end. The first cannula assembly may have one or more mating connectors at or near its proximal end. The one or more mating connectors of the first cannula assembly may engage with the one or more connectors of the pump assembly such that the first cannula assembly is coupled to the pump assembly. The second cannula assembly may have one or more mating connectors at or near its proximal end.

[0014]

[0014] In some embodiments, the first cannula assembly may be configured to be attached to the pump assembly by a clinician prior to a medical procedure. In some embodiments, the first cannula assembly may be removably attachable to the pump assembly.

[0015]

[0015] The kit may include a pigtail assembly. The pigtail assembly may be configured to be connected to the distal portion of the first cannula assembly, the second cannula assembly, or both. In some embodiments, the pigtail may be fixedly attached to the distal end of the first cannula assembly such that the first cannula assembly and the pigtail can be attached to the pump assembly as a single, combined assembly. In some embodiments, the pigtail is fixedly attached to an inflow cage on the first and / or second cannula assembly. In some embodiments, the pigtail is removably attachable to a first inflow cage on the first and / or second cannula assembly.

[0016]

[0016] In some embodiments, the first cannula assembly may include a first cannula and a first inflow cage, and the second cannula assembly may include a second cannula and a second inflow cage. In some embodiments, the first cannula is longer than the second cannula. In some embodiments, the first cannula may be curved. In some embodiments, the second cannula may be straight.

[0017]

[0017] The kit may include a third cannula assembly that includes a third cannula and a third inflow cage. The third cannula assembly may have one or more fitting connectors, and the third cannula assembly is different from the first and / or second cannula assemblies.

[0018]

[0018] In some embodiments, each fitting connector may include a threaded portion. In some embodiments, each fitting connector, each connector, or both may have a coating that includes an additive (e.g., silicone).

[0019]

[0019] In some embodiments, one mating connector may include a detent, and one connector may include at least one wall defining an opening that at least partially extends through the wall, the opening being configured to receive at least a portion of the detent. In some embodiments, each mating connector may include a detent, and each connector may include at least one wall defining an opening that at least partially extends through the wall, each opening being configured to receive at least a portion of one detent of the mating connector. In some embodiments, each mating connector further includes a silicone gasket, and the detent is positioned between the silicone gasket and the connector.

[0020]

[0020] In some embodiments, each mating connector, each connector, or both may include a magnetic element.

[0021]

[0021] The kit may include a controller configured to control the pump assembly.

[0022]

[0022] In some embodiments, the kit may include an inflow assembly. The inflow assembly may be attachable to the first cannula assembly and / or the second cannula assembly.

[0023]

[0023] In some embodiments, the first cannula assembly may include a sensor.

[0024]

[0024] In some embodiments, a method of providing a PVAD having a pump assembly and a plurality of cannula assemblies is provided. The method may include selecting a first cannula assembly of the plurality of cannula assemblies based on patient characteristics. The method may also include attaching the first cannula assembly to the pump assembly by connecting one or more connectors of the first cannula assembly to one or more connectors of the pump assembly. In some embodiments, the method may include inserting at least a portion of the PVAD into a patient.

[0025]

[0025] In some embodiments, the plurality of cannula assemblies may include an inflow assembly that includes a connector coupled to a proximal portion of the inflow assembly configured to connect to a mating connector coupled to a distal portion of different cannula assemblies.

[0026]

[0026] In some embodiments, the PVAD may include a pigtail assembly configured to be connected to a distal portion of the first cannula assembly.

[0027]

[0027] In some embodiments, the pigtail may be fixedly attached to the distal end of the first cannula assembly such that the first cannula assembly and the pigtail can be attached to the pump assembly as a single, combined assembly. In some embodiments, the pigtail is fixedly attached to an inflow cage on the first and / or second cannula assemblies. In some embodiments, the pigtail is removably attachable to a first inflow cage on the first and / or second cannula assemblies.

[0028]

[0028] In some embodiments, the first cannula assembly may include a first cannula and a first inflow cage, and the second cannula assembly may include a second cannula and a second inflow cage. In some embodiments, the first cannula is longer than the second cannula. In some embodiments, the first cannula may be curved. In some embodiments, the second cannula may be straight.

[0029]

[0029] In some embodiments, the pump assembly may include a motor operably connected to an impeller, the impeller being configured to flow blood through a first inlet cage, at least one of the cannula assemblies, or a combination thereof.

[0030]

[0030] In some embodiments, the PVAD may include a controller configured to control the pump assembly. In some embodiments, the first cannula assembly may be attached to the pump assembly by a clinician prior to a medical procedure. In some embodiments, the first cannula assembly may be removably attachable to the pump assembly.

[0031]

[0031] In some embodiments, a percutaneous ventricular assist device may be provided. The PVAD may include a pump assembly having a tip and a proximal end. The PVAD may include a first cannula assembly having a first cannula and a sensor. The first cannula assembly may have a tip and a proximal end. The proximal end may be attachable to the pump assembly. The tip may have one or more connectors. The PVAD may include a second cannula assembly having a second cannula and a first inflow cage. The second cannula may include one or more mating connectors engageable with one or more connectors of the first cannula assembly such that the second cannula assembly may be attachable to the first cannula assembly by a clinician prior to a medical procedure.

[0032]

[0032] In some embodiments, the PVAD may include a pigtail operably coupled to the tip portion of the second cannula assembly. In some embodiments, the PVAD is a heart pump using a catheter. In some embodiments, the pump assembly may include a motor operably connected to an impeller. The impeller may be configured to flow blood through the first inlet cage of the second cannula assembly, the first cannula assembly, the second cannula assembly, or a combination thereof. In some embodiments, one or more connectors may include threaded connectors.

[0033]

[0033] In some embodiments, one or more mating connectors, one or more connectors, or both may have a coating. The coating may include an additive. The additive may include silicone.

[0034]

[0034] In some embodiments, one or more mating connectors may include a backstop. In some embodiments, one or more connectors may include at least one wall defining an opening that extends at least partially through the wall. The opening may be configured to receive a portion of the backstop.

[0035]

[0035] In some embodiments, each mating connector, each connector, or both may include a magnetic element.

[0036]

[0036] In some embodiments, a method may be provided. The method may include providing a ventricular assist device having a pump assembly and a first cannula assembly, the first cannula assembly may have a first cannula. The providing step may include reducing the length of the first cannula of the first cannula assembly to achieve a defined length of the first cannula. In some embodiments, reducing the length of the first cannula may include removing the length of the first cannula. In some embodiments, the providing step may include attaching the first cannula assembly to the pump assembly via one or more connectors and one or more corresponding mating connectors. In some embodiments, the first cannula assembly includes an inlet cage. In some embodiments, the providing step may include attaching a second cannula assembly to the first cannula assembly via one or more connectors and one or more corresponding mating connectors. In some embodiments, the second cannula assembly may include an inlet cage. In some embodiments, each of the first and / or second cannula assemblies may include a sensor. In some embodiments, the first cannula may be permanently attached to the pump assembly.

Brief Description of the Drawings

[0037] Brief Description of the Drawings

Figure 1

[0037] A schematic diagram of an embodiment of a percutaneous ventricular assist device.

Figure 2A

[0038] It is a schematic partial cross-sectional view of an embodiment of a threaded connector and a mating connector.

Figure 2B

[0039] It is a schematic cross-sectional view of an embodiment of a connector using a detent and a mating connector.

Figure 2C

[0040] It is a schematic partial cross-sectional view of an embodiment of a connector using a magnet and a mating connector.

Figure 3A

[0041] It is a schematic view of an embodiment of a percutaneous ventricular assist device.

Figure 3B

[0042] It is a schematic view of an embodiment of a percutaneous ventricular assist device.

Figure 3C

[0043] It is a schematic view of an alternative embodiment of a percutaneous ventricular assist device.

Figure 3D

[0044] It is a schematic view of yet another embodiment of a percutaneous ventricular assist device.

Figure 4

[0045] It is a diagram of a blood pump placed to pass through the aorta and extending into the left ventricle through the aortic valve.

Figure 5

[0046] It is a schematic partial cross-sectional view of an embodiment of a third cannula assembly.

Figure 6

[0047] It is a flowchart of an embodiment of a method.

Figure 7

[0048] It is a schematic view of an embodiment of a percutaneous ventricular assist device.

Best Mode for Carrying Out the Invention

[0038] Detailed Description

[0049] Different types of blood pumps are known, such as axial blood pumps, centrifugal blood pumps, or hybrid - type blood pumps, and blood flow is caused by both axial and radial forces. One such example of a blood pump is the Impella® line of blood pumps from Abiomed of Danvers (e.g., Impella 2.5®, Impella CP®, Impella 5.5®, etc.). Intravascular blood pumps can be inserted into a patient's blood vessels via a catheter, for example, through the aorta.

[0039]

[0050] Current pumps using catheters use cannulas that are designed to generally fit most patients for certain indications. Correspondingly, such devices are designed to cover a wide range of implementation forms while not being able to be modified to meet the needs of a wide range of patients suffering from various conditions. Thus, this can limit a clinician's ability to provide more personalized care and / or enable treatment of more niche clinical indications (e.g., pediatric direct right - ventricular support and non - cardiac support, such as for the kidneys).

[0040]

[0051] Considering the above, the inventors recognized the benefits of a system that can be configured by the clinician performing the treatment to meet the needs of more patients and / or treatments.

[0041]

[0052] Disclosed herein is a mechanical circulatory support (MCS) device (e.g., a percutaneous ventricular assist device or PVAD) having a specific combination of a pump assembly, a connector, a cannula assembly, and / or an inflow assembly to provide greater flexibility to medical staff when treating specific conditions in a particular individual. In this regard, in some embodiments, the device can include modular units that can be configured by a clinician (e.g., a surgeon and / or an interventional cardiologist) to properly fit a patient prior to implantation.

[0042]

[0053] In some embodiments, the PVAD may include a catheter-based blood pump or a heart pump that provides mechanical circulatory support.

[0043]

[0054] Referring now to the figures, as seen in FIG. 1, in some embodiments, the percutaneous ventricular assist device may include a blood pump 100 having a pump assembly 110 and a cannula assembly 120.

[0044]

[0055] In some embodiments, the cannula assembly includes a proximal end 161 and a distal end 162. In some embodiments, the cannula assembly may have a cannula 122 and an inlet cage 124 (also referred to herein as an inflow cage). In some embodiments, the inlet cage 124 may be positioned on the distal side of the cannula 122.

[0045]

[0056] In some embodiments, the cannula 122 may have an inner surface 173 and an outer surface 172 having a sidewall therebetween. The inner surface may define a lumen extending from the proximal end of the cannula to the distal end of the cannula. As will be appreciated, in such embodiments, during use of the device, fluid may be moved through the lumen.

[0046]

[0057] The shape of the cannula 122 may vary as needed. In some embodiments, the cannula may be curved (see, e.g., FIG. 1). In some embodiments, the cannula may be straight (see, e.g., cannula 123 in FIG. 3A). As will be appreciated, in some embodiments, the cannula may have a straight portion and a curved portion. The cannula may also have different diameters.

[0047]

[0058] As can be seen similarly in FIG. 1, the pump assembly may have a proximal end 151 and a distal end 152. In some embodiments, the pump assembly may include a motor 114 operably connected to an impeller 118. In some embodiments, the impeller may be configured to flow blood through an opening 126 in the inlet cage 124, through the cannula 122, and out through an opening 116 in the pump assembly 110.

[0048]

[0059] As will be appreciated, in some embodiments, the pump assembly may be configured such that the blood flow can be reversed. That is, in some embodiments, the impeller may be configured to flow blood through an opening 116 in the pump assembly 110, through the cannula 122, and out through an opening 126 in the inlet cage 124.

[0049]

[0060] The pump assembly may have an inner surface 171 and an outer surface 170 having side walls therebetween. The inner surface may define a lumen extending at least partially from the distal end of the pump assembly towards the proximal end.

[0050]

[0061] As described herein, the pump may include a modular unit such that a clinician can appropriately configure the pump for a particular patient and / or condition. In some embodiments, the pump may be configured such that a clinician can attach a desired cannula assembly to the pump assembly to prepare the pump. In this regard, the pump assembly may have a connector that engages a corresponding connector of the cannula. For example, the pump assembly may have a connector 112 at the distal end of the pump assembly configured to engage a mating connector 128 at the proximal end of the cannula assembly. The connector and the mating connector may be joined together to form the pump assembly in some embodiments. In some embodiments, the connector and the mating connector may be joined such that the cannula assembly and the pump assembly can be fixedly attached together.

[0051]

[0062] In some embodiments, the inner surface 173 of the cannula assembly can interact with the outer surface 170 of the pump assembly. In some embodiments, the outer surface 172 of the cannula assembly can interact with the inner surface 171 of the pump assembly.

[0052]

[0063] The pump assembly 110 can have one or more connectors at or near its tip, and the cannula assembly 120 can have one or more mating connectors at or near its proximal end that are engageable with one or more connectors of the pump assembly such that the first cannula assembly can be attached to the pump assembly. In some embodiments, the mating connector is configured to be fixedly attached to the connector. In some embodiments, the mating connector is configured to be removably attached to the connector.

[0053]

[0064] In some embodiments, the first cannula assembly can be configured to be attached to the pump assembly by a clinician prior to a medical procedure.

[0054]

[0065] Referring to FIG. 2A, in some embodiments, the cannula assembly 220 can have a mating connector 240 that includes one or more threads 260 (each thread can include a separate mating connector in some embodiments). The pump assembly 210 can have a connector 230 that includes one or more recesses 262 (each recess can be a separate connector in some embodiments) configured to receive the threads. It is readily understood that the reverse is also contemplated, that is, the pump assembly can have a connector that includes one or more threads, and the cannula assembly can have a mating connector that includes a recess for receiving the threads. Further, FIG. 2A shows the connector 230 including the mating connector portion when assembled, and it is readily understood that the reverse can be readily achieved.

[0055]

[0066] As can be appreciated with reference to FIG. 2A, in some embodiments, to connect the pump assembly and the cannula assembly, the cannula can be threaded onto the pump assembly. In such embodiments, the shape and size of one or more threads can correspond to the shape and size of one or more recesses.

[0056]

[0067] In some embodiments, each mating connector, each connector, or both have a coating that includes an additive. In some embodiments, the coating includes silicone.

[0057]

[0068] Referring to FIG. 2B, in some embodiments, the mating connector 241 can include a detent 270. In such a configuration, the connector 231 can include a connector wall 252 that defines a first opening 272 that extends at least partially through the connector wall, and the first opening 272 can be configured to receive at least a portion of the detent 270. As can be appreciated, in some embodiments, the first opening can be configured to receive the entire detent. In some embodiments, the mating connector can include two or more detents (each detent being a separate mating connector in some embodiments), and the connector can include two or more openings (each opening in the wall being a separate connector in some embodiments). As can be appreciated, the shape and size of the detent can correspond to the shape and size of the detent. Further appreciated, the connector is shown as having one or more openings for receiving a mating connector having one or more detents, but in some embodiments, the mating connector can include one or more openings for receiving one or more detents of the connector.

[0058]

[0069] In some embodiments, the connector may include a mating connector wall 250 that defines a second opening 274 that extends at least partially through the mating connector wall, and the opening 274 is held by at least a portion of the detent 270. In some embodiments, the opening 274 may be at least partially covered by a collar 278, which is configured such that when the mating connector and the connector are properly positioned, at least a portion of the detent extends out of the mating connector portion 241 and into the first opening of the connector portion 231.

[0059]

[0070] In some embodiments, the mating connector may include a gasket 276, such as a silicone gasket. The gasket may be arranged such that the detent 270 is positioned between the gasket 276 and the connector 231.

[0060]

[0071] In various embodiments, one or more detents may be used. In some embodiments, one mating connector includes a detent, and one connector includes at least one wall that defines an opening that extends at least partially through the wall, and the opening is configured to receive a portion of the detent. In some embodiments, each mating connector includes a detent, and each connector includes at least one wall that defines an opening that extends at least partially through the wall, and the opening is configured to receive a portion of the detent.

[0061]

[0072] In other embodiments, the pump assembly and the cannula assembly may be held together magnetically. For example, in some embodiments, the connector may have one or more magnets and / or one or more ferromagnetic portions to which the magnets may be coupled. In some embodiments, the mating connector may have one or more magnets and / or one or more ferromagnetic portions to which the magnets may be coupled. In some embodiments, the one or more magnets may include permanent magnets. In some embodiments, the one or more magnets may include electromagnets.

[0062]

[0073] Referring to FIG. 2C, the pump assembly 212 may have a connector portion 232 with magnets 280, 281. The cannula assembly 222 may have a mating connector portion 242 including one magnet 282 and a ferromagnetic portion 283. In this way, when the mating connector is inserted into the connector, the first magnet 280 in the connector is coupled to the magnet 282 in the mating connector, and the second magnet 281 in the connector is coupled to the ferromagnetic portion 283. If there are two or more magnets or ferromagnetic portions, each magnet or ferromagnetic portion may include a separate connector or mating connector as needed.

[0063]

[0074] As will be appreciated, the mating connector and the connector may have other suitable engagement portions (e.g., press-fit and / or snap-fit arrangements) for attaching the cannula assembly to the pump assembly. Further, as will be recognized, in some embodiments, attaching the cannula assembly and the pump assembly (or other suitable assemblies) to each other may lock the assemblies together such that they cannot be separated during use of the pump.

[0064]

[0075] In some embodiments, a 1:1 correlation of the connector to the mating connector may exist. For example, in some embodiments, there may be a single check valve received in a single opening in the wall. In other embodiments, the number of connectors and mating connectors may vary. For example, the correlation may be 3:1 to 1:3 in some embodiments. In still other embodiments, the correlation is 10:1 to 1:10.

[0065]

[0076] As will be appreciated, in some embodiments, two or more types of connectors may be used to connect the pump assembly and the cannula assembly of the pump, for example, for redundancy. For example, in some embodiments, the mating connector may include both a thread and a check valve that engage a connector having a corresponding thread and a wall opening.

[0066]

[0077] Referring again to FIG. 1, in some embodiments, the pump may include a pigtail 130. The pigtail may be operably connected to the distal portion of the cannula assembly 120.

[0067]

[0078] In some embodiments, the pigtail may be fixedly attached to the distal end 162 of the cannula assembly 120 such that the cannula assembly 120 and the pigtail 130 can be attached to the pump assembly as a single integrated assembly. In some embodiments, the pigtail 130 may be fixedly attached to the inflow cage 124.

[0068]

[0079] In some embodiments, the pigtail 130 may be removably attachable to the inflow cage 124. This can be accomplished in various ways. For example, the proximal end of the pigtail may include a snap connection, a press fit, a screw type connector, or any other suitable reversible or removable connector, and the cannula assembly may include a suitable mating portion to provide the connection.

[0069]

[0080] As described herein, the pump may include a modular system such that a clinician can select a desired style and fit of the pump. Referring to FIG. 3A, in some embodiments, the PVAD may include a second cannula assembly 121 having a proximal end 163 and a distal end 164. The second cannula assembly may include a second cannula 123 and a second inflow cage 125. The second inflow cage may have one or more openings 127 configured to allow blood to enter and exit the second cannula 123. The second cannula assembly may similarly include a mating connector 129 engageable with a connector of the pump assembly such that the second cannula assembly can be attached to the pump assembly. In this regard, each of the first and second cannulas may have the same mating connector for engagement with the connector of the pump assembly.

[0070]

[0081] In some embodiments, at least one feature of the second cannula assembly 121 is different from the first cannula assembly 120. For example, in some embodiments, the second cannula assembly may have a straight cannula, while the first cannula assembly may have a bent cannula (or at least a partially bent cannula). In some embodiments, the maximum outer diameter of the second cannula assembly may be different from the maximum outer diameter of the first cannula assembly. In some embodiments, the distance from the proximal end to the distal end of the second cannula assembly (e.g., the length of the proximal cannula) is different from the distance from the proximal end to the distal end of the first cannula assembly.

[0071]

[0082] In some embodiments, either the first cannula assembly or the second cannula assembly is configured to be attached to the pump assembly by a clinician prior to a medical procedure. In this regard, the physician may select a cannula of an appropriate length and / or style for the appropriate procedure and / or patient.

[0072]

[0083] In some embodiments, a system for ventricular assist is provided. The system may include an embodiment of a percutaneous ventricular assist device as disclosed herein and a controller configured to control the percutaneous ventricular assist device.

[0073]

[0084] In some embodiments, the pump device may include three or more assemblies that can be coupled together. For example, as shown in FIG. 3B, the connector portion 112 at the tip of the pump assembly 110 can be coupled to the fitting connection portion 302 at the proximal end 301 of the first cannula assembly 300 including the cannula 303. The connector 304 at the tip 305 of the cannula 303 can then be coupled to the fitting connector portion 312 at the proximal end 311 of the cannula 313 of the second cannula assembly 310, the inflow cannula assembly. The inflow cannula assembly 310 may include an inflow cage 314 coupled to the tip of the cannula 313. As will be appreciated, various designs of these cannula assemblies can be used. Further, although a single intermediate cannula assembly 300 (e.g., the first cannula assembly) is shown in FIG. 3B, a plurality of such cannulas can be coupled together prior to connection to the inflow assembly 310 (also referred to as the inlet assembly).

[0074]

[0085] In some embodiments, as shown in FIG. 3D, the first cannula assembly may include a sensor 326, such as a pressure or flow sensor, configured to measure one or more parameters of the patient and / or the pump. In some embodiments, the sensor can be used to help determine whether the pump is operating correctly and / or providing appropriate support for the patient. For example, the sensor can assist in determining the proper position of the pump in the patient and / or the proper speed of the pump. In such embodiments, the first cannula assembly can be configured such that the length of the first cannula provides an optimal position for the sensor in the body (e.g., the heart). As will be appreciated, the pump may also have a second sensor positioned at another suitable location.

[0075]

[0086] The combination of the cannula and the inflow cage can be combined in a manner different from that shown in FIG. 3B. For example, as shown in FIG. 3C, the inflow assembly 330 may include an inflow cage 332 and a connector portion 331. In some embodiments, the thread 335 is a connector coupled to the proximal end portion of the inflow assembly. The thread may also be integrally formed with the inflow cage. In such embodiments, the connector is configured to connect to the fitting connector in the fitting connector portion 323 (the connector coupled to the distal end portion of the first cannula assembly, here the cannula assembly 320). In this embodiment, the cannula assembly 320 includes a cannula 322 and a fitting connector 321 at the proximal end 324 of the cannula assembly, and the fitting connector is configured to connect to the connector coupled to the distal end portion of the pump assembly at the connector portion 112, here the thread 340.

[0076]

[0087] In some embodiments, as shown in FIG. 3D, the first cannula assembly 300 can be attached (e.g., fixedly and / or permanently attached) to the pump assembly, and only the cannula 300 assembly has a connector 304 that couples to the fitting connector of the second inflow cannula assembly 310. As will be appreciated, in such embodiments, the inflow cannula assembly 110 can be formed with different lengths, and the clinician selects the desired inflow cannula assembly for attachment to the pump assembly 300.

[0077]

[0088] FIG. 4 shows an embodiment in which an intravascular blood pump having a catheter 410 is inserted into a patient's heart. For example, as shown in this figure, in some embodiments, the blood pump can be inserted retrograde into the descending aorta 411. As is well known, the descending aorta is part of the aorta 412 that first rises from the heart and then descends, and has an aortic arch 414. At the beginning of the aorta 412, there is an aortic valve 415 that connects the left ventricle 416 to the aorta 412, through which the intravascular blood pump can extend. As will be appreciated, the blood pump can be inserted into other suitable parts of the body.

[0078]

[0089] As will be appreciated, in view of the above, the intravascular blood pump assembly may include a pump assembly 450 coupled to the distal end of the catheter hose 420 and having a motor section 451, a pump assembly 452 disposed axially therefrom, and a cannula assembly 453 protruding distally from the distal end of the pump assembly 452. The cannula assembly may include an inflow cage 430 located at its end, the inflow cage having an opening 454 as described above, or the pump assembly may include an inflow cage assembly. A tip 455 may be provided on the distal side of the inflow cage 454, which may be a flexible tip configured, for example, as a "pigtail" or J-shaped. Different lines and devices that may be important for operating the pumping device 450 extend through the catheter hose 420. As will be appreciated, in view of the above, a clinician can select an appropriate pump assembly, a first and / or second catheter assembly and / or an inflow assembly and, as shown, assemble a desired pump for implantation in a patient.

[0079]

[0090] In some embodiments, the pump may include one or more electrical connectors 428 and / or one or more optical fibers 429 attached to a controller 490 at its proximal end. The optical fibers may be part of, for example, an optical sensor (e.g., a pressure sensor), the sensor head of which may be located near the inflow cage 430 (e.g., see sensor 326 in FIG. 3D), in the pump section or in the pump section or a combination thereof. In some embodiments, the controller then converts the electrical or optical signal into information that can be displayed, for example, on a display screen 491.

[0080]

[0091] In some embodiments, a PVAD kit may be provided. Referring to FIG. 3A, in some embodiments, the kit may include a pump assembly 110 having a connector portion 112 that may include one or more connectors at or near the distal end portion. In some embodiments, the kit may include a first cannula assembly 120 having a mating connector portion 128 that may include one or more mating connectors at or near the proximal end portion of the first cannula assembly. In some embodiments, the kit may have a second cannula assembly (e.g., the second cannula assembly 121 of FIG. 3A, the second cannula 320 of FIG. 3C, and / or the second inflow cannula 310 of FIGS. 3B and 3D) having corresponding mating connectors at or near the proximal end portion of the second cannula assembly. In still other embodiments, the kit may include an inflow cage assembly with one or more connectors or mating connectors.

[0081]

[0092] In some embodiments, the second cannula assembly may be the same as the first cannula assembly. In some embodiments, the second cannula assembly may be different from the first cannula assembly.

[0082]

[0093] In some embodiments, one or more mating connectors of the first cannula assembly may be configured to engage with one or more connectors of the pump assembly such that the first cannula assembly is or can be coupled to the pump assembly.

[0083]

[0094] In some embodiments, one or more mating connectors of the second cannula assembly may be configured to engage with one or more connectors of the pump assembly such that the second cannula assembly is or can be coupled to the pump assembly.

[0084]

[0095] In some embodiments, the kit may include a pigtail assembly 130 configured to be connected to the distal end portion of the first cannula assembly, the second cannula assembly, or both.

[0085]

[0096] In some embodiments, the pigtail can be fixedly attached to the distal end 162 of the cannula assembly 120 such that the cannula assembly 120 and the pigtail 130 can be attached to the pump assembly as a single combined assembly. In some embodiments, the pigtail 130 can be fixedly attached to the first inflow cage 124. In some embodiments, the pigtail 130 can be fixedly attached to the second inflow cage 125.

[0086]

[0097] In some embodiments, the pigtail 130 can be removably attachable to the first inflow cage 124. In some embodiments, the pigtail 130 can be removably attachable to the second inflow cage 125.

[0087]

[0098] In some embodiments, at least one feature of the second cannula assembly 121 is different from the first cannula assembly 120. For example, in some embodiments, the second cannula assembly can have a straight cannula while the first cannula assembly can have a bent cannula. In some embodiments, the maximum outer diameter of the second cannula assembly is different from the maximum outer diameter of the first cannula assembly. In some embodiments, the distance from the proximal end to the distal end of the second cannula assembly is different from the distance from the proximal end to the distal end of the first cannula assembly. In some embodiments, the first cannula is longer than the second cannula. In some embodiments, one of the first and second cannulas can include a sensor.

[0088]

[0099] In some embodiments, the kit can include a third cannula assembly. As seen in FIG. 5, the third cannula assembly 500 can include a third cannula 510 and a third inflow cage 520. The third cannula assembly can include a mating connector portion 530. The mating connector portion can include one or more mating connectors 532, 533 (here, a thread 532 and a magnet 530).

[0089]

[0100] In some embodiments, at least one feature of the third cannula assembly 500 is different from that of the first cannula assembly 120, the second cannula assembly 121, or both. For example, in some embodiments, the second cannula assembly and the third cannula assembly may each have a straight cannula, while the first cannula assembly may have a bent cannula. In some embodiments, the maximum outer diameter of the third cannula assembly is different from the maximum outer diameter of the first cannula assembly, the second cannula assembly, or both. In some embodiments, the distance from the proximal end to the distal end of the third cannula assembly is different from the distance from the proximal end to the distal end of the first cannula assembly, the second cannula assembly, or both. In some embodiments, the third cannula is longer than the first cannula, the second cannula, or both.

[0090]

[0101] As can be seen in FIGS. 1, 2A, 2C, and 5, it is understood that the mating connector portion of the disclosed cannula assembly can be related to its associated cannula in different ways. For example, referring to FIG. 5, in some embodiments, the sidewall 535 forming the mating connector 530 can be coupled to the surface of the cannula. For example, the outer surface 536 of the sidewall 535 is coupled to the inner surface 526 of the sidewall 525 of the cannula 510 (e.g., via an adhesive, heat bonding, etc.). In other embodiments, the proximal end portion of the sidewall forming the cannula can be considered the mating connector portion.

[0091]

[0102] In some embodiments, each mating connector can include a threaded portion. In some embodiments, each mating connector, each connector, or both can have a coating that includes an additive (e.g., silicone).

[0092]

[0103] In some embodiments, one mating connector may include a detent, and one connector may include at least one wall defining an opening that extends at least partially through the wall, the opening being configured to receive at least a portion of the detent. In some embodiments, each mating connector may include a detent, and each connector may include at least one wall defining an opening that extends at least partially through the wall, each opening being configured to receive at least a portion of one detent of the mating connector. In some embodiments, each mating connector further includes a silicone gasket, and the detent is positioned between the silicone gasket and the connector.

[0093]

[0104] In some embodiments, each mating connector, each connector, or both may include a magnetic element.

[0094]

[0105] In some embodiments, the kit may include a controller configured to control the pump assembly. In some embodiments, the first cannula assembly may be attachable to the pump assembly by a clinician prior to a medical procedure. In some embodiments, the first cannula assembly is removably attachable to the pump assembly.

[0095]

[0106] In some embodiments, a method of providing a percutaneous ventricular assist device having a pump assembly and a plurality of cannula assemblies may be used.

[0096]

[0107] Referring to FIG. 6, method 600 may include selecting 610 a first cannula assembly of the plurality of cannula assemblies based on patient characteristics and / or a procedure being performed on the patient.

[0097]

[0108] In some embodiments, the characteristics may include a diagnosis or test result, the patient's age, the patient's size, and / or another symptom of the patient.

[0098]

[0109] The method may include attaching a first cannula assembly to a pump assembly by connecting one or more connectors of the first cannula assembly to one or more connectors of the pump assembly 620.

[0099]

[0110] In some embodiments, the method includes attaching a second cannula assembly (e.g., a cannula inflow assembly) to the first cannula assembly. In some embodiments, the method includes attaching an inflow assembly to the cannula assembly.

[0100]

[0111] In some embodiments, the method may include inserting a part or all of a percutaneous ventricular assist device into a patient 630 (see, e.g., FIG. 4).

[0101]

[0112] In some embodiments, the plurality of cannula assemblies may include a second cannula assembly and / or a third cannula assembly. In some embodiments, the second cannula assembly includes a cannula and an inflow cage.

[0102]

[0113] In some embodiments, the plurality of cannula assemblies includes an inflow assembly having a connector coupled to a proximal portion of the inflow assembly, the connector configured to connect to a mating connector coupled to a distal portion of a different cannula assembly.

[0103]

[0114] In some embodiments, one of the first cannula assembly and / or the second or third cannula may include a pigtail assembly configured to be connected to a distal portion of the first cannula assembly, the second cannula assembly, or both.

[0104]

[0115] In some embodiments, the pigtail can be fixedly attached to the distal end of the cannula assembly such that the cannula assembly and the pigtail can be attached to the pump assembly as a single combined assembly. In some embodiments, the pigtail can be fixedly attached to the first inflow cage. In some embodiments, the pigtail can be fixedly attached to the second inflow cage.

[0105]

[0116] In some embodiments, the pigtail can be removably attachable to the first inflow cage.

[0106]

[0117] In some embodiments, at least one feature of the second cannula assembly is different from the first cannula assembly. For example, in some embodiments, the second cannula assembly can have a straight cannula while the first cannula assembly can have a bent cannula. In some embodiments, the maximum outer diameter of the second cannula assembly is different from the maximum outer diameter of the first cannula assembly. In some embodiments, the distance from the proximal end to the distal end of the second cannula assembly is different from the distance from the proximal end to the distal end of the first cannula assembly.

[0107]

[0118] In some embodiments, either the first cannula assembly or the second cannula assembly is configured to be attached to the pump assembly by a clinician prior to a medical procedure.

[0108]

[0119] In some embodiments, the pump assembly can include a motor operably connected to an impeller. In some embodiments, the impeller can be configured to flow blood through an opening in the inlet cage, through the cannula, and out through an opening in the pump assembly.

[0109]

[0120] In some embodiments, method 600 includes controlling the pump assembly using a controller 640 to cause blood to flow through one or more of the plurality of cannula assemblies of the assembled pump. In some embodiments, the method may include transmitting one or more characteristics of the patient and / or the pump via a sensor and controlling the pump based on the sensed data. For example, in some embodiments, controlling the pump may include changing the speed of the pump and / or changing the position of the pump.

[0110]

[0121] In some embodiments, method 600 includes removing the pump assembly from the patient 650, for example, after treatment is complete.

[0111]

[0122] Embodiments are illustrated and described in which a desired pump is formed by connecting together one or more assemblies (e.g., a pump assembly, a cannula assembly, and / or an inflow assembly), although in other embodiments, the desired pump may be provided in other suitable ways. For example, referring to FIG. 7, in some embodiments, the pump may include a large cannula assembly 720 that can be sized to accommodate the patient and / or the size of the procedure. For example, in some embodiments, the cannula may include one or more regions 721, 722, 723 that can be selectively removable to achieve a desired length. In some embodiments, the tip region 721 and / or one or more intermediate regions 722 may be removed. In some embodiments, the proximal region 723 and / or one or more intermediate regions 722 may be removed. In some embodiments, each region may include a first portion 725 intended to be cut or otherwise used as a separation point and a second portion 724 not intended to be cut or otherwise used as a separation point. For example, in some embodiments, a clinician may cut and remove the length of the cannula assembly until the desired length is achieved. In other embodiments, the entire length of the cannula may be configured such that the clinician can cut and remove any desired length. In some embodiments, the cannula assembly may be fixedly attached to the pump assembly (e.g., without the need for attachment via one or more connectors prior to use) such that it is only necessary for the clinician to remove the non-essential length of the cannula assembly before inserting the cannula assembly into the patient. As will be appreciated, the length of the cannula assembly may also be removed in other suitable ways, such as by folding and / or peeling a specific length of the cannula by having one or more telescoping portions within the cannula assembly and / or another portion of the pump assembly, or via other suitable methods.

[0112]

[0123] As is further appreciated, in some embodiments, the length of the cannula assembly can be adjusted and the cannula assembly can then be attachable to the pump assembly and / or the inflow assembly. For example, in some embodiments, the cannula assembly can be configured such that one or more connectors (e.g., mating connectors) are attachable to the cannula assembly such that the cannula assembly can then be attached to the pump assembly. In this regard, shortening of the cannula assembly can occur at the proximal end of the cannula assembly. In other embodiments, the distal end of the cannula assembly can be shortened and the distal end of the cannula assembly has a plurality of connectors that can engage the inlet assembly to attach the inlet assembly to the cannula assembly.

[0113]

[0124] Embodiments of the present disclosure are described in detail with reference to the figures, in which like reference numerals indicate like or identical elements. It is to be understood that the disclosed embodiments are merely examples of the present disclosure, which can be implemented in various forms. Well-known functions or structures are not described in detail to avoid obscuring the present disclosure with unnecessary detail. Accordingly, the specific structural and functional details disclosed herein are not to be construed as limiting, but rather as a representative basis for the claims and as a basis for teaching one skilled in the art to use the present disclosure in any suitable detailed structure in various ways.

[0114]

[0125] One skilled in the art can recognize or acknowledge many equivalents to the specific embodiments of the invention described herein with only ordinary experimentation. Such equivalents are intended to be encompassed by the following claims.

Claims

1. A percutaneous ventricular assist device, comprising: A pump assembly having a tip and a base end, the pump assembly having one or more connectors at or near the tip; A first cannula assembly including a first cannula, the first cannula having a tip and a base end, the base end including one or more mating connectors engageable with the one or more connectors of the pump assembly, the first cannula assembly being configured to be attached to the pump assembly by a clinician prior to a medical procedure; A percutaneous ventricular assist device comprising the above.

2. The percutaneous ventricular assist device according to claim 1, wherein the first cannula assembly includes a first inflow cage attached to the first cannula assembly.

3. The percutaneous ventricular assist device according to claim 1, wherein the first cannula assembly is removably attachable to the pump assembly.

4. The percutaneous ventricular assist device according to claim 1, further comprising a pigtail operably connected to the tip portion of the first cannula assembly.

5. The percutaneous ventricular assist device according to claim 4, wherein the pigtail is fixedly attached to the tip of the first cannula assembly such that the first cannula assembly and the pigtail can be attached to the pump assembly as a single assembled unit.

6. The percutaneous ventricular assist device according to claim 5, wherein the pigtail is fixedly attached to the first inflow cage of the first cannula assembly.

7. The percutaneous ventricular assist device according to claim 4, wherein the pigtail is removably attachable to the first inflow cage of the first cannula assembly.

8. The percutaneous ventricular assist device further comprises a second cannula assembly including a second cannula and a second inflow cage, The second cannula assembly has a tip and a base end, the base end of the second cannula assembly including one or more mating connectors being engageable with the connectors of the pump assembly such that the second cannula assembly is attachable to the pump assembly, The second cannula assembly is different from the first cannula assembly. The percutaneous ventricular assist device according to claim 1, wherein the first cannula assembly or the second cannula assembly is configured to be attached to the pump assembly by a clinician before a medical treatment.

9. The percutaneous ventricular assist device according to claim 1, which is a heart pump using a catheter.

10. The percutaneous ventricular assist device according to claim 8, wherein the pump assembly includes a motor operably connected to an impeller, and the impeller is configured to flow blood through a first inlet cage of the first cannula assembly, the first cannula assembly or a combination thereof.

11. The percutaneous ventricular assist device according to claim 1, wherein each fitting connector includes a threaded portion.

12. The percutaneous ventricular assist device according to claim 11, wherein each fitting connector, each connector or both have a coating containing an additive.

13. The percutaneous ventricular assist device according to claim 12, wherein the additive includes silicone.

14. The percutaneous ventricular assist device according to claim 1, wherein one fitting connector includes a detent, and one connector includes at least one wall defining an opening extending at least partially through the wall, and the opening is configured to receive a part of the detent.

15. The percutaneous ventricular assist device according to claim 1, wherein each fitting connector includes a detent, and each connector includes at least one wall defining an opening extending at least partially through the wall, and the opening is configured to receive a part of the detent.

16. The percutaneous ventricular assist device according to claim 15, wherein each fitting connector further includes a silicone gasket, and the detent is positioned between the silicone gasket and the connector.

17. The percutaneous ventricular assist device according to claim 1, wherein each fitting connector, each connector or both include a magnetic element.

18. A system for ventricular assist, comprising: The percutaneous ventricular assist device according to any one of claims 1 to 17; and A controller configured to control the percutaneous ventricular assist device. A system including the above.

19. A kit, comprising: A pump assembly having one or more connectors at or near a tip portion. A first cannula assembly having one or more fitting connectors at or near the proximal end of the first cannula assembly A second cannula assembly having one or more fitting connectors at or near the proximal end of the second cannula assembly, the second cannula assembly being different from the first cannula assembly A kit comprising the one or more fitting connectors of the first cannula assembly engaging with the one or more connectors of the pump assembly such that the first cannula assembly is coupled to the pump assembly

20. The kit according to claim 19, further comprising a pigtail assembly configured to be connected to the distal end portion of the first cannula assembly, the second cannula assembly or both

21. The kit according to claim 20, wherein the pigtail is fixedly attached to the distal end of the first cannula assembly such that the first cannula assembly and the pigtail can be attached to the pump assembly as a single combined assembly

22. The kit according to claim 21, wherein the first cannula assembly includes a first cannula and a first inflow cage, and the pigtail is fixedly attached to the first inflow cage

23. The kit according to claim 20, wherein the first cannula assembly includes a first cannula and a first inflow cage, and the pigtail is removably attachable to the first inflow cage

24. The kit according to claim 19, wherein the first cannula assembly includes a first cannula and a first inflow cage, and the second cannula assembly includes a second cannula and a second inflow cage

25. The kit according to claim 24, wherein the first cannula is longer than the second cannula

26. The kit according to claim 25, wherein the first cannula is bent

27. The kit according to claim 26, wherein the second cannula is straight

28. The kit according to claim 19, further comprising a third cannula assembly including a third cannula and a third inflow cage, the third cannula assembly having one or more fitting connectors, the third cannula assembly being different from the first cannula assembly, the second cannula assembly or both

29. The kit according to claim 19, wherein each mating connector includes a threaded portion.

30. The kit according to claim 19, wherein one mating connector includes a detent, and one connector includes at least one wall defining an opening extending at least partially through the wall, the opening being configured to receive a portion of the detent.

31. The kit according to claim 19, wherein each mating connector includes a detent, and each connector includes at least one wall defining an opening extending at least partially through the wall, the opening being configured to receive a portion of the detent.

32. The kit according to claim 19, wherein each mating connector further includes a silicone gasket, and the detent is positioned between the silicone gasket and the connector.

33. The kit according to claim 19, wherein each mating connector, each connector or both include a magnetic element.

34. The kit according to claim 19, further including a controller configured to control the pump assembly.

35. The kit according to claim 19, wherein the first cannula assembly is configured to be attached to the pump assembly by a clinician prior to a medical procedure.

36. The kit according to claim 19, wherein the first cannula assembly is removably attachable to the pump assembly.

37. The kit according to claim 19, further including an inflow assembly, the inflow assembly being attachable to the first cannula assembly and / or the second cannula assembly.

38. The kit according to claim 19, wherein the first cannula assembly includes a sensor.

39. A method of providing a percutaneous ventricular assist device having a pump assembly and a plurality of cannula assemblies, comprising: selecting a first cannula assembly of the plurality of cannula assemblies based on patient characteristics; attaching the first cannula assembly to the pump assembly by connecting one or more connectors of the first cannula assembly to one or more connectors of the pump assembly. A method including the above steps.

40. The method according to claim 39, further including inserting the percutaneous ventricular assist device into a patient.

41. The method according to claim 39, further comprising attaching the inflow assembly to a first cannula via a connector coupled to a proximal portion of the inflow assembly, the first cannula including a fitting connector coupled to a distal portion of the first cannula assembly.

42. The method according to claim 39, wherein the first cannula assembly includes a first cannula and a first inlet cage.

43. The method according to claim 39, wherein the percutaneous ventricular assist device includes a pigtail assembly configured to be connected to a distal portion of the first cannula assembly.

44. The method according to claim 43, wherein the pigtail is fixedly attached to a distal end of the first cannula assembly such that the first cannula assembly and the pigtail can be attached to the pump assembly as a single combined assembly.

45. The method according to claim 44, wherein the first cannula assembly includes a first cannula and a first inflow cage, and the pigtail is fixedly attached to the first inflow cage.

46. The method according to claim 43, wherein the first cannula assembly includes a first cannula and a first inflow cage, and the pigtail is removably attachable to the first inflow cage.

47. The method according to claim 39, wherein the first cannula assembly includes a first cannula and a first inflow cage.

48. The method according to claim 47, wherein the plurality of cannula assemblies includes a second cannula assembly including a second cannula and a second inflow cage.

49. The method according to claim 48, wherein the first cannula is longer than the second cannula.

50. The method according to claim 49, wherein the first cannula is curved.

51. The method according to claim 50, wherein the second cannula is straight.

52. The method according to claim 39, wherein the pump assembly includes a motor operably connected to an impeller, the impeller being configured to flow blood through a first inlet cage, at least one of the plurality of cannula assemblies, or a combination thereof.

53. The method according to claim 39, wherein the percutaneous ventricular assist device further includes a controller configured to control the pump assembly.

54. The method according to claim 39, wherein the first cannula assembly is attached to the pump assembly by a clinician before a medical treatment.

55. The method according to claim 39, wherein the first cannula assembly is removably attachable to the pump assembly.

56. A percutaneous ventricular assist device, A pump assembly having a tip and a base end, A first cannula assembly having a first cannula and a sensor, the first cannula assembly having a tip and a base end, the base end being attached to the pump assembly, and the tip having one or more connectors. A second cannula assembly having a second cannula and a first inflow cage, the second cannula including one or more mating connectors engageable with the one or more connectors of the first cannula assembly such that the second cannula assembly can be attached to the first cannula assembly by a clinician before a medical treatment. A percutaneous ventricular assist device including the above.

57. The percutaneous ventricular assist device according to claim 56, further including a pigtail operably coupled to a tip portion of the second cannula assembly.

58. The percutaneous ventricular assist device according to claim 56, which is a heart pump using a catheter.

59. The pump assembly includes a motor operably connected to an impeller, and the impeller is configured to flow blood through a first inlet cage of the second cannula assembly, the first cannula assembly, the second cannula assembly, or a combination thereof. The percutaneous ventricular assist device according to claim 56.

60. The percutaneous ventricular assist device according to claim 56, wherein the one or more connectors include threaded connectors.

61. The percutaneous ventricular assist device according to claim 56, wherein the one or more mating connectors, the one or more connectors, or both have a coating containing an additive.

62. The percutaneous ventricular assist device according to claim 61, wherein the additive includes silicone.

63. The one or more mating connectors include a backstop, and the one or more connectors include at least one wall defining an opening that at least partially extends through the wall, the opening being configured to receive a portion of the backstop, the percutaneous ventricular assist device of claim 56.

64. The percutaneous ventricular assist device of claim 56, wherein each mating connector, each connector, or both include a magnetic element.

65. A method comprising providing a ventricular assist device having a pump assembly and a first cannula assembly, the first cannula assembly having a first cannula, the providing step comprising reducing the length of the first cannula of the first cannula assembly to achieve a defined length of the first cannula comprising, method.

66. The method of claim 65, wherein reducing the length of the first cannula includes removing the length of the first cannula.

67. The method of claim 65, wherein the providing step includes attaching the first cannula assembly to the pump assembly via one or more connectors and one or more corresponding mating connectors.

68. The method of claim 65, wherein the first cannula assembly includes an inlet cage.

69. The method of claim 65, wherein the providing step includes attaching a second cannula assembly to the first cannula assembly via one or more connectors and one or more corresponding mating connectors.

70. The method of claim 69, wherein the second cannula assembly includes an inlet cage.

71. The method according to any one of claims 68 to 70, wherein each of the first and / or second cannula assemblies includes a sensor.

72. The method of claim 65, wherein the first cannula is permanently attached to the pump assembly.

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